LOCUS       NM_012607               3843 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus neurofilament heavy chain (Nefh), mRNA.
ACCESSION   NM_012607
VERSION     NM_012607.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3843)
  AUTHORS   Liu,X., Xu,W., Zhang,Z., Liu,H., Lv,L., Han,D., Liu,L., Yao,A. and
            Xu,T.
  TITLE     Vascular Endothelial Growth Factor-Transfected Bone Marrow
            Mesenchymal Stem Cells Improve the Recovery of Motor and Sensory
            Functions of Rats With Spinal Cord Injury
  JOURNAL   Spine (Phila Pa 1976) 45 (7), E364-E372 (2020)
   PUBMED   32168135
REFERENCE   2  (bases 1 to 3843)
  AUTHORS   Li,J., Gu,Y., An,H., Zhou,Z., Zheng,D., Wang,Z., Wen,Z., Shen,H.Y.,
            Wang,Q. and Wang,H.
  TITLE     Cerebrospinal fluid light and heavy neurofilament level increased
            in anti-N-methyl-d-aspartate receptor encephalitis
  JOURNAL   Brain Behav 9 (8), e01354 (2019)
   PUBMED   31313506
REFERENCE   3  (bases 1 to 3843)
  AUTHORS   Ehler,J., Petzold,A., Wittstock,M., Kolbaske,S., Gloger,M.,
            Henschel,J., Heslegrave,A., Zetterberg,H., Lunn,M.P., Rommer,P.S.,
            Grossmann,A., Sharshar,T., Richter,G., Noldge-Schomburg,G. and
            Sauer,M.
  TITLE     The prognostic value of neurofilament levels in patients with
            sepsis-associated encephalopathy - A prospective, pilot
            observational study
  JOURNAL   PLoS One 14 (1), e0211184 (2019)
   PUBMED   30677080
  REMARK    Erratum:[PLoS One. 2019 Feb 20;14(2):e0212830. doi:
            10.1371/journal.pone.0212830.. PMID: 30785958]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3843)
  AUTHORS   Mages,B., Aleithe,S., Altmann,S., Blietz,A., Nitzsche,B.,
            Barthel,H., Horn,A.K.E., Hobusch,C., Hartig,W., Krueger,M. and
            Michalski,D.
  TITLE     Impaired Neurofilament Integrity and Neuronal Morphology in
            Different Models of Focal Cerebral Ischemia and Human Stroke Tissue
  JOURNAL   Front Cell Neurosci 12, 161 (2018)
   PUBMED   29967576
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3843)
  AUTHORS   Zhang,X., Li,Z., Zhang,Q., Chen,L., Huang,X., Zhang,Y., Liu,X.,
            Liu,W. and Li,W.
  TITLE     Mechanisms Underlying H2O2-Evoked Carbonyl Modification of
            Cytoskeletal Protein and Axon Injury in PC-12 Cells
  JOURNAL   Cell Physiol Biochem 48 (3), 1088-1098 (2018)
   PUBMED   30041238
REFERENCE   6  (bases 1 to 3843)
  AUTHORS   Klosen,P. and van den Bosch de Aguilar,P.
  TITLE     Spontaneous perikaryal neurofilament phosphorylation in the
            septofimbrial nucleus of the rat
  JOURNAL   Neurosci Lett 139 (1), 108-113 (1992)
   PUBMED   1407676
REFERENCE   7  (bases 1 to 3843)
  AUTHORS   Pennypacker,K., Fischer,I. and Levitt,P.
  TITLE     Early in vitro genesis and differentiation of axons and dendrites
            by hippocampal neurons analyzed quantitatively with neurofilament-H
            and microtubule-associated protein 2 antibodies
  JOURNAL   Exp Neurol 111 (1), 25-35 (1991)
   PUBMED   1898595
REFERENCE   8  (bases 1 to 3843)
  AUTHORS   Chin,S.S. and Liem,R.K.
  TITLE     Transfected rat high-molecular-weight neurofilament (NF-H)
            coassembles with vimentin in a predominantly nonphosphorylated form
  JOURNAL   J Neurosci 10 (11), 3714-3726 (1990)
   PUBMED   2230956
REFERENCE   9  (bases 1 to 3843)
  AUTHORS   Schlaepfer,W.W. and Bruce,J.
  TITLE     Simultaneous up-regulation of neurofilament proteins during the
            postnatal development of the rat nervous system
  JOURNAL   J Neurosci Res 25 (1), 39-49 (1990)
   PUBMED   2108255
REFERENCE   10 (bases 1 to 3843)
  AUTHORS   Dautigny,A., Pham-Dinh,D., Roussel,C., Felix,J.M., Nussbaum,J.L.
            and Jolles,P.
  TITLE     The large neurofilament subunit (NF-H) of the rat: cDNA cloning and
            in situ detection
  JOURNAL   Biochem Biophys Res Commun 154 (3), 1099-1106 (1988)
   PUBMED   2457365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1, CB585094.1 and CB582861.1.
            
            On Oct 17, 2007 this sequence version replaced NM_012607.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M37227.1, M21964.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840122,
                                           SAMN14984016 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-563               JAXUCZ010000014.1  84053851-84054413   c
            564-1151            CB585094.1         1-588
            1152-1690           CB582861.1         60-598
            1691-3843           JAXUCZ010000014.1  84044428-84046580   c
FEATURES             Location/Qualifiers
     source          1..3843
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3843
                     /gene="Nefh"
                     /gene_synonym="Nfh"
                     /note="neurofilament heavy chain"
                     /db_xref="GeneID:24587"
                     /db_xref="RGD:3159"
     exon            1..935
                     /gene="Nefh"
                     /gene_synonym="Nfh"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..3247
                     /gene="Nefh"
                     /gene_synonym="Nfh"
                     /note="NF-H; 200 kDa neurofilament protein; neurofilament
                     triplet H protein; neurofilament, heavy polypeptide"
                     /codon_start=1
                     /product="neurofilament heavy polypeptide"
                     /protein_id="NP_036739.2"
                     /db_xref="GeneID:24587"
                     /db_xref="RGD:3159"
                     /translation="MMSFGGADALLGAPFAPLHGGGSLHYALSRKAGAGGTRSAAGSS
                     SGFHSWARTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCVVAAVAARSEKEQLQ
                     ALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRAAMGELYEREVREMRGAVLRL
                     GAARGQLRLEQEHLLEDIAHVRQRLDEEARQREEAEAAARALARFAQEAEAARVELQK
                     KAQALQEECGYLRRHHQEEVGELLGQIQGCGAAQAQAQAEARDALKCDVTSALREIRA
                     QLEGHTVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEA
                     LKSTKESLERQRSELEDRHQVDMASYQDAIQQLDNELRNTKWEMAAQLREYQDLLNVK
                     MALDIEIAAYRKLLEGEECRIGFGPSPFSLTEGLPKIPSMSTHIKVKSEEKIKVVEKS
                     EKETVIVEEQTEEIQVTEEVTEEEDKEAQGEEEEEAEEGGEEAATTSPPAEEAASPEK
                     ETKSPVKEEAKSPAEAKSPAEAKSPAEAKSPAEVKSPAVAKSPAEVKSPAEVKSPAEA
                     KSPAEAKSPAEVKSPATVKSPGEAKSPAEAKSPAEVKSPVEAKSPAEAKSPASVKSPG
                     EAKSPAEAKSPAEVKSPATVKSPVEAKSPAEVKSPVTVKSPAEAKSPVEVKSPASVKS
                     PSEAKSPAGAKSPAEAKSPVVAKSPAEAKSPAEAKPPAEAKSPAEAKSPAEAKSPAEA
                     KSPAEAKSPVEVKSPEKAKSPVKEGAKSLAEAKSPEKAKSPVKEEIKPPAEVKSPEKA
                     KSPMKEEAKSPEKAKTLDVKSPEAKTPAKEEAKRPADIRSPEQVKSPAKEEAKSPEKE
                     ETRTEKVAPKKEEVKSPVEEVKAKEPPKKVEEEKTPATPKTEVKESKKDEAPKEAQKP
                     KAEEKEPLTEKPKDSPGEAKKEEAKEKKAAAPEEETPAKLGVKEEAKPKEKAEDAKAK
                     EPSKPSEKEKPKKEEVPAAPEKKDTKEEKTTESKKPEEKPKMEAKAKEEDKGLPQEPS
                     KPKTEKAEKSSSTDQKDSQPSEKAPEDKAAKGDK"
     exon            936..1135
                     /gene="Nefh"
                     /gene_synonym="Nfh"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1260
                     /gene="Nefh"
                     /gene_synonym="Nfh"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..3843
                     /gene="Nefh"
                     /gene_synonym="Nfh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgtcccgg ccccgcactc ccgctccgcc ggcggccgca cctgctccgg ccatgatgag
       61 cttcggcggc gccgatgcgc tgctgggcgc cccgttcgcg ccgctgcacg gaggaggcag
      121 cctgcactac gcgctgagcc gcaaggcagg cgccggcggc acccgctccg cggccggctc
      181 ctccagcggc ttccattcgt gggcgcggac gtcggtgagc tccgtgtccg cctcgcccag
      241 ccgcttccgc ggcgccggcg ccgcctcgag caccgactcg ctagacaccc taagcaatgg
      301 cccagagggc tgcgtggtgg cggcggtggc tgcgcgcagc gagaaggagc agctgcaggc
      361 gctcaacgac cgcttcgcgg gctacatcga taaggtgagg cagcttgagg cgcacaaccg
      421 cagcctggaa ggcgaggcgg cggcgctgcg gcagcagcaa gccggccgcg ccgccatggg
      481 cgagctgtac gagcgcgagg tgcgcgagat gcgcggggcc gtgctgcgcc tgggggcggc
      541 gcgcgggcag ctgcgcctgg agcaggagca cttgctggag gacatcgcgc acgtccgcca
      601 gcggctggac gaggaggccc ggcagcgcga ggaagcggag gcggcggccc gcgccctagc
      661 ccgcttcgcg caggaggcgg aagcggcgcg cgtggagctg cagaagaagg cgcaggcgct
      721 gcaggaagag tgcggctacc tgcggcgcca ccaccaggag gaggtgggcg agctgctcgg
      781 tcagattcag ggctgcggtg ccgcgcaggc gcaggctcag gccgaggctc gggacgccct
      841 caagtgcgac gtgacgtcgg cgctgcggga gatccgcgcg cagctcgaag gacacacggt
      901 gcagagtacg ctgcagtcag aggagtggtt ccgagtgaga ttggaccgac tctcagaggc
      961 agccaaagtg aacacggatg ctatgcgctc tgcccaagag gagataactg agtaccggcg
     1021 gcagctgcag gccaggacca cagagttgga ggcactgaaa agcaccaagg agtcactgga
     1081 gaggcagcgc tctgagctgg aggaccgtca tcaggtagac atggcctcct accaggatgc
     1141 aattcagcag ctggacaatg agctgagaaa caccaaatgg gagatggccg cgcagctccg
     1201 agagtaccag gacctgctca acgtcaagat ggccctggat attgagatcg ctgcttacag
     1261 aaaactcctg gaaggcgaag agtgtcggat tggctttgga cccagtccct tctctcttac
     1321 tgagggactc ccaaaaattc cctccatgtc cactcacata aaagtcaaaa gcgaagagaa
     1381 gataaaagta gtagaaaaat cggagaagga aaccgtcatt gtagaggaac agacagaaga
     1441 gatccaggtg acagaagaag tgacagaaga ggaggacaaa gaggcccaag gggaggaaga
     1501 agaagaggca gaagagggag gagaagaagc agcaactacg tctccccctg cagaagaggc
     1561 tgcatctcca gaaaaggaaa ccaagtctcc tgtgaaagaa gaggccaagt ccccagctga
     1621 ggccaagtcc ccagctgagg ccaagtcacc agctgaggcc aagtccccag ctgaggtcaa
     1681 atctccagct gtggccaagt ccccagctga agtcaaatct ccagctgagg tcaaatctcc
     1741 agctgaggcc aagtcaccag ctgaggccaa gtcaccagct gaggtcaaat ctccagctac
     1801 agtgaagtct ccaggtgagg ccaagtcccc agctgaggcc aagtcaccag ctgaggtcaa
     1861 atctccagtg gaggccaagt caccagctga ggccaagtct ccagcttcag tgaagtcccc
     1921 aggtgaggcc aagtcaccag ctgaggccaa gtcaccagct gaggtcaaat ctccagctac
     1981 agtgaagtcc ccagttgagg ccaagtcacc agctgaggtc aaatctccag ttacagtgaa
     2041 gtccccagct gaggccaagt caccagttga ggtcaaatct ccagcttcgg tgaagtcccc
     2101 aagtgaagcc aagtcaccag ctggagccaa gtcaccagct gaggccaagt caccagttgt
     2161 ggccaaatca ccagctgagg ccaagtcacc agctgaggcc aagcctccag ctgaggccaa
     2221 gtcaccagct gaggccaagt ctccagctga ggccaagtct ccagctgagg ccaagtcacc
     2281 agctgaggcc aagtcacctg ttgaggtaaa atctccagag aaggccaaga gccccgtgaa
     2341 ggaaggtgca aaatccctag ctgaggccaa gtcccctgag aaggccaagt cccctgtgaa
     2401 ggaagagatc aagcctccag ctgaggtgaa atcccccgag aaggccaaga gccccatgaa
     2461 ggaggaggcc aagtctcctg agaaggccaa gactctggat gtgaagtctc cagaagccaa
     2521 gactccagcg aaggaggaag caaagcgccc cgcagacatc agatcccctg agcaggtcaa
     2581 aagtcctgcc aaggaggagg ccaagtcccc cgagaaggaa gagaccagga ctgaaaaggt
     2641 ggctcccaag aaggaagagg tgaagtcccc tgtggaggag gtaaaagcca aagaaccccc
     2701 aaagaaggtg gaggaggaga agacaccagc cacaccaaag acagaggtga aggagagcaa
     2761 gaaagatgaa gctcccaagg aggcccagaa gcccaaggcg gaggagaagg agcctctcac
     2821 agaaaagccc aaggactctc cgggggaagc caagaaggaa gaggctaaag agaagaaggc
     2881 ggcggcccca gaggaggaga cgcccgccaa gttgggcgtg aaggaagagg ctaaacccaa
     2941 agagaaggca gaagacgcca aggccaaaga acctagcaaa ccctcagaga aggagaaacc
     3001 gaagaaggag gaggtgccgg cagcaccaga gaagaaagac accaaggagg agaagactac
     3061 ggagtccaag aagcctgagg agaaacccaa aatggaggcc aaggccaagg aggaggacaa
     3121 gggccttccc caagagccta gcaaacccaa gacagaaaag gctgaaaagt cctctagcac
     3181 agaccaaaaa gacagccagc cctcagagaa ggccccagag gacaaggctg ccaagggaga
     3241 caagtaagag gacgagaggg acacccagaa tagccaaaga aactcaggac ggccccggta
     3301 ctcaagggtt ggtgtaataa agtttatttc ttcctttccc tccgtaagaa gaaacaccac
     3361 ttagatggcg ggcccgccct caccaaacag gaatttctat taggattaag ttagcaagag
     3421 aagataaccc tgagccctgc ctccccaaca ccgaaagccc tccccaggtg atggacaatt
     3481 atgatagctt atcgtagccg aacgtgatgt attgctgaac gctccacgta aaacgcgtga
     3541 ctaaaaactg ccccccctcc tttccaagta agtgcattca cttcccgtat gtcctaccga
     3601 caggtgaccg cagtaatgaa tgagcagtta gaaatgcatt atgcttgaaa tgttgtaacc
     3661 tattcccgaa tgccttcttg ttttccaaag gagcggtcag gcccttgccc ggtacacgct
     3721 cctggaagag ctgcagcagg tgaggcaggg cgctggccgc tgaaccaggc cagggtgtgc
     3781 tgtccactga agtccacttt cgattgcttc cgtgcaataa aaccaagtgc ttctgaaata
     3841 caa
//
