LOCUS       NM_182953               2316 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus NIMA-related kinase 6 (Nek6), transcript variant
            1, mRNA.
ACCESSION   NM_182953 XM_231188
VERSION     NM_182953.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2316)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
REFERENCE   2  (bases 1 to 2316)
  AUTHORS   Rapley,J., Nicolas,M., Groen,A., Regue,L., Bertran,M.T.,
            Caelles,C., Avruch,J. and Roig,J.
  TITLE     The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a
            novel site necessary for mitotic spindle formation
  JOURNAL   J Cell Sci 121 (Pt 23), 3912-3921 (2008)
   PUBMED   19001501
REFERENCE   3  (bases 1 to 2316)
  AUTHORS   Yin,M.J., Shao,L., Voehringer,D., Smeal,T. and Jallal,B.
  TITLE     The serine/threonine kinase Nek6 is required for cell cycle
            progression through mitosis
  JOURNAL   J Biol Chem 278 (52), 52454-52460 (2003)
   PUBMED   14563848
REFERENCE   4  (bases 1 to 2316)
  AUTHORS   Belham,C., Roig,J., Caldwell,J.A., Aoyama,Y., Kemp,B.E., Comb,M.
            and Avruch,J.
  TITLE     A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the
            Nek6 and Nek7 kinases
  JOURNAL   J Biol Chem 278 (37), 34897-34909 (2003)
   PUBMED   12840024
REFERENCE   5  (bases 1 to 2316)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   6  (bases 1 to 2316)
  AUTHORS   Hashimoto,Y., Akita,H., Hibino,M., Kohri,K. and Nakanishi,M.
  TITLE     Identification and characterization of Nek6 protein kinase, a
            potential human homolog of NIMA histone H3 kinase
  JOURNAL   Biochem Biophys Res Commun 293 (2), 753-758 (2002)
   PUBMED   12054534
REFERENCE   7  (bases 1 to 2316)
  AUTHORS   Belham,C., Comb,M.J. and Avruch,J.
  TITLE     Identification of the NIMA family kinases NEK6/7 as regulators of
            the p70 ribosomal S6 kinase
  JOURNAL   Curr Biol 11 (15), 1155-1167 (2001)
   PUBMED   11516946
REFERENCE   8  (bases 1 to 2316)
  AUTHORS   Kandli,M., Feige,E., Chen,A., Kilfin,G. and Motro,B.
  TITLE     Isolation and characterization of two evolutionarily conserved
            murine kinases (Nek6 and nek7) related to the fungal mitotic
            regulator, NIMA
  JOURNAL   Genomics 68 (2), 187-196 (2000)
   PUBMED   10964517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and BC160820.1.
            
            On Mar 22, 2013 this sequence version replaced NM_182953.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.12338.1,
                                           SRR26643290.11456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000003.1  42693994-42694089
            97-108              JAXUCZ010000003.1  42731797-42731808
            109-2275            BC160820.1         133-2299
            2276-2316           JAXUCZ010000003.1  42765986-42766026
FEATURES             Location/Qualifiers
     source          1..2316
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..2316
                     /gene="Nek6"
                     /note="NIMA-related kinase 6"
                     /db_xref="GeneID:360161"
                     /db_xref="RGD:727779"
     exon            1..96
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            97..215
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1067
                     /gene="Nek6"
                     /EC_number="2.7.11.34"
                     /note="nimA-related protein kinase 6; never in mitosis
                     A-related kinase 6; NIMA (never in mitosis gene a)-related
                     expressed kinase 6"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek6"
                     /protein_id="NP_891998.1"
                     /db_xref="GeneID:360161"
                     /db_xref="RGD:727779"
                     /translation="MAGQPSHMPHGGSPNHLCHVLGPAHPPDPQRHPNTLSFRCSLAD
                     FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNH
                     PNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAV
                     EHMHSRRVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPER
                     IHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSE
                     KLRELVSMCIYPDPNHRPDIEYVHQVAKQMHVWTSST"
     exon            216..356
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            357..419
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            420..530
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            531..639
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            640..747
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            748..842
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..956
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
     exon            957..2316
                     /gene="Nek6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggcggct gaacccggcg gactagctgc ggccgcagcg ccgccaattc gcgtgcgact
       61 cgcgcttgcc cgccgccgag agagccgcca gcgccgcctg taacctcgtg agtctggcat
      121 gcaagatggc aggacagccc agccacatgc ctcatggagg gagcccaaac cacctctgcc
      181 acgtgctggg gcctgcacac cctccggacc cacagaggca cccaaacacc ctgtcttttc
      241 gctgctcact ggcagacttc caaatcgaga agaagattgg ccgaggacag ttcagtgagg
      301 tctacaaagc cacctgcctg ctggacagga agacagtggc tctgaagaag gtgcagattt
      361 ttgagatgat ggatgccaaa gccagacagg actgtgtcaa agaaattggt ctcctaaagc
      421 aactgaacca tccaaacatc attaagtacc tggactcctt catcgaagac aatgagctga
      481 acattgtgct ggagttggct gacgcaggtg acctctcaca gatgatcaag tatttcaaga
      541 agcagaagcg gcttatccct gagaggactg tgtggaagta cttcgtgcag ctgtgcagcg
      601 ctgtggagca catgcattcc cgacgtgtga tgcaccgaga catcaagcct gccaacgtgt
      661 tcatcacagc tacgggcatc gtgaagcttg gtgacctcgg cctgggccgc ttcttcagct
      721 cagagaccac tgcagcccac tcgctagtgg gaacaccata ctatatgtca cccgagagga
      781 tccacgagaa tggctacaac ttcaagtcag acatctggtc cctaggctgc ctgctgtatg
      841 agatggcagc tcttcagagc cccttctatg gagataagat gaatctcttc tccctctgcc
      901 agaagattga gcagtgtgac tacccgcctc tcccggggga gcactactct gagaagcttc
      961 gggaactggt cagcatgtgc atctaccccg accctaacca ccgacctgac attgagtatg
     1021 tgcaccaggt ggctaaacag atgcacgtct ggacatccag cacctgaatg ccacacctca
     1081 gcaaagccaa acgccacgtg tcttacttga gtcctctccc caagtggtac ctggaagccc
     1141 ccacagccaa gaccagagga ctctcagctg cctcccaaag gtggctacct ctgccactga
     1201 gctgaaggca gctgggttat ggtcaaactc cagagtcctt tctttgaact gctgcagaca
     1261 atctgagctg ggctttagtg ggggaggggc ttggcagtca tcaaaagccc tgtgcctact
     1321 gaaatgtgaa cctctgcctg gctgccccag acctgtccag gcccacactg tcaggagacc
     1381 tgaagggagc tgggtgactg gtgtgggcaa gactctgttg gtttagttct tagttccttc
     1441 ctatacaatc agactgagtg cttcatttac tctcttgtaa agggatacaa tgaaaataat
     1501 ggtttagagt agggatttcg ctagtatttt ctctgcattt gctaatttga tgaatgacag
     1561 tgaggaggag cacctagcac ccggcatttc ggcgtaagtg gcgtctggga gacaggaggg
     1621 ttctcatgat cttctgatcc ctgccttgta ccatcctcac ctgctggaac gctatggctc
     1681 acttcaggac agtccacggc acttcatcca ccaggaagac agcaagaaaa tgccaaaaac
     1741 tttgctctca cactgttctt ttcaaattct ggttctgtat cttcctagtg acctgggcaa
     1801 ggtgttggtc tttctgggcc ttcgtttcct catctgcaaa tgggactaat aaggtatcta
     1861 tcttccaggt ggctgacagg atttaaacaa aagatgttat tcagctgggc cagtttaagc
     1921 atgttatccc agcacttgag aggtagaggc aggaggatca agaatccaag gttgccctga
     1981 gcaatacagg aagtttgaaa caggaatgaa ctacataaat aagaccctgt ctcaaaaata
     2041 aaccaaccaa caaaagccaa accaacagag atgcagatca gccagcagtg gcaggtgatc
     2101 caaaaatatg gcctgtcacc ccttcagaaa attcaagtca tggaccattc gtgtcaagaa
     2161 ttaaaatata attgtattat gtgcaggaaa agcagaaata tgttcactta ctttttattc
     2221 ccaacaggat taactgtgaa gactaactta taaatgtgaa tttaaggaaa ctgaagtgtt
     2281 ggaggaaaca gtctgaattt tgttcttcta tgctag
//
