LOCUS       NM_001108346            3914 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NIMA-related kinase 7 (Nek7), mRNA.
ACCESSION   NM_001108346 XM_001066105 XM_006249926 XM_341127
VERSION     NM_001108346.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3914)
  AUTHORS   Li,D., Wang,L., Ou,J., Wang,C., Zhou,J., Lu,L., Wu,Y. and Gao,J.
  TITLE     Reactive oxygen species induced by uric acid promote NRK-52E cell
            apoptosis through the NEK7-NLRP3 signaling pathway
  JOURNAL   Mol Med Rep 24 (4) (2021)
   PUBMED   34414459
  REMARK    GeneRIF: Reactive oxygen species induced by uric acid promote
            NRK52E cell apoptosis through the NEK7NLRP3 signaling pathway.
REFERENCE   2  (bases 1 to 3914)
  AUTHORS   Ramachandran,H., Engel,C., Muller,B., Dengjel,J., Walz,G. and
            Yakulov,T.A.
  TITLE     Anks3 alters the sub-cellular localization of the Nek7 kinase
  JOURNAL   Biochem Biophys Res Commun 464 (3), 901-907 (2015)
   PUBMED   26188091
REFERENCE   3  (bases 1 to 3914)
  AUTHORS   Cerone,M.A., Burgess,D.J., Naceur-Lombardelli,C., Lord,C.J. and
            Ashworth,A.
  TITLE     High-throughput RNAi screening reveals novel regulators of
            telomerase
  JOURNAL   Cancer Res 71 (9), 3328-3340 (2011)
   PUBMED   21531765
REFERENCE   4  (bases 1 to 3914)
  AUTHORS   Belham,C., Roig,J., Caldwell,J.A., Aoyama,Y., Kemp,B.E., Comb,M.
            and Avruch,J.
  TITLE     A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the
            Nek6 and Nek7 kinases
  JOURNAL   J Biol Chem 278 (37), 34897-34909 (2003)
   PUBMED   12840024
REFERENCE   5  (bases 1 to 3914)
  AUTHORS   Belham,C., Comb,M.J. and Avruch,J.
  TITLE     Identification of the NIMA family kinases NEK6/7 as regulators of
            the p70 ribosomal S6 kinase
  JOURNAL   Curr Biol 11 (15), 1155-1167 (2001)
   PUBMED   11516946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Oct 18, 2022 this sequence version replaced
            XM_006249926.4, NM_001108346.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.41144.1,
                                           SRR26360194.970132.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000013.1  52700671-52700823   c
            154-236             JAXUCZ010000013.1  52644920-52645002   c
            237-377             JAXUCZ010000013.1  52629899-52630039   c
            378-440             JAXUCZ010000013.1  52620388-52620450   c
            441-551             JAXUCZ010000013.1  52618673-52618783   c
            552-660             JAXUCZ010000013.1  52604627-52604735   c
            661-768             JAXUCZ010000013.1  52603675-52603782   c
            769-863             JAXUCZ010000013.1  52590748-52590842   c
            864-977             JAXUCZ010000013.1  52586730-52586843   c
            978-3914            JAXUCZ010000013.1  52573730-52576666   c
FEATURES             Location/Qualifiers
     source          1..3914
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3914
                     /gene="Nek7"
                     /note="NIMA-related kinase 7"
                     /db_xref="GeneID:360850"
                     /db_xref="RGD:1311160"
     exon            1..153
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            154..236
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1088
                     /gene="Nek7"
                     /EC_number="2.7.11.34"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 7; nimA-related protein kinase 7; never in mitosis
                     A-related kinase 7; NIMA (never in mitosis gene a)-related
                     kinase 7"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek7"
                     /protein_id="NP_001101816.1"
                     /db_xref="GeneID:360850"
                     /db_xref="RGD:1311160"
                     /translation="MDEQPQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQ
                     FSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFI
                     EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHR
                     DIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSD
                     IWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICIN
                     PDPEKRPDIAYVYDVAKRMHACTASS"
     exon            237..377
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            378..440
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            441..551
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            552..660
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            661..768
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            769..863
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            864..977
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
     exon            978..3914
                     /gene="Nek7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagccggga ggatgggccg ctgctaggct cgcagtggga agcgccggcc gatcagggtg
       61 ggagccggcg cttgcagtgg cgcgggcaga ggcgatcggc ccgggatcgc gcagccctgc
      121 agcccgcgtg gatcgagctg cccgggcgcc ctgaatcctc aagtcccagt tgagtcagaa
      181 tggatgaaca accacaagga atgcaagggc cccctgttcc tcagttccag ccgcagaagg
      241 cattacgacc agatatgggc tataatactt tagccaactt ccgaatagaa aagaaaattg
      301 gacgtggaca atttagtgaa gtttatagag catcctgtct cctggatgga gttccagtag
      361 ctttaaaaaa agtgcagata tttgatttaa tggatgccaa agcacgtgcc gattgtatca
      421 aagaaataga tctccttaag caactcaacc atccaaatgt aattaaatat tatgcatcat
      481 tcattgaaga taatgagctg aacatagttt tggagttagc agatgctggt gacctctcca
      541 gaatgataaa gcactttaag aaacaaaaga ggctaatccc tgagaggact gtttggaaat
      601 acttcgttca gctctgcagt gcactggacc acatgcattc tcgaagagtc atgcacagag
      661 atataaaacc agctaatgtg ttcattacag ccactggggt agtcaaactt ggagatcttg
      721 gacttggtcg gttcttcagc tccaaaacca cagctgcaca ttctttagtg ggcacgcctt
      781 actacatgtc tccagagagg atccatgaga acggatacaa cttcaagtct gacatctggt
      841 ctctcggctg tctgctgtat gagatggcgg cgttgcagag tcctttctac ggagacaaga
      901 tgaatctgta ctctctgtgt aagaagatag aacagtgtga ctacccacct ctcccatcag
      961 atcactattc cgaggagctc cgacagttag ttaatatatg catcaaccca gatccggaga
     1021 agcgaccgga catcgcctac gtttatgatg tggcaaagag gatgcatgcc tgtaccgcca
     1081 gcagctaaac tgtacgagac cctgaagacg gcgacttaaa taacttaaaa gtgtttttgt
     1141 gcaaatcata cctccccgct tttgtctggg tgttaagatt actatttcag agctaatgcg
     1201 ctttgaatcc ttaaccagtt ttcatatgag cttcattttc taccaggctc agtcaccttc
     1261 ccaaccccca actctgggat gctcagattg catcaaggac gcaagcacaa gaggttttaa
     1321 gggcgtaagg tttgagaatt gtttagcgtt tctgctgaga gattgtgttt ctagatagta
     1381 agtgccaggt ggaggaggac acagaggcac tgtctggagg gaggaggcag aacccgagga
     1441 aagacctgag catgtgacac gtttgttttt aagtcactta acggacatcc tagtggacat
     1501 aattgtgaag ttctttgttt ttttttaagt ttgaagtaca tgttttattt agttcttagc
     1561 attatagttt tcgaatataa ttcttatact aaatgcagac atgaactttt gagaaagatt
     1621 gaaaattttt agtttataca ctcaaaatgc aactattaaa tgtgaaaaca tagaggacga
     1681 aatgtgagtt ggacactgaa agtctcgtgt tttaatgcct ttgaaagcct ttttgtgttt
     1741 aaatggtgtg aatgaagcca ttttaaaagt ggttaaggac ttgtttgcct ggcgtgatag
     1801 tcatttttaa agttgcacat tgctcaaggc tttgtgttct tactgtacat ttgaagaata
     1861 ttctggaata atcttgtagt aactatagtt caatttcttt acaaatctaa atacacttaa
     1921 ctcatagcta tacactgtaa tgtaagtgta tatttttatt catatattga atgaagtttt
     1981 gatcagttcc ccttcagaat ttttttttat tcaagttact ttcttattta tattgtgtgt
     2041 gcattttatc cactaaatgt ttcagattct ctgacaacga actccctttg taaaagagat
     2101 ttggtatgcc aacacttttc ttagattgaa acttttttta aaaaactttt gggccattct
     2161 gtgtgcatct gttttatctt gttaggaaga gaagatgtat gttaaaatgt gcctgtggat
     2221 gtcgatgttg tttgacaggg ttataatttt agagtatgtg taaggccatg gagactggcc
     2281 cttaatagac agaaccatta ggagagcagc gtttctgtgg agacactttg gagtaaagta
     2341 ctatatttgt gtatgaagat gacagacatg ggtgatgctc attttagtta agaaaaaaat
     2401 ataaaaagga gagctattta ggaaaccctg aggtggaatt tgttttccct gaatgtcttc
     2461 atcttaatac caaccagtgt cttgaaagac ttgtggagcc aaagaacaga gcggccgtgg
     2521 cggttgcaga acactgtgtc ccatgattga acattgggaa ggcttatcct gctggtgggg
     2581 cagcttgtac tgtggccaaa agagctcttg ggtttgtttt ctcacagagt attctttcta
     2641 tagttattgt caagcaatct gtaagttttc aaaatagtgg ctcgtctttt aattggctgt
     2701 gcttgctgtc ttagacaagg gacatctggt tggtttttca tcctgaaggc tgaactgggt
     2761 gtgtcccaga tcttagtggc tcagagcatt tatccagagg cgtgaagaaa gctgcttctg
     2821 gcgaccattt atttgtattg tgctatgtcc actctaatgt cacaggactg accgagatgc
     2881 aatatcccct gcctacaaga gtcattttct ttccatcttt gaaaacaaaa ggttctgccc
     2941 ggcattggtg gtgcatactt ttaatctcag cacttggagg gcagaggcag gtggatctct
     3001 atgagttcca ggacagcctg ggctacacag agaaaagcct atctcaaaaa aaccaaaacc
     3061 gaatcaatga aaatacaagg cttatccctt gtagtgattt tgctttgtga atcggtcttc
     3121 taaaaaatgg gggaggggga ctggggggag ctggagacct taatggttag ggatggtcac
     3181 tgtcctttag tccaagtgtt catatccacc ccacctccaa agaatctact gtgtaacaat
     3241 aaattcagtg tgatatttgc aaatggttat ggagttgatt agaatttcta atcttaacca
     3301 tcacctataa aatatactct ttatatttct gtttatgagt aatttgatat gaagttgaat
     3361 gttggaactg aactgatttg agtaacaggt caaattaaag gtacggctga tttgaaacct
     3421 tgcttgaaca ttggtactag ttacccaggg gaaaatgggc agtaactgcg gttggcacgc
     3481 tgaggtatgg ggtggtgaat gtagggtagc ctcatctgca gtgctcaaaa aggtctaatg
     3541 attgtagagc tagcaagatg ccgctgccaa gtcaagagcg ctctaccgtt cctaagtgcg
     3601 tccattacaa aacacctgtc ttgtatccgt aaactccagg tgttgctctt aacctgtcct
     3661 gtatttatta tagccaagaa gctgttattc acacagatta ttcttttgaa tcgaatgtat
     3721 tgttcatcac ccacaagtgc acactctttg cctctgatcc ccacagtact gtaatatgaa
     3781 tttcttttgt gaaatacgtt ttattttgtt atgctttaaa tgtacatgca agagaactct
     3841 gttattagct tcagaaactg tacaatatcg taatataaat atataaaaat aaaagatgag
     3901 tactgtaagt ttga
//
