LOCUS       NM_001419532            7174 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus neogenin 1 (Neo1), mRNA.
ACCESSION   NM_001419532 XM_039082412
VERSION     NM_001419532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7174)
  AUTHORS   Hong,N., Kim,M.H., Min,C.K., Kim,H.J. and Lee,J.H.
  TITLE     The co-expression of Neogenin with SOX2 in hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 490 (2), 453-459 (2017)
   PUBMED   28623139
  REMARK    GeneRIF: Neogenin colocalizes with SOX2 in dissociated hippocampal
            neurons.
REFERENCE   2  (bases 1 to 7174)
  AUTHORS   van Erp,S., van den Heuvel,D.M.A., Fujita,Y., Robinson,R.A.,
            Hellemons,A.J.C.G.M., Adolfs,Y., Van Battum,E.Y., Blokhuis,A.M.,
            Kuijpers,M., Demmers,J.A.A., Hedman,H., Hoogenraad,C.C.,
            Siebold,C., Yamashita,T. and Pasterkamp,R.J.
  TITLE     Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance
            Receptors by ADAM Proteases
  JOURNAL   Dev Cell 35 (5), 537-552 (2015)
   PUBMED   26651291
REFERENCE   3  (bases 1 to 7174)
  AUTHORS   Schnichels,S., Heiduschka,P. and Julien,S.
  TITLE     RGMA and neogenin protein expression are influenced by lens injury
            following optic nerve crush in the rat retina
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 250 (1), 39-50 (2012)
   PUBMED   21887516
REFERENCE   4  (bases 1 to 7174)
  AUTHORS   Koeberle,P.D., Tura,A., Tassew,N.G., Schlichter,L.C. and
            Monnier,P.P.
  TITLE     The repulsive guidance molecule, RGMa, promotes retinal ganglion
            cell survival in vitro and in vivo
  JOURNAL   Neuroscience 169 (1), 495-504 (2010)
   PUBMED   20457227
  REMARK    GeneRIF: The addition of RGMa increased retinal ganglion cell
            survival. This effect was mediated by the Neogenin receptor.
REFERENCE   5  (bases 1 to 7174)
  AUTHORS   Lee,D.H., Zhou,L.J., Zhou,Z., Xie,J.X., Jung,J.U., Liu,Y., Xi,C.X.,
            Mei,L. and Xiong,W.C.
  TITLE     Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin
            expression and iron homeostasis
  JOURNAL   Blood 115 (15), 3136-3145 (2010)
   PUBMED   20065295
  REMARK    Erratum:[Blood. 2010 Jul 8;116(1):151. Lee, Dai-Hoon [corrected to
            Lee, Dae-Hoon]; Zhou, Li-Juau [corrected to Zhou, Li-Juan]; Xie,
            Jiau-Xiu [corrected to Xie, Jian-Xin]]
REFERENCE   6  (bases 1 to 7174)
  AUTHORS   Conrad,S., Genth,H., Hofmann,F., Just,I. and Skutella,T.
  TITLE     Neogenin-RGMa signaling at the growth cone is bone morphogenetic
            protein-independent and involves RhoA, ROCK, and PKC
  JOURNAL   J Biol Chem 282 (22), 16423-16433 (2007)
   PUBMED   17389603
  REMARK    GeneRIF: RGMa-mediated neogenin signal transduction pathway
            involved in axonal guidance.
            Erratum:[J Biol Chem. 2010 Dec 31;285(53):42140]
REFERENCE   7  (bases 1 to 7174)
  AUTHORS   Niederkofler,V., Salie,R. and Arber,S.
  TITLE     Hemojuvelin is essential for dietary iron sensing, and its mutation
            leads to severe iron overload
  JOURNAL   J Clin Invest 115 (8), 2180-2186 (2005)
   PUBMED   16075058
REFERENCE   8  (bases 1 to 7174)
  AUTHORS   Kang,J.S., Yi,M.J., Zhang,W., Feinleib,J.L., Cole,F. and
            Krauss,R.S.
  TITLE     Netrins and neogenin promote myotube formation
  JOURNAL   J Cell Biol 167 (3), 493-504 (2004)
   PUBMED   15520228
  REMARK    Erratum:[J Cell Biol. 2023 Oct 2;222(10):e20040503909082023c. doi:
            10.1083/jcb.20040503909082023c.. PMID: 37702713]
REFERENCE   9  (bases 1 to 7174)
  AUTHORS   Ren,X.R., Ming,G.L., Xie,Y., Hong,Y., Sun,D.M., Zhao,Z.Q., Feng,Z.,
            Wang,Q., Shim,S., Chen,Z.F., Song,H.J., Mei,L. and Xiong,W.C.
  TITLE     Focal adhesion kinase in netrin-1 signaling
  JOURNAL   Nat Neurosci 7 (11), 1204-1212 (2004)
   PUBMED   15494733
REFERENCE   10 (bases 1 to 7174)
  AUTHORS   Keino-Masu,K., Masu,M., Hinck,L., Leonardo,E.D., Chan,S.S.,
            Culotti,J.G. and Tessier-Lavigne,M.
  TITLE     Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
  JOURNAL   Cell 87 (2), 175-185 (1996)
   PUBMED   8861902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 7, 2023 this sequence version replaced XM_039082412.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               JAXUCZ010000008.1  68321659-68322152   c
            495-812             JAXUCZ010000008.1  68275133-68275450   c
            813-1088            JAXUCZ010000008.1  68269394-68269669   c
            1089-1242           JAXUCZ010000008.1  68265613-68265766   c
            1243-1379           JAXUCZ010000008.1  68262478-68262614   c
            1380-1534           JAXUCZ010000008.1  68251445-68251599   c
            1535-1655           JAXUCZ010000008.1  68249757-68249877   c
            1656-1875           JAXUCZ010000008.1  68226110-68226329   c
            1876-2030           JAXUCZ010000008.1  68221750-68221904   c
            2031-2179           JAXUCZ010000008.1  68217155-68217303   c
            2180-2318           JAXUCZ010000008.1  68216614-68216752   c
            2319-2368           JAXUCZ010000008.1  68213710-68213759   c
            2369-2516           JAXUCZ010000008.1  68211916-68212063   c
            2517-2627           JAXUCZ010000008.1  68209402-68209512   c
            2628-2822           JAXUCZ010000008.1  68208271-68208465   c
            2823-2918           JAXUCZ010000008.1  68202511-68202606   c
            2919-3142           JAXUCZ010000008.1  68200829-68201052   c
            3143-3281           JAXUCZ010000008.1  68200609-68200747   c
            3282-3389           JAXUCZ010000008.1  68198137-68198244   c
            3390-3584           JAXUCZ010000008.1  68196644-68196838   c
            3585-3617           JAXUCZ010000008.1  68195999-68196031   c
            3618-3686           JAXUCZ010000008.1  68192969-68193037   c
            3687-3834           JAXUCZ010000008.1  68188157-68188304   c
            3835-4073           JAXUCZ010000008.1  68183328-68183566   c
            4074-4166           JAXUCZ010000008.1  68182752-68182844   c
            4167-4325           JAXUCZ010000008.1  68178958-68179116   c
            4326-4589           JAXUCZ010000008.1  68175202-68175465   c
            4590-4726           JAXUCZ010000008.1  68172931-68173067   c
            4727-7174           JAXUCZ010000008.1  68169716-68172163   c
FEATURES             Location/Qualifiers
     source          1..7174
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..7174
                     /gene="Neo1"
                     /note="neogenin 1"
                     /db_xref="GeneID:81735"
                     /db_xref="RGD:619837"
     exon            1..494
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..4810
                     /gene="Neo1"
                     /codon_start=1
                     /product="neogenin precursor"
                     /protein_id="NP_001406461.1"
                     /db_xref="GeneID:81735"
                     /db_xref="RGD:619837"
                     /translation="MAAEREAGRLLSTSSSRRCCPPRPLLLLLPLLLLLGRPASGAAA
                     AKNGSPPQSAGASVRTFTPLYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWKKDGT
                     FLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLAVA
                     GLPRFTSQPEPSSIYVGNSGILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLV
                     ISNATEGDEGLYRCIVESGGPPKFSDEAELKVLQESEEMLDLVFLMRPSSMIKVIGQS
                     AVLPCVASGLPAPVIRWMKNEDVLDTESSGRLALLAGGSLEISDVTEDDAGTYFCVAD
                     NGNKTIEAQAELTVQVPPEFLKQPANIYARESMDIVFECEVTGKPAPTVKWVKNGDVV
                     IPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHDVAIPTLPP
                     TSLTSATTDHLAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFY
                     TKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPE
                     VQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYYMEKGTDKEQDVDVSSHS
                     YTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIV
                     IHWQPPSSATQNGQITGYKIRYRKASRKSDVTETVVTGTQLSQLIEGLDRGTEYNFRV
                     AALTVNGTGPATDWLSAETFESDLDESRVPEVPSSLHVRPLVTSIVVSWTPPENQNIV
                     VRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESA
                     VTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQ
                     KITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTW
                     SMTAHGATFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVN
                     AEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSS
                     DKMPNDQALGSAGKGGRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSIGVI
                     TIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNCKDVKPPDLWIHHERLELK
                     PIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRR
                     GMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPSSPWPIGT
                     SMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQS
                     LPTAHVRPSHPLKSFAVPAIPPPGPPIYDPALPSTPLLSQQALNHHLHSVKTASIGTL
                     GRSRPPMPVVVPSAPEVQEATRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA"
     exon            495..812
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1088
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1242
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1379
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1534
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1655
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1875
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2030
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2179
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2318
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2368
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2516
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2627
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2822
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2918
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3142
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3281
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3389
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3584
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3617
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3686
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3834
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..4073
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4166
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4325
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4589
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4726
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..7174
                     /gene="Neo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgccccc ctcgctctac cgtgaggagc ccgagtcggc ggcgggtggc ggcgcctgga
       61 acctggagag accgagccac cccccagctc tcgcccggaa tgtactgact ctccttctct
      121 gctctcctcc ccgccccgct gcaggaggga ggcgcccgca gtctttcccc ctgggcgcgc
      181 gagggggcct cgcgggccgg gccgggccgg gctggagccg agcctgcggc gcagggaccg
      241 gctgaagcgc gctgagggaa gggcgcgagc gctccgcggc gctgtcgccg ccgccgccgc
      301 cgccgccgcc gccgccgctc gtggggtaga gatggcggcg gagcgtgaag ccgggcgact
      361 cctcagcacc tcctcctccc ggcgctgctg cccgccacgg ccgctgctgc tgttgctgcc
      421 gctgctgctg ctgctcgggc gcccggcgtc cggcgccgcg gccgcgaaga acggctcccc
      481 gccgcagtcc gcaggagcca gtgttcgaac attcactccg ctttattttc tggtggagcc
      541 agtagacaca ctgtcagtta gaggctcttc tgttatattg aattgctccg catattctga
      601 gccttctcca aatattgaat ggaagaaaga tgggactttt ttaaacttag tgtcagatga
      661 tcgccgccag cttctcccag atggatctct attcatcagc aatgtggtgc attccaaaca
      721 caataagcct gatgaaggtt tctatcagtg tgtagccacg gttgataatc ttggaactat
      781 cgtcagcaga acagccaagc tcgcagtagc aggtcttcca agatttacca gccaaccaga
      841 accttcctca atctatgttg gaaacagtgg aattctgaat tgtgaagtta atgcagattt
      901 ggtcccattt gttagatggg aacagaacag acagcccctt cttttggatg acaggattgt
      961 caaacttcca agtggaacac tggttatcag caatgcgact gaaggagacg agggactcta
     1021 ccgctgcatt gttgaaagtg gtgggccacc aaagtttagt gatgaagctg aattgaaagt
     1081 tcttcaagaa tctgaggaaa tgctagactt ggtatttttg atgcgaccgt cttctatgat
     1141 caaagtcatt ggtcagagtg cagtgttgcc atgtgttgcc tcaggacttc ctgctccagt
     1201 cattaggtgg atgaagaatg aagacgtgct tgacacagaa agctctggaa ggttggcctt
     1261 gctagcagga ggcagtttgg agatcagtga tgtcactgag gatgatgctg ggacttattt
     1321 ctgtgtagct gataatggaa ataagacaat tgaagctcag gcagagctta ccgtgcaagt
     1381 gcctcctgag ttcttgaaac aacctgctaa catatacgct cgtgaatcca tggatattgt
     1441 attcgaatgt gaagtcactg ggaagccagc tccaactgtg aagtgggtca agaatgggga
     1501 tgtagttatc ccaagtgatt actttaaaat tgtaaaggaa cataatcttc aagttttggg
     1561 tctggtgaaa tcagatgaag ggttctatca atgcattgct gagaatgatg ttggaaatgc
     1621 acaagctgga gctcagctga taatccttga gcatgatgtt gccatcccaa cattacctcc
     1681 cacttcactg accagtgcca ctactgacca tctagcacca gccacaacgg gaccactacc
     1741 ttcagctcct cgagatgtcg tggcctccct ggtctctact cgcttcatta aattgacatg
     1801 gcgtacacct gcatcagatc ctcatggaga caatctcacc tattctgtgt tctacaccaa
     1861 ggaaggggtt gctagggagc gtgttgagaa taccagtcag ccaggagaga tgcaggtgac
     1921 tattcaaaac ttaatgccag caactgttta catcttcaaa gttatggctc aaaacaagca
     1981 tggttctgga gagagctcag ctcctctacg agtagaaaca cagcctgagg ttcagctccc
     2041 tggcccagca cctaatatcc gagcttatgc aacatcacct acttctatca ctgtcacatg
     2101 ggaaacacca ttatctggca atggggaaat tcaaaattac aaattgtact acatggaaaa
     2161 aggaacggat aaagaacagg atgttgatgt ttcaagtcac tcctatacta ttaatggact
     2221 gaagaaatac acggaatata gtttccgagt ggtggcctac aataaacatg gtcctggagt
     2281 gtctacacag gatgttgctg ttcgaacatt atcagatgtg cccagtgctg ctcctcagaa
     2341 tctgtcctta gaagtgagaa attcaaagag tatagtgatc cactggcagc ccccttcctc
     2401 agccacacaa aatgggcaga ttactggcta caagattcgg tatcgaaagg cctcccgaaa
     2461 aagtgatgtc actgagaccg tggtaactgg gacacagctg tctcagctga ttgaaggtct
     2521 tgatcggggg acagaatata acttccgagt agctgctctc acagtcaatg gtacaggtcc
     2581 cgcaactgat tggctgtctg ctgagacctt tgaaagtgac ctagatgaat ctcgtgttcc
     2641 tgaagtgcct agctctcttc atgtccgtcc acttgtcact agcattgtag tgagctggac
     2701 tcctccagag aaccagaaca ttgtggttcg agggtacgcc attggttacg gcattggcag
     2761 ccctcatgcc cagaccatca aagtggacta caaacagcgc tattacacca tcgaaaactt
     2821 ggatccaagc tctcattacg tgattacctt gaaagcattt aacaatgttg gtgaaggcat
     2881 ccctctttat gagagtgctg tgaccagacc tcacacagac acttctgaag ttgatttatt
     2941 tgttattaat gctccataca ctccagtgcc agatcccact cccatgatgc caccagtggg
     3001 agttcaggct tccattctga gtcacgacac cataagaatt acctgggcag acaactccct
     3061 gcccaaacac cagaagatta cagactcccg ctactacaca gtccggtgga agaccaacat
     3121 cccagcaaac accaagtaca agaatgcaaa cgcaacaacg ttaagctatt tggttactgg
     3181 tttaaagcca aacacactgt atgagttctc tgtgatggtg accaaaggca gaaggtcaag
     3241 cacgtggagt atgacagctc atggtgctac ctttgaatta gttcctactt ctccacctaa
     3301 ggatgtgaca gttgtgagta aagaaggaaa accgagaacg ataatagtga actggcagcc
     3361 tccctctgaa gctaatggca agattacagg ttacatcatc tattacagca cagatgtgaa
     3421 tgcagagatc catgactggg tgattgaacc tgttgtggga aacaggctga ctcaccagat
     3481 tcaagagtta acactcgaca caccatacta cttcaaaatc caggcccgga actcaaaggg
     3541 catggggccc atgtctgaag ctgtgcagtt cagaacacct aaagcggact cctctgataa
     3601 aatgcctaat gaccaagcct taggatcagc agggaaagga ggccgactac cagacctagg
     3661 atccgactac aaacctccaa tgagtggcag caacagcccc catgggagcc ccacctctcc
     3721 tctagacagc aatatgctgc tggtcatcat tgtctccatc ggcgtcatca ccatcgtagt
     3781 ggttgtgatc attgctgtct tttgtacccg gcgcaccacc tctcaccaga agaagaaacg
     3841 agctgcgtgc aaatcagtga acggctccca taagtacaag ggcaattgca aagacgtgaa
     3901 gcctccggac ctgtggatcc atcatgagag gctggagttg aagcctattg acaagtctcc
     3961 agatccaaac cctgtcatga ctgatactcc aatccctcgg aactctcaag atatcacacc
     4021 agtcgacaat tccatggata gcaatatcca tcaaaggcgg aattcataca gagggcatga
     4081 gtcagaggac agcatgtcta ccctggctgg aaggagggga atgagaccaa aaatgatgat
     4141 gccctttgac tctcagccac ctcagcctgt gattagtgcc catcccatcc attccctcga
     4201 taaccctcac catcatttcc actccagcag cctcgcttct ccagcccgca gtcacctcta
     4261 ccacccaagc agcccatggc ccattggcac atccatgtcc ctttcagaca gggccaattc
     4321 cacagaatct gttcgaaata cccccagcac ggacaccatg ccagcatcct cgtctcaaac
     4381 atgctgcact gatcatcagg atcctgaagg tgctactagc tcttcttact tggccagctc
     4441 ccaggaggaa gactcaggcc agagtcttcc cacagctcat gttcgccctt cccacccatt
     4501 gaagagcttc gccgtaccag caatcccacc cccgggacct cctatctatg atcctgcact
     4561 gccaagcaca ccattactgt cccagcaagc tctcaaccat caccttcact cagtgaaaac
     4621 agcctccatc gggactttag gaaggagccg gcctcctatg ccagtggttg taccgagtgc
     4681 ccctgaggta caggaggcca ccaggatgct ggaagactcc gagagtagct atgaaccaga
     4741 tgagctgacc aaagagatgg cccacctgga aggactcatg aaggacctaa atgccatcac
     4801 aacggcttga tgaccttcac ctggacagga ctccaagtct gagtctcgaa gtcttggaac
     4861 tgaaccttga aaacaaggaa ttgtacagag tacgagagga cagcacttga gagcaggagc
     4921 cagcaaacca gccagtgcct ccatgtgggg tcggctctgg gcacagccac ctgccttctg
     4981 gtcagcctgg atcatgcttg tgtcgaggca gcttccctct gcctgctgat agcctgcagg
     5041 actgggcact atgggccaag attttgtgtc cagagaagag gcaagaagta cgacctgcct
     5101 tttactttgt ggtcagtggc tgtgtctctg tgctgcaact gcatcacttt tatggagtgt
     5161 agacattggc atttatgtac aattttgtgt cctattttat tttaccttaa aacactatca
     5221 gaagccaagt gatgtcctct gcaagcagtt gacacttgac tgctgttccc agttccttac
     5281 ggaaagtcat cgacagtgag gtggtttgac accattggca ggcattggct tgttctgggt
     5341 ttcgtttctg ttttttaatt atgagacgtt gcatcctctg ccagctgtta atccatcact
     5401 ttgaggggag gacatgttgt attgctgttt gtaagcattt ttattatttt tttattataa
     5461 ttattaaagg cctgactttc tcctctcatc actgtgagat tacggatatt tgaatgaaat
     5521 gtaacattga aaagacttgt ttgctgcttt ctgtcagatt cagtattggg gtggggttgg
     5581 ggattgggaa tagtaaatgg aggggcggct gaggccccgt gaatgtttct gtcaatgtac
     5641 tttgtaccag aagcctgcag agaatggaag cagtatcttt agtgtccttt cctggcatgt
     5701 ccatcttgtg tcactgcata gcaactggag ttttgctcgg atctggttat aaattcttgt
     5761 acactgggtg gttttgatga tttagctgcc ctggtatctt ggtcatttcc tttttggagt
     5821 gtccaccctg aggtccctgg ggatgtttgt ttaattgcca agtagagcct cagcctgact
     5881 ccagagaagc tggagagcac aggggagact ccctttgtgt tgctattact ggttctcttt
     5941 ggaaagttaa atgctaaggc aggagcttgg cttcctgttc caaataggaa tcctgcttct
     6001 ctgggtgcca gccctcagcc aggcatccct catgcccaca ttgcagaagc tctcctgagc
     6061 acatcaacca ggatgagagg cttccccact cgtgtctgga cttaattctg taaggagcag
     6121 agaacagaaa tagtgaagag agggtcgtgg aagcaggtgc cttcatctgt cccagcagct
     6181 cagccaaatc ccagttagaa tgaggcagca ggaggttcca ggtgtactga gggctcagcc
     6241 acacacagaa gactgcagag tgttaaagag gtaagctgag gtgtgtattt ggttgttttt
     6301 tatgttaatg tataatgaaa agtataagac taaccctcag gcttcatctt ctccaacaga
     6361 tccctggagg acaggataga aagtaaattg ggcttgggct ccttagccag tgagcccact
     6421 cagactacca ttggctgtcc tagcctccct gtcctggaac atgggttgta ttatcctttt
     6481 ttaggtcggt tttacccttt ttactttcaa caagatgagc tctttgtatg attgtgggtg
     6541 tgggatttga aaaatgcagt gatctaactc ttgttgctct tcaagagcac caggcagggt
     6601 tctgggacaa ccagtgtgct ttgactgtcc tacaaaaagc tgtcagagca ttctggcctc
     6661 ctggaggcta gattcctcag acagtgtctg gcctttgccc acagagcatg ctaggttgtt
     6721 tagagcattc cttcccttgg accccagcac ttctgttacc tcagggcctt ggtacctgga
     6781 tactgccaca gaatttcgat ggggtgggga gggatgtatt tttaaataaa gtaacttaaa
     6841 agttggggaa tttttttaaa ttcagaaaat gcaaagctat tctgtcttac accatttcac
     6901 aatttgatgt gtcttatatt ttcctgtaat tctggaaact aaaccattgt gtgtcttgtg
     6961 tcctagttga gctgtgctca gcagcttcct tcagggaggt gtggaacgaa tgtgtctgct
     7021 gcctggctga ggggcctgaa gggctgctgg gactggccct gcacacactt gttcggcctt
     7081 ttctgtaatt gatgctgtaa aactctatgg ctttttaaaa tcaatttcat gtttttattt
     7141 agtattggaa atccaataca cttttttaat ccaa
//
