LOCUS       NM_019326               2460 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuronal differentiation 2 (Neurod2), mRNA.
ACCESSION   NM_019326
VERSION     NM_019326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   van Weert,L.T.C.M., Buurstede,J.C., Mahfouz,A., Braakhuis,P.S.M.,
            Polman,J.A.E., Sips,H.C.M., Roozendaal,B., Balog,J., de Kloet,E.R.,
            Datson,N.A. and Meijer,O.C.
  TITLE     NeuroD Factors Discriminate Mineralocorticoid From Glucocorticoid
            Receptor DNA Binding in the Male Rat Brain
  JOURNAL   Endocrinology 158 (5), 1511-1522 (2017)
   PUBMED   28324065
  REMARK    GeneRIF: A NeuroD family member binding to an additional motif near
            the Glucocorticoid receptor response element seems to drive
            specificity for Mineralocorticoid receptor over glucocorticoid
            receptor binding at hippocampal binding sites.
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Chen,F., Moran,J.T., Zhang,Y., Ates,K.M., Yu,D., Schrader,L.A.,
            Das,P.M., Jones,F.E. and Hall,B.J.
  TITLE     The transcription factor NeuroD2 coordinates synaptic innervation
            and cell intrinsic properties to control excitability of cortical
            pyramidal neurons
  JOURNAL   J Physiol 594 (13), 3729-3744 (2016)
   PUBMED   27146976
  REMARK    GeneRIF: Our results reveal an important function for NeuroD2 in
            balancing synaptic neurotransmission and intrinsic excitability and
            offer insight into how these processes are coordinated during
            cortical development.
REFERENCE   3  (bases 1 to 2460)
  AUTHORS   Ravanpay,A.C., Hansen,S.J. and Olson,J.M.
  TITLE     Transcriptional inhibition of REST by NeuroD2 during neuronal
            differentiation
  JOURNAL   Mol Cell Neurosci 44 (2), 178-189 (2010)
   PUBMED   20346398
REFERENCE   4  (bases 1 to 2460)
  AUTHORS   Yang,Y., Kim,A.H., Yamada,T., Wu,B., Bilimoria,P.M., Ikeuchi,Y., de
            la Iglesia,N., Shen,J. and Bonni,A.
  TITLE     A Cdc20-APC ubiquitin signaling pathway regulates presynaptic
            differentiation
  JOURNAL   Science 326 (5952), 575-578 (2009)
   PUBMED   19900895
REFERENCE   5  (bases 1 to 2460)
  AUTHORS   Ravanpay,A.C. and Olson,J.M.
  TITLE     E protein dosage influences brain development more than family
            member identity
  JOURNAL   J Neurosci Res 86 (7), 1472-1481 (2008)
   PUBMED   18214987
REFERENCE   6  (bases 1 to 2460)
  AUTHORS   Rodriguez-Rodriguez,R.A., Tabernero,A., Velasco,A., Lavado,E.M. and
            Medina,J.M.
  TITLE     The neurotrophic effect of oleic acid includes dendritic
            differentiation and the expression of the neuronal basic
            helix-loop-helix transcription factor NeuroD2
  JOURNAL   J Neurochem 88 (5), 1041-1051 (2004)
   PUBMED   15009660
  REMARK    GeneRIF: The transduction pathway by which oleic acid induces the
            expression of genes responsible for neuronal differentiation
            appears to be mediated by the transcription factor NeuroD2, a
            regulator of terminal neuronal differentiation
REFERENCE   7  (bases 1 to 2460)
  AUTHORS   Lin,C.H., Stoeck,J., Ravanpay,A.C., Guillemot,F., Tapscott,S.J. and
            Olson,J.M.
  TITLE     Regulation of neuroD2 expression in mouse brain
  JOURNAL   Dev Biol 265 (1), 234-245 (2004)
   PUBMED   14697366
REFERENCE   8  (bases 1 to 2460)
  AUTHORS   Farah,M.H., Olson,J.M., Sucic,H.B., Hume,R.I., Tapscott,S.J. and
            Turner,D.L.
  TITLE     Generation of neurons by transient expression of neural bHLH
            proteins in mammalian cells
  JOURNAL   Development 127 (4), 693-702 (2000)
   PUBMED   10648228
REFERENCE   9  (bases 1 to 2460)
  AUTHORS   Konishi,Y., Ohkawa,N., Makino,Y., Ohkubo,H., Kageyama,R.,
            Furuichi,T., Mikoshiba,K. and Tamura,T.
  TITLE     Transcriptional regulation of mouse type 1 inositol
            1,4,5-trisphosphate receptor gene by NeuroD-related factor
  JOURNAL   J Neurochem 72 (4), 1717-1724 (1999)
   PUBMED   10098882
REFERENCE   10 (bases 1 to 2460)
  AUTHORS   Kume,H., Maruyama,K., Tomita,T., Iwatsubo,T., Saido,T.C. and
            Obata,K.
  TITLE     Molecular cloning of a novel basic helix-loop-helix protein from
            the rat brain
  JOURNAL   Biochem Biophys Res Commun 219 (2), 526-530 (1996)
   PUBMED   8605021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 25, 2020 this sequence version replaced NM_019326.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.63724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000010.1  83824066-83824277   c
            213-2460            JAXUCZ010000010.1  83820733-83822980   c
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2460
                     /gene="Neurod2"
                     /note="neuronal differentiation 2"
                     /db_xref="GeneID:54276"
                     /db_xref="RGD:3166"
     exon            1..212
                     /gene="Neurod2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..2460
                     /gene="Neurod2"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1366
                     /gene="Neurod2"
                     /note="brain bHLH protein KW8; neurogenic differentiation
                     2"
                     /codon_start=1
                     /product="neurogenic differentiation factor 2"
                     /protein_id="NP_062199.2"
                     /db_xref="GeneID:54276"
                     /db_xref="RGD:3166"
                     /translation="MLTRLFSEPGLLSDVPKFASWGDGDDDEPRSDKGDAPPQPPPAP
                     GSGAPGPARATKPVSLRGEEVPEPTLAEVKEEGELGGEEEEEEEEEEGLDEAEGERPK
                     KRGPKKRKMTKARLERSKLRRQKANARERNRMHDLNAALDNLRKVVPCYSKTQKLSKI
                     ETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTE
                     QGADGAGRFHGSGGPFAMHPYPYPCSRLAGAQCQAAGGLGGGAAHALRTHGYCAAYET
                     LYAAAGGGGASPDYNSSEYEGPLSPPLCLNGNFSLKQDSSPDHEKSYHYSMHYSALPG
                     SRPAGHGLVFGSSAVRGGVHSENLLSYDMHLHHDRGPMYEELNAFFHN"
ORIGIN      
        1 aggctggtac cccgcctggt agagatgcca cactcgctcc gcggctcgca tggcgctctg
       61 aagacgccgg cgcccgccgc cttgaggaac cgctgccccc gctccctgaa gatgggggaa
      121 caatgaaata agcgagaaga ttcctcttct cccccctctc tctcttgccc ccctccccct
      181 cccctcccct ctccccttga ctcctctctg aggcaccatg ctgacccgcc tgttcagcga
      241 gcccggcctc ctctcggacg tgcccaagtt cgccagctgg ggcgacggcg acgacgacga
      301 gccgaggagc gacaagggcg acgcgccgcc gcagcctcct cctgctccag ggtcaggggc
      361 tccaggaccc gctcgggcca ccaagccagt gtctcttcgt ggagaagagg tccctgaacc
      421 cacgttggct gaggtcaagg aggaaggaga gctgggcggc gaggaggagg aggaagagga
      481 ggaggaggaa ggactagacg aggcggaagg cgagcggccc aagaagcgcg ggccgaagaa
      541 acgcaagatg accaaggcgc gcctggagcg ctccaagctg cggcgacaga aggccaacgc
      601 gcgggagcgc aaccgcatgc acgacctgaa cgcggcgctg gacaacctgc gcaaggtggt
      661 gccctgctac tccaagacgc agaagctgtc caagatcgaa acgctgcgcc tggccaagaa
      721 ctacatctgg gctctctcgg agatcttgcg ctccgggaag cggccggatc tggtgtccta
      781 cgtgcagact ctgtgcaagg ggctgtcaca gcccaccacg aatctggtgg ccggctgcct
      841 gcagctgaac tctcgtaact tcctcacgga gcagggcgcg gacggcgccg gccgctttca
      901 cggctcgggt ggcccgttcg ccatgcatcc gtacccgtac ccgtgctcgc gcctagcagg
      961 cgcacagtgc caggcggccg gcggcctggg cggaggcgcg gcgcacgccc tgcggaccca
     1021 cggctactgc gccgcctacg agacgctgta cgcggcggcg ggtggcggcg gcgccagccc
     1081 ggactacaac agctccgagt acgagggtcc gctcagtccc ccgctctgtc tcaacggcaa
     1141 cttctcgctc aagcaggact cgtcccccga tcacgagaag agctaccact actctatgca
     1201 ctactcggcg ctgcccggct cccggcccgc gggccacggg ctggtcttcg gctcgtcggc
     1261 cgtgcgcggg ggcgtccact cggagaatct cttgtcttac gatatgcacc ttcaccacga
     1321 tcggggcccc atgtacgagg agctcaacgc gtttttccat aactgagacc tcgcgccgac
     1381 ctctcttttt ctttgccttt gtccggcccc ctagccccag ccccacgagc tcaggggctc
     1441 ccacggactc cagcgccggg cgcgcggggc gcgggccgcc ggttctgcag ctctccagag
     1501 cggcgtggtc tcttacctgt gggtggcccg tcccaggggc ctcgtttgcc tctggggact
     1561 cgccttctct ctctccccag cgggcttcct cctcccttct ctcctggaga gcatctctgg
     1621 ggacctcccg ccaggccctc ccaggagact ccctccacat tcccaaactt gggttttctc
     1681 tccccgcctc ccagcaggcc agaggcagtt ggtaaggggc tgctgagttt cggggatagt
     1741 gtctcctcca cttatggtta ctttaaaaaa acaggcacag agctgcccag gccgaaaaga
     1801 gttggtatct cttccttctc gaagaggcca aagccagggc gcccaaacgc cttcacccca
     1861 acacgaatct ccgcgttttt tattttttat tttggtggga ggggatgtgg attgagagga
     1921 aagagagagg ccaagccaat ttgtaactag aaccattttt ccttttccct ttttaaaaaa
     1981 aagaaaacaa acatacaaaa ggaaaaaaat agaaaaagga aaaaaaaaag ctgagaggca
     2041 acggaggccg aactcagagt ccggatcgga gagaaaacgc agtaagaact tttagaagca
     2101 ataaaaggca aataataata ataaaaaata ctaccaataa taatttttaa aaagacacaa
     2161 atatctatgc aaggaggttc tgactgagcc tagcagccgg acccgggatg ctccttgggt
     2221 ccgctggctg ccccgcccac gcgcggatct gtgcactttg gtgaagtggg ggcccgcacc
     2281 gcccctcccc ccagtttctt acaatcaatg actcggagat ttggaacccc agtgccactg
     2341 ccctcctccc gccctgtccc gttgtgcgtc atactgtttt ctaaaaacct gtttccaaat
     2401 ttgtatggaa tggcaaactg ttggggggtt cggtttgggg agggagggtt tgcatgagag
//
