LOCUS       NM_001013134            2722 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NIMA-related kinase 4 (Nek4), mRNA.
ACCESSION   NM_001013134 XM_001060008 XM_001060068 XM_224610
VERSION     NM_001013134.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Nguyen,C.L., Possemato,R., Bauerlein,E.L., Xie,A., Scully,R. and
            Hahn,W.C.
  TITLE     Nek4 regulates entry into replicative senescence and the response
            to DNA damage in human fibroblasts
  JOURNAL   Mol Cell Biol 32 (19), 3963-3977 (2012)
   PUBMED   22851694
REFERENCE   2  (bases 1 to 2722)
  AUTHORS   Coene,K.L., Mans,D.A., Boldt,K., Gloeckner,C.J., van Reeuwijk,J.,
            Bolat,E., Roosing,S., Letteboer,S.J., Peters,T.A., Cremers,F.P.,
            Ueffing,M. and Roepman,R.
  TITLE     The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are
            linked to cilium integrity through interaction with Nek4
            serine/threonine kinase
  JOURNAL   Hum Mol Genet 20 (18), 3592-3605 (2011)
   PUBMED   21685204
REFERENCE   3  (bases 1 to 2722)
  AUTHORS   Hayashi,K., Igarashi,H., Ogawa,M. and Sakaguchi,N.
  TITLE     Activity and substrate specificity of the murine STK2
            Serine/Threonine kinase that is structurally related to the mitotic
            regulator protein NIMA of Aspergillus nidulans
  JOURNAL   Biochem Biophys Res Commun 264 (2), 449-456 (1999)
   PUBMED   10529384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474046.1.
            
            On or before Sep 11, 2008 this sequence version replaced
            XM_001060068.1, XM_001060008.1, XM_224610.4, NM_001013134.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2722
                     /gene="Nek4"
                     /note="NIMA-related kinase 4"
                     /db_xref="GeneID:306252"
                     /db_xref="RGD:1304995"
     exon            1..231
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2520
                     /gene="Nek4"
                     /EC_number="2.7.11.1"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 4; NIMA (never in mitosis gene a)-related kinase 4"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek4"
                     /protein_id="NP_001013152.2"
                     /db_xref="GeneID:306252"
                     /db_xref="RGD:1304995"
                     /translation="MPQAAYCYLRVVGRGSYGEVTLVKHRRDGKQYVIKKLNLRNASS
                     RERRAAEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQL
                     LPESQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHS
                     DMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRI
                     IEGKLPPMPKVYSAELAELIRTMLSRRPEERPSVRSILRQPYIKHHISLFLEATKAKT
                     SKNNVKNCDSRAKPVAAVVSRKEEPNHEMIPYQPRSSEGSAVHATGEDKCLSQEKPVD
                     IGPLKSPASLEGHTGKQDMNRTAESCATVSRINIDILPAERRDSAKDGTVEEGRPQHV
                     DASNEVDRQCSISQEKERLQGNSKSSDQPENLLPRWSSGGGDGEGNELVKLLYSSGKD
                     QKPQQDQVTSGCILEDQDSIHPRLQPHSSVSEPSLSRQRRQRKREQTNHGRAKSQLQE
                     SPPRLVPSHPDTGKADIISTQQSDGNQSGPVARSVNGSRSSSTASSKDRPLSARERRR
                     LKQSQEEMLPSGPAVQRTPSSVEPVKPQEEDQPIPAQRFSSDCNITQVNPTLLREKKR
                     LIHGLSEDELSSSTSSTDKSDGDSREGKSHTNEMRDLVQLMTQTLRLEAKESCEDLHV
                     PNPGSEFRLHRKYRDTLVLHGKAAEEGEPPCVELPPGITPGSEKIRRIVEVLRADVIQ
                     GLGVQLLEQVYDLLEEEDELEREARLQEHMGDKYTTYSVKARQLKFFEENVSF"
     exon            232..498
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            499..696
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            697..804
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..959
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1101
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1503
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1653
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1803
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1870
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2004
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2090
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2293
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2427
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2722
                     /gene="Nek4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggccgggc ctggaagctc ctacaccggg tgggccgcga ttatggacga cttcacttcc
       61 agtcgggcat gagcggggcc tcccgctgcc ttatgcgccg ctaccgcagc ttcccgactg
      121 taggcctcct tcgggaacat gccccaagcc gcatactgtt acttgcgggt cgtgggcagg
      181 ggtagttacg gggaggtgac gctcgtgaag catcggcggg acggcaagca gtatgtcatc
      241 aaaaagctga acctccggaa tgcctccagc cgggagcgtc gagcggcaga gcaggaggct
      301 cagctcctgt ctcagttgaa gcaccccaac attgtcacct acaaagagtc atgggagggc
      361 ggagacggtc tgctctacat cgtcatgggc ttctgcgaag gaggcgatct gtaccggaag
      421 ctcaaggagc agaaggggca gcttctgcct gagagtcagg tggtggagtg gtttgtccag
      481 atcgccatgg ccttgcagta cttacatgag aagcacatcc ttcatcgaga tctgaaaact
      541 cagaatgtct tcctaacaag aacaaacatc atcaaagtag gtgacctagg cattgcccga
      601 gtgttggaga atcacagtga catggcgagc accctcattg gcacacccta ttacatgagt
      661 cctgagctgt tctccaacaa accctacaac tataagtcgg atgtttgggc tttgggatgc
      721 tgcgtgtatg aaatggccac cctgaagcat gcttttaatg caaaagacat gaattcttta
      781 gtttatcgga ttattgaagg aaagttgcca ccaatgccaa aagtttacag tgcggagctg
      841 gcagagctga taagaaccat gttgagcagg agacctgagg agaggccctc tgtgcggagc
      901 atcctgcggc agccctacat aaaacaccac atctccttgt tcttggaggc caccaaggcg
      961 aaaacttcca aaaataatgt taaaaactgt gactccagag ccaaacccgt tgctgctgta
     1021 gtttccagaa aggaagaacc aaatcatgaa atgattccct accagccacg ctcttctgag
     1081 ggctccgctg tacatgccac gggtgaagat aaatgtctgt cccaagaaaa accagtggac
     1141 attggtccct tgaaatcacc tgctagtctc gaaggccaca ctggcaaaca agacatgaac
     1201 aggactgcag agtcgtgtgc cacagtcagt aggataaata tcgatatctt acctgcagaa
     1261 aggagggact cagcaaaaga tggcacagtt gaggagggcc gaccacagca cgtggatgct
     1321 tctaatgaag tagaccgtca atgcagtatt tctcaagaga aggagaggct acagggcaac
     1381 agcaagtcta gtgatcagcc ggaaaatctc cttcccagat ggtcctctgg tggtggtgat
     1441 ggggaaggga atgaactggt gaagctgttg tactcctcgg gtaaagacca aaagccacag
     1501 caggatcaag ttactagcgg gtgtattcta gaagatcagg acagcatcca cccaagactg
     1561 cagccgcaca gctctgtatc tgaaccttct ttgtcccggc agcgaaggca gagaaaaagg
     1621 gaacagacga accacggtcg ggcaaagagc cagctccaag aatcaccccc tcgtcttgtg
     1681 ccttctcacc ctgatactgg gaaagcagat atcataagta cacagcaaag tgatggaaac
     1741 caaagtggac ctgtggctag gtctgtgaat ggttcaaggt ctagttcgac agcgtcatca
     1801 aaggatcggc cattatcagc cagagagagg agacgactaa agcagtcgca ggaagagatg
     1861 ctcccctcag gccctgcagt tcagagaact ccaagttcag tagagccagt gaaaccacag
     1921 gaagaagacc aacccatccc tgcccaacga ttctcttctg actgcaacat cactcaggtg
     1981 aatcccacac tcctgaggga aaagaagaga ctgatccatg gactgtctga ggatgagtta
     2041 agttcttcca caagctcaac tgataaatca gatggggatt ccagggaggg gaaaagtcat
     2101 acaaatgaaa tgagagactt ggtgcagctg atgactcaga ctctgaggct ggaagctaaa
     2161 gagagctgtg aagatcttca tgtaccaaac ccagggtcag agttcagact tcatcgcaag
     2221 tatcgagaca cgctggtgct ccacggcaag gctgcggaag agggggagcc cccctgtgtg
     2281 gagttacctc caggtatcac accaggttct gaaaagatca ggagaatagt tgaagtctta
     2341 agagctgatg tgatccaggg cctgggggtt cagcttttag agcaggtgta tgatcttttg
     2401 gaggaggaag atgagttgga gagagaggca cgattacagg agcacatggg agacaagtat
     2461 acaacttaca gtgtgaaagc tcgccagttg aagttttttg aagaaaatgt gagtttttga
     2521 ggtttgttct aacatgctgc cagaactaaa gatctatttt caaaggtttt ttcatcttaa
     2581 aaaacctgtt tcagtcattt ggaggctgac taccatcctt tgatatcgct tggagtcttc
     2641 ttaccataaa aaactgaaga gtttgaaaca atatgaaaca agttcacaaa agaaaaaaaa
     2701 ctttgaatat catgtttatg ag
//
