LOCUS       NM_001401624            3806 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus neuralized E3 ubiquitin protein ligase 1
            (Neurl1), transcript variant 1, mRNA.
ACCESSION   NM_001401624 XM_006231510
VERSION     NM_001401624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3806)
  AUTHORS   Taal,K., Tuvikene,J., Rullinkov,G., Piirsoo,M., Sepp,M., Neuman,T.,
            Tamme,R. and Timmusk,T.
  TITLE     Neuralized family member NEURL1 is a ubiquitin ligase for the
            cGMP-specific phosphodiesterase 9A
  JOURNAL   Sci Rep 9 (1), 7104 (2019)
   PUBMED   31068605
  REMARK    GeneRIF: Neuralized family member NEURL1 is a ubiquitin ligase for
            the cGMP-specific phosphodiesterase 9A.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3806)
  AUTHORS   Jaagura,M., Taal,K., Koppel,I., Tuvikene,J., Timmusk,T. and
            Tamme,R.
  TITLE     Rat NEURL1 3'UTR is alternatively spliced and targets mRNA to
            dendrites
  JOURNAL   Neurosci Lett 635, 71-76 (2016)
   PUBMED   27780737
  REMARK    GeneRIF: endogenous NEURL1 mRNAs with both longer and shorter
            3'UTRs are enriched in the neurites of cultured rat primary
            hippocampal neurons. Both NEURL1 3'UTRs can mediate transport of
            reporter mRNAs into dendrites in primary hippocampal neurons.
REFERENCE   3  (bases 1 to 3806)
  AUTHORS   Pavlopoulos,E., Trifilieff,P., Chevaleyre,V., Fioriti,L.,
            Zairis,S., Pagano,A., Malleret,G. and Kandel,E.R.
  TITLE     Neuralized1 activates CPEB3: a function for nonproteolytic
            ubiquitin in synaptic plasticity and memory storage
  JOURNAL   Cell 147 (6), 1369-1383 (2011)
   PUBMED   22153079
REFERENCE   4  (bases 1 to 3806)
  AUTHORS   Teider,N., Scott,D.K., Neiss,A., Weeraratne,S.D., Amani,V.M.,
            Wang,Y., Marquez,V.E., Cho,Y.J. and Pomeroy,S.L.
  TITLE     Neuralized1 causes apoptosis and downregulates Notch target genes
            in medulloblastoma
  JOURNAL   Neuro Oncol 12 (12), 1244-1256 (2010)
   PUBMED   20847082
REFERENCE   5  (bases 1 to 3806)
  AUTHORS   Schweisguth,F.
  TITLE     Regulation of notch signaling activity
  JOURNAL   Curr Biol 14 (3), R129-R138 (2004)
   PUBMED   14986688
  REMARK    Review article
REFERENCE   6  (bases 1 to 3806)
  AUTHORS   Timmusk,T., Palm,K., Belluardo,N., Mudo,G. and Neuman,T.
  TITLE     Dendritic localization of mammalian neuralized mRNA encoding a
            protein with transcription repression activities
  JOURNAL   Mol Cell Neurosci 20 (4), 649-668 (2002)
   PUBMED   12213446
REFERENCE   7  (bases 1 to 3806)
  AUTHORS   Pavlopoulos,E., Kokkinaki,M., Koutelou,E., Mitsiadis,T.A.,
            Prinos,P., Delidakis,C., Kilpatrick,M.W., Tsipouras,P. and
            Moschonas,N.K.
  TITLE     Cloning, chromosomal organization and expression analysis of Neurl,
            the mouse homolog of Drosophila melanogaster neuralized gene
  JOURNAL   Biochim Biophys Acta 1574 (3), 375-382 (2002)
   PUBMED   11997106
REFERENCE   8  (bases 1 to 3806)
  AUTHORS   Vollrath,B., Pudney,J., Asa,S., Leder,P. and Fitzgerald,K.
  TITLE     Isolation of a murine homologue of the Drosophila neuralized gene,
            a gene required for axonemal integrity in spermatozoa and terminal
            maturation of the mammary gland
  JOURNAL   Mol Cell Biol 21 (21), 7481-7494 (2001)
   PUBMED   11585928
REFERENCE   9  (bases 1 to 3806)
  AUTHORS   Ruan,Y., Tecott,L., Jiang,M.M., Jan,L.Y. and Jan,Y.N.
  TITLE     Ethanol hypersensitivity and olfactory discrimination defect in
            mice lacking a homolog of Drosophila neuralized
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9907-9912 (2001)
   PUBMED   11481456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 16, 2022 this sequence version replaced XM_006231510.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.8456.1,
                                           SRR26643297.5678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               JAXUCZ010000001.1  256008160-256008584
            426-667             JAXUCZ010000001.1  256074099-256074340
            668-989             JAXUCZ010000001.1  256074672-256074993
            990-1679            JAXUCZ010000001.1  256087089-256087778
            1680-1826           JAXUCZ010000001.1  256091459-256091605
            1827-3806           JAXUCZ010000001.1  256092240-256094219
FEATURES             Location/Qualifiers
     source          1..3806
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3806
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /note="neuralized E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:309459"
                     /db_xref="RGD:1307021"
     exon            1..425
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..2065
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuralized-like homolog; neuralized-like protein 1A;
                     neuralized homolog 1A; E3 ubiquitin-protein ligase NEURL1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL1 isoform 1"
                     /protein_id="NP_001388553.1"
                     /db_xref="GeneID:309459"
                     /db_xref="RGD:1307021"
                     /translation="MGNNFSSVSSLQRGNPSRASRGHPQNLKDSIGSSFPVPSHRCHH
                     KQKHCPPALSGGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLI
                     YEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEE
                     FANEGNIIAFWVDKKGRVFYRINESAAMLFFSGVRTADPLWALVDVYGLTRGVQLLDS
                     ELVLPDCLRPRSFTALRRPSLRCEADEARLSVSLCDLNVPGADGEDGAPPAGCPIPQN
                     SLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARLEHGRDERALVFTSRPVRV
                     AETIFIKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGP
                     LHSGDILGLVVNADGELHLSHNGAPAGMQLCVDASQPLWMLFSLHGAITQVRILGSTI
                     MAERGGPSLPCSPASTPTSPSALGSRLSDPLLSTCGSGPLGGSAGGTAPNSPVSLPES
                     PVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYSCGLRLKKALHACCPICRRPIKD
                     IIKTYRSS"
     exon            426..667
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            668..989
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1679
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1826
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..3806
                     /gene="Neurl1"
                     /gene_synonym="Neurl; Neurl1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcccacc cgcagccgga acccgagctc cagcaccagg cagagcgcag cggcgcgcgc
       61 cgcgggccgg ggcccagggg cccggccgcc ccgggcgcgg ggcatgggag cccggtaacc
      121 cggcggtgcg aggacccccg cggcgggcag gacccgccga gcgaagaccg ccaagcccag
      181 ggagagccag agacagcgaa ccgcccgccc ccagccgcag ccccgccagg gccctccccc
      241 ggcggcgcgc acccgcgcgc gcacacactt gcacaccttt cctccgcttg tgcccagcct
      301 cgcctggccc ccgccggagc accccagggg ggccgatgcc atgggtaaca acttctccag
      361 tgtctcctct ctgcagcgag gaaaccccag ccgtgcgtcg cggggccacc cccagaacct
      421 caaagactcc atcgggagct ccttcccggt cccctctcac cgatgccatc acaagcagaa
      481 gcattgcccg cccgcgctgt caggtggggg gctcccggcc acaccgctgc tcttccaccc
      541 ccacactaag ggctcccaga tcctcatgga cctcagccac aaggccgtca agaggcaggc
      601 cagcttctgt aatgccatca ccttcagcaa ccgccccgtc ctcatctacg agcaagtcag
      661 gctgaagatc accaagaagc agtgctgctg gagcggggcc ctgcgacttg gcttcaccag
      721 caaggaccct tcccgcatcc accccgactc actgcccaag tacgcctgcc ctgacctggt
      781 gtcccagagt ggcttctggg ccaaagcgtt gcctgaggag tttgccaacg agggcaacat
      841 cattgccttc tgggtggaca agaagggccg agtcttctac cggatcaatg agtcggctgc
      901 catgctgttc ttcagcgggg ttcgaacggc ggacccgctc tgggccctgg tggacgtcta
      961 cggcctcaca cggggtgtcc agctgctaga cagcgagctg gtgctgcctg actgcctgag
     1021 gccgcgctcc ttcaccgcgc tgcggcggcc gtcgctgcgg tgcgaggcgg acgaggcgcg
     1081 cctgtctgtg agcctgtgcg acctcaacgt gccgggagcc gacggcgagg acggcgcacc
     1141 gcccgccggc tgcccgatcc cgcagaactc gctcaactct cagcacagcc gcgcgctgcc
     1201 ggcgcagctc gacggcgacc tgcgcttcca cgctctgcgc gccggcgcgc acgtccgcat
     1261 cctggacgag caaaccgtgg cgcgcctaga gcacgggcgc gacgagcgcg cgctcgtctt
     1321 caccagccgg ccggtgcgcg tggccgagac catcttcatc aaggtcacgc gctcaggcgg
     1381 tgcgcgacca ggagcgctgt ccttcggggt caccacgtgt gaccctggca cgctgcggcc
     1441 cgccgacctg cccttcagcc ccgaggccct ggtggaccgc aaggagttct gggcggtgtg
     1501 tcgcgtgcct gggcctctgc acagtggtga catcctgggc ctggtggtca atgcggacgg
     1561 agagctgcac ctaagtcaca acggcgcgcc ggccggcatg cagctatgcg tggacgcctc
     1621 gcagcccctc tggatgctct tcagcctgca cggcgccatc acgcaggtcc gcatccttgg
     1681 ctccaccatc atggctgaac ggggtggccc atctctcccc tgctcacctg cctccactcc
     1741 aacctcgccc agtgccctgg gcagccgcct ctctgacccc ctgctcagca catgcggttc
     1801 tgggcccctg ggtggctctg ctggcggaac agcccccaac tcacctgtga gcctgcccga
     1861 gtcaccagtg accccgggtc tgggccagtg gagcgatgaa tgcaccattt gctatgaaca
     1921 cgcagtggat acagtcatct acacgtgtgg ccacatgtgc ctgtgctact cctgtggcct
     1981 gcgcctcaag aaggccctgc acgcctgctg ccccatctgc cgtcgcccca tcaaggacat
     2041 catcaagacc taccgcagct cctagcccac tgcagagccc cacccgcacg cccacttctg
     2101 cagactgcag cccagcacca gccgagggca aagccaacag ggtcccttcc ttctacagtt
     2161 tgcaaactct ccctcctttg tccattaaac atgggaaacc aaggtccctg aaggtttggg
     2221 ctgagagggt ctcaggcagg gaggtggggc acaagtagtg aacggagggg ggggagaagg
     2281 gtaccccacc atctctcctc tttacacaga tttctgcatg ctgaggggct gaagtagcgt
     2341 ttcagcttgt tgccatccct cccgagctag gcagatttct aggttgtgca gcccgcgtgg
     2401 catcttggag agagttagcg aacatgtagc ttctgggcag ctgcaaactg catgccgtgt
     2461 ctctttctcc ttacccacag cgggtagaca gacaggctgc agatcccaag tcctacgtcc
     2521 ttgacctcac gtcgacctgc cacgtccagg acgccccgtt tgccctgatt ttcgccaatc
     2581 atctcactgg tgccgtttcc cagggtgccc tgcggtaaag gctgactcgg gcctttctgt
     2641 tgtcggggtc tcaaaagaac aggtccacag tcacacttaa ggcctgccct ccctcatctc
     2701 ggcctgggct ggtcttgcca tcgtttgcct gggagggaca ggacccttcg gtggggtggg
     2761 ggtttcctgg cccatagaca gccccttttc cttattttaa tttatttatt tatttggttg
     2821 atgggtcttg ttgatgggtt atgttccaac ctgggttctc ctaaaatact gctgttgtgc
     2881 ggggggaggg ctgccaggtg aagggaagca aggagtagcc acccagaata atctgccccc
     2941 aacacaaggc tcatgggcag tcctgctcac cctgaggtag aattccaggc tggaggcctc
     3001 ccaagaggtg gatgagcctc tcatgggtgg gaaccaccca catccacctg tgcccttcct
     3061 ctctggattg gagctccatt agtgtggctg gttctgatgt ctttaaggac atcagacgtt
     3121 ctggaaggtt gtcaacatgt gggtcaggga ccagaataga gaccctagtt agaagaggga
     3181 ggacggatcc tgaaagccag gctctgctcc taagggggtg tctgctattt acggccccca
     3241 gtcctacctg cctgttctgg gttactgtgg agttgtagcc taggctttcc cagcctttca
     3301 gtcctcggcc ctcatggctg gttttatacc cacagaggtg acttctgcct taagaggcaa
     3361 ggtctgtgtc tctgtcccgg ccactgggca gccgtgtggc tctgaccaca ggtcaccccc
     3421 tcccccaaac tccagcttcc cctgggtaaa agtttggggg tggaactttt tccgtgcagc
     3481 tcctgggagt tcttctcagg tctcttcgga ggaatgtact ggggaagcct tgagaatgga
     3541 tgccagggta agcctttgcc cacacggggg agtctgggcc acccctagtc tcacctctcc
     3601 agtcactggc cctggtaggt tctttcaggc tggagctggc acgtcgagct ggggctcatc
     3661 ctagcggtgg gggaaaggcc ccagtacaga gctgcgtggc tggagatggg aaaagaagcc
     3721 attgtccatc ctgctagttc agaggtagca ttgcctcctt tgtgaactgg gtcactgtgt
     3781 ttgtgaataa aggtgatttc gtacca
//
