LOCUS       NM_001308239            6213 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus nestin (Nes), transcript variant 1, mRNA.
ACCESSION   NM_001308239 XM_006232600
VERSION     NM_001308239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6213)
  AUTHORS   Cizkova,D., Zurmanova,J.M., Gerykova,L., Kouvelas,A., Heles,M.,
            Elsnicova,B., Galatik,F., Silhavy,J., Pravenec,M. and Mokry,J.
  TITLE     Nestin expression in intact and hypertrophic myocardium of
            spontaneously hypertensive rats during aging
  JOURNAL   J Muscle Res Cell Motil 45 (2), 41-51 (2024)
   PUBMED   36690826
  REMARK    GeneRIF: Nestin expression in intact and hypertrophic myocardium of
            spontaneously hypertensive rats during aging.
REFERENCE   2  (bases 1 to 6213)
  AUTHORS   Motoyoshi,A., Saitoh,F., Iida,T. and Fujieda,H.
  TITLE     Nestin Regulates Muller Glia Proliferation After Retinal Injury
  JOURNAL   Invest Ophthalmol Vis Sci 64 (14), 8 (2023)
   PUBMED   37934159
  REMARK    GeneRIF: Nestin Regulates Muller Glia Proliferation After Retinal
            Injury.
REFERENCE   3  (bases 1 to 6213)
  AUTHORS   Zhou,J.J., Li,H., Qian,Y.L., Quan,R.L., Chen,X.X., Li,L., Li,Y.,
            Wang,P.H., Meng,X.M., Jing,X.L. and He,J.G.
  TITLE     Nestin represents a potential marker of pulmonary vascular
            remodeling in pulmonary arterial hypertension associated with
            congenital heart disease
  JOURNAL   J Mol Cell Cardiol 149, 41-53 (2020)
   PUBMED   32950539
  REMARK    GeneRIF: Nestin represents a potential marker of pulmonary vascular
            remodeling in pulmonary arterial hypertension associated with
            congenital heart disease.
REFERENCE   4  (bases 1 to 6213)
  AUTHORS   Tsyba,D.L., Kirik,O.V., Kolpakova,M.E., Yakovleva,A.A. and
            Korzhevskii,D.E.
  TITLE     Expression of Nestin and Glial Fibrillary Acidic Protein in the
            Marginal Ischemic Zone of the Brain in SHR Rats
  JOURNAL   Bull Exp Biol Med 169 (4), 576-581 (2020)
   PUBMED   32910393
  REMARK    GeneRIF: Expression of Nestin and Glial Fibrillary Acidic Protein
            in the Marginal Ischemic Zone of the Brain in SHR Rats.
REFERENCE   5  (bases 1 to 6213)
  AUTHORS   Wang,Y., Du,X., Wang,D., Wang,J. and Du,J.
  TITLE     Effects of Bisphenol A Exposure during Pregnancy and lactation on
            Hippocampal Function in Newborn Rats
  JOURNAL   Int J Med Sci 17 (12), 1751-1762 (2020)
   PUBMED   32714078
  REMARK    GeneRIF: Effects of Bisphenol A Exposure during Pregnancy and
            lactation on Hippocampal Function in Newborn Rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6213)
  AUTHORS   Lardon,J., Rooman,I. and Bouwens,L.
  TITLE     Nestin expression in pancreatic stellate cells and angiogenic
            endothelial cells
  JOURNAL   Histochem Cell Biol 117 (6), 535-540 (2002)
   PUBMED   12107504
  REMARK    GeneRIF: Nestin in the pancreas is primarily expressed in reactive
            stellate cells, or pericytes, and endothelial cells during active
            angiogenesis.
REFERENCE   7  (bases 1 to 6213)
  AUTHORS   Schmidt-Kastner,R. and Humpel,C.
  TITLE     Nestin expression persists in astrocytes of organotypic slice
            cultures from rat cortex
  JOURNAL   Int J Dev Neurosci 20 (1), 29-38 (2002)
   PUBMED   12008072
  REMARK    GeneRIF: Persistent expression of nestin in cultured cortical glial
            cells indicates a different time course of glial maturation in
            vitro, due to altered trophic stimulation/ neuronal maturation or
            degeneration of the vasculature.
REFERENCE   8  (bases 1 to 6213)
  AUTHORS   Yaworsky,P.J. and Kappen,C.
  TITLE     Heterogeneity of neural progenitor cells revealed by enhancers in
            the nestin gene
  JOURNAL   Dev Biol 205 (2), 309-321 (1999)
   PUBMED   9917366
REFERENCE   9  (bases 1 to 6213)
  AUTHORS   Shibata,T., Yamada,K., Watanabe,M., Ikenaka,K., Wada,K., Tanaka,K.
            and Inoue,Y.
  TITLE     Glutamate transporter GLAST is expressed in the radial
            glia-astrocyte lineage of developing mouse spinal cord
  JOURNAL   J Neurosci 17 (23), 9212-9219 (1997)
   PUBMED   9364068
REFERENCE   10 (bases 1 to 6213)
  AUTHORS   Lendahl,U., Zimmerman,L.B. and McKay,R.D.
  TITLE     CNS stem cells express a new class of intermediate filament protein
  JOURNAL   Cell 60 (4), 585-595 (1990)
   PUBMED   1689217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 28, 2015 this sequence version replaced XM_006232600.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF538924.1, SRR26643290.8681.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-913               JAXUCZ010000002.1  175736588-175737500
            914-1038            JAXUCZ010000002.1  175738468-175738592
            1039-1112           JAXUCZ010000002.1  175740263-175740336
            1113-6213           JAXUCZ010000002.1  175740531-175745631
FEATURES             Location/Qualifiers
     source          1..6213
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..6213
                     /gene="Nes"
                     /note="nestin"
                     /db_xref="GeneID:25491"
                     /db_xref="RGD:3162"
     exon            1..913
                     /gene="Nes"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..5809
                     /gene="Nes"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="nestin isoform 1"
                     /protein_id="NP_001295168.1"
                     /db_xref="GeneID:25491"
                     /db_xref="RGD:3162"
                     /translation="MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLR
                     AQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLAR
                     ERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPR
                     RPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRG
                     ARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQ
                     SQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKP
                     NFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIP
                     PISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHF
                     PDDLTSLATTLNPHHPTLEAKDGESSESRVSSIFQEDEGQIWELVEKEADIEVKVENS
                     SAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGH
                     LGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGT
                     LKRFSSLGKESQEVVRPSKEGNLESWTAFKEESQHPLGFPGAEDQMLERLVEKEDQSF
                     PRSPEEEDQEACRPLQKENQEPLGYEEAEGQILERLIEKESQESLRSPEEEDQEAGRS
                     LQKENQEPLGYEEAEGQILERLIEKESQESLRSAEEEDQEACRSLQKENQEPLGYEEA
                     EDQILERLIEKESQESLRSPEEEDQEAGRSLQKENQEPLGYEEAEDQMLERLIEKESQ
                     ESLKSPEENQRIGKPLERENQKSLRYLEENQETFVPLESRNQRPLRSLEVEEEEQRIV
                     KPLEKVSQDSLGSLAEENVQPLRYLEEDNCINKSLLEDKTHKSLGSLEDRNGDSIIIP
                     QESETQVSLRPPEEEDQRIVNHLEKESQEFSRSSEEEEQVMERSLEGENHESLSSVEK
                     EDQMVESQLEKESQDSGKSLEDESQETFGPLEKENAESLRSLAGQDQEEQKLEQETQQ
                     TLRAVGNEQMAVSPPEKVDPELPKPLGNDQEIARSLGKENQESLVSLKEKGIETVKSL
                     ETEIIEPLETAEEDLERRKSIDTQEPLWSTEVARETVEPPEDEPPGSLGSVDENRETL
                     TSLEKESQELSSLGKWNVETRVEDSQQCLQVEEGLQEEQHQESLREVKQELPSSGNQQ
                     RWEDVVEGKAVGQEAPLATTGVGTEDKAELHLRGQGGEEEAAAEGELLQDIVGEAWSL
                     GSSEPKEQRVPAEALDNLEGGALEVPVAQSMPEVTERDEDRAQAGEQDSIEVTLGLEA
                     ARTGLELEQEVVGLEDPRHFAREEAIPPSLGEESVKAKIAQGLEGPGKEPKEAGALDS
                     GILELPKTSSEALECQGHEESESMEGWEEEEASLETSDHEGSDAPQPRPPETEEDEGA
                     QAALTAPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGSEALERVENEPEFG
                     LGEIPEGLQDWEEGREESEADDLGETLPDSTPLGLYLRSPASPKWDLAGEQRLSPQGD
                     AGKEDWGPAVPAAQGLSGPPEEEEEQGHGSDLSSEEFEDLGTEASLLPGVPKEVADHV
                     GQVPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEGAESGAQWWGSGASGGGCK
                     VQDIAQRGDPVQESVGVSGLWDDGLRGAAANVPALEMVSQDSAEPSGSEESESASLEG
                     EEGQVTDHLDAPQEVTSMVPGVGDAFDIGGQSPNLDSEQVNGKMENGLEQAEGQVVLD
                     GDEDQELLLQGQEVGALKVPLVASPVHLGPSQPLKFTLSGVDGDSWSSGED"
     exon            914..1038
                     /gene="Nes"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1112
                     /gene="Nes"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..6213
                     /gene="Nes"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggagtt ctccgcttcc gctgggtcac tgtcgccgct acttcttttc aacccctaaa
       61 agctccacgg gccactccct tctctagtgc tccacgtccg cttgccctcg ggggccagac
      121 cagcgacatg gagggttgcg tcggggaaga atcttttcag atgtgggagc tcaatcgacg
      181 cctggaggcc tacctgaccc gggtcaagac gctagaagag caaaaccagc tgctcagcgc
      241 cgagcttggg ggactccggg cgcagtccgg agacacctcc tggagagccc gagccgatga
      301 cgagctggca tccctgcgga tcctcgtcga tcagcgctgg cgggagaagc tcgaggctga
      361 ggtgcagcgc gacaaccttg cggaagagct ggagagcgtg gcgggccggt gccagcaggt
      421 gcggcttgct cgggagcgga ccgtccagga ggccgcctgc agccggcgcg cactcgaggc
      481 ggagaagaat gcgcggggct ggctgagcac ccaggcggcc gagctggagc gggagttaga
      541 ggctctgcga gccgcgcacg aggaggagcg cgcacacctg aacgcccagg ccgcctgtgc
      601 gcctcgccgg ccccccgcac cgccccacgg atccccggtc cgggcccccg aagtcgagga
      661 tctggccagg cgactaggcg aagtgtggcg cggggcggtg cgtgactacc aggagcgcgt
      721 ggctcacatg gaaagctcgc tgggtcaggc acgcgagcgg ctgagccaag ccgtgcgggg
      781 cgctcgggag tgtcgcttag aggtgcaaca gctgcaggct gatcgcgaca gcctccagga
      841 gcgcagagaa gcgctggaac agagattgga aggccgctgg caggaccggc tgcaggccac
      901 tgataagttc cagctggctg tggaagccct ggagcaggag aagcaaggtc tacagagtca
      961 gatcgctcag atcctggaag gtgggcagca actggcacac ctcaagatgt cccttagtct
     1021 ggaggtggct acatacagga ctctgctgga ggctgagaac tctcggttgc agacacctgg
     1081 acgaggttcc caggcttctc ttggctttct ggaccccaag ctgaagccga atttccttgg
     1141 gataccagag gaccagtacc tgggatctgt gctccctgcc ctcagcccca catccttccc
     1201 ttcccccttg cctaataccc ttgagactcc tgtgacagcc ttcctgaaga ctcaggagtt
     1261 ccttcaggcc agaaccccca ccttggccag cactcccatc ccacctatat ctgaggctcc
     1321 ctgtcctcca aatgcagagg tcagagccca ggaggtccct ctttctctgc tccagacaca
     1381 ggctccagag cccctttggg ctgaggccac agtgcctagt tcttctgcta tcctcccaga
     1441 actagaggaa cctgggggca agcagcaggg tcacttccct gatgatctga cctccttagc
     1501 cacaaccctc aaccctcacc accctacttt agaggctaaa gatggagaat ccagtgagtc
     1561 tagagtttct agcatattcc aggaagatga ggggcaaatc tgggaactgg tagagaaaga
     1621 agcagatata gaggtaaaag tagaaaacag ctcagcccag aaaacacaag aaagtggtct
     1681 ggacacagaa gaaacccagg attcccaggg acctttgcag aaggaaacac tgaaggctct
     1741 aggagaggag ccactgatgt ctctgaaaat ccagaactat gagacagcag ggaaagagaa
     1801 ttgcaattct tctacagaag gccacctggg aacactagaa ggcccagaaa aagaaaagca
     1861 aataccacta aagtctttag aagaaaagaa tgtagagtca gagaaaactc tagaaaatgg
     1921 ggttcctgta ctatctgagc ttttaggaaa agaagacaca agaacagagg atcaagaatt
     1981 aatgtctcct aaaggtacac taaagagatt ttcatctcta ggaaaggaaa gtcaagaagt
     2041 agtgaggcct tcaaaagagg ggaacctaga atcatggaca gcttttaaag aggagagcca
     2101 acacccactg ggatttccag gagctgagga ccagatgctt gagagactgg tagagaaaga
     2161 ggatcagagc ttcccaaggt ctccagagga agaggaccag gaggcatgta gacctctgca
     2221 gaaagagaat caggaaccac tagggtatga agaagcagag ggccagatac ttgagagact
     2281 gatagaaaaa gagagtcagg agtccctgag gtctccagaa gaagaggacc aggaggcagg
     2341 tagatctctg cagaaagaga atcaggagcc actagggtat gaagaagcag agggccagat
     2401 acttgagaga ctgatagaaa aagagagtca ggagtccctg agatctgcag aagaagagga
     2461 ccaggaggca tgtagatctc tgcagaaaga gaatcaggag ccactagggt atgaagaagc
     2521 agaggaccag atacttgaga gactgataga aaaagagagt caggagtccc tgaggtctcc
     2581 agaagaagag gaccaggagg caggtagatc tctgcagaaa gagaatcagg agccactagg
     2641 gtatgaagaa gcagaggacc agatgcttga gagactgata gaaaaagaga gtcaggagtc
     2701 cctgaagtct ccagaagaaa accagaggat tgggaagcct ctagaaagag agaatcagaa
     2761 atctctgagg tatcttgaag aaaaccagga gacttttgta ccactagaaa gcaggaacca
     2821 gaggccactg agatctctag aagtagaaga ggaggagcag agaattgtga aacctctaga
     2881 aaaagtgagt caggattccc tcggatctct agcagaagag aatgtgcagc cactgaggta
     2941 tctggaagaa gataactgca taaataagag ccttctagaa gacaagactc acaagtcctt
     3001 ggggtctctt gaagatagaa atggggatag cattattata ccacaagaaa gtgagaccca
     3061 ggtttcattg aggcctccag aagaggagga ccagaggatt gtgaaccatc tagaaaaaga
     3121 aagtcaggag ttctcaaggt cttcagaaga agaagagcag gtgatggaga gatctctaga
     3181 aggagagaac catgaatcac tgagttctgt agaaaaagag gaccagatgg ttgagagcca
     3241 actagagaaa gagagtcagg actcagggaa gtctcttgaa gatgagagcc aggagacttt
     3301 tggacctctg gaaaaagaga atgcagagtc cctgagatct ctagcaggac aggaccaaga
     3361 ggaacagaag cttgaacaag agacccaaca aacactgagg gctgtaggga atgagcagat
     3421 ggcagtgagc ccaccagaaa aggtggatcc agagttaccg aagcctcttg gaaatgacca
     3481 ggaaatagct agatctcttg gaaaagagaa tcaagagtca ctagtgtcac tgaaagaaaa
     3541 aggtatagag acagtgaagt ctttagaaac agagatcata gaaccactgg agactgcaga
     3601 agaggacctg gaaagaagga agtctataga tactcaggag ccattgtggt ctactgaagt
     3661 ggctagagag acagtagaac ctccagaaga tgagccccca ggatcgctag ggtctgtgga
     3721 tgagaaccga gagacactga catcccttga aaaggagagt caagaactga gctctctggg
     3781 caagtggaac gtagagacca gggtagagga cagtcagcag tgcctgcaag tagaagaggg
     3841 tctgcaggag gaacagcacc aagagtctct gagagaggtg aagcaggagc tgcctagctc
     3901 tggaaatcaa cagcggtggg aggatgtggt ggagggcaaa gcagtgggtc aggaagcacc
     3961 tctggcaacc acaggagtgg gaactgagga taaggcagag ttgcatctga gggggcaagg
     4021 tggagaggaa gaagctgcag cagagggaga gctgttgcag gatattgtgg gggaggcctg
     4081 gagtctgggg agctctgagc ccaaggagca gagggtccct gctgaggccc tcgacaacct
     4141 ggaaggaggg gccttagagg tcccagttgc tcagtcaatg ccagaggtga cagagcgaga
     4201 tgaggataga gcccaagcag gtgaacaaga ctccatagag gtgacccttg ggttagaggc
     4261 tgccagaact ggactggaac tcgagcagga agtggtaggg ctagaggacc caaggcattt
     4321 tgccagggag gaggccattc ccccatccct gggggaggaa agtgtgaagg caaagatagc
     4381 tcagggcttg gaagggcctg gaaaggaacc aaaagaggca ggtgctctgg actcggggat
     4441 ccttgaattg cccaagacta gcagcgaggc tctggaatgc cagggccatg aagagtctga
     4501 gtccatggag ggctgggaag aagaggaggc ctcactggag acttcagatc atgagggcag
     4561 tgatgcccct cagcccaggc ccccagaaac agaagaagat gagggtgcac aggcagcact
     4621 gacagcccct ggtcccaagc tcttggaacc ctgttcaccc atcccaatcc tgacagatgc
     4681 ccatgagctg cagccccagg ctgaggggat ccaggaggct ggctggcagc cagaagctgg
     4741 gtctgaagca ctagaaaggg tagaaaatga gccagagttt ggtcttgggg agatcccgga
     4801 gggcctccag gattgggaag agggcagaga agaaagcgag gcagatgatc taggggaaac
     4861 tctccctgac tctactcccc tgggcctcta cctgaggtcc cctgcttctc caaagtggga
     4921 tctggctgga gaacagaggc tttcccctca aggggatgcc gggaaggaag actggggtcc
     4981 tgctgtcccc gctgcccagg gcctcagtgg tccaccggaa gaggaggagg agcaaggcca
     5041 tggctctgac ctatcatctg aagagtttga ggacctaggg actgaggcct ctcttcttcc
     5101 aggggttccc aaggaggtag cagatcacgt gggccaagtg cccccggtac tgcagcctgc
     5161 atgctgggat cagggtgggg aatctgatgg gtttgctgat gaggaagaaa gtggggagga
     5221 gggagaggaa gaagatgctg atgaggaagg agcagagtca ggagctcagt ggtgggggtc
     5281 aggggcctct ggtggaggct gcaaggtcca ggatattgcc caaagaggag acccggtaca
     5341 ggagtctgtg ggtgtcagtg gtctctggga tgatggcttg agaggtgctg cagctaatgt
     5401 tcctgcccta gagatggtat ctcaggacag tgctgagcct tctgggtcag aggagtctga
     5461 gtctgcttcc ttggaggggg aggaaggtca agtgactgac catttagatg ctccccagga
     5521 ggtgaccagc atggtcccgg gggtaggaga tgcctttgac attggtggcc agagccccaa
     5581 cttggactca gaacaagtga atgggaaaat ggagaatgga ctagaacagg ctgaggggca
     5641 ggtggtcctg gatggggacg aggatcaaga actcctatta cagggacagg aggtgggtgc
     5701 tctaaaggtt cctttggtag catctcctgt gcatctaggc ccaagccagc ccctgaagtt
     5761 cactctgagt ggggtagatg gggattcctg gtcctcaggg gaagactaga aactgcccct
     5821 ctggctctga ggatgtactg gtggggatgt ccctccctgc tctgggtgac cactcttagc
     5881 tttgataact tgacccatgg tatttgtcct ggagagttgt ggctgggctg agcaagggag
     5941 gtgagatcct cctgaaggct caggagttcc aggcctatag ttctaccccc tctttcttct
     6001 gtggctcacc tgctggaaga ggcctgggcc cagagctttc ccacaaggct gttctggcca
     6061 cagcttgcta gccttgccta ccacctgcac aaggtctggt ctggtgtatg cccaggggag
     6121 ctgagggcag catttatctg acccttcatc tcagcctgct gagagcttgt tcctctcttc
     6181 ctccctgaat aaagccgtat ccctacctac aaa
//
