LOCUS       NM_001393673            2393 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuraminidase 3 (Neu3), transcript variant 2,
            mRNA.
ACCESSION   NM_001393673 XM_008759665
VERSION     NM_001393673.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Lipina,C., Nardi,F., Grace,H. and Hundal,H.S.
  TITLE     NEU3 sialidase as a marker of insulin sensitivity: Regulation by
            fatty acids
  JOURNAL   Cell Signal 27 (9), 1742-1750 (2015)
   PUBMED   26022181
  REMARK    GeneRIF: findings implicate NEU3 as a potential biomarker of
            insulin sensitivity, and provide novel mechanistic insight into the
            regulation of NEU3 expression.
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Kappagantula,S., Andrews,M.R., Cheah,M., Abad-Rodriguez,J.,
            Dotti,C.G. and Fawcett,J.W.
  TITLE     Neu3 sialidase-mediated ganglioside conversion is necessary for
            axon regeneration and is blocked in CNS axons
  JOURNAL   J Neurosci 34 (7), 2477-2492 (2014)
   PUBMED   24523539
  REMARK    GeneRIF: activation of Neu3 sialidase is an essential step in
            regeneration occurring in PNS (sensory) but not CNS (retinal) axons
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Da Silva,J.S., Hasegawa,T., Miyagi,T., Dotti,C.G. and
            Abad-Rodriguez,J.
  TITLE     Asymmetric membrane ganglioside sialidase activity specifies axonal
            fate
  JOURNAL   Nat Neurosci 8 (5), 606-615 (2005)
   PUBMED   15834419
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Sasaki,A., Hata,K., Suzuki,S., Sawada,M., Wada,T., Yamaguchi,K.,
            Obinata,M., Tateno,H., Suzuki,H. and Miyagi,T.
  TITLE     Overexpression of plasma membrane-associated sialidase attenuates
            insulin signaling in transgenic mice
  JOURNAL   J Biol Chem 278 (30), 27896-27902 (2003)
   PUBMED   12730204
  REMARK    GeneRIF: NEU3 participates in the control of insulin signaling via
            modulation of gangliosides and interaction with Grb2
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Hasegawa,T., Feijoo Carnero,C., Wada,T., Itoyama,Y. and Miyagi,T.
  TITLE     Differential expression of three sialidase genes in rat development
  JOURNAL   Biochem Biophys Res Commun 280 (3), 726-732 (2001)
   PUBMED   11162581
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Monti,E., Bassi,M.T., Papini,N., Riboni,M., Manzoni,M.,
            Venerando,B., Croci,G., Preti,A., Ballabio,A., Tettamanti,G. and
            Borsani,G.
  TITLE     Identification and expression of NEU3, a novel human sialidase
            associated to the plasma membrane
  JOURNAL   Biochem J 349 (Pt 1), 343-351 (2000)
   PUBMED   10861246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 2, 2021 this sequence version replaced XM_008759665.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.4098.1,
                                           SRR26643297.2710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000001.1  163560756-163560997 c
            243-454             JAXUCZ010000001.1  163556142-163556353 c
            455-2393            JAXUCZ010000001.1  163549850-163551788 c
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2393
                     /gene="Neu3"
                     /note="neuraminidase 3"
                     /db_xref="GeneID:117185"
                     /db_xref="RGD:619881"
     exon            1..242
                     /gene="Neu3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..454
                     /gene="Neu3"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1504
                     /gene="Neu3"
                     /EC_number="3.2.1.18"
                     /note="membrane sialidase; ganglioside sialidase;
                     N-acetyl-alpha-neuraminidase 3; sialidase 3 (membrane
                     sialidase)"
                     /codon_start=1
                     /product="sialidase-3"
                     /protein_id="NP_001380602.1"
                     /db_xref="GeneID:117185"
                     /db_xref="RGD:619881"
                     /translation="MEEVSSCSLRSTLFQQEEQNRITYRIPALLYIPPTHTFLAFAEM
                     RTSSRDEDAVYLVFRRGVMKGCSVEWGPQQPLMEATLPGHRTMSPCPVWEKNTGRVYL
                     FFICVQGHVSERWQLLWGRNAARLCFLYSEDSGCSWGEVKDLTEEVVGSEMKHWATFA
                     VGPGHGIQLQSGRLLIPAYAYLISCWFLCFPCSVKPHSLMFYSDDLGVTWHCGKFIKP
                     QVTGECQVAEVPGKAGNLVLYCSARTPNKFRAEAFSTDSGDCFQKPTLNQQLCEPRGG
                     CQGSVVSTRPLKMPYTCQDSSGKDVPSTQKCPLMDRSLEVEEGAGAPSGTWLLYSHPT
                     NKKKRMNLGIYYNQNPLEVNYWSRPWILNRGPSGYSDLAVVEGQGLFACLFECGERHE
                     DEKIDFCLFSDQEVLSCDDCTSPSSN"
     exon            455..2393
                     /gene="Neu3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtggctt ggccggggag attgactccc ggatgctgtc cttatcaagc ctctggcgcc
       61 tgctctcctg tatgtccctt ctgccccgag ctgtctcatt actgccagct cttgcgcagc
      121 tttgtctggg tttgtttcca cgtctgtggt ttctgtcgcc gctaccctgt ctccatcgcc
      181 cagctcagct tctggccttc ctccgatact ccacgggaga gcccagagag cctccggagc
      241 tgaagtcatg gaagaagttt catcctgctc cctccgcagc actctgttcc agcaggaaga
      301 acagaacagg attacctacc ggatcccagc actgctgtac attcctccca cccacacctt
      361 cctggccttc gcagagatgc gtacctcaag cagagatgag gatgctgtct acctggtgtt
      421 cagacgaggg gtgatgaagg ggtgctctgt tgagtggggc ccccaacagc cactgatgga
      481 ggccacatta cctgggcatc gcaccatgag cccctgccct gtgtgggaga agaatactgg
      541 ccgtgtatac ctgtttttca tctgcgtgca gggccatgtt agtgagcgct ggcagcttct
      601 gtggggcagg aatgctgccc gtctctgctt cctttacagt gaggactctg ggtgctcgtg
      661 gggtgaagtg aaagatttga ctgaggaagt cgttggctca gagatgaagc actgggccac
      721 gtttgctgtg ggcccaggtc atggcatcca gctgcagtcg gggaggctgc tcattcccgc
      781 ctatgcctac ttgatatcat gctggtttct ctgctttcca tgttcagtca agccccattc
      841 cctaatgttc tacagtgatg acttaggagt cacatggcac tgtggcaagt tcattaagcc
      901 ccaggtgaca ggggagtgcc aagtggcaga agtgcctggg aaggctggta accttgtgct
      961 ctactgcagt gcccgaacac caaacaaatt ccgagcagag gcttttagca ctgatagtgg
     1021 tgactgcttt cagaaaccaa ccctgaacca acaactctgc gagcctcgtg gtggctgcca
     1081 aggtagtgta gtgagcaccc ggcctttgaa gatgccatac acatgtcaag actcaagtgg
     1141 taaagatgtt ccctctactc agaaatgccc tctgatggac agatctctgg aggtggagga
     1201 aggagctgga gcaccatcag ggacatggct cttgtactca catccaacta acaagaagaa
     1261 gagaatgaac ctaggcatct actacaacca aaaccccttg gaggtgaact actggtcccg
     1321 cccgtggatc ttgaaccgtg ggcccagtgg ctactctgac ctggctgtgg tagaaggaca
     1381 gggcttgttc gcgtgcttat ttgagtgtgg ggagaggcat gaggatgaga agattgactt
     1441 ttgtctgttt tcagaccaag aggtcctgag ctgtgacgac tgtaccagcc ctagtagcaa
     1501 ctaaggccaa ataaagactg atgggtgagg cccagctgtc cacagaaggg agtggcaatg
     1561 gcagctggga tagcagaggt ctctgatgtc cacagaaaat ctaagaacta atgatctgct
     1621 ccttgcattt ttttccagtt ttccctcaaa cgagcatagt aaaaattgtg ccatatctta
     1681 cacaacaagg ctctttgagc tgggagtttg gagactgtgc tgtagttgtg gctctgctgt
     1741 tggcttgctt caggactctg gatgtatccc tgaactcttt ggacatcgag tctccatttg
     1801 tataatgaga agattggtgc aggatctctt cccttccctt cccttccctt cccttccctt
     1861 cccttccctt cccttccctt cccttccctt cccttccctt cccttccctt cccttccctt
     1921 cccttccttt cccttccctt cccttccttt cccttccctt ctttccttcc cttcttttct
     1981 tattaaaagg agaggctgtg tgctcacttc ctgctccaca aaccctggat tctgatctga
     2041 attggagcca cagacttgtc ttttcaaatg attcactgct cacctgagta ttaggtgcta
     2101 agtaggtgct ttaggctaga agaaagatct gtgttgtatt tttaataaga aaaaaatcgc
     2161 gttatccttc caatcatacc cagagctgtg caaattctct atcttaggag acttgagggc
     2221 tggagagatg gctcagtggt taagagcact gactgctctt ccagaggtcc tgagttcaaa
     2281 tcccagcaac cacagggtga ctcacaacca tctgtaatgg gatctgatgc cctcttctgg
     2341 tgtgcatgaa gacaacaaca gtgtacttaa atgtgataat aaataaataa atc
//
