LOCUS       NM_001398677            2306 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neurogenin 2 (Neurog2), mRNA.
ACCESSION   NM_001398677 XM_008761481
VERSION     NM_001398677.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Liu,X.H., Ning,F.B., Zhao,D.P., Chang,Y.Y., Wu,H.M., Zhang,W.H. and
            Yu,A.L.
  TITLE     Role of miR-211 in a PC12 cell model of Alzheimer's disease via
            regulation of neurogenin 2
  JOURNAL   Exp Physiol 106 (4), 1061-1071 (2021)
   PUBMED   33527539
  REMARK    GeneRIF: Role of miR-211 in a PC12 cell model of Alzheimer's
            disease via regulation of neurogenin 2.
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Tang,L., Lu,X., Zhu,R., Qian,T., Tao,Y., Li,K., Zheng,J., Zhao,P.,
            Li,S., Wang,X. and Li,L.
  TITLE     Adipose-Derived Stem Cells Expressing the Neurogenin-2 Promote
            Functional Recovery After Spinal Cord Injury in Rat
  JOURNAL   Cell Mol Neurobiol 36 (5), 657-667 (2016)
   PUBMED   26283493
  REMARK    GeneRIF: transplantation of neurogenin2-overexpressed
            adipose-derived stem cells promote the functional recovery from
            spinal cord injury
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Dai,X., Lu,X., Cheng,F., Hao,H., Qian,T., Yu,W., Tang,L. and Li,L.
  TITLE     Neurogenin 2 enhances the neuronal differentiation of skin-derived
            precursors
  JOURNAL   Int J Neurosci 125 (5), 367-374 (2015)
   PUBMED   24946204
  REMARK    GeneRIF: This study demonstrated that Neurogenin 2 enhances the
            neuronal differentiation of skin-derived precursors.
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Cheng,F., Lu,X.C., Hao,H.Y., Dai,X.L., Qian,T.D., Huang,B.S.,
            Tang,L.J., Yu,W. and Li,L.X.
  TITLE     Neurogenin 2 converts mesenchymal stem cells into a neural
            precursor fate and improves functional recovery after experimental
            stroke
  JOURNAL   Cell Physiol Biochem 33 (3), 847-858 (2014)
   PUBMED   24685606
  REMARK    GeneRIF: Ngn2 was sufficient to convert MSCs into a neural
            precursor fate and transplantation of Ngn2-MSCs was advantageous
            for the treatment of stroke rats.
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Itoh,Y., Moriyama,Y., Hasegawa,T., Endo,T.A., Toyoda,T. and
            Gotoh,Y.
  TITLE     Scratch regulates neuronal migration onset via an
            epithelial-mesenchymal transition-like mechanism
  JOURNAL   Nat Neurosci 16 (4), 416-425 (2013)
   PUBMED   23434913
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Lee,S.K., Lee,B., Ruiz,E.C. and Pfaff,S.L.
  TITLE     Olig2 and Ngn2 function in opposition to modulate gene expression
            in motor neuron progenitor cells
  JOURNAL   Genes Dev 19 (2), 282-294 (2005)
   PUBMED   15655114
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Schuurmans,C., Armant,O., Nieto,M., Stenman,J.M., Britz,O.,
            Klenin,N., Brown,C., Langevin,L.M., Seibt,J., Tang,H.,
            Cunningham,J.M., Dyck,R., Walsh,C., Campbell,K., Polleux,F. and
            Guillemot,F.
  TITLE     Sequential phases of cortical specification involve
            Neurogenin-dependent and -independent pathways
  JOURNAL   EMBO J 23 (14), 2892-2902 (2004)
   PUBMED   15229646
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Lin,C.H., Stoeck,J., Ravanpay,A.C., Guillemot,F., Tapscott,S.J. and
            Olson,J.M.
  TITLE     Regulation of neuroD2 expression in mouse brain
  JOURNAL   Dev Biol 265 (1), 234-245 (2004)
   PUBMED   14697366
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Seibt,J., Schuurmans,C., Gradwhol,G., Dehay,C., Vanderhaeghen,P.,
            Guillemot,F. and Polleux,F.
  TITLE     Neurogenin2 specifies the connectivity of thalamic neurons by
            controlling axon responsiveness to intermediate target cues
  JOURNAL   Neuron 39 (3), 439-452 (2003)
   PUBMED   12895419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2021 this sequence version replaced XM_008761481.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840105,
                              SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000002.1  218767205-218767595
            392-2306            JAXUCZ010000002.1  218767858-218769772
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2306
                     /gene="Neurog2"
                     /gene_synonym="Ngn2"
                     /note="neurogenin 2"
                     /db_xref="GeneID:295475"
                     /db_xref="RGD:1309061"
     exon            1..391
                     /gene="Neurog2"
                     /gene_synonym="Ngn2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..2306
                     /gene="Neurog2"
                     /gene_synonym="Ngn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..1184
                     /gene="Neurog2"
                     /gene_synonym="Ngn2"
                     /codon_start=1
                     /product="neurogenin-2"
                     /protein_id="NP_001385606.1"
                     /db_xref="GeneID:295475"
                     /db_xref="RGD:1309061"
                     /translation="MFVKSETLELKEEEEVLMLLGSASPASATLTPMSSSADEEEDEE
                     LRRPGAARGQRGAEAGQGVQGSSASGAGGCRPGRLLGLVHECKRRPSRARAVSRGAKT
                     AETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNY
                     IWALTETLRLADHCAGGGSLQGALFSEAVLLSPGAALGASGDSPSPSSSWSCTNSPAS
                     SSNSTSPYSCTLSPASPGSDVDYWQPPPPEKHRYAPHLPLARDCI"
ORIGIN      
        1 gccagacacg cagccactga accacaagca gctcggcttt aactggagtg cttgggagtc
       61 gcgtgccagc agccgcacgg ccagggactg actgacagac ggacacgcac gagcacaaca
      121 cacgagaccc aggcgggctg ccgcggtcgc ccgggctctt ggcaaagtcg cccagcagaa
      181 aggccccccg cagaggtgcg ccgaggaagc gccaagccgg cggcgcggag gacaccgtgc
      241 tccgttccgg gctgcgggga cattcccaga cacacacaca cacacacgcg cgcgcgcgcg
      301 cacacacaca cacacacaca cacacacaca cacacacacc ccacacacac cagagcagca
      361 gctgcaccgc gacacatctg gagccgggta ggatgttcgt caagtccgag actctggagt
      421 tgaaggagga agaggaggta ctgatgctgc tgggttcggc ttccccagcc tcggcgaccc
      481 tgactccgat gtcctccagc gcggacgagg aggaggacga ggagctgcgc cggccaggcg
      541 ccgcgcgtgg gcagcgcggg gcggaagccg ggcagggggt gcagggcagt tcggcgtcgg
      601 gtgccggggg ttgccggcca gggaggctgc tgggcctggt gcacgagtgc aagcgtcgcc
      661 cgtcgcgcgc acgggccgtc tcccgaggcg ccaagactgc ggagacggtg cagcgcatca
      721 agaagacccg caggctcaaa gccaacaacc gcgagcgcaa ccgcatgcac aacctgaacg
      781 ccgcgctgga cgcgctgcgc gaggtgctgc ccaccttccc cgaggacgcc aagctcacga
      841 agatcgagac gctccgcttc gcccacaatt acatctgggc gctcaccgag accctccgcc
      901 tggcggacca ctgcgcgggc ggtggcagcc tccagggggc gctcttctcc gaggcggtgc
      961 tgctgagccc cggagcggcg ctcggcgcca gcggggacag cccttcgcca tcctcctcct
     1021 ggagctgcac caacagcccc gcgtcctcct ccaactccac gtccccatac agctgcactt
     1081 tatcacccgc tagccccggg tcagacgtgg actactggca gcccccacct ccggagaagc
     1141 accgttatgc acctcacctg cccctcgcca gggactgtat ctagagcagc cgggtctccc
     1201 tctttcgtcc tctacctggc cctcttccca cctttctcct gtcccccagc ctccgtgccc
     1261 cgcactccac ttcacagagc agaggtggcc tttgctatcc cctcggctgc tggtgcattc
     1321 gggtgtggag acccgctttg atttattgaa gatgtgagga tttatggtca aaggattatg
     1381 gcgtgcgggg ttgcggtggg agttggggct gggagggggg tggacttcgt gagactataa
     1441 agagactgag gaaaagtacc ataactaacg agtgtgcaga gcagactgac gatcttcccc
     1501 tctctggaag ctgctgctgg agagctccgg ccagcagttc gtgtgaatct ctcagaggga
     1561 atgcaactgg tccctgtgat cttttcacct tcatttttat atagagatgt taatgtcaat
     1621 cgaaagaaat gtatcttagc atctgaatga atttacccgt aataatatta tccacacatt
     1681 tgcaatggct ggcatctgct ctattcccat tgctgttcgc aggctgtggg aatttcacct
     1741 gtcaaaccaa actttccctc tctgatgtgc actttgtttt ttttcccaga ttcgtcacaa
     1801 tgcctattgt cccgcccttc tctttccttt tctctccatt ttgccatctg tctcttatga
     1861 tttataaggg gaaaaacttg ttttgttaga gggccaggtt agaagtcatt gtataatttg
     1921 taggcttttg taaggattga atgcaagcgt ggaaatttag gctgaattct ctatcaaaag
     1981 aaaaaatgtg aagggaaagg gaaaaatcag gagggaggat cgcttcatgc attatttatc
     2041 tcgacctttt gggggagaag gaactccccc atcctttcaa gagattaaaa ataaatcaac
     2101 agtctgaaaa cctaagcaga cacggggcat taccaggatc agccacacac gtgtttcctt
     2161 ctatttattt tgaagaaaaa tttcatggga aaagtatgta tttttttgta tattctacag
     2221 agtttattct agtatgtatt gacatctcaa agaacaagga aattgttctg tgattaagct
     2281 ataaataaag tatctaattt tcctaa
//
