LOCUS       NM_001025754            1768 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus nei-like DNA glycosylase 1 (Neil1), mRNA.
ACCESSION   NM_001025754 XM_345944
VERSION     NM_001025754.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1768)
  AUTHORS   Ma,H., Wang,J., Abdel-Rahman,S.Z., Hazra,T.K., Boor,P.J. and
            Khan,M.F.
  TITLE     Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced
            splenic toxicity
  JOURNAL   Toxicol Appl Pharmacol 251 (1), 1-7 (2011)
   PUBMED   21145906
  REMARK    GeneRIF: In the spleen aniline-induced oxidative stress is
            associated with an induction of NEIL1/2.
REFERENCE   2  (bases 1 to 1768)
  AUTHORS   Das,A., Boldogh,I., Lee,J.W., Harrigan,J.A., Hegde,M.L.,
            Piotrowski,J., de Souza Pinto,N., Ramos,W., Greenberg,M.M.,
            Hazra,T.K., Mitra,S. and Bohr,V.A.
  TITLE     The human Werner syndrome protein stimulates repair of oxidative
            DNA base damage by the DNA glycosylase NEIL1
  JOURNAL   J Biol Chem 282 (36), 26591-26602 (2007)
   PUBMED   17611195
REFERENCE   3  (bases 1 to 1768)
  AUTHORS   Takao,M., Kanno,S., Kobayashi,K., Zhang,Q.M., Yonei,S., van der
            Horst,G.T. and Yasui,A.
  TITLE     A back-up glycosylase in Nth1 knock-out mice is a functional Nei
            (endonuclease VIII) homologue
  JOURNAL   J Biol Chem 277 (44), 42205-42213 (2002)
   PUBMED   12200441
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099125.1.
            
            [WARNING] On Mar 14, 2025 this sequence was replaced by
            NM_001025754.2.
            
            On Jul 22, 2005 this sequence version replaced XM_345944.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099125.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1768
                     /gene="Neil1"
                     /note="nei-like DNA glycosylase 1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
     exon            1..90
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..547
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1277
                     /gene="Neil1"
                     /EC_number="4.2.99.18"
                     /note="endonuclease VIII-like 1; nei endonuclease
                     VIII-like 1"
                     /codon_start=1
                     /product="endonuclease 8-like 1"
                     /protein_id="NP_001020925.1"
                     /db_xref="GeneID:367090"
                     /db_xref="RGD:1306077"
                     /translation="MPEGPELHLASHFVNEICKGLVFGGCVEKSSVSRNPEVPFESSA
                     YHISALARGKELRLTLSPLPGSHPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFY
                     TAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRP
                     ICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRLSPELTLSQKVKA
                     KLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYAVPGMSSLRDRHG
                     RTIWFQGDPGPLAPKGGRSRKKKSQETQLEAEDRKEDPPSKSISRTQRARKHCPKNVP
                     QQSEGASLPQNLETPAVPEKGKRRGRRASTGRHRGPKSKPDTQPREAGEISAS"
     exon            548..667
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..731
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..831
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..959
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..987
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1049
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1206
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1728
                     /gene="Neil1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctttccc agcgtgctct gaagtttggc aggcgactgg gattaacccc ttactgatgc
       61 tgccccccgg ttgagcagca accggagcag ggcccagcca ttcctccttc agaatgccgg
      121 agggcccaga gctgcacctg gccagccact ttgtgaatga gatatgtaaa gggctggtat
      181 tcggtgggtg tgtggagaag tcctctgtca gccgaaaccc ggaggtgccc tttgagagca
      241 gtgcctacca catctcagct ttagcccgag gcaaggagct gcgcttgaca ttgagccccc
      301 tgcctgggtc ccatccccct cagaaaccac tgtcccttgt cttccgcttt ggtatgtctg
      361 gatccttcca gctggtaccc gcagaagcac tgccgcgcca cgcccatcta cgtttctata
      421 cggccccacc tgccccccgg cttgcccttt gcttcgtaga catccgccgc tttggccact
      481 gggaccctgg aggtgaatgg cagccaggcc gcggaccctg tgtcttgttg gagtatgaac
      541 ggttcagaga gaacgtgctt cggaacctat cggacaaagc ctttgaccgg cccatctgcg
      601 aggccttgtt ggaccagagg ttcttcaatg gaatcggcaa ctatctgcgg gcagagatct
      661 tgtatcggct gaagatcccc ccttttgaga aggcccgtac agttctagag gccctgcaac
      721 agtgccggct gagcccagag ctgaccctga gccagaaggt caaggccaaa ctgcagaacc
      781 cagacctgct ggaactgtgt cacttggtgc ccaaggaagt ggttcagctg gggggcaaag
      841 gctatgggcc agagcgtgga gaggaagatt ttgctgcctt tcgagcctgg cttcggtgct
      901 atgctgtgcc aggcatgagc tccctgagag accggcatgg ccgtaccatt tggttccagg
      961 gtgatcctgg acccttggca cccaaagggg gcagatcccg aaaaaagaag tcacaggaaa
     1021 cacagctgga ggctgaggac agaaaagagg accctccaag caagtccatt tccaggactc
     1081 agagggccag gaagcactgt cctaagaatg tacctcaaca gtctgaaggg gccagcctcc
     1141 cacaaaacct ggaaacccct gcagtccctg agaaaggaaa gagaaggggg agacgggcga
     1201 gcacaggccg ccacagagga ccaaagagta agcctgatac tcaacccagg gaggctgggg
     1261 agatttcagc ctcataggta gaggtatcct tccctgatga cttgctatca atctagggga
     1321 atgtctgaat ccctagaacc agtatttgta gggctacatg ccctgggccc tgtgattttt
     1381 ttcctgcaca actgttgtct gaggtggggt ctcctgtgtc ctatccttga atccatatgt
     1441 acctgaagat gacattgaac tcctcctgtt tgatcttcct gcttcgtttc catggtcact
     1501 gggatttgca ggtgtgagct gagccaccac accctgctga tttgctaccg tttattttct
     1561 caagacaagg gtttctctgt gtagccctgg ctgtcctaga actcatgctg tagaccaagc
     1621 tggcctcaag ctctgagatc tgcctgcttc tgcctcccaa agtgttggaa atgtatgcta
     1681 tcccaagtga aaaccattat caaattaata aatttgaact tctcagtgaa aaaaaaaaaa
     1741 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
