LOCUS       NM_001109237            1953 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus neuronal differentiation 6 (Neurod6), mRNA.
ACCESSION   NM_001109237 XM_001059051 XM_575489
VERSION     NM_001109237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1953)
  AUTHORS   Uittenbogaard M, Baxter KK and Chiaramello A.
  TITLE     The neurogenic basic helix-loop-helix transcription factor NeuroD6
            confers tolerance to oxidative stress by triggering an antioxidant
            response and sustaining the mitochondrial biomass
  JOURNAL   ASN Neuro 2 (2), e00034 (2010)
   PUBMED   20517466
  REMARK    GeneRIF: NeuroD6 confers tolerance to oxidative stress by
            triggering an antioxidant response.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1953)
  AUTHORS   Uittenbogaard M, Baxter KK and Chiaramello A.
  TITLE     NeuroD6 genomic signature bridging neuronal differentiation to
            survival via the molecular chaperone network
  JOURNAL   J Neurosci Res 88 (1), 33-54 (2010)
   PUBMED   19610105
  REMARK    GeneRIF: our findings support the notion that NeuroD6 links
            neuronal differentiation to survival via the network of molecular
            chaperones and endows the cells with increased stress tolerance.
REFERENCE   3  (bases 1 to 1953)
  AUTHORS   Uittenbogaard M and Chiaramello A.
  TITLE     The basic helix-loop-helix transcription factor Nex-1/Math-2
            promotes neuronal survival of PC12 cells by modulating the dynamic
            expression of anti-apoptotic and cell cycle regulators
  JOURNAL   J Neurochem 92 (3), 585-596 (2005)
   PUBMED   15659228
  REMARK    GeneRIF: This study provides first evidence of the underlying
            mechanism by which the basic helix-loop-helix transcription factor
            Nex1/Math-2 of the NeuroD-subfamily promotes an active
            anti-apoptotic program essential to the survival of neurons.
REFERENCE   4  (bases 1 to 1953)
  AUTHORS   Uittenbogaard M, Martinka DL and Chiaramello A.
  TITLE     The basic helix-loop-helix differentiation factor Nex1/MATH-2
            functions as a key activator of the GAP-43 gene
  JOURNAL   J Neurochem 84 (4), 678-688 (2003)
   PUBMED   12562512
REFERENCE   5  (bases 1 to 1953)
  AUTHORS   Schwab MH, Bartholomae A, Heimrich B, Feldmeyer D, Druffel-Augustin
            S, Goebbels S, Naya FJ, Zhao S, Frotscher M, Tsai MJ and Nave KA.
  TITLE     Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D)
            regulate terminal granule cell differentiation in the hippocampus
  JOURNAL   J Neurosci 20 (10), 3714-3724 (2000)
   PUBMED   10804213
  REMARK    Erratum:[J Neurosci 2000 Nov 1;20(21):8227]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474011.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059051.1, XM_575489.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY314321.1, CD568140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1953
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1953
                     /gene="Neurod6"
                     /gene_synonym="RGD1562793"
                     /note="neuronal differentiation 6"
                     /db_xref="GeneID:500137"
                     /db_xref="RGD:1562793"
     exon            1..135
                     /gene="Neurod6"
                     /gene_synonym="RGD1562793"
                     /inference="alignment:Splign:2.1.0"
     exon            136..1953
                     /gene="Neurod6"
                     /gene_synonym="RGD1562793"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1170
                     /gene="Neurod6"
                     /gene_synonym="RGD1562793"
                     /note="neurogenic differentiation 6"
                     /codon_start=1
                     /product="neurogenic differentiation factor 6"
                     /protein_id="NP_001102707.1"
                     /db_xref="GeneID:500137"
                     /db_xref="RGD:1562793"
                     /translation="MLTLPFDESVVMPESQMCRKFARQCEDQKQIKKPESFPKQVVLR
                     GKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVKFRRQEANAR
                     ERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLT
                     FVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELAT
                     PPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQE
                     ETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAV
                     FHN"
ORIGIN      
        1 cactttttag agatcaatga gatagtgcag atacacacag atctagaggc tccaggagac
       61 gatgcgacac tcagcctgaa aagatttgga agatccaaaa tgaaaactga ttattgaatg
      121 aaattaaaac ctaaggtaaa ttaaggttaa agaaccatgt taacactacc gtttgacgag
      181 tctgtcgtaa tgcccgaatc ccagatgtgc agaaagtttg ctagacaatg tgaggaccag
      241 aaacaaatta agaaaccaga gagttttcca aaacaagttg tccttcgagg aaagagcatt
      301 aaaagggccc ccggagaaga aaccgagaaa gaggaggagg aggaagacag agaggaagaa
      361 gatgagaatg gcttgcccag aaggaggggt ctcaggaaaa aaaagaccac caaactacga
      421 ttggaaaggg tcaagttcag gagacaggaa gccaatgcac gagagaggaa ccggatgcac
      481 ggcctcaatg atgctctgga caatttgcga aaagtggtcc cctgttactc taaaacccaa
      541 aaactgtcca aaatagaaac tttacggctg gccaaaaatt acatctgggc actttctgaa
      601 attctgagga ttggcaagag accggatctg ctcacgttcg tccaaaactt atgcaaaggt
      661 ctttctcagc caactacaaa cttggtggca ggctgcttac agctcaacgc caggagtttc
      721 ctgatgggtc agggtgggga ggctgcccac cacacaaggt caccctactc cacattctac
      781 ccaccctacc acagccctga gctggccact cccccagggc atgggactct tgataattcc
      841 aagtccatga aaccctacaa ttactgcagt gcatatgaat ccttctatga aagtacttcc
      901 cctgagtgtg ccagccctca gtttgaaggt cccttaagtc ctcccccaat taactataat
      961 gggatatttt ccctgaagca agaagaaacc ttggactatg gcaaaaatta caattatggc
     1021 atgcattact gtgcagtgcc acccaggggt ccccttgggc agggtgccat gttcaggttg
     1081 cccaccgaca gccacttccc ttacgactta catctgcgca gccaatctct cactatgcaa
     1141 gatgaattaa atgcagtttt tcataattaa tgaggaaaat gaaaataaac agtggtcatt
     1201 cacctcccac tctaattaag acaaagcaga tgcttgtggg ctgagtaatt ggcacaactc
     1261 tatctaaggt gtttactagt ttctgaagtg tgtttcaaag attgtgaaca ttttctatgt
     1321 cataataaat ctcttttcgt atgagaattt cttttccttc cctcttgtct gtatcacact
     1381 gtgatgattc tctctctctc tcttactggc aggatttttt ctttcttgtt ttagttcctt
     1441 tcaaattccc ttaatttggt taacaaggcg tcgaagagta tgttgcggag taaagacagc
     1501 acacggcata cttcggtgtc tatttcggtt gtacagttat gatgaagatg catgttataa
     1561 aaaaatcaga taagtaaaat gtgtttataa ttactaggac tcatatatgt atctctgaaa
     1621 ttttaggttt ttaaactatc aagagctaac cctgaaatta aaagacgcat tcgaggatgt
     1681 acaacaatat caaaagctat gcaattttct gtttattagg gacaaaacta aatgtaatga
     1741 ctattcctcc tcaagcgttt tccagaggag gaaacacagt atttggggga ggttatcagt
     1801 gtcataattg ggggacaatt aattcagtca caaagaaaaa tattagcact tgttttgtat
     1861 tgttcaggat tcttctgtac aggtttgtta cggtgtataa ttgtgttttc catcctagag
     1921 tttaaaagca attaaacata gatatttcca ctt
//
