LOCUS       NM_001105942            3311 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neuronal differentiation 4 (Neurod4), mRNA.
ACCESSION   NM_001105942 XM_001069193 XM_001069240 XM_001069285 XM_222370
VERSION     NM_001105942.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Wang,J. and Liu,G.
  TITLE     Protective effect of microRNA-340-5p against oxygen-glucose
            deprivation/reperfusion in PC12 cells through targeting neuronal
            differentiation 4
  JOURNAL   Mol Med Rep 22 (2), 964-974 (2020)
   PUBMED   32468054
  REMARK    GeneRIF: Protective effect of microRNA3405p against oxygenglucose
            deprivation/reperfusion in PC12 cells through targeting neuronal
            differentiation 4.
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Dai,J., Xu,L.J., Han,G.D., Sun,H.L., Zhu,G.T., Jiang,H.T., Yu,G.Y.
            and Tang,X.M.
  TITLE     MiR-137 attenuates spinal cord injury by modulating NEUROD4 through
            reducing inflammation and oxidative stress
  JOURNAL   Eur Rev Med Pharmacol Sci 22 (7), 1884-1890 (2018)
   PUBMED   29687839
  REMARK    GeneRIF: miR-137 promoted the recovery of spinal cord injury by
            degrading NEUROD4 to relieve the spinal cord inflammation and the
            progression of oxidative stress, thus promoting the recovery of
            spinal cord injury.
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   Ohsawa,R., Ohtsuka,T. and Kageyama,R.
  TITLE     Mash1 and Math3 are required for development of branchiomotor
            neurons and maintenance of neural progenitors
  JOURNAL   J Neurosci 25 (25), 5857-5865 (2005)
   PUBMED   15976074
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Bhattacharya,S., Dooley,C., Soto,F., Madson,J., Das,A.V. and
            Ahmad,I.
  TITLE     Involvement of Ath3 in CNTF-mediated differentiation of the late
            retinal progenitors
  JOURNAL   Mol Cell Neurosci 27 (1), 32-43 (2004)
   PUBMED   15345241
REFERENCE   5  (bases 1 to 3311)
  AUTHORS   Inoue,T., Hojo,M., Bessho,Y., Tano,Y., Lee,J.E. and Kageyama,R.
  TITLE     Math3 and NeuroD regulate amacrine cell fate specification in the
            retina
  JOURNAL   Development 129 (4), 831-842 (2002)
   PUBMED   11861467
REFERENCE   6  (bases 1 to 3311)
  AUTHORS   Tomita,K., Moriyoshi,K., Nakanishi,S., Guillemot,F. and Kageyama,R.
  TITLE     Mammalian achaete-scute and atonal homologs regulate neuronal
            versus glial fate determination in the central nervous system
  JOURNAL   EMBO J 19 (20), 5460-5472 (2000)
   PUBMED   11032813
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001105942.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1710469.1,
                                           SRR26360190.432952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663598, SAMN17050745
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000007.1  7752753-7752824     c
            73-3311             JAXUCZ010000007.1  7740852-7744090     c
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3311
                     /gene="Neurod4"
                     /note="neuronal differentiation 4"
                     /db_xref="GeneID:288821"
                     /db_xref="RGD:1310434"
     exon            1..72
                     /gene="Neurod4"
                     /inference="alignment:Splign:2.1.0"
     exon            73..3311
                     /gene="Neurod4"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1074
                     /gene="Neurod4"
                     /note="neurogenic differentiation 4"
                     /codon_start=1
                     /product="neurogenic differentiation factor 4"
                     /protein_id="NP_001099412.2"
                     /db_xref="GeneID:288821"
                     /db_xref="RGD:1310434"
                     /translation="MAKMYMKSKDMVELVNTQSWMDKGLSSQNEMEEQERRPGSYGML
                     GTLMEEHDSIEEEEEEEEDGDKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHG
                     LNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTLEGKGFVEMLCK
                     GLSQPTSNLVAGCLQLGPQSALLEKREEKSPICDSTVSVHSFNYQSPGLPSPPYGHME
                     THPLHLKPQPFKSLGDSFGSHPPDCSTPPYEGPLTPPLSISGNFSLKQEGSPDLEKSY
                     NFMPHYTSASVSSGHVHSTPFQTGTPRYDVPVDLTYDSYPHHGIGTQINTIFSD"
ORIGIN      
        1 tcagatcaca ggagctgccc agagactgtg gtactgaaag agctactcgc gggagctgac
       61 tccgggaaag agaatctata gatggcaaaa atgtacatga aatccaagga tatggtggag
      121 ctggtcaaca cacaatcctg gatggacaaa ggtctgagct ctcaaaatga gatggaggag
      181 caagagagaa gaccagggtc ttatggaatg cttggaacct taatggaaga gcatgacagt
      241 attgaagagg aggaagaaga ggaagaagat ggagataagc ctaaaagaag aggccccaag
      301 aaaaagaaga tgactaaagc tcgcctggaa aggttcaggg ctcgaagagt caaggccaat
      361 gctagagaac gaacccggat gcatggcctg aatgatgcct tggataatct tagaagagtc
      421 atgccatgtt actctaaaac tcaaaagctt tccaagatag agactcttcg actggcaagg
      481 aactacatct gggccttgtc tgaagtcttg gaaactggtc agacacttga agggaaggga
      541 tttgtggaaa tgctatgtaa aggtctctct cagcccacaa gcaacctggt tgctggatgc
      601 ctccaactgg ggcctcaatc tgccctcttg gagaagcgtg aggaaaaatc tccaatttgt
      661 gactctactg tctctgtcca cagcttcaac tatcagtctc cagggctccc cagccctcct
      721 tatggccata tggaaacaca tcctctccat ctcaagcctc aaccatttaa gagtttggga
      781 gactcttttg ggagccatcc acctgactgc agtacccccc cttatgaggg tccactcaca
      841 ccacccctga gtattagtgg caacttctcc ttaaagcaag agggctcccc cgacttggaa
      901 aaatcctaca acttcatgcc acattatacc tctgcaagtg taagttcagg gcatgtgcat
      961 tcaacgccct tccagactgg cactccacgc tatgatgttc ctgtagacct gacctatgat
     1021 tcctaccccc accacggtat tggaactcag atcaatacaa tcttctccga ttagagcaat
     1081 aagataacca ccaaaatttc agagaatgaa atggagatgt tttccatgtt tctggtggct
     1141 gagctaaact ctcagagaat ttcaaagaac cttgatagac atcaacatag tggtcccagt
     1201 ttgttcagaa ctctctgtat ctgctaactt tcttctcgtt aactcctcac attggacctg
     1261 tcttatattt gggatcctca agtgaacata tttgatggtt tggggccaca tagtaataga
     1321 acagagagcc taggctctgc tccagtggtg ccaaagactg actggatgct ctgcccatta
     1381 actttccatt tccagtgttt gttgctttct aataaatatg aagcaactgt tctaaatcaa
     1441 catatacctt tcatctcttg tacattttta aaactgaaaa gcaataaaag gaaacagcct
     1501 aaatgaaatg attatacaga actgaaaggg ccatcaggta tatgtctgtt ggcttataga
     1561 acacaaaatt tgtgtgtttg acaactcatc tttgtgtcta tttaactata acttctagag
     1621 cctaaaataa taacatggat gttaccataa atagccaaga atgttcttga agagattagc
     1681 tctacttctt actgtgccga aaggtatcca caaacttttt agtgattgca gagccaggaa
     1741 ataagcctca tacaaacttt gttcttgata ctatttaaaa aacaactgtc ttagtactag
     1801 gagtcaagca agagagaatt gagatttctg ttctgtgaca cagaaatatc acccagctca
     1861 tttcttagct tctaagaact gaagggctgt gggaatttgg gtgttcaggt gcttcagtta
     1921 gaatcagaac tcagccaggt tcagtctgta gagcaataaa atggtggttg gctgacaccc
     1981 aactaacaca tgaaggactc tgcctcacat ctaaccactg gggaaaatct ggattttctc
     2041 tagcaagatg aatttcactg tttaaagtga tatgattaca gccacagagt tttgtccact
     2101 ccagtaccat gtattctagg acaataggca ctaatcagtc ttgaatcctc acaacataaa
     2161 tgtgactcct gactccactg atcgtttctt tgtcttcatt ttcaagatat catgctatca
     2221 tgctattatc aagcaaaatt ttgattagaa tcaaaattaa gggtcaatga aggtttttgt
     2281 ttgtatcttc agcataggtt ttaatcagtt ttaagaaagt ttattttctt tatgtggcat
     2341 cttttttatt ttgtatccac actggctttg ccaagtttct cttctgagaa attagctctg
     2401 agaaatttta ctatcatgat ccatcttcca cagccattat ttaggttcaa ctcaagaata
     2461 taaatagctt attaatttat agtgggtgag gatacatctc taaggataaa atttacaata
     2521 tcaatgacag aagaacatgt tatctatcta ccaaactata tatatgtatc ttttttcttt
     2581 attgctctta tttatttctt cacactgtga gttactttat gtccatctta ttgcagtact
     2641 tactctcctc taccttggac ctttggctta taaatatgtt taaaagtttg caaagaagtc
     2701 ttaaacaact gattcaacac cttgaatcgc cctcgtggga ataggaaagg agaattattt
     2761 atagagtcat cccatataat tttttgagaa tttgctgttc ttacctagta tttatgttta
     2821 tagataattg ctttctgcat tatttattag atactattta tttaatttat tttccccctt
     2881 ttatgtttaa attttagtcc catagatata tccttaaagc ctcagtggga aagtagctta
     2941 taagtttgga ctgagagaaa aggagaaatt ggttcttgat tgcttgtgat gcttttatta
     3001 aaaaagagca ataatttgaa tagctatgca aattaacggc tttagatttt ttcttttgag
     3061 gcacaacaga gttacatttt tatttatgcc tttagagaat ggagtacatg tgaaccaaga
     3121 ctatataaac ctgtgaagaa agattttata attgaataca aatttagtac tgtaccatgc
     3181 ttggaaagaa ctcgttcttt aaataatgtc tagtcttctg agaatgtttt tagataaaaa
     3241 tgaagcaatt gtttaaaaga aatgactgtt ttctctccct tttccagtaa taaagctttg
     3301 agtgttctta c
//
