LOCUS       NM_019218               2489 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus neuronal differentiation 1 (Neurod1), mRNA.
ACCESSION   NM_019218 XM_001067404
VERSION     NM_019218.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Li,R., Li,X., Huang,Y., Qiu,H., Li,L. and Bi,Z.
  TITLE     LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced
            Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis
  JOURNAL   World Neurosurg 147, e293-e305 (2021)
   PUBMED   33340723
  REMARK    GeneRIF: LncRNA SOX2OT Knockdown Alleviates
            Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating
            miR-331-3p/Neurod1 Axis.
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Jeon,S.J., Kim,J.W., Kim,K.C., Han,S.M., Go,H.S., Seo,J.E.,
            Choi,C.S., Ryu,J.H., Shin,C.Y. and Song,M.R.
  TITLE     Translational regulation of NeuroD1 expression by FMRP: involvement
            in glutamatergic neuronal differentiation of cultured rat primary
            neural progenitor cells
  JOURNAL   Cell Mol Neurobiol 34 (2), 297-305 (2014)
   PUBMED   24338128
  REMARK    GeneRIF: NeuroD1, an essential regulator of glutamatergic neuronal
            differentiation, as a new mRNA target interacting with FMRP in
            co-immunoprecipitation experiments.
REFERENCE   3  (bases 1 to 2489)
  AUTHORS   Ahmed,M., Xu,J. and Xu,P.X.
  TITLE     EYA1 and SIX1 drive the neuronal developmental program in
            cooperation with the SWI/SNF chromatin-remodeling complex and SOX2
            in the mammalian inner ear
  JOURNAL   Development 139 (11), 1965-1977 (2012)
   PUBMED   22513373
REFERENCE   4  (bases 1 to 2489)
  AUTHORS   Zhang,H., Wang,W.P., Guo,T., Yang,J.C., Chen,P., Ma,K.T., Guan,Y.F.
            and Zhou,C.Y.
  TITLE     The LIM-homeodomain protein ISL1 activates insulin gene promoter
            directly through synergy with BETA2
  JOURNAL   J Mol Biol 392 (3), 566-577 (2009)
   PUBMED   19619559
REFERENCE   5  (bases 1 to 2489)
  AUTHORS   Mehmood,R., Yasuhara,N., Oe,S., Nagai,M. and Yoneda,Y.
  TITLE     Synergistic nuclear import of NeuroD1 and its partner transcription
            factor, E47, via heterodimerization
  JOURNAL   Exp Cell Res 315 (10), 1639-1652 (2009)
   PUBMED   19272376
  REMARK    GeneRIF: The nuclear import of NeuroD1 and E47 is energy-dependent
            and involves the Ran-mediated pathway.
REFERENCE   6  (bases 1 to 2489)
  AUTHORS   Miyata,T., Maeda,T. and Lee,J.E.
  TITLE     NeuroD is required for differentiation of the granule cells in the
            cerebellum and hippocampus
  JOURNAL   Genes Dev 13 (13), 1647-1652 (1999)
   PUBMED   10398678
REFERENCE   7  (bases 1 to 2489)
  AUTHORS   Noma,T., Yoon,Y.S. and Nakazawa,A.
  TITLE     Overexpression of NeuroD in PC12 cells alters morphology and
            enhances expression of the adenylate kinase isozyme 1 gene
  JOURNAL   Brain Res Mol Brain Res 67 (1), 53-63 (1999)
   PUBMED   10101232
REFERENCE   8  (bases 1 to 2489)
  AUTHORS   Mutoh,H., Naya,F.J., Tsai,M.J. and Leiter,A.B.
  TITLE     The basic helix-loop-helix protein BETA2 interacts with p300 to
            coordinate differentiation of secretin-expressing enteroendocrine
            cells
  JOURNAL   Genes Dev 12 (6), 820-830 (1998)
   PUBMED   9512516
REFERENCE   9  (bases 1 to 2489)
  AUTHORS   Naya,F.J., Huang,H.P., Qiu,Y., Mutoh,H., DeMayo,F.J., Leiter,A.B.
            and Tsai,M.J.
  TITLE     Diabetes, defective pancreatic morphogenesis, and abnormal
            enteroendocrine differentiation in BETA2/neuroD-deficient mice
  JOURNAL   Genes Dev 11 (18), 2323-2334 (1997)
   PUBMED   9308961
REFERENCE   10 (bases 1 to 2489)
  AUTHORS   Kawakami,H., Maruyama,H., Yasunami,M., Ohkubo,H., Hara,H.,
            Saida,T., Nakanishi,S. and Nakamura,S.
  TITLE     Cloning and expression of a rat brain basic helix-loop-helix factor
  JOURNAL   Biochem Biophys Res Commun 221 (1), 199-204 (1996)
   PUBMED   8660336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 15, 2021 this sequence version replaced NM_019218.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092367.1, SRR26360194.2253518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000003.1  84770379-84770454   c
            77-2489             JAXUCZ010000003.1  84766483-84768895   c
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2489
                     /gene="Neurod1"
                     /note="neuronal differentiation 1"
                     /db_xref="GeneID:29458"
                     /db_xref="RGD:3165"
     exon            1..76
                     /gene="Neurod1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..2489
                     /gene="Neurod1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1161
                     /gene="Neurod1"
                     /note="BHF-1; basic helix-loop-helix factor 1; neurogenic
                     differentiation 1"
                     /codon_start=1
                     /product="neurogenic differentiation factor 1"
                     /protein_id="NP_062091.1"
                     /db_xref="GeneID:29458"
                     /db_xref="RGD:3165"
                     /translation="MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELE
                     AMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEEDDQKPKRRGPKKKKMTKARLERFKLR
                     RMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSG
                     KSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHP
                     YSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPP
                     LSINGNFSFKHEPSTEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNI
                     MSFDSHSHHERVMSAQLNAIFHD"
ORIGIN      
        1 cgcccacgca gaaggcaagg tgtcccgagg ctccagggtt atgagatcgt cactattcag
       61 aaccttttaa caacaggaag tggaaacatg accaaatcat acagcgagag cgggctgatg
      121 ggcgagcctc agccccaagg tcccccaagc tggacagacg agtgcctcag ttctcaggac
      181 gaggaacacg aggcagacaa gaaggaggat gagcttgaag ccatgaatgc agaggaggac
      241 tctctgagaa atgggggaga ggaggaggat gaagatgagg atctggaaga ggaggaagag
      301 gaggaggaag aggaggatga tcaaaagccc aagagacggg gccccaaaaa gaaaaagatg
      361 accaaggcgc gcctagagcg ttttaaatta agacgcatga aggccaatgc ccgcgagcgg
      421 aaccgcatgc acgggctgaa tgcggcgctg gacaacctga gaaaggtggt accctgctac
      481 tctaagacac agaagctgtc taagatagag acactgcgct tggccaagaa ctatatctgg
      541 gctctgtcag agatcctgcg ctcaggcaaa agcccagacc tcgtctcctt tgtacagaca
      601 ctctgcaaag gtttgtccca gcccactacc aatttggtgg ctggctgctt gcagctcaac
      661 ccccggactt tcttgcctga gcagaatccg gacatgcccc cacacctgcc aaccgccagc
      721 gcttccttcc cggtgcatcc ctactcctac cagtcccctg gactgcccag cccgccctac
      781 ggcaccatgg acagctccca tgtcttccac gtcaagccgc cgccacacgc ctacagcgca
      841 gccctggagc ccttctttga aagcccccta actgattgca ccagcccttc ctttgacgga
      901 cccctcagcc cgccgctcag catcaatggc aacttctctt tcaaacacga accatccacc
      961 gagtttgaaa aaaattatgc ctttaccatg cactaccctg cagcgaccct ggcagggccc
     1021 caaagccacg gatcaatctt ctcctcgggt gccgctgctc ctcgctgtga gatccccata
     1081 gacaatatta tgtctttcga tagccattcg catcatgagc gagtcatgag tgcccagctt
     1141 aatgccatct ttcacgatta gaggcacgtc agtttcacca ttcccgggaa acgaatccac
     1201 tgtgcttaca gtgactgtcc tgtttacaga aggcagccct tttgataaca ttgctgcaaa
     1261 gtgcaaatac tcgaagcttc aagggatata tgtatttatt gtcgttactg cctttggaag
     1321 aaacagggga tcaaagttcc tgttcacctt atctattgtt ttctatagct cttctatttt
     1381 aaaaaataat agtacagtaa agtaaaaaag gaaaatgtgt accacgaatt tcgtgtagct
     1441 gtattcagat cgtattaatt atctgatcgg gataaaaaaa tcaagcaata attaggatct
     1501 atgcaatttt taaactagta atgggccaat taaagtatat ataaatatat atttttcaac
     1561 cagcatttta ctacttgtta cctttcccat gccgaattat tttgttgtga ttttgtacag
     1621 aatttttaat gactttttat aacgtggatt tcctatttta aaaccatgca gcttcatcaa
     1681 tttttataca tatcagaaaa gtagaattat atctaattta tacaaaaata atttaactaa
     1741 tttaaaccag cagaaaagtg cttagaaagt tattgcgttg ccttagcact tctttcttct
     1801 ctaattgtaa aaaaaaaaaa atagaaaaga aaagagaaaa acaacaaatt gcacaatttg
     1861 agcaattcat ctcactttaa agtctttccc tctccctaaa gtagaaacca gacccataac
     1921 actcaagagg aaaaaaagaa atgcattcct tatcaaaaca tatcgattca ttccttgcac
     1981 acgcttgtaa atacataata taaataaatg ccaacacaca ctcctttaaa tcaaaagctg
     2041 ctcgactatc acccacaatt tgcactcttt ctttttagtc tttcacttct ttgaagtcaa
     2101 tgatttttat ggagtgtctg acgttattga tgtttcgaga aaatataaat gcatgatttt
     2161 atacatagtc aaacaaatgg tggcttgtca tctattcatg taataaatct gagcctaaat
     2221 ttattcaggt tgttgatgtt ggggtttata cctgtgtagt caattagtac agtagtttaa
     2281 ataaaattca aaccatctga tccataatta gaacaatagc tattgcatgt aaaatgcagt
     2341 ccagaataag tgctgtttgc gatgtgatgc tggtactact ggaatggaca tgtactgtaa
     2401 tcttgttcgt aatcctgtgt attatggtgt aatgcacaat ttagaaaact ctcatgcagt
     2461 tgcaataaaa atagtattga aaatcaaaa
//
