LOCUS       NM_001106082            4896 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus NIMA-related kinase 1 (Nek1), mRNA.
ACCESSION   NM_001106082 XM_001053608 XM_214340
VERSION     NM_001106082.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4896)
  AUTHORS   Sonntag T, Moresco JJ, Vaughan JM, Matsumura S, Yates JR 3rd and
            Montminy M.
  TITLE     Analysis of a cAMP regulated coactivator family reveals an
            alternative phosphorylation motif for AMPK family members
  JOURNAL   PLoS One 12 (2), e0173013 (2017)
   PUBMED   28235073
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4896)
  AUTHORS   El Hokayem J, Huber C, Couve A, Aziza J, Baujat G, Bouvier R,
            Cavalcanti DP, Collins FA, Cordier MP, Delezoide AL, Gonzales M,
            Johnson D, Le Merrer M, Levy-Mozziconacci A, Loget P,
            Martin-Coignard D, Martinovic J, Mortier GR, Perez MJ, Roume J,
            Scarano G, Munnich A and Cormier-Daire V.
  TITLE     NEK1 and DYNC2H1 are both involved in short rib polydactyly
            Majewski type but not in Beemer Langer cases
  JOURNAL   J Med Genet 49 (4), 227-233 (2012)
   PUBMED   22499340
REFERENCE   3  (bases 1 to 4896)
  AUTHORS   Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
            Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
            and Andersen JS.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 4896)
  AUTHORS   Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S,
            Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB,
            Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH and
            Rauch A.
  TITLE     NEK1 mutations cause short-rib polydactyly syndrome type majewski
  JOURNAL   Am J Hum Genet 88 (1), 106-114 (2011)
   PUBMED   21211617
REFERENCE   5  (bases 1 to 4896)
  AUTHORS   Hilton LK, White MC and Quarmby LM.
  TITLE     The NIMA-related kinase NEK1 cycles through the nucleus
  JOURNAL   Biochem Biophys Res Commun 389 (1), 52-56 (2009)
   PUBMED   19699716
REFERENCE   6  (bases 1 to 4896)
  AUTHORS   Chen Y, Craigen WJ and Riley DJ.
  TITLE     Nek1 regulates cell death and mitochondrial membrane permeability
            through phosphorylation of VDAC1
  JOURNAL   Cell Cycle 8 (2), 257-267 (2009)
   PUBMED   19158487
REFERENCE   7  (bases 1 to 4896)
  AUTHORS   Chen Y, Chen PL, Chen CF, Jiang X and Riley DJ.
  TITLE     Never-in-mitosis related kinase 1 functions in DNA damage response
            and checkpoint control
  JOURNAL   Cell Cycle 7 (20), 3194-3201 (2008)
   PUBMED   18843199
REFERENCE   8  (bases 1 to 4896)
  AUTHORS   Mahjoub MR, Trapp ML and Quarmby LM.
  TITLE     NIMA-related kinases defective in murine models of polycystic
            kidney diseases localize to primary cilia and centrosomes
  JOURNAL   J Am Soc Nephrol 16 (12), 3485-3489 (2005)
   PUBMED   16267153
REFERENCE   9  (bases 1 to 4896)
  AUTHORS   Polci R, Peng A, Chen PL, Riley DJ and Chen Y.
  TITLE     NIMA-related protein kinase 1 is involved early in the ionizing
            radiation-induced DNA damage response
  JOURNAL   Cancer Res 64 (24), 8800-8803 (2004)
   PUBMED   15604234
REFERENCE   10 (bases 1 to 4896)
  AUTHORS   Upadhya P, Birkenmeier EH, Birkenmeier CS and Barker JE.
  TITLE     Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic
            effects including a progressive polycystic kidney disease in mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 217-221 (2000)
   PUBMED   10618398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000279.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001106082.4.
            
            On Nov 27, 2020 this sequence version replaced NM_001106082.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JACYVU010000279.1  9021811-9021888     c
            79-226              JACYVU010000279.1  9015515-9015662     c
            227-323             JACYVU010000279.1  9015033-9015129     c
            324-421             JACYVU010000279.1  9010902-9010999     c
            422-505             JACYVU010000279.1  9006722-9006805     c
            506-573             JACYVU010000279.1  9003593-9003660     c
            574-660             JACYVU010000279.1  9003386-9003472     c
            661-715             JACYVU010000279.1  9002387-9002441     c
            716-916             JACYVU010000279.1  8998324-8998524     c
            917-977             JACYVU010000279.1  8993089-8993149     c
            978-1129            JACYVU010000279.1  8990474-8990625     c
            1130-1189           JACYVU010000279.1  8982792-8982851     c
            1190-1249           JACYVU010000279.1  8982127-8982186     c
            1250-1297           JACYVU010000279.1  8981997-8982044     c
            1298-1372           JACYVU010000279.1  8981781-8981855     c
            1373-1536           JACYVU010000279.1  8976372-8976535     c
            1537-1639           JACYVU010000279.1  8967780-8967882     c
            1640-1723           JACYVU010000279.1  8952595-8952678     c
            1724-1801           JACYVU010000279.1  8952164-8952241     c
            1802-1897           JACYVU010000279.1  8951364-8951459     c
            1898-2026           JACYVU010000279.1  8945489-8945617     c
            2027-2092           JACYVU010000279.1  8942725-8942790     c
            2093-2321           JACYVU010000279.1  8942423-8942651     c
            2322-2474           JACYVU010000279.1  8936623-8936775     c
            2475-2636           JACYVU010000279.1  8934693-8934854     c
            2637-2745           JACYVU010000279.1  8931174-8931282     c
            2746-2834           JACYVU010000279.1  8929804-8929892     c
            2835-3073           JACYVU010000279.1  8928791-8929029     c
            3074-3225           JACYVU010000279.1  8912471-8912622     c
            3226-3434           JACYVU010000279.1  8909472-8909680     c
            3435-3565           JACYVU010000279.1  8908714-8908844     c
            3566-3698           JACYVU010000279.1  8907889-8908021     c
            3699-4896           JACYVU010000279.1  8902396-8903593     c
FEATURES             Location/Qualifiers
     source          1..4896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p12"
     gene            1..4896
                     /gene="Nek1"
                     /note="NIMA-related kinase 1"
                     /db_xref="GeneID:290705"
                     /db_xref="RGD:1309375"
     exon            1..78
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..226
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3712
                     /gene="Nek1"
                     /EC_number="2.7.11.1"
                     /note="NIMA (never in mitosis gene a)-related expressed
                     kinase 1; NIMA (never in mitosis gene a)-related kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase Nek1"
                     /protein_id="NP_001099552.2"
                     /db_xref="GeneID:290705"
                     /db_xref="RGD:1309375"
                     /translation="MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKE
                     REESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGTLFQE
                     DQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELA
                     RTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISG
                     SFPPVSLHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFC
                     LKTVSKFGPQPIPGKRPASGQGVSSFVPAQKITKPSAKYGVPITYKKYGDKKLLEKKP
                     PPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQLKRQ
                     EKQRLERINRAREQGWRNVLRAGGSGEVKASFFGSGGAVSPSPCSPRGQYEHYHAIFD
                     QMQQLRAEDNEARWKGRIYGRWLPERQKGHLGVERAKQVEEFLQRKQEAMQNKARAEG
                     HVVYLARLRQIRLQNFNERQQIKAKLRGENKEAGGTKGQDATEEADMRLKKMESLKAQ
                     ANARAAVLKEQLERKRKEAYEREKKVWEEHLVVRVKSSDVPPSMEHHEAGGSPSQQQM
                     KPVISVTSALKEVGLDGSLTESQETSEEMEKSNNAISSKREILRRLNENLKAQEDEKE
                     KHHHADSCETVGHRDEREYEKENAISSDRKKWEMGGQLVIPLDEVTLDASFSASEKHT
                     VGEVIKLDSSGSPRKVWGKSPTDSVLKILGEAELQLQTELLENTPFKSEVCVEEENYK
                     PLLTGEENLQCISKEVNPSATVDTETNSPKFAKVSPAMSEGNVEEPDDLETEVLQEPS
                     AIPSDGSLPPVVNEVWTRAKATGLEDSIAVQQNDVCEERIPGTVDQSCKDHIEPAGND
                     SPQSGCDEEKSVQPELFFQKVVHSKDLNLVQSAHRSPEEAIPIRSHSDSPPKAKSKNS
                     LLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIEELEDEHIK
                     EGPSDCEDIVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSNVERAARGTD
                     VPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFE
                     VYEKVKAIHEDEDENIEISSTIVENILGTEHQHLYAKILHLVMADGAYQEDNDE"
     exon            227..323
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..421
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..505
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..573
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..660
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..715
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..916
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..977
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1129
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1189
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1249
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1297
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1372
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1536
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1639
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1723
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1801
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1897
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2026
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2092
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2321
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2474
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2636
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2745
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2834
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3073
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3225
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3434
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3565
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3698
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..4896
                     /gene="Nek1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tataggaaga ccctgccgca tttagactgg tgcttatggt cgtcactgtt gttctgattc
       61 aggtcccgtg tcattgagca tatgtataaa aatgccttaa taaagaacca tggagaagta
      121 tgttagacta cagaagattg gagaaggttc atttggaaaa gctgttcttg ttaaatctac
      181 agaggatggc agacattatg tcatcaagga aattaacatc tcaagaatgt ccgataaaga
      241 aagagaagaa tcaaggagag aggtcgcagt gttggcaaac atgaagcatc caaatattgt
      301 ccaatacaaa gaatcattcg aagaaaatgg ctctctctac atagtaatgg attactgtga
      361 aggaggtgat ctgtttaaac gaataaatgc tcagaaaggc actttgtttc aagaagatca
      421 gattttggac tggtttgttc agatatgttt ggctttgaag catgtacacg atagaaaaat
      481 tcttcaccga gacataaagt cacagaacat atttctaacc aaagatggga cagtgcagct
      541 tggagatttt ggaattgctc gagttctcaa tagtactgta gagctggctc gaacttgcat
      601 agggactcca tactacttgt cacctgaaat ctgtgaaaac aagccttaca acaataaaag
      661 tgacatttgg gctttgggct gtgtccttta tgagttgtgt acacttaaac atgcatttga
      721 agctggaaac atgaaaaacc tggtactgaa gataatatct ggatcctttc ctccagtgtc
      781 tctacattat tcctatgatc tccgcagctt gctctctcag ctgtttaaaa gaaatcctag
      841 ggatagacca tcagtcaact ccatattgga gaaaggcttt atagctaaac gaatcgaaaa
      901 gtttctctca cctcagctta ttgcagaaga attttgtctg aaaacagttt caaagtttgg
      961 accacagcct atcccaggta aaagaccagc atcaggacaa ggtgtcagtt cttttgtccc
     1021 tgctcagaaa atcacaaagc cttctgctaa atatggagtg cctataacat ataagaagta
     1081 cggagataaa aagttacttg aaaaaaaacc acccccaaag cataagcagg cccatcagat
     1141 tccagtgaag aaaatgaatt ctggagaaga aaggaagaaa atgtctgagg aagcagcaaa
     1201 aaaacgaagg ttggaattta ttgagaaaga aaagaagcaa aaggatcaga tcaggttcct
     1261 gaaggctgag cagctgaaga ggcaagagaa gcagcggttg gagaggataa atagggccag
     1321 ggaacaagga tggaggaatg ttttaagggc tggtggaagc ggtgaagtaa aggcttcctt
     1381 ttttggcagt ggaggagctg tgtctccatc accttgttct cctcggggcc agtatgaaca
     1441 ttaccatgcc atctttgacc aaatgcagca gctaagagca gaagataatg aagcgagatg
     1501 gaaagggaga atatatggtc gatggctccc tgaaaggcaa aaaggacacc taggtgtaga
     1561 gagagccaaa caagtggaag aattcctaca gcgtaaacaa gaagctatgc agaataaagc
     1621 ccgagcagaa ggacatgtgg tttatctggc aagactgagg caaataagac tacaaaattt
     1681 taatgagcgc caacagatta aagccaaact tcgtggtgag aataaagaag ctggtggtac
     1741 caaaggacaa gacgcaactg aagaggctga catgaggctc aaaaagatgg agtcacttaa
     1801 ggcccaagca aatgcacgtg ctgctgtact aaaagaacag ctagagcgaa aaagaaagga
     1861 agcttatgaa agagaaaaga aagtgtggga agaacatttg gtggtgaggg taaaaagctc
     1921 agatgtccct ccatctatgg agcatcatga agcaggtggt tctccatcac agcagcagat
     1981 gaaacctgtt atttctgtga cttcagcttt gaaagaagtg ggcctggatg gaagtttaac
     2041 tgagtcccaa gaaacttcag aagaaatgga aaagagtaac aatgctattt caagtaagcg
     2101 agaaatactg cgtaggctga atgaaaatct taaagctcaa gaggatgaaa aggaaaagca
     2161 tcatcacgct gattcttgtg agaccgttgg tcacagagat gagagagagt atgagaagga
     2221 aaatgccatt tcctctgatc gcaagaaatg ggagatggga ggtcagcttg tgattcctct
     2281 ggatgaagtg acactggatg catccttctc tgcttctgaa aaacatactg tgggagaggt
     2341 tattaagtta gattctagtg gctctccaag aaaagtctgg gggaaaagcc ctacagattc
     2401 tgtgctgaag atacttggag aagctgaatt acagctacag acagaactac tagaaaacac
     2461 gccttttaaa agtgaggttt gtgttgaaga ggagaactac aaacccctac tcactggaga
     2521 agagaatctg cagtgtattt caaaagaagt aaacccatca gccactgttg atactgaaac
     2581 aaacagtcca aagtttgcta aggtgtctcc agcaatgtcc gaaggaaatg tggaagaacc
     2641 tgatgatttg gaaacagaag ttctacaaga gccaagtgcc ataccctcag atgggagttt
     2701 gccgcctgtt gttaatgagg tgtggaccag agctaaggca actgggttgg aggatagcat
     2761 tgctgtgcag cagaatgacg tttgtgaaga gcgaattcca gggactgtgg accagtcctg
     2821 taaggatcat atagaacctg caggaaacga ttctccgcag tctggctgtg atgaagagaa
     2881 gtcagtacag ccagaattgt ttttccagaa agtggttcac tccaaggact tgaacttagt
     2941 tcagtcagct catcgttccc cagaagaagc aattccaatt cgatctcact ctgattctcc
     3001 accaaaagct aaaagcaaga attccctact gattggactt tccactggtc tgtttgatgc
     3061 aaacaaccca aagatgctga ggacctgttc acttccagac ctttccaagc tcttcagaac
     3121 cctaatggat gttcccactg tgggagacgt tcatcaagac agtcttgaaa tagaggagct
     3181 tgaggatgaa catattaaag aagggccctc ggattgcgag gacattgtat ttgaagaaac
     3241 tgacacagat ttacaggagc ttcaggcctc aatggagcag ctgcttaggg agcaacccgg
     3301 tgacgaatac agtgaggagg aagagtctgt cttaaaaagc agcaatgtgg agcgggcagc
     3361 aagagggaca gatgtcccag atgaggagga caaccccagc agtgaaagcg ccctaaacga
     3421 ggaatggcac tcagataaca gtgatgctga gactactagt gagtgtgaat atgacagtgt
     3481 ctttaaccat ttagaggaac taagacttca cttggaacaa gaaatgggct ttgaaaagtt
     3541 ctttgaggtc tatgagaaag taaaggctat tcatgaggat gaagatgaaa atattgaaat
     3601 ttcttcaacc atagtcgaga acatcttggg cactgagcat cagcaccttt atgccaagat
     3661 tctgcatcta gtcatggcag acggagccta tcaggaagat aatgatgaat aaacctcagg
     3721 acattcttta atagtcaact ataagaacac atttgaactt ggctcataat acaagcttcc
     3781 tgggaaatag acattattta tgaaaaaaac agatttaaga cgggaatgct tattgcatga
     3841 aaaaaattga gaagtgtggt ttttttttcc tcacatttta tctactttat tttgttgatt
     3901 ggattctaca gctgactctc atagaatgta tgtttcttta aattacccca ccaaagcatt
     3961 gactcagaac tggaaattta ccatgcaata ggaactactt ttgtggaaga attgcctata
     4021 tcaaaaaggc ctgcttttgg gtgtttcatt taaatttcag catgcctttt tttttttttt
     4081 tttttttttt tttttttgtc cctgtctagc attttcatcc tggctagcat ttctacatca
     4141 actcttgtca agggctctgt tcaaatctct acatttagaa gatgaaattc tagccttgaa
     4201 gtttgttttc tttagttttt atccaccact ggccctccct gagctagccc ggtgggaaca
     4261 ggccatagaa gcaatcctaa aaatcactaa gatttggtat tgaaggatag caaggttgta
     4321 ttccctgaca cttcaacgtt ccttacttct tctgtctcta tagaccagaa gcgctgtatc
     4381 taaaaatcag gctgtaagtt taaacctagc agatagcata aaattgcctt tttatttttt
     4441 aactccttgc atacatgtgc ctcagtggtt gcctgtgttc agaaggagag aggggccttt
     4501 ttcttttggc actgtggcag tttagtaact gctatgggga aatgtttcct attcttttca
     4561 gtgtgaggat ttaaccaggt cagtacaatg atggtcacat agtttcagtt atgtgaacct
     4621 atacatagaa acagttatag tttccaaatt tgccaagtat acatggtgtc attatctaca
     4681 atccagacat tcctaataaa ataaaagcag aaatgtgggc ttcttggtac caatcagcct
     4741 gattggtgta acctgtcatc tgaaatgtgg actcttacct tgtagcacta ttagtactgt
     4801 attgacttta ttatgtatat tatttctaac atccaaaagt aaatagttga tttttatatt
     4861 tttattttgt actattaaat ttttattatg tatctg
//
