LOCUS       NM_021682               1808 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Rattus norvegicus neuronal growth regulator 1 (Negr1), mRNA.
ACCESSION   NM_021682
VERSION     NM_021682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Lamoureux,L., Simon,S.L.R., Waitt,B. and Knox,J.D.
  TITLE     Proteomic Screen of Brain Glycoproteome Reveals Prion Specific
            Marker of Pathogenesis
  JOURNAL   Proteomics 18 (1) (2018)
   PUBMED   29087046
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Boender,A.J., van Rozen,A.J. and Adan,R.A.
  TITLE     Nutritional state affects the expression of the obesity-associated
            genes Etv5, Faim2, Fto, and Negr1
  JOURNAL   Obesity (Silver Spring) 20 (12), 2420-2425 (2012)
   PUBMED   22627920
  REMARK    GeneRIF: expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is
            affected by nutritional state in these two areas, and the
            relationship
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   Sugimoto,C., Morita,S. and Miyata,S.
  TITLE     Overexpression of IgLON cell adhesion molecules changes
            proliferation and cell size of cortical astrocytes
  JOURNAL   Cell Biochem Funct 30 (5), 400-405 (2012)
   PUBMED   22374746
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Lee,A.W., Hengstler,H., Schwald,K., Berriel-Diaz,M., Loreth,D.,
            Kirsch,M., Kretz,O., Haas,C.A., de Angelis,M.H., Herzig,S.,
            Brummendorf,T., Klingenspor,M., Rathjen,F.G., Rozman,J.,
            Nicholson,G., Cox,R.D. and Schafer,M.K.
  TITLE     Functional inactivation of the genome-wide association study
            obesity gene neuronal growth regulator 1 in mice causes a body mass
            phenotype
  JOURNAL   PLoS One 7 (7), e41537 (2012)
   PUBMED   22844493
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Hashimoto,T., Maekawa,S. and Miyata,S.
  TITLE     IgLON cell adhesion molecules regulate synaptogenesis in
            hippocampal neurons
  JOURNAL   Cell Biochem Funct 27 (7), 496-498 (2009)
   PUBMED   19711485
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Hashimoto,T., Yamada,M., Maekawa,S., Nakashima,T. and Miyata,S.
  TITLE     IgLON cell adhesion molecule Kilon is a crucial modulator for
            synapse number in hippocampal neurons
  JOURNAL   Brain Res 1224, 1-11 (2008)
   PUBMED   18602091
  REMARK    GeneRIF: These results demonstrate the alteration of modulatory
            function of Kilon for the number of dendritic synapses concomitant
            with changes in its localization and detergent solubility during
            neuronal culture development.
REFERENCE   7  (bases 1 to 1808)
  AUTHORS   Miyata,S., Matsumoto,N., Taguchi,K., Akagi,A., Iino,T., Funatsu,N.
            and Maekawa,S.
  TITLE     Biochemical and ultrastructural analyses of IgLON cell adhesion
            molecules, Kilon and OBCAM in the rat brain
  JOURNAL   Neuroscience 117 (3), 645-658 (2003)
   PUBMED   12617969
REFERENCE   8  (bases 1 to 1808)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Plaschke,M., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     IG-molecule Kilon shows differential expression pattern from LAMP
            in the developing and adult rat hippocampus
  JOURNAL   Hippocampus 10 (6), 632-644 (2000)
   PUBMED   11153709
REFERENCE   9  (bases 1 to 1808)
  AUTHORS   Funatsu,N., Miyata,S., Kumanogoh,H., Shigeta,M., Hamada,K.,
            Endo,Y., Sokawa,Y. and Maekawa,S.
  TITLE     Characterization of a novel rat brain
            glycosylphosphatidylinositol-anchored protein (Kilon), a member of
            the IgLON cell adhesion molecule family
  JOURNAL   J Biol Chem 274 (12), 8224-8230 (1999)
   PUBMED   10075727
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_021682.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017139.1, SRR26643299.12582.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               JAXUCZ010000002.1  248283476-248283720
            246-478             JAXUCZ010000002.1  248581732-248581964
            479-604             JAXUCZ010000002.1  248718504-248718629
            605-736             JAXUCZ010000002.1  248771701-248771832
            737-857             JAXUCZ010000002.1  248846778-248846898
            858-1009            JAXUCZ010000002.1  248860931-248861082
            1010-1808           JAXUCZ010000002.1  249014740-249015538
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..1808
                     /gene="Negr1"
                     /note="neuronal growth regulator 1"
                     /db_xref="GeneID:59318"
                     /db_xref="RGD:708416"
     exon            1..245
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1134
                     /gene="Negr1"
                     /note="kilon protein; kindred of IgLON"
                     /codon_start=1
                     /product="neuronal growth regulator 1 precursor"
                     /protein_id="NP_067714.1"
                     /db_xref="GeneID:59318"
                     /db_xref="RGD:708416"
                     /translation="MVLLAQGACCSNQWLAAVLLSLCSCLPAGQSVDFPWAAVDNMLV
                     RKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNV
                     DVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTINEGTNVTLTCLATGKP
                     EPAISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVKKVRVVVNFA
                     PTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKRLFNGQQGIIIQNFSTRSIL
                     TVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSACDLFSCWSLALTLS
                     SVISIFYLKNAILQ"
     exon            246..478
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..604
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..736
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..857
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1009
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1808
                     /gene="Negr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgcctg gttatcgggc agcctcgcca gcagcagggg gtgggagccg acgctgccgg
       61 agagcgagca gcctggcagg cacggacatg gtgctcctgg cgcagggcgc ttgttgctcg
      121 aaccagtggc tggcggcggt gcttctgagc ctgtgctctt gcctcccggc tgggcagagc
      181 gtggacttcc cctgggcggc cgtggacaac atgctggtga ggaaaggtga cacggcggtg
      241 ctcaggtgtt acttggaaga cggagcatca aagggcgcct ggctcaacag gtcaagtatc
      301 atttttgctg gaggtgacaa gtggtcagtg gaccctcgag tttccatttc cacattgaat
      361 aaaagggact acagcctcca gatacagaac gttgatgtga cagatgatgg cccgtacacc
      421 tgttctgtgc agacccaaca cacaccacgg acgatgcagg ttcatctcac tgtgcaagtt
      481 ccaccgaaaa tatatgacat ctcaaatgac atgaccatca atgaaggaac caacgtcacc
      541 cttacttgtt tggccactgg gaagccagag cccgccattt cctggaggca tatctcccca
      601 tcagcaaaac catttgaaaa tggacaatat ttggacattt atggaattac aagagaccag
      661 gctggggagt acgaatgcag tgcagagaac gatgtatcat tcccagatgt gaagaaagtg
      721 agagtggtcg tgaactttgc gcctacaatt caggaaatta aatctggcac agtgacccct
      781 ggacgcagtg gactgataag atgtgagggt gcaggtgtgc cgccgccagc cttcgagtgg
      841 tacaaaggag agaagagact cttcaatggc caacaaggaa ttatcattca gaattttagc
      901 acaagatcca tcctcacagt gaccaacgtg acacaggagc acttcggcaa ctatacttgt
      961 gtggctgcca acaagttggg cacaaccaac gcgagcctgc ccctcaaccc tccaagcaca
     1021 gcccagtatg gaattactgg gagcgcctgt gacctcttct cctgctggag ccttgcgttg
     1081 acactatctt ctgtcatcag catattctac ctgaagaatg ccatcctaca atgaatctaa
     1141 agacccatga aaggctttca aggagtctct gggagtgctg acggctggat ccaatctggt
     1201 gcagttaggt tgaagcagcg tgggatacaa tcggccgtct gtacgagggt gacacctttt
     1261 gtctgtggaa tcgctggttg tgtaaatact ttcattctcc tctccttttg attagacaca
     1321 cgaccttgtg aagcactgca cattgtccct ttttttaaga tgtgaaaggt ctgaacttac
     1381 ttttagagga tattaattgt gatttcatgt ttgtaatcta caacttttca agagcattca
     1441 gtcgtggtct gctaggcttc cggctgtagt ttacataaca aatattgcag tgaacccatg
     1501 attctttaag gctgcaatac aagggttcca tgccctgttt caataagagt caacccacat
     1561 ttacaaagat gcattttttt cttttttgat aaaaattcaa ataatattgc cttcagatca
     1621 tttcttcaaa atataacaca tatctagatg tccctgctcg catgacatcc aggttttgga
     1681 aatgagcctt gtaatataac tcgctatgct tctccttcta atttcagcat gggtgtgcct
     1741 tcataaaaaa taatctcttt gtctctgaca aatacttaat gttttcctaa accttgcaat
     1801 ttggaagc
//
