LOCUS       NM_031070               3376 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus neural EGFL like 2 (Nell2), mRNA.
ACCESSION   NM_031070 XM_346813
VERSION     NM_031070.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   Ha,C.M., Kim,D.H., Lee,T.H., Kim,H.R., Choi,J., Kim,Y., Kang,D.,
            Park,J.W., Ojeda,S.R., Jeong,J.K. and Lee,B.J.
  TITLE     Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene
            Expression
  JOURNAL   Mol Cells 45 (8), 537-549 (2022)
   PUBMED   35950455
  REMARK    GeneRIF: Transcriptional Regulatory Role of NELL2 in
            Preproenkephalin Gene Expression.
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Kim,H.R., Kim,D.H., An,J.Y., Kang,D., Park,J.W., Hwang,E.M.,
            Seo,E.J., Jang,I.H., Ha,C.M. and Lee,B.J.
  TITLE     NELL2 Function in Axon Development of Hippocampal Neurons
  JOURNAL   Mol Cells 43 (6), 581-589 (2020)
   PUBMED   32597395
  REMARK    GeneRIF: NELL2 Function in Axon Development of Hippocampal Neurons.
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Jeong,J.K., Kim,J.G., Kim,H.R., Lee,T.H., Park,J.W. and Lee,B.J.
  TITLE     A Role of Central NELL2 in the Regulation of Feeding Behavior in
            Rats
  JOURNAL   Mol Cells 40 (3), 186-194 (2017)
   PUBMED   28301916
  REMARK    GeneRIF: Report shows that neural tissue-enriched multifunctional
            protein, NELL2 is a regulatory component of feeding behavior,
            possibly through a modulation of neuronal activity in the
            hypothalamus.
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Zhou,S.S. and Li,P.
  TITLE     Effects of NELL2 on the regulation of GnRH expression and puberty
            in female rats
  JOURNAL   Genet Mol Res 13 (3), 6672-6682 (2014)
   PUBMED   25177948
  REMARK    GeneRIF: Data indicate that RNA interference of NEL-like protein 2
            (NELL2) reduced NELL2 and gonadotropin-releasing hormone (GnRH)
            expression at multiple stages of sexual development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   Ha,C.M., Hwang,E.M., Kim,E., Lee,D.Y., Chang,S., Lee,B.J.,
            Hong,S.G. and Park,J.Y.
  TITLE     The molecular mechanism of NELL2 movement and secretion in
            hippocampal progenitor HiB5 cells
  JOURNAL   Mol Cells 36 (6), 527-533 (2013)
   PUBMED   24352699
  REMARK    GeneRIF: Results suggest that the N-terminal region of NELL2
            determines both the pattern of its intracellular expression and
            transport and may affect the cellular activity of cells in a
            paracrine or autocrine manner.
REFERENCE   6  (bases 1 to 3376)
  AUTHORS   Aihara,K., Kuroda,S., Kanayama,N., Matsuyama,S., Tanizawa,K. and
            Horie,M.
  TITLE     A neuron-specific EGF family protein, NELL2, promotes survival of
            neurons through mitogen-activated protein kinases
  JOURNAL   Brain Res Mol Brain Res 116 (1-2), 86-93 (2003)
   PUBMED   12941464
REFERENCE   7  (bases 1 to 3376)
  AUTHORS   Kim,H., Ha,C.M., Choi,J., Choi,E.J., Jeon,J., Kim,C., Park,S.K.,
            Kang,S.S., Kim,K. and Lee,B.J.
  TITLE     Ontogeny and the possible function of a novel epidermal growth
            factor-like repeat domain-containing protein, NELL2, in the rat
            brain
  JOURNAL   J Neurochem 83 (6), 1389-1400 (2002)
   PUBMED   12472893
  REMARK    GeneRIF: NELL2 may play an important role in the development of the
            CNS as well as maintenance of neural functions, by regulating the
            intracellular machinery involving Ca2+ signaling, synaptic
            transport and/or release of vesicles
REFERENCE   8  (bases 1 to 3376)
  AUTHORS   Kuroda,S. and Tanizawa,K.
  TITLE     Involvement of epidermal growth factor-like domain of NELL proteins
            in the novel protein-protein interaction with protein kinase C
  JOURNAL   Biochem Biophys Res Commun 265 (3), 752-757 (1999)
   PUBMED   10600492
REFERENCE   9  (bases 1 to 3376)
  AUTHORS   Kuroda,S., Oyasu,M., Kawakami,M., Kanayama,N., Tanizawa,K.,
            Saito,N., Abe,T., Matsuhashi,S. and Ting,K.
  TITLE     Biochemical characterization and expression analysis of neural
            thrombospondin-1-like proteins NELL1 and NELL2
  JOURNAL   Biochem Biophys Res Commun 265 (1), 79-86 (1999)
   PUBMED   10548494
REFERENCE   10 (bases 1 to 3376)
  AUTHORS   Beckmann,G., Hanke,J., Bork,P. and Reich,J.G.
  TITLE     Merging extracellular domains: fold prediction for laminin G-like
            and amino-terminal thrombospondin-like modules based on homology to
            pentraxins
  JOURNAL   J Mol Biol 275 (5), 725-730 (1998)
   PUBMED   9480764
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 18, 2021 this sequence version replaced NM_031070.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY089719.1, U48245.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000007.1  128541872-128542127 c
            257-342             JAXUCZ010000007.1  128541198-128541283 c
            343-471             JAXUCZ010000007.1  128540665-128540793 c
            472-622             JAXUCZ010000007.1  128473333-128473483 c
            623-796             JAXUCZ010000007.1  128442600-128442773 c
            797-893             JAXUCZ010000007.1  128442405-128442501 c
            894-966             JAXUCZ010000007.1  128440191-128440263 c
            967-1049            JAXUCZ010000007.1  128439936-128440018 c
            1050-1178           JAXUCZ010000007.1  128438955-128439083 c
            1179-1281           JAXUCZ010000007.1  128437285-128437387 c
            1282-1373           JAXUCZ010000007.1  128399684-128399775 c
            1374-1476           JAXUCZ010000007.1  128396324-128396426 c
            1477-1605           JAXUCZ010000007.1  128386874-128387002 c
            1606-1731           JAXUCZ010000007.1  128353465-128353590 c
            1732-1854           JAXUCZ010000007.1  128306889-128307011 c
            1855-1950           JAXUCZ010000007.1  128304154-128304249 c
            1951-2091           JAXUCZ010000007.1  128245333-128245473 c
            2092-2285           JAXUCZ010000007.1  128235375-128235568 c
            2286-2462           JAXUCZ010000007.1  128234152-128234328 c
            2463-2687           JAXUCZ010000007.1  128231985-128232209 c
            2688-3376           JAXUCZ010000007.1  128222333-128223021 c
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..3376
                     /gene="Nell2"
                     /note="neural EGFL like 2"
                     /db_xref="GeneID:81734"
                     /db_xref="RGD:620999"
     exon            1..256
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..342
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2738
                     /gene="Nell2"
                     /note="protein kinase C-binding protein NELL2; NEL-like
                     protein 2; rCG50753-like; NEL-like 2"
                     /codon_start=1
                     /product="protein kinase C-binding protein NELL2
                     precursor"
                     /protein_id="NP_112332.2"
                     /db_xref="GeneID:81734"
                     /db_xref="RGD:620999"
                     /translation="MHAMESRVLLRTFCVILGLEAVWGLGVDPSLQIDVLSELELGES
                     TAGVRQVPGLHNGTKAFLFQDSPRSIKAPIATAERFFQKLRNKHEFTILVTLKQIHLN
                     SGVILSIHHLDHRYLELESSGHRNEIRLHYRSGTHRPHTEVFPYILADAKWHKLSLAF
                     SASHLILHIDCNKIYERVVEMPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQ
                     GFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILSKTSAKLSRAEQRMNRLDQCYCERT
                     CTMKGTTYREFESWTDGCKNCTCLNGTIQCETLVCPAPDCPAKSAPAYVDGKCCKECK
                     STCQFQGRSYFEGERSTVFSASGMCVLYECKDQTMKLVENAGCPALDCPESHQIALSH
                     SCCKVCKGYDFCSEKHTCMENSVCRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEG
                     RHYCRENTMCVNTPGSFLCICQTGYIRIDDYSCTEHDECLTNQHNCDENALCFNTVGG
                     HNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSEGF
                     VQCDSRANCINLPGWYHCECRDGYHDNGMFAPGGESCEDIDECGTGRHSCANDTICFN
                     LDGGYDCRCPHGKNCTGDCVHDGKVKHNGQIWVLENDRCSVCSCQTGFVMCRRMVCDC
                     ENPTVDLSCCPECDPRLSSQCLHQNGETVYNSGDTWVQDCRQCRCLQGEVDCWPLACP
                     EVECEFSVLPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECT
                     LCQCKNGHVCCSVDPQCLQEL"
     exon            343..471
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..622
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..796
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..893
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..966
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1049
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1178
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1281
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1373
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1476
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1605
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1731
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1854
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1950
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2091
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2285
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2462
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2687
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..3376
                     /gene="Nell2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcactacc catctccgcc tgtctcccta gcgtgtccag cttcacctag gagtcctgtg
       61 tgctttggct gggttccttt tcccgcccgg gagggggtgc cctgcgcctg gggctgccga
      121 gcggtgtgag cgtctaagtg agggcttccc tcttttgccc gaggcggccg ggtgcctttc
      181 tttgcaacct cgccttctgc ggctgggtgg tcctttctct cgccgggttt ggagacacgc
      241 tcccgatttc gaggggaggg agacgatgga ctgagacgat gcacgccatg gaatcccggg
      301 tattactgag aacgttctgc gtgatcctcg ggctcgaagc ggtttgggga cttggtgtgg
      361 acccctccct acagattgac gtcttatcag agttagaact tggggagtcc acagctggag
      421 tgcgccaagt cccaggactg cataatggga cgaaagcctt cctcttccaa gattctccca
      481 gaagcataaa agcacccatt gctacagctg agcggttttt ccagaagctg aggaataaac
      541 acgagttcac aattctggtg accctgaaac agatccactt aaattcggga gtcattctct
      601 ccatccacca cttggatcac aggtacctgg aactggaaag cagcggccac cggaatgaga
      661 tcagactgca ttaccgctct ggaactcacc gcccgcacac ggaagtgttt ccttacattt
      721 tggctgatgc caagtggcac aagctctcct tagccttcag tgcctcccac ttaattttac
      781 acatcgactg caacaagatc tatgaacgag tggtggaaat gccttctaca gacttgcctc
      841 tgggcaccac attttggttg ggacagagaa ataacgcaca cgggtatttt aagggaataa
      901 tgcaagatgt gcaattactt gtcatgcccc aggggttcat cgctcagtgc ccggatctta
      961 atcgaacctg tccaacatgc aacgacttcc atgggcttgt gcagaaaatc atggagctgc
     1021 aggacatttt atcgaagacg tcagccaagt tgtctagagc tgaacaacga atgaacaggc
     1081 tggatcagtg ctactgtgag cggacgtgca ccatgaaggg aaccacctac cgggagttcg
     1141 agtcctggac agacggctgc aagaactgca catgcttgaa tgggaccatc cagtgcgaga
     1201 ctctggtctg ccctgctccc gactgcccgg ctaaatcggc tccagcgtac gtggatggca
     1261 agtgctgtaa ggagtgcaag tccacctgcc agttccaggg gcggagctac tttgagggag
     1321 aaaggagcac agtcttctca gcttccggaa tgtgcgtctt gtatgaatgc aaggatcaga
     1381 ccatgaagct tgttgagaac gccggctgcc cggctttaga ttgccccgag tctcatcaga
     1441 tcgccttgtc tcacagctgc tgcaaggttt gcaaaggtta tgacttctgt tctgagaagc
     1501 atacatgcat ggagaactca gtctgcagga acctgaacga cagggcagtg tgcagctgcc
     1561 gggatggttt ccgggccctc cgggaggaca atgcctactg tgaagacatt gacgagtgtg
     1621 cagaggggcg ccattactgc cgtgagaaca ccatgtgtgt gaacacaccg ggctctttcc
     1681 tgtgtatctg ccaaacaggg tacatcagaa tcgacgatta ctcgtgtacg gaacatgacg
     1741 agtgcctcac aaaccagcac aattgtgacg agaacgcttt gtgctttaac accgttggag
     1801 gtcacaactg cgtctgcaag cctggctaca ctgggaatgg aaccacgtgc aaagctttct
     1861 gcaaagacgg ctgcagaaac ggaggtgcct gcattgctgc caatgtctgt gcttgcccac
     1921 aaggcttcac cggacccagc tgtgagacag acattgatga gtgctctgag ggctttgttc
     1981 agtgtgacag ccgtgccaac tgcattaacc tgcctgggtg gtaccactgt gagtgcagag
     2041 atggctacca tgacaatggg atgtttgcac caggtggaga atcctgtgaa gatattgatg
     2101 aatgtgggac tgggaggcac agctgtgcca atgacaccat ttgcttcaac ttggacggtg
     2161 gctacgattg ccggtgtccc catggaaaga actgcacagg ggactgcgtg cacgacggga
     2221 aagtcaaaca caacggccag atctgggtgc tggagaacga caggtgctct gtgtgttcct
     2281 gccagactgg atttgttatg tgtcgacgga tggtctgtga ctgcgaaaac cccacagttg
     2341 acctctcctg ctgccctgag tgcgacccaa ggctgagcag ccagtgcctg catcaaaacg
     2401 gggaaaccgt gtacaacagc ggtgacacct gggtccagga ttgccgtcag tgccgctgct
     2461 tgcaaggaga agttgactgc tggcccctgg cttgcccaga ggtagagtgt gaatttagtg
     2521 tccttcctga gaacgagtgc tgcccacgct gtgtcaccga tccttgtcag gctgacacca
     2581 tccgcaatga catcaccaaa acctgcctgg acgagatgaa cgtggttcgc ttcactgggt
     2641 cttcctggat caagcacggc acagagtgca ccctctgcca gtgcaagaac ggccacgtgt
     2701 gctgctcagt ggacccacag tgcctccagg agctgtgaag ttaactgcct catgggagat
     2761 acctgttcaa agaatgattt ctcatttaaa aagaccaaaa aacaaaaaag aaaaaaagtg
     2821 atgtgcggcc agccaaatgc aactgtgtca atggctgggc agactgatgg cgattacggc
     2881 tctgtagagc tttgaggaac atcactgagg aaaccagatg gcagttccgc ctttactgtt
     2941 cctgggatca ccttacggag aaatggctgt gaatcacagg ccttgacatc cccagccctg
     3001 gagaagaagc ctgagcccat cagctctggg gaagtctctc cctctctccc tccctccgca
     3061 ggcacaggac atgtcctagc tcagactctt cctgaaccag cgaggttcct cactgaagcc
     3121 gtggaatgaa aggcagtgag tgagctatat tttcagaatc caagaagctg acacatctgt
     3181 acagtgcact ccgaaccctg aaacaagcta ttgtaatgat aaaatactgc acaggcatgg
     3241 ttatgtaaca ttttctaacc ggagaagtca ccccaccccc atttcctcgt ttactgcact
     3301 taatgttatt tggtttgaat ttgttcagta gaagctcgtt cttgtgcaaa ataaaataac
     3361 tatttctctt acctta
//
