LOCUS       NM_019207               1520 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus neurogenin 1 (Neurog1), mRNA.
ACCESSION   NM_019207 XM_346496
VERSION     NM_019207.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Zhang,X., Zhu,C., Luo,Q., Dong,J., Liu,L., Li,M., Zhu,H., Ma,X. and
            Wang,J.
  TITLE     Impact of siRNA targeting of beta-catenin on differentiation of rat
            neural stem cells and gene expression of Ngn1 and BMP4 following in
            vitro hypoxic-ischemic brain damage
  JOURNAL   Mol Med Rep 14 (4), 3595-3601 (2016)
   PUBMED   27573468
  REMARK    GeneRIF: beta-Catenin siRNA reduces Ngnl1 and increases BMP4 mRNA
            expression levels in rat neural stem cells.
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Itoh,Y., Moriyama,Y., Hasegawa,T., Endo,T.A., Toyoda,T. and
            Gotoh,Y.
  TITLE     Scratch regulates neuronal migration onset via an
            epithelial-mesenchymal transition-like mechanism
  JOURNAL   Nat Neurosci 16 (4), 416-425 (2013)
   PUBMED   23434913
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Velkey,J.M. and O'Shea,K.S.
  TITLE     Expression of Neurogenin 1 in mouse embryonic stem cells directs
            the differentiation of neuronal precursors and identifies unique
            patterns of down-stream gene expression
  JOURNAL   Dev Dyn 242 (3), 230-253 (2013)
   PUBMED   23288605
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Schroder,J.C., Lassig,A.K., Galetzka,D., Peters,A., Castle,J.C.,
            Diederich,S., Zechner,U., Muller-Forell,W., Keilmann,A. and
            Bartsch,O.
  TITLE     A boy with homozygous microdeletion of NEUROG1 presents with a
            congenital cranial dysinnervation disorder [Moebius syndrome
            variant]
  JOURNAL   Behav Brain Funct 9, 7 (2013)
   PUBMED   23419067
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Ahmed,M., Xu,J. and Xu,P.X.
  TITLE     EYA1 and SIX1 drive the neuronal developmental program in
            cooperation with the SWI/SNF chromatin-remodeling complex and SOX2
            in the mammalian inner ear
  JOURNAL   Development 139 (11), 1965-1977 (2012)
   PUBMED   22513373
REFERENCE   6  (bases 1 to 1520)
  AUTHORS   Balmer,C.W. and LaMantia,A.S.
  TITLE     Loss of Gli3 and Shh function disrupts olfactory axon trajectories
  JOURNAL   J Comp Neurol 472 (3), 292-307 (2004)
   PUBMED   15065125
REFERENCE   7  (bases 1 to 1520)
  AUTHORS   Lin,C.H., Stoeck,J., Ravanpay,A.C., Guillemot,F., Tapscott,S.J. and
            Olson,J.M.
  TITLE     Regulation of neuroD2 expression in mouse brain
  JOURNAL   Dev Biol 265 (1), 234-245 (2004)
   PUBMED   14697366
REFERENCE   8  (bases 1 to 1520)
  AUTHORS   Lo,L., Dormand,E., Greenwood,A. and Anderson,D.J.
  TITLE     Comparison of the generic neuronal differentiation and neuron
            subtype specification functions of mammalian achaete-scute and
            atonal homologs in cultured neural progenitor cells
  JOURNAL   Development 129 (7), 1553-1567 (2002)
   PUBMED   11923194
  REMARK    GeneRIF: Comparison of the generic neuronal differentiation and
            neuron subtype specification functions of mammalian achaete-scute
            and atonal homologs in cultured neural progenitor cells.
REFERENCE   9  (bases 1 to 1520)
  AUTHORS   Farah,M.H., Olson,J.M., Sucic,H.B., Hume,R.I., Tapscott,S.J. and
            Turner,D.L.
  TITLE     Generation of neurons by transient expression of neural bHLH
            proteins in mammalian cells
  JOURNAL   Development 127 (4), 693-702 (2000)
   PUBMED   10648228
REFERENCE   10 (bases 1 to 1520)
  AUTHORS   Ma,Q., Kintner,C. and Anderson,D.J.
  TITLE     Identification of neurogenin, a vertebrate neuronal determination
            gene
  JOURNAL   Cell 87 (1), 43-52 (1996)
   PUBMED   8858147
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019207.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U67777.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1520              JAXUCZ010000017.1  8368096-8369615
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1520
                     /gene="Neurog1"
                     /gene_synonym="Neurod3; Ngn1"
                     /note="neurogenin 1"
                     /db_xref="GeneID:29410"
                     /db_xref="RGD:3167"
     exon            1..1520
                     /gene="Neurog1"
                     /gene_synonym="Neurod3; Ngn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..978
                     /gene="Neurog1"
                     /gene_synonym="Neurod3; Ngn1"
                     /note="neurogenic differentiation factor 3; neurogenic
                     basic-helix-loop-helix protein; NGN-1; neurogenic
                     differentiation 3"
                     /codon_start=1
                     /product="neurogenin-1"
                     /protein_id="NP_062080.1"
                     /db_xref="GeneID:29410"
                     /db_xref="RGD:3167"
                     /translation="MPAPLETCLSDLDCASSNSGSDLSSFLTDEEDCARLQPLASTSG
                     LSVPARRSAPTLSGASNVPGGQDEEQERRRRRGRARVRSEALLHSLRRSRRVKANDRE
                     RNRMHNLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGG
                     ARERLLPPQCVPCLPGPPSPASDTESWGSGAAASPCATVASPLSDPSSPSASEDFTYG
                     PGGPLFSFPGLPKDLLHTTPCFIPYH"
ORIGIN      
        1 gagctgatct gatcgccggc gacatcactc gggagaccag cccggcgcgt ggcccctgca
       61 ggcgaggcga ggaggccaag cccattccct ccctgagccc ctgcgatctt ccccggccct
      121 cgcgcctgca gcaggcacag gctagccgcg ggtcatacgg acagtaagtg cgcttcgaag
      181 gccgtgcact cggcccacat tcaagccctc caaacctccc gtccgtccgt ccgtcctgca
      241 acgatgcctg cccctttgga gacctgtctc tctgacctcg actgcgccag cagcaacagc
      301 ggcagcgacc tgtccagttt cctcaccgac gaggaggact gtgccaggct ccagccccta
      361 gcttccacct cagggctgtc cgtgccagcc cgcaggagcg cgcccaccct ctccggggca
      421 tcgaacgttc ccggtggcca ggacgaagag caggagcggc ggcgacggcg aggtcgcgcg
      481 cgggtgcggt ccgaggcgct gctgcactcg ctgcggagga gccgtcgcgt caaggccaac
      541 gatcgcgagc gcaaccgtat gcataacctc aacgctgcgc tggacgctct gcgcagcgtg
      601 ctgccctcgt tccccgacga caccaagctc accaagattg agacgctgcg cttcgcctac
      661 aactacatct gggccctggc tgagacactg cgcctggcag atcaagggct cccggggggc
      721 ggtgcccggg agcgcctcct gcctccgcag tgtgtcccct gcctgcccgg tcccccgagc
      781 ccggccagcg atacagagtc ctggggctcc ggggccgctg cctccccctg cgctactgtg
      841 gcgtcaccac tctctgaccc cagtagtccc tcggcttcag aagacttcac ctatggcccg
      901 ggtggtcccc ttttctcctt tcctggcctg cccaaagacc tcctccatac gacaccctgc
      961 ttcatcccgt accactaggc ctttgcaaga caacgttaat actttcttcc tgccccagtc
     1021 taagagcaat agatggggga gccggctgaa gcctcgggga ccacccttac ccccaggtgg
     1081 atgctgggag ctttaaagag gggagggata cctgaccact tgctaggttg ccgcaccctc
     1141 gctgagaagc tgcccctcgg actgtttccc cacgccccag caccggcccc tcctgcccgc
     1201 cccccagacg gcctttcggt ttttttttgc actttctgaa cttcacaaaa cctcctttgt
     1261 gactggctca gaactgaccc cagccaccac ttcagtgtga tttggaaaag ggacagatga
     1321 gcccctgaag acgaggtgaa aagtcaattt tacaatttgt agaactctaa tgaagaaaaa
     1381 cgagcatgaa aattcggttt gagccggctg acaatacaat gaaaaggctt aaaaaaaagg
     1441 agacacaagg agtgggcttc atgcattatg gatcccgacc cccaccactg tgggcttgct
     1501 cccggaagaa cctgagtgct
//
