LOCUS       NM_001413824            5824 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NIMA-related kinase 11 (Nek11), mRNA.
ACCESSION   NM_001413824 XM_017595682
VERSION     NM_001413824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5824)
  AUTHORS   Melixetian,M., Klein,D.K., Sorensen,C.S. and Helin,K.
  TITLE     NEK11 regulates CDC25A degradation and the IR-induced G2/M
            checkpoint
  JOURNAL   Nat Cell Biol 11 (10), 1247-1253 (2009)
   PUBMED   19734889
REFERENCE   2  (bases 1 to 5824)
  AUTHORS   Noguchi,K., Fukazawa,H., Murakami,Y. and Uehara,Y.
  TITLE     Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells
  JOURNAL   J Biol Chem 279 (31), 32716-32727 (2004)
   PUBMED   15161910
REFERENCE   3  (bases 1 to 5824)
  AUTHORS   Noguchi,K., Fukazawa,H., Murakami,Y. and Uehara,Y.
  TITLE     Nek11, a new member of the NIMA family of kinases, involved in DNA
            replication and genotoxic stress responses
  JOURNAL   J Biol Chem 277 (42), 39655-39665 (2002)
   PUBMED   12154088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 9, 2022 this sequence version replaced XM_017595682.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1750384.1,
                                           SRR26643293.47110.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000008.1  114905087-114905162 c
            77-380              JAXUCZ010000008.1  114902734-114903037 c
            381-546             JAXUCZ010000008.1  114847438-114847603 c
            547-665             JAXUCZ010000008.1  114813025-114813143 c
            666-730             JAXUCZ010000008.1  114801142-114801206 c
            731-857             JAXUCZ010000008.1  114799888-114800014 c
            858-1007            JAXUCZ010000008.1  114789228-114789377 c
            1008-1086           JAXUCZ010000008.1  114789040-114789118 c
            1087-1175           JAXUCZ010000008.1  114787314-114787402 c
            1176-1272           JAXUCZ010000008.1  114783451-114783547 c
            1273-1387           JAXUCZ010000008.1  114777431-114777545 c
            1388-1548           JAXUCZ010000008.1  114733274-114733434 c
            1549-1609           JAXUCZ010000008.1  114710472-114710532 c
            1610-1706           JAXUCZ010000008.1  114694079-114694175 c
            1707-5824           JAXUCZ010000008.1  114646010-114650127 c
FEATURES             Location/Qualifiers
     source          1..5824
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..5824
                     /gene="Nek11"
                     /note="NIMA-related kinase 11"
                     /db_xref="GeneID:315978"
                     /db_xref="RGD:1308801"
     exon            1..76
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            77..380
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1980
                     /gene="Nek11"
                     /EC_number="2.7.11.1"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 11; NIMA (never in mitosis gene a)- related kinase
                     11"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek11"
                     /protein_id="NP_001400753.1"
                     /db_xref="GeneID:315978"
                     /db_xref="RGD:1308801"
                     /translation="MLKFQETAKCGPTAIPVYPPTVIARRYVLQQKLGSGSFGTVYLV
                     SDKKAKHGEELKVLKEISVGELNPNESVQASMEAQLLSTLNHPAIVRFHESFMEQGTF
                     CIITEYCEGRDLDYKIQEYKEAGKIFPDNQIVEWFIQLLLGVDYMHERRILHRDLKSK
                     NIFLKNNLPKIGDFGVSRLLMGSCELATTLTGTPYYMSPEALKHQGCDAKSDIWSLAC
                     ILYEMCCMDHAFSGSNFLSVVLNIVEGNTPSLPDRYPRELNIIMSRMLNKSPSLRPSA
                     AEILKAPYVEERLQQLMYKHPEATLEDKRNSACQKEAAHAVNAIKITEGRRYKENNKR
                     AKELRSQNFGSVSAHVLQELDELTLESLSQPQSLPCLNLDELEPSLEGTIVDLGHYEI
                     PEDPLVAEQYYADVFDSCSEDSGEQEEEMAFSEAGGDMREEGSPPTYRTNQQDSDTDA
                     LVGCLEHVLGYTSLDTKTNTSAVADVSPGPTVFNSAMARTKVKRMKESAVQKLGTETF
                     EEVYDYLKRARHQNAREAEIWEHLETVVPLASDCFEVDQLLYFEELLLTMEGKESSLQ
                     SPHCEACRKKPVKSIHFCDNS"
     exon            381..546
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            547..665
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            666..730
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            731..857
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1007
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1086
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1175
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1272
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1387
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1548
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1609
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1706
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..5824
                     /gene="Nek11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacaaccac accggtccaa gctgtgagct tcaggctgag gcttggcagg gcgccgccaa
       61 ctggggacct gtgaagttgc ttttagacat gatctgtgga gttctcagga ttctggcatc
      121 aatcaacact tcctgttcga cttttggacc gtcagctcgg ctgcccgact gttgtttctg
      181 tgagtgaaca agccagtttt tatcttgttt ggagcaatgc tgaaattcca agagactgct
      241 aagtgtggac ccacagccat tcctgtgtac ccacccactg tgattgcaag aagatacgtt
      301 ctccaacaga agcttggcag cgggagtttt ggaactgtct atctggtgtc agacaagaaa
      361 gccaagcatg gagaggaact aaaagtactg aaggaaatct ctgttggaga attaaatcca
      421 aatgaaagtg tgcaggccag tatggaagcc cagctcctgt ccacgctaaa ccatccggcc
      481 atcgtcaggt tccacgaaag cttcatggag cagggtacat tttgcattat cacggagtac
      541 tgtgagggcc gagatctgga ctataaaatc caggaatata aagaagctgg gaaaatcttt
      601 cctgacaatc agatagtgga atggtttatc cagttgctgc ttggagttga ttacatgcat
      661 gagaggagga tacttcatcg agacttgaaa tcaaagaata tatttctgaa aaataatcta
      721 cccaaaattg gggactttgg agtttctcgg ctgctgatgg gttcatgtga gctggctaca
      781 actctaaccg ggactcccta ttatatgagt ccagaggccc tgaagcacca aggctgtgat
      841 gccaagtctg acatctggtc actggcatgc attttatacg agatgtgttg catggatcat
      901 gcgttttctg gctccaattt cttgtctgtg gttttgaata tcgttgaagg caacacgcct
      961 tcactccctg acagataccc acgagaacta aacatcatca tgtcacgcat gttgaacaag
     1021 agtccctccc tgagaccgtc ggctgcagag attttaaaag ccccttacgt ggaagagcgc
     1081 cttcagcagc tgatgtataa acatccagag gcgacactgg aagacaagag gaactcagcc
     1141 tgtcagaagg aggctgccca tgcagttaac gccataaaga ttactgaagg aagaagatat
     1201 aaagaaaata acaaaagggc caaagaacta agatcccaga actttgggtc tgtgagtgcc
     1261 catgtgctcc aggaattaga tgaactgact ctggagagcc tgtctcaacc tcagtccctt
     1321 ccttgcctga acctcgatga acttgagccc agtttagaag gcaccattgt tgacctcgga
     1381 cattatgaga tcccagaaga cccgcttgtt gctgaacaat attatgctga tgtatttgat
     1441 tcctgttctg aagacagtgg ggagcaggag gaagaaatgg cattttcaga agcaggggga
     1501 gacatgagag aggagggatc cccacctaca tacagaacaa accaacagga cagcgataca
     1561 gatgcgctgg ttgggtgttt ggaacatgtc ctgggttaca cctctctaga cacaaagacc
     1621 aacaccagtg cagtggcaga tgtgtctcct ggaccaactg ttttcaacag tgcaatggct
     1681 aggaccaagg tgaagcgcat gaaggaatca gctgtacaga agctaggaac ggaaacattt
     1741 gaggaagtct atgattacct caagagagca aggcatcaga atgccagaga agcagagatc
     1801 tgggagcatc tggagacagt ggttcctctg gccagtgact gctttgaagt tgaccagctc
     1861 ctctattttg aggagttgct gctgaccatg gaaggaaaag agtccagtct ccagagcccg
     1921 cactgtgaag cctgccgaaa gaagcctgtc aagagtatac atttctgtga caattcatga
     1981 agtttacact ctagactata tcgtgggaaa ctagtgcgta actggagcca ctaccctccc
     2041 ttttgctcct ggtcagatgt aagggtatct atggagaggt ctggctggct gcctaggctt
     2101 agagtcacag gtcaaggtca tggatgaagt ctggcatcct gaatggcttt ccctcagatg
     2161 tacaatcctc ggggtttcca atagggtggg agcattctga agacacaaga attctgtact
     2221 ctgtccatcc agggcaagcc cggtgcctga ccacttgtga gctccaggaa gaatggccag
     2281 cttgtgatgg ccacggggca ccagcctggc cagtggcctg ttcatctcca atgatgtagt
     2341 tttgatcagc actttcttct atgactaaca tgcacacagt gcatatattt aagcctggat
     2401 tgaaaatcca caaagcgtct cccttctgtg atttatttcc agccttcact tataaagcat
     2461 taaaggcttg attcagaata aatacaaatt tcatctttat aagacaaatc tcctattcta
     2521 tctttttctt agctaacagt gtttctcagc ttgtgggtca tgaccccctt ggggttgcgt
     2581 atcagatgtt tacattatag ttcataacag tagcaaaatt acagttatga ggtagcaata
     2641 aaataacttt atgcttaaag gtcaccacaa catgagtcac agcgttagga aggctgaatg
     2701 tcaccgttcg ataatcacat attgttaaat gtaacatccg tgtaaaggta atttttgttt
     2761 tgttttgttt gctgtttgtt actactaaaa caaaactatt acacacaaat gtaatatcag
     2821 ttggtgtttt aaagatttaa tttatatatc tgagtgtttt gtctgcatgt atgcatgtgt
     2881 gtcatgtgta tctttcctcc aacaccaaga acatttcagc caatgtcctg ctgcaaggaa
     2941 gctacatcac gatagcaatt ccccatgatt ccatcttcta attgtgtttt ctgcaatggc
     3001 cagatgtagg ccagaaacag attcagagga aatgaactgc tataatcacc atgatggcag
     3061 gaggtctagg ggtcatgcca ttggtgttca acttcttcct catacagatt atggcagaac
     3121 tattgtcaaa cattgctact ttgctatgta tctattcctg ttttacacac acacacacac
     3181 acacacacac acacacacac acacacacac acccccctct tccttctctt tgcttcattt
     3241 ctgttttact ctccctgtaa ctggatccta ctttctttca acatgctagt tgatgtctaa
     3301 tcttaaggaa gatcgcagtg tctttgcctg gtgttggagg aaaaccttta tggttagtct
     3361 acctgaacct ctgtcatcaa atcttcatcc ctgagcactt ccttcaccaa ggttctactg
     3421 tcactgttgc aaacacattc caaaagataa tcactttcag acactttgaa tagcccttgg
     3481 tggctactcc aaagatacaa atgagtggct ggctgatagg accagctttg ccttccagaa
     3541 gtctctaacc cacttcaccc tgctaagcca ccagtagagc ctcagagtaa ccatcactag
     3601 ggtcctcagt tcttccctaa tttcagaaaa cagttcataa ctatggctcg accaatacat
     3661 acatacatat tcatatattc atatatatac ataaatatac tgatagatat actctaggaa
     3721 tacaatggtc attagaattt atgtagtact gtcccacagc aaagcctatt gaaatgtaat
     3781 cttcgttttg agacagtaaa gtgagactag gtgggacctt taagaggtga ttgggtcagg
     3841 ggactctgcc tacctggatg atggaatcaa tgattcatgg atcatctcga aactaggtct
     3901 gtctgttata aaacagagca gtgactcctc tggccatgtg atgacctgtg ccacctgaga
     3961 attcttcaaa gagtctctat cagcaagaag gttttcaata gatgtggcct tttaaccttt
     4021 gacttccagc atctaaaact gtaacgtgag tgaatctttg tttttataaa ttacctagtg
     4081 tcttagttag gatttctatc gctgtgaaga gacatcatga ccacagtgag tcttataaag
     4141 aaaaagattt cattggggct ggctagccat ttcagaggtt tagctctcta ttgtcatggc
     4201 ggggagcatg gcagcattca ggcagacatg gtgctggaga aggagctaag ggttctaccc
     4261 acagatgagc gggcagcagg aagtgaactg gctcgagctg ttgaaatctc aaagcctacc
     4321 acctccagca atgccacacc tactacactt aagtgccact ccctatagaa ctgtgggggc
     4381 cattttcatt caagcaacca cacctagtct ctgggtacta aagtagtctg ttatagcaat
     4441 gggagacaga caagatatcc agaacggaca acttgactcc acattagtct gggtggcgat
     4501 ccttcggcag ctagaaatgt ttttgttgat ccacagtgtg attcgctctg ataagtggag
     4561 ttgtctggtt cacttcacca ctcactatac tccctgcctg tggccttgta cctttaaggc
     4621 tgtttgctct gactctgagt ttcaactcgg agcctgagtt ggctgagttg gaagtgtgtt
     4681 gctcccttgg atatgttctg tcatcctgct gtcctctcca gcctgtccac ctatcccatg
     4741 agcatgggag ttggagcaca gccatcctgg ggcagcccag cctctgtaca acaagacaca
     4801 gccgtctaga caatccacaa actccagagc aacagagcaa tgtgtatcgt catatgttac
     4861 ctgtggtttg tgcttgatca tcacaataaa ctaacctggc tttccatcct ctctctgaca
     4921 ttcaaatccc ctaaatttat ttggggcagg ggcattgact tttactaatt gagagggggt
     4981 agtctcaaat aaactgtggc attttagaaa aaaaatagaa atattctttt tcaaaatagc
     5041 tgaggcaaag cacgaaccct gtgtttttgg cagaagctgt ctaggaacag ctaaggcaag
     5101 caagtgagtt ttcaggagat ggccaaccgc tttgcatggc tgtgctggat gagtgctaag
     5161 atgcagagtc cttagagact ccatcccagg attgctactt gctgctgatg tgcctttcct
     5221 gtcactatta catagcccag tggttcctgg gcatcagccc acccaattgg gcaaatttct
     5281 tgcagatcaa catgaagatg tactttcatg tagtaatact gtgtagacaa attgatgatt
     5341 acactattcc tgataatgat tttatagaat atctaaatag atacaagtaa tttccaagcc
     5401 ctttatagaa taaaaggata caaatagagt tctgtaactt tcatgtgtca cagactaatt
     5461 acactaggaa aagaaagcag gcttcaaaca aattcataac caaggcaaac attctaggtt
     5521 agatgtgaga ccattatctg gtaactaaag gtcataaact tggaatgtat aattcattgt
     5581 agatgcaagg acaggaaata aaatattaac tagtttatat aaaacttcaa atgatttgtc
     5641 tcttagcaaa accatgctaa cctgtgacat aaaaattatt gctttaaact tatagcaaac
     5701 ttatggatct aaaagctaca taatgaatgt ttagtcaaat actagtctta atggaaagac
     5761 atgtaaacaa acaaaaaaac ttaataaaac aaacaaacaa aaaaagaaag acatgtaaaa
     5821 aaaa
//
