LOCUS       NM_001107270            1042 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus nei-like DNA glycosylase 2 (Neil2), mRNA.
ACCESSION   NM_001107270 XM_001064764 XM_224276
VERSION     NM_001107270.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Ma H, Wang J, Abdel-Rahman SZ, Hazra TK, Boor PJ and Khan MF.
  TITLE     Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced
            splenic toxicity
  JOURNAL   Toxicol Appl Pharmacol 251 (1), 1-7 (2011)
   PUBMED   21145906
  REMARK    GeneRIF: In the spleen aniline-induced oxidative stress is
            associated with an induction of NEIL1/2.
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Conlon KA, Miller H, Rosenquist TA, Zharkov DO and Berrios M.
  TITLE     The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase
            beta bind microtubules in situ and in vitro
  JOURNAL   DNA Repair (Amst) 4 (4), 419-431 (2005)
   PUBMED   15725623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474023.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_224276.3, XM_001064764.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132291 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1042
                     /gene="Neil2"
                     /note="nei-like DNA glycosylase 2"
                     /db_xref="GeneID:305957"
                     /db_xref="RGD:1312033"
     exon            1..30
                     /gene="Neil2"
                     /inference="alignment:Splign:2.1.0"
     exon            31..184
                     /gene="Neil2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1039
                     /gene="Neil2"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 2"
                     /codon_start=1
                     /product="endonuclease 8-like 2"
                     /protein_id="NP_001100740.1"
                     /db_xref="GeneID:305957"
                     /db_xref="RGD:1312033"
                     /translation="MPEGPSVRKFHHLVSPFVGQKVVKTGGSSKKLHPATFQSLWLQD
                     AQVHGKKLFLQFDPDEEMEPLSRSPQPVQGMWQKEAGNPEPALGPSAQETSVGPCGSG
                     EPGPSTSDGPYDLRGKKPLAEAQRWLEVRFGLFGSIWVNDFSRAKKANKRGDWIDPVP
                     RLVLHFSGGGFLAFYNCQMSWSPPPVIEPTCDILSEKFHRGQALEALSQAQPVCYTLL
                     DQRYFSGLGNIIKNEALYRARIHPLSLGSFLSPSSLEALVDHVVEFSTDWLRDKFQGK
                     ERHTQIYQKEQCPSGHQVMKETFGPPDGLQRLTWWCPQCQPQLSSEGPQNLLSS"
     exon            185..528
                     /gene="Neil2"
                     /inference="alignment:Splign:2.1.0"
     exon            529..725
                     /gene="Neil2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1042
                     /gene="Neil2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaccctcg ccctagcgac gaaacccaag ctctctgtcg gtagagatgc cagaagggcc
       61 gtctgtgagg aagtttcacc atctcgtctc cccctttgtg ggccagaagg tggtcaagac
      121 aggcggcagc agtaagaagc tacaccctgc cacctttcag tctttgtggc tccaggatgc
      181 tcaggtgcat gggaaaaaat tattcctcca gtttgatcca gatgaggaga tggagcccct
      241 cagccgcagc ccacagcctg tacaaggaat gtggcagaaa gaagctggga acccagagcc
      301 agccttgggt cccagtgctc aggaaacttc tgtaggcccc tgtgggtctg gagagcctgg
      361 tcccagtaca tctgatggcc cttacgatct caggggaaag aagcctttag cagaggccca
      421 gaggtggctg gaggtcaggt tcggtttgtt tggcagtatc tgggtgaatg acttctccag
      481 agcaaagaaa gctaacaaaa gaggtgactg gatagaccca gtgcccaggc tggtactcca
      541 ttttagtggt ggtggcttcc tggcatttta taattgccag atgtcatgga gccctccccc
      601 agtgattgag cccacctgtg acatcttgtc tgaaaagttc catcgaggac aagccttgga
      661 agctctaagc caggctcagc ctgtgtgcta cacactatta gaccagagat acttctcagg
      721 attagggaac attataaaga atgaagcctt gtacagagca aggatccatc ccctgtctct
      781 tggttcattc ctgagtcctt cctctctgga ggcccttgtg gatcatgtgg tggagttcag
      841 cacagattgg cttcgggaca aattccaagg caaggaacgg cacacacaga tctaccagaa
      901 ggaacaatgt ccttctggtc accaagttat gaaggagaca tttgggcccc cagatgggct
      961 ccagaggctc acctggtggt gccctcaatg ccagccccag ctgtcatctg aggggccaca
     1021 gaatctactg tcctcctaaa ac
//
