LOCUS       NM_017130               1693 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus neuraminidase 2 (Neu2), mRNA.
ACCESSION   NM_017130
VERSION     NM_017130.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Wang,L., Seino,J., Tomotake,H., Funakoshi,Y., Hirayama,H. and
            Suzuki,T.
  TITLE     Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in
            Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer
            Cells-Evidence for the Physical Interaction of NEU2 and GBA3
  JOURNAL   Biomolecules 5 (3), 1499-1514 (2015)
   PUBMED   26193330
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Mozzi,A., Mazzacuva,P., Zampella,G., Forcella,M.E., Fusi,P.A. and
            Monti,E.
  TITLE     Molecular insight into substrate recognition by human cytosolic
            sialidase NEU2
  JOURNAL   Proteins 80 (4), 1123-1132 (2012)
   PUBMED   22228546
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Rossi,S., Stoppani,E., Martinet,W., Bonetto,A., Costelli,P.,
            Giuliani,R., Colombo,F., Preti,A., Marchesini,S. and Fanzani,A.
  TITLE     The cytosolic sialidase Neu2 is degraded by autophagy during
            myoblast atrophy
  JOURNAL   Biochim Biophys Acta 1790 (8), 817-828 (2009)
   PUBMED   19371771
  REMARK    GeneRIF: This study demonstrates that Neu2 enzyme degradation
            occurs in atrophic myotubes via macroautophagy and independently of
            proteasome activation.
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Fanzani,A., Giuliani,R., Colombo,F., Rossi,S., Stoppani,E.,
            Martinet,W., Preti,A. and Marchesini,S.
  TITLE     The enzymatic activity of sialidase Neu2 is inversely regulated
            during in vitro myoblast hypertrophy and atrophy
  JOURNAL   Biochem Biophys Res Commun 370 (2), 376-381 (2008)
   PUBMED   18384747
  REMARK    GeneRIF: Neu2 enzymatic activity is causally linked to proper
            muscle differentiation and growth.
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Garige,M., Azuine,M.A. and Lakshman,M.R.
  TITLE     Chronic ethanol consumption upregulates the cytosolic and plasma
            membrane sialidase genes, but down regulates lysosomal membrane
            sialidase gene in rat liver
  JOURNAL   Metabolism 55 (6), 803-810 (2006)
   PUBMED   16713441
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   Fanzani,A., Giuliani,R., Colombo,F., Zizioli,D., Presta,M.,
            Preti,A. and Marchesini,S.
  TITLE     Overexpression of cytosolic sialidase Neu2 induces myoblast
            differentiation in C2C12 cells
  JOURNAL   FEBS Lett 547 (1-3), 183-188 (2003)
   PUBMED   12860410
  REMARK    GeneRIF: role during in vitro myoblast differentiation
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Uehara,F., Ohba,N. and Miyagi,T.
  TITLE     [Immunohistochemical localization of cytosolic sialidase in the
            epithelium of rat cornea and conjunctiva]
  JOURNAL   Nippon Ganka Gakkai Zasshi 101 (9), 707-710 (1997)
   PUBMED   9311229
REFERENCE   8  (bases 1 to 1693)
  AUTHORS   Sato,K. and Miyagi,T.
  TITLE     Involvement of an endogenous sialidase in skeletal muscle cell
            differentiation
  JOURNAL   Biochem Biophys Res Commun 221 (3), 826-830 (1996)
   PUBMED   8630046
REFERENCE   9  (bases 1 to 1693)
  AUTHORS   Sato,K. and Miyagi,T.
  TITLE     Genomic organization and the 5'-upstream sequence of the rat
            cytosolic sialidase gene
  JOURNAL   Glycobiology 5 (5), 511-516 (1995)
   PUBMED   8563137
REFERENCE   10 (bases 1 to 1693)
  AUTHORS   Miyagi,T., Konno,K., Emori,Y., Kawasaki,H., Suzuki,K., Yasui,A. and
            Tsuik,S.
  TITLE     Molecular cloning and expression of cDNA encoding rat skeletal
            muscle cytosolic sialidase
  JOURNAL   J Biol Chem 268 (35), 26435-26440 (1993)
   PUBMED   8253770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1 and BC091154.1.
            
            On Mar 8, 2007 this sequence version replaced NM_017130.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16300.1, FQ213221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000009.1  95711988-95712165
            179-1693            BC091154.1         108-1622
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..1693
                     /gene="Neu2"
                     /note="neuraminidase 2"
                     /db_xref="GeneID:29204"
                     /db_xref="RGD:3164"
     exon            1..178
                     /gene="Neu2"
                     /inference="alignment:Splign:2.1.0"
     exon            179..390
                     /gene="Neu2"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1329
                     /gene="Neu2"
                     /EC_number="3.2.1.18"
                     /note="N-acetyl-alpha-neuraminidase 2; cytosolic
                     sialidase"
                     /codon_start=1
                     /product="sialidase-2"
                     /protein_id="NP_058826.2"
                     /db_xref="GeneID:29204"
                     /db_xref="RGD:3164"
                     /translation="METCPVLQKETLFHTEVYAYRIPALLYLKKQKTLLAFAEKRASR
                     TDEHAELIVLRRGSYNGATNHVKWQPEEVVTQAQLEGHRSMNPCPLYDKQTKTLFLFF
                     IAVPGRVSEQHQLQTRVNVTRLCRVTSTDYGMNWSPVQDLTETTIGSTHQDWATFAVG
                     PGHCLQLRNRAGSLLVPAYAYQKLHPVHKPTPFAFCFISLDHGHTWELGNFVSENSLE
                     CQVAEVGTGAHRVVYLNARSFIGARVQAQSPNDGLDFQDNQVVSKLVEPPHGCHGSVV
                     AFHSPTSKPDALDMWLLYTHPTDSRNRTNLGVYLNQTPLDPTAWSEPTLLATGTCAYS
                     DLQNMGRGPDGSPQFGCLYESGNYDEIIFLMFTLKQAFPTVHGAQ"
     exon            391..1665
                     /gene="Neu2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggacagc tgcagagagc cacttagcaa gctcctctac tctcctcagg gttagcagct
       61 gaaggttgtc acacatctgt tgtgagggga actggttatg gcaggaatct atacaaaacc
      121 cactttttcg attcttgggt agaagactgc caggacgcta cagccgcact ggcgaacgat
      181 ctcaggccca tggagacctg ccccgtcctc cagaaagaga cgctgttcca cacagaagtc
      241 tatgcttaca gaatccctgc tctgctctac ctgaagaagc agaagaccct gctggccttt
      301 gcagaaaagc gagccagcag gacggatgag catgctgagt tgattgtcct gcgaagaggg
      361 agctacaatg gagccaccaa ccatgtcaag tggcaacctg aggaagtggt gacccaagcc
      421 cagctggagg gccaccgctc catgaatcca tgtcccttgt atgacaagca aacaaagacc
      481 ctcttccttt tcttcattgc tgtccctggg cgtgtatcag aacagcatca gctccaaact
      541 agggttaatg tcacacggct atgccgtgtc accagcaccg attatgggat gaactggagc
      601 cccgtccagg acctcacaga gaccaccatt ggcagcaccc accaggactg ggccacattt
      661 gctgtgggtc cagggcactg tctgcagctg cggaacagag ctgggagcct gctggtacct
      721 gcttatgcct accagaagct gcaccctgtc cataaaccta ccccctttgc cttctgcttc
      781 atcagccttg accacgggca cacgtgggaa ctagggaact ttgtgtctga gaactcactg
      841 gagtgtcagg tggctgaggt tggcactggt gctcataggg tggtatatct caatgctagg
      901 agcttcatag gagctagagt ccaggcacaa agtcctaacg atggcctgga tttccaggac
      961 aaccaggtag taagtaagct tgtagagccc ccccacgggt gtcatggaag tgtggtcgcc
     1021 ttccacagcc ccacctctaa gccagatgcc ttagacatgt ggctgcttta tacccaccct
     1081 acggactcca ggaatagaac caacctgggc gtgtacctca accagacgcc actagatccc
     1141 acagcctggt cagagcccac cctgctagcc acgggcacct gtgcctactc agacttgcag
     1201 aatatggggc gtggccctga tgggtcccca cagtttgggt gcctgtatga atcaggtaac
     1261 tatgacgaga tcattttcct catgttcacc ctgaagcaag cttttcccac agtacatggt
     1321 gctcagtgac ctcattgcat gtggcttcca aagggcttcc tgtgcttcag aacacccgtc
     1381 tctctttcct tccagcatcc tctggactct tgaatccagc tcttgggtct gttccttggg
     1441 agtatacaga gagtttggtc tcttgactct tagcaagttt tgttctttca gcctccgaaa
     1501 gtgggttcta ttttcagccc agaaatcaaa ggagcctgac tttcctcagc ctgtatgtat
     1561 aaaggctgcc actctgcatg ttggctgtca ctatgttagc ttaacctgcc tgtttcccca
     1621 tgcctagttt ttggatgaat attaataaat taattatcct actcaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaa
//
