LOCUS       NM_031522               1931 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus neuraminidase 1 (Neu1), mRNA.
ACCESSION   NM_031522
VERSION     NM_031522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Guo,Z., Tuo,H., Tang,N., Liu,F.Y., Ma,S.Q., An,P., Yang,D.,
            Wang,M.Y., Fan,D., Yang,Z. and Tang,Q.Z.
  TITLE     Neuraminidase 1 deficiency attenuates cardiac dysfunction,
            oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in
            diabetic cardiomyopathy mice
  JOURNAL   Int J Biol Sci 18 (2), 826-840 (2022)
   PUBMED   35002528
  REMARK    GeneRIF: Neuraminidase 1 deficiency attenuates cardiac dysfunction,
            oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in
            diabetic cardiomyopathy mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Inim,M.D., Ibrahim,M.A., Isah,M.B. and Onyike,E.
  TITLE     Variations in the mRNA expression level of UDP-GlcNAc
            epimerase/ManNAc kinase and neuraminidase 1 genes in organs of type
            2 diabetic animals
  JOURNAL   Glycoconj J 38 (1), 129-134 (2021)
   PUBMED   33608771
  REMARK    GeneRIF: Variations in the mRNA expression level of UDP-GlcNAc
            epimerase/ManNAc kinase and neuraminidase 1 genes in organs of type
            2 diabetic animals.
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Haxho,F., Haq,S. and Szewczuk,M.R.
  TITLE     Biased G protein-coupled receptor agonism mediates Neu1 sialidase
            and matrix metalloproteinase-9 crosstalk to induce transactivation
            of insulin receptor signaling
  JOURNAL   Cell Signal 43, 71-84 (2018)
   PUBMED   29277445
  REMARK    GeneRIF: These findings uncover a biased GPCR agonist-induced IR
            transactivation signaling axis, mediated by Neu1 sialidase and the
            modification of insulin receptor glycosylation.
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Nomura,K., Vilalta,A., Allendorf,D.H., Hornik,T.C. and Brown,G.C.
  TITLE     Activated Microglia Desialylate and Phagocytose Cells via
            Neuraminidase, Galectin-3, and Mer Tyrosine Kinase
  JOURNAL   J Immunol 198 (12), 4792-4801 (2017)
   PUBMED   28500071
  REMARK    GeneRIF: study concludes that activated microglia release Gal-3 and
            a neuraminidase that desialylates microglial and PC12 surfaces,
            enabling Gal-3 binding to PC12 (neuron-like) cells and their
            phagocytosis via Mer tyrosine kinase (MerTK).
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Bonardi,D., Ravasio,V., Borsani,G., d'Azzo,A., Bresciani,R.,
            Monti,E. and Giacopuzzi,E.
  TITLE     In silico identification of new putative pathogenic variants in the
            NEU1 sialidase gene affecting enzyme function and subcellular
            localization
  JOURNAL   PLoS One 9 (8), e104229 (2014)
   PUBMED   25153125
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Hasegawa,T., Feijoo Carnero,C., Wada,T., Itoyama,Y. and Miyagi,T.
  TITLE     Differential expression of three sialidase genes in rat development
  JOURNAL   Biochem Biophys Res Commun 280 (3), 726-732 (2001)
   PUBMED   11162581
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Rottier,R.J., Bonten,E. and d'Azzo,A.
  TITLE     A point mutation in the neu-1 locus causes the neuraminidase defect
            in the SM/J mouse
  JOURNAL   Hum Mol Genet 7 (2), 313-321 (1998)
   PUBMED   9425240
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Bonten,E., van der Spoel,A., Fornerod,M., Grosveld,G. and d'Azzo,A.
  TITLE     Characterization of human lysosomal neuraminidase defines the
            molecular basis of the metabolic storage disorder sialidosis
  JOURNAL   Genes Dev 10 (24), 3156-3169 (1996)
   PUBMED   8985184
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   Samollow,P.B., Ford,A.L. and VandeBerg,J.L.
  TITLE     Biochemical characteristics and subcellular localizations of rat
            liver neuraminidase isozymes: a paradox resolved
  JOURNAL   Biochem Genet 28 (5-6), 283-298 (1990)
   PUBMED   2393382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883045.1.
            
            On Sep 28, 2009 this sequence version replaced NM_031522.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100639.1, AB035722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               BX883045.1         118943-119266
            325-517             BX883045.1         119632-119824
            518-780             BX883045.1         120163-120425
            781-963             BX883045.1         121836-122018
            964-1186            BX883045.1         122143-122365
            1187-1931           BX883045.1         122462-123206
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1931
                     /gene="Neu1"
                     /note="neuraminidase 1"
                     /db_xref="GeneID:24591"
                     /db_xref="RGD:3163"
     exon            1..324
                     /gene="Neu1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1413
                     /gene="Neu1"
                     /EC_number="3.2.1.18"
                     /note="sialidase-1; lysosomal sialidase;
                     N-acetyl-alpha-neuraminidase 1; sialidase 1 (lysosomal
                     sialidase)"
                     /codon_start=1
                     /product="sialidase-1 precursor"
                     /protein_id="NP_113710.2"
                     /db_xref="GeneID:24591"
                     /db_xref="RGD:3163"
                     /translation="MVGAEPSRPPGPPSYWTGRRGQGLAAIFLLLVSAAGSEARTEDD
                     FSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKF
                     IAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGVVFLIYTLCAHKVNCQV
                     ASTMLVWSKDDGVSWSPPRNLSVDIGTEMFAPGPGSGIQKQREPWKGRLIVCGHGTLE
                     RDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQ
                     NNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEY
                     RVNLTLRWSFSNGTSWQKERVQLWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLN
                     RYTESISMVKISVYGTL"
     exon            325..517
                     /gene="Neu1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..780
                     /gene="Neu1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..963
                     /gene="Neu1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1186
                     /gene="Neu1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1931
                     /gene="Neu1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgggtca catgcggatg tcggacagct gggtggacta attggagtcg cggcagcgtg
       61 gaccaaggcc ccctccaagg ggagggttcg gagtgacgtg cgcgctttta aagggtcgag
      121 gtcagctgac cgcttgccac cggtgaccac ttcgtggacg gggattgggg attgcgggga
      181 gccatggtgg gggcagagcc aagcagaccc ccgggaccac cgagctactg gacaggccgg
      241 cggggtcagg ggctcgcagc gatcttcctg ctcctggtgt ccgcggcggg atcagaggcc
      301 aggacagagg atgacttcag cctggtgcag ccgctggtga ccatggagca attgctgtgg
      361 gtgagcggga agcagatcgg ctccgtagac acttttcgaa tcccgctcat cacagccacc
      421 cctcggggca cgctcctggc cttcgctgag gctaggaaaa agtctgcatc cgatgagggg
      481 gccaagttca tcgctatgag gaggtccaca gaccagggta gcacgtggtc ctctacggct
      541 ttcattgtag acgacgggga ggcctccgat gggctgaacc tgggggctgt ggtgaacgac
      601 gtagacacag gagtggtgtt cctcatctat accctctgtg ctcacaaggt caactgccag
      661 gtggcctcta ccatgctggt ttggagtaag gatgacggcg tttcctggag cccaccgcgg
      721 aatctctccg tggatattgg cacagagatg tttgcccctg gacccggctc tggcattcag
      781 aaacagcggg agccttggaa gggccggctc attgtgtgtg gacacgggac gctggagcga
      841 gatggggtct tctgtctcct cagtgatgac cacggtgcct cctggcacta tgggactgga
      901 gtgagcggca ttcccttcgg ccagcccaaa cacgatcacg atttcaaccc cgacgagtgc
      961 cagccctacg agcttccaga cggctcagtc atcatcaacg cccggaacca gaataactac
     1021 cactgccgct gcaggatcgt cctccgcagc tatgacgcct gtgacaccct caggccccgg
     1081 gatgtgacct tcgaccctga gctcgtggac cctgtggtag ctgcaggagc gctagccacc
     1141 agctccggca ttgtcttctt ctccaatcca gcccatcccg agtaccgagt gaacctgacc
     1201 ctgcgctgga gcttcagcaa tggcacatcc tggcagaagg agagggtcca gttgtggccg
     1261 ggacccagcg gctactcatc cctgacagcc ctggaaaaca gcacggacgg gaagaagcag
     1321 cccccgcagc tgttcgttct gtacgagaaa ggactgaacc ggtacacgga gagcatctcc
     1381 atggtcaaaa tcagcgtcta cggcacgctc tgagccgcgc gcctaaggac accaagtcct
     1441 ggaccctgac ttcacagctc tctggaccgt gtgcagaggg tgcctgaaac acagctcttc
     1501 ctccgaattc cccttcaacg gggaagtcac tccgttatga cttaacgccc agcttcctct
     1561 tcccagagag gaagtccctc cctcaccagg aacactgttt ttccagaatg ttggggatgg
     1621 tccctgtcca ttctcctcca ggacagcgga gctgttcctt tctgggacag gatgggggag
     1681 gggctccccc tggagaggtg aatagatatg aactcaggga actgggaagg cctggtgtcc
     1741 tagggtattg gaggcaggta ctagatgtga ttgctgaaag tccccggggc agagtgtcct
     1801 ttcagtgcaa ggataaacac acacacacac acacacacac acacacacac acatgtgcac
     1861 cccctgatta tttatgaatc gaaatatttg tgacttaaaa tttttaatgc aaaaaaaaaa
     1921 gtgtttgtgg a
//
