LOCUS       NM_001142652            5842 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus neuralized E3 ubiquitin protein ligase 1B
            (Neurl1b), mRNA.
ACCESSION   NM_001142652 XR_008077
VERSION     NM_001142652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5842)
  AUTHORS   Rullinkov G, Tamme R, Sarapuu A, Lauren J, Sepp M, Palm K and
            Timmusk T.
  TITLE     Neuralized-2: expression in human and rodents and interaction with
            Delta-like ligands
  JOURNAL   Biochem Biophys Res Commun 389 (3), 420-425 (2009)
   PUBMED   19723503
REFERENCE   2  (bases 1 to 5842)
  AUTHORS   Song R, Koo BK, Yoon KJ, Yoon MJ, Yoo KW, Kim HT, Oh HJ, Kim YY,
            Han JK, Kim CH and Kong YY.
  TITLE     Neuralized-2 regulates a Notch ligand in cooperation with Mind
            bomb-1
  JOURNAL   J Biol Chem 281 (47), 36391-36400 (2006)
   PUBMED   17003037
REFERENCE   3  (bases 1 to 5842)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000219.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001142652.3.
            
            On Oct 27, 2022 this sequence version replaced NM_001142652.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ414761.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JACYVU010000219.1  4818227-4818363     c
            138-683             JACYVU010000219.1  4801190-4801735     c
            684-1376            JACYVU010000219.1  4793732-4794424     c
            1377-1502           JACYVU010000219.1  4791981-4792106     c
            1503-5842           JACYVU010000219.1  4787316-4791655     c
FEATURES             Location/Qualifiers
     source          1..5842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5842
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /note="neuralized E3 ubiquitin protein ligase 1B"
                     /db_xref="GeneID:303019"
                     /db_xref="RGD:1564984"
     exon            1..137
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1747
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase NEURL3; neuralized 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL1B"
                     /protein_id="NP_001136124.1"
                     /db_xref="GeneID:303019"
                     /db_xref="RGD:1564984"
                     /translation="MGNTVHRTLPDSSPPARLLATRPCYGPGPERRAVLGEAPRFHAQ
                     AKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFT
                     AHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVND
                     GEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESTFADTLTPLRLGQARLSACPPPGS
                     HDAANFDNNELENNQVVAKLGHLALGRPDAAVPCVARERARPASSPALLDAELRFHAT
                     RGPDVSLSADRRLACAPRPDGGRTLVFSERPLRPGESLCVEVGRPGLAAPAAVAFGIT
                     SCDPGALRPSELPADPAALLDRKEYWVVARAGPVPSGGDALSFTLRPGGDVLLAVNGR
                     PRGRLLCVDTSQALWAFFAVRGGVAGQLRLLGTVQSGPEATTPSGSFSGSQDDSDSDM
                     TFGVNQSSSASESSLVTAPSSPLSPPVSPAFSAPEPAGSRNGECTVCFDSEVDTVIYT
                     CGHMCLCHSCGLRLRRQARACCPICRRPIKDVIKIYRP"
     exon            138..683
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1376
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1502
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..5842
                     /gene="Neurl1b"
                     /gene_synonym="Neurl2; RGD1564984"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccatctgc cgcccgccgg tcgccggtgc agcggcaatg ccccgcagcc cggcctcggc
       61 ccccggcccg cccagctagc cccgcgccgc gactctcgga gcagcgatgg gcaacacggt
      121 gcaccggacc ctgccagact ccagccctcc tgcacgcctc ctggccaccc ggccttgcta
      181 cggcccgggc ccggagaggc gagcggtcct gggcgaggcg ccacgcttcc acgcgcaggc
      241 caagggcaag aacgtgcgtc tagacggtca ctcgcgcagg gccacgcgac ggaacagctt
      301 ctgcaacgga gtcaccttca cgcagcggcc cattcgcctg tacgagcagg tgcggttgcg
      361 cctggtggct gtgcgtcctg gctggagcgg cgcgctgcgc ttcggcttca ctgcgcacga
      421 cccgtcgctc atgagcgcac aggatatccc caagtacgcc tgccccgacc tggtcacacg
      481 acctggatac tgggccaagg cgctgccgga gaacctggcg ctgcgggaca cggtgctggc
      541 ctactgggct gatcgtcacg gtcgcgtctt ctatagtgtc aatgatggcg aaccagtgct
      601 gttccactgc ggcgtggccg tgggaggccc actctgggca ctcatcgacg tctatggcat
      661 cacggacgag gtgcagctgc tggaaagcac cttcgcagac acgctgaccc cgctgcgcct
      721 gggccaggcc cgcctcagcg cctgcccgcc tccgggcagc cacgatgctg ccaacttcga
      781 taataacgag ctggagaata accaggtggt agccaagctg ggtcacctgg ctctcggccg
      841 tccggacgcc gccgtcccgt gcgtggcccg cgaacgcgcg aggcccgcct cctcacccgc
      901 gctgctggac gctgagctgc gcttccacgc cacgcgcggc cccgacgtga gcctgtctgc
      961 ggaccgcagg ctagcctgcg cgccccgccc cgacggcggc cgcacgcttg tgttctccga
     1021 gcggccgctg cggcccgggg agagcctgtg cgtggaagtg gggcgcccgg ggctggcggc
     1081 gcccgcagct gtggccttcg gcatcacgtc ctgcgatcct ggcgcgctgc ggccatccga
     1141 gctgcccgcc gatcccgctg cgctgctgga ccgcaaggaa tactgggtgg tggcgcgcgc
     1201 cgggcccgtg cccagcggag gcgacgcact cagcttcacg ctgcgaccgg gcggcgacgt
     1261 cctgctggcg gtgaacgggc gcccgcgggg acgcttgctg tgcgtggaca cctcgcaggc
     1321 gctctgggcc ttcttcgctg tgcgcggtgg tgtggcgggt cagctgcgtc tcctgggcac
     1381 cgtacagtcc ggtcctgagg ccacaactcc atcagggtcc ttcagtggct ctcaggatga
     1441 cagcgattcg gacatgacct tcggggtcaa ccagtcgtca tcagcatcag aatcgtctct
     1501 ggtgacagcc cccagctccc cactgagtcc cccagtgtcc ccggccttct ctgcacccga
     1561 gccggccggc agcaggaatg gagagtgcac ggtgtgcttc gacagcgagg tggacacggt
     1621 catctacacg tgtggacaca tgtgcctgtg ccacagctgc ggcctgcggc tccgaaggca
     1681 ggcacgggcc tgctgtccta tctgccgtcg gcccatcaag gatgttatca agatctatag
     1741 gccgtagccg tgcagctggc tcggccaaag cgaggtcacc tttctgaagc ccctgctagg
     1801 tgggcgacac catggctacc agggagcccg gggtcaggag ccatctcttg tctgccactc
     1861 cgcagtgatg agcaaggcag gacaggtgtg gagatgaggc cctgggggcc agaggccagg
     1921 cgagctttgt ttcgtctgtc tcaaacatac gttgccccca aaagcctgtc ccaggattca
     1981 gctcaggaac tgcctggcag atcacctgcc tcttggtgac cttcagctgg gaaagggtac
     2041 cctctgtctg tgcaatgctt ctttggggtt gggttgagtg tgtgtgtgtg tgtggggtgg
     2101 ggggcggaga cagcacagag aatgtgtgag agagagagag tgtgtgagtg ttttatgcag
     2161 ggatccgtct cctggagggt atttaacact aaggaatgtg caatctgggc ccaaatgtta
     2221 atgtgatggt tgtccacttt ctggggattt ggttttctgc aatgagctag ctttgaacac
     2281 acaaggcctg aacctacaca gagctccctg ggtggcactc agattttcta agggaaagca
     2341 aaaataactc actgtttaca gctccaagca gcagctcctg ctgaggggag gaggtgggcg
     2401 gagaacatca gagaacaagt ggcttttgct tcttactcag actaggagtg gtcttcccat
     2461 ggccctgagg acaggtgccc aagctctagc atctagattc cttcatcccc agccagtaga
     2521 acacctcagc cccgtcccta catgctctgg agttttgtga tgtccctcct gttcttgggg
     2581 acaacaccat atctcccgtg gtagaaataa aagctttggg catgtcccgg tgaccagctg
     2641 tcagaagcta gaagacccag accccctcta gtccttgtcc tgaccctctc attttcctgt
     2701 tggtgattat ggtgttaact acactggtta ctcatgagga gaggactgaa aatgttcccc
     2761 actcctgggc ctgtttgccg gcatttccct ggccccggcc ctgtcaccct ctccctgggt
     2821 cagacttgtt tctgtaggct tgccattgtt gatgctgtgg ttgtgcgtgc cacccctccc
     2881 ttctgaagag ccgtgggttg tactggatgt acgtccacct accctgagct gtaccttcag
     2941 aggagtcctt ggtctctctc ttctctgttc ctacttggaa gcctggtgcc agggcactgg
     3001 cgagacctgc tcaggttttt tagaggaagc ttgagacacc ttgccaggag caacggtttt
     3061 cctcacagct cctaatctgg ccctctcttc ctgtgacaga gggaagagag gggaagaata
     3121 gcttccgtct tcctctctca gcaagagtct ctgagagctt ggttttcctt ggagacacca
     3181 ggacacatga ccaccttttc actctagggt gaattttttt gtttgttttt agtttcttgg
     3241 tttgttgtcg ttttggtttt tcctgaaatt cactctgtag accaggctgg cctcaaactc
     3301 agagatctgc ctgcttctgc ctcccgagtg ctgggagtgc accaccactg ccctggtgca
     3361 gctgaatcct ttaaggagct accgaaacgc ttgtttgcct cagtgagagt ctgagaatca
     3421 cagcacaatt tccacagcca accttatagc ttctacacgt gctgggcttg ggtagaccct
     3481 cctcatcgcc ggtgatgacc ggctttctgg gcagccactg gccctgtctg actctaatct
     3541 gtaactgcca cagtttcagt ggaaggggaa caagctctcc ttcgcttctt gccctcacag
     3601 ttagaccctt gagttgcagc aggggtcacc catagccacc accaggacgt caacagctga
     3661 ggtcctagac gcaggggtgg accaggcctg cccctggtga cctgttacta ggacagaaac
     3721 caggacagac ctgtttaacc tgttttgcta tttcccatag agcaaagggg ggtgtttctg
     3781 ttctaaaagt ccggtatttg ccctaggggc agtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3841 tgtgtgtgtg tgtgtgtgtg tgttttatct caacaagggg caggagggaa aagaagccag
     3901 tgtctttcat accattcacg tgcctgggca ctgagttaaa gagacacctt tgtataagac
     3961 cctgtgtata ggttttagtg ccatattgag tcccatcgga gacttggctg gttagagggc
     4021 tcaccatctt atgggcagct gcgaaagtca cacccacctt agcctcagga tgctgggatg
     4081 cagcttccag gtcagctgcg ggacacaggt actagggtcc atgaaataca gcgttgttct
     4141 cgtttggcaa gtgagctctg agatcttgtg agactcttaa ggatcacaaa acaggaagtg
     4201 gcagggctgg gattccagtc cccacaccta gcctgggcct gcctgcccta cttctcagga
     4261 agctcaacac tgcctgagtc ttctttctgg agactcacct ggaaccccac acctgtgtag
     4321 aaggttccgg gccacagtcc cgaggagaca gatgtcctcc aaggctcatg cgctcgctgc
     4381 ccatctgcac tggggcgtca tgctttggac agagacttta ggccacccct ttctgggacc
     4441 ttgggccact cccttctcag gcagcacccc agcccggttt ccaggctcac tgcccattgt
     4501 gccctgtgaa cctcaaaagc caagagtagg atggggaggc caagtggcct cccatccatg
     4561 gcagccatac ccctgtccac tgaaactttc tggaaaagag ttgtttcctg ggctaagtgg
     4621 actcctcctc ttattggttg accatcttgg ggcagctgtc ctgcccaggc ttcgacacac
     4681 tttttcactt gttcaacatc cgctcaccag cctggctcgt gatcaggaca tgatgttgaa
     4741 gactgggaca aaagacaagg cccgtgggca gctcttaggc cagaggccag atcattaact
     4801 gttttgatca ctctggagtt ggggcttatg ctagcacata gtaggtactc agaccaggag
     4861 cctggttagg agtggttagt gaagtagcct cccatacaca tggacacaaa gtcatttaaa
     4921 aacgtttgct gagtgccctc aggatgtcag ctgctgtaag ggggcacaga gagcaagcgc
     4981 ccagccctga tgcctgagtg gtgccgtcaa caagacaggg tggagcacgt gggctttctt
     5041 gaccattctg ttgccttgga tccatctagt taaatgccca cagagcttcc cgcacccaca
     5101 ttaaggggtt ttttgtggtg agctcttggc aaacaaccaa gaccccacaa gttaatgacc
     5161 accttcaggt cctacaggga gtctctgggg agataactcc ctgctacgtc caggctctgg
     5221 ggggtccaca agagctgcga acggcatcgt gcagccttgg agcacgggga ggggtaactg
     5281 ctctgtccat cttgccctgg ctggggacgc ggctcaggaa cactcagcct cccagtgttt
     5341 aatattttag tgtctcactg tttcacccaa gtccccaatg gaactaccca tatgacaatc
     5401 tgtctgtgcc ttatggaagt gagtgtgtgt gtgtgtctgt gtctgtgtgt gtgcactttt
     5461 atcctttaaa gtgcaaccct tcaatgtgga caagaagcta gcagatgcgg ttgggctcca
     5521 gacatcagca gggagtccct gagaccctct tgcggattgc ggttggactg aaagtattca
     5581 tccccaccca tccccactag ctgtgtacag accctttgaa acatgtctgt cctttctggt
     5641 tcaatactgt ggctctccaa tactgtctac tctttgggga actgtactaa aggcctgaga
     5701 gcttggggag tgagcttggg aagggtttgc gctggtcttt gtgtgttgtg tgttctgata
     5761 tttgtctgtt tttatctgtt ttatattaac ataactttcc tgtttgaaaa caaataaaac
     5821 tttggcttgg tacaaaaaaa aa
//
