LOCUS       NM_001011922            4370 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus neural precursor cell expressed, developmentally
            down-regulated 9 (Nedd9), mRNA.
ACCESSION   NM_001011922 XM_225245
VERSION     NM_001011922.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4370)
  AUTHORS   Latasa MJ, Jimenez-Lara AM and Cosgaya JM.
  TITLE     Retinoic acid regulates Schwann cell migration via NEDD9 induction
            by transcriptional and post-translational mechanisms
  JOURNAL   Biochim Biophys Acta 1863 (7 Pt A), 1510-1518 (2016)
   PUBMED   27085739
  REMARK    GeneRIF: Retinoic acid regulates Schwann cell migration by inducing
            NEDD9 levels by both transcriptional and post-translational
            mechanisms.
REFERENCE   2  (bases 1 to 4370)
  AUTHORS   Huang,Y., Clarke,F., Karimi,M., Roy,N.H., Williamson,E.K.,
            Okumura,M., Mochizuki,K., Chen,E.J., Park,T.J., Debes,G.F.,
            Zhang,Y., Curran,T., Kambayashi,T. and Burkhardt,J.K.
  TITLE     CRK proteins selectively regulate T cell migration into inflamed
            tissues
  JOURNAL   J Clin Invest 125 (3), 1019-1032 (2015)
   PUBMED   25621495
REFERENCE   3  (bases 1 to 4370)
  AUTHORS   Zheng P and Dean J.
  TITLE     Role of Filia, a maternal effect gene, in maintaining euploidy
            during cleavage-stage mouse embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7473-7478 (2009)
   PUBMED   19376971
REFERENCE   4  (bases 1 to 4370)
  AUTHORS   Singh MK, Dadke D, Nicolas E, Serebriiskii IG, Apostolou S,
            Canutescu A, Egleston BL and Golemis EA.
  TITLE     A novel Cas family member, HEPL, regulates FAK and cell spreading
  JOURNAL   Mol Biol Cell 19 (4), 1627-1636 (2008)
   PUBMED   18256281
REFERENCE   5  (bases 1 to 4370)
  AUTHORS   Sasaki T, Iwata S, Okano HJ, Urasaki Y, Hamada J, Tanaka H, Dang
            NH, Okano H and Morimoto C.
  TITLE     Nedd9 protein, a Cas-L homologue, is upregulated after transient
            global ischemia in rats: possible involvement of Nedd9 in the
            differentiation of neurons after ischemia
  JOURNAL   Stroke 36 (11), 2457-2462 (2005)
   PUBMED   16210561
  REMARK    GeneRIF: Nedd9 has a role in the differentiation of neurons after
            ischemia
REFERENCE   6  (bases 1 to 4370)
  AUTHORS   Merrill RA, See AW, Wertheim ML and Clagett-Dame M.
  TITLE     Crk-associated substrate (Cas) family member, NEDD9, is regulated
            in human neuroblastoma cells and in the embryonic hindbrain by
            all-trans retinoic acid
  JOURNAL   Dev Dyn 231 (3), 564-575 (2004)
   PUBMED   15376324
  REMARK    GeneRIF: Nedd9_predicted is regulated in the embryonic hindbrain by
            all-trans retinoic acid.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000288.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_001011922.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001011922.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085812.1, SRR8487231.141921.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JACYVU010000288.1  8863936-8864050
            116-559             JACYVU010000288.1  8883891-8884334
            560-661             JACYVU010000288.1  8904972-8905073
            662-763             JACYVU010000288.1  8905544-8905645
            764-2005            JACYVU010000288.1  8906545-8907786
            2006-2095           JACYVU010000288.1  8909142-8909231
            2096-4370           JACYVU010000288.1  8911486-8913760
FEATURES             Location/Qualifiers
     source          1..4370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4370
                     /gene="Nedd9"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated 9"
                     /db_xref="GeneID:291044"
                     /db_xref="RGD:1306276"
     exon            1..115
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2605
                     /gene="Nedd9"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 9"
                     /codon_start=1
                     /product="enhancer of filamentation 1"
                     /protein_id="NP_001011922.1"
                     /db_xref="GeneID:291044"
                     /db_xref="RGD:1306276"
                     /translation="MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWW
                     LCSLHGRQGIVPGNRVKLLIGPVQEPSSHEQPTPGPMHQNFGQQKLYQVPNSQAAPRD
                     TIYQVPPSYQNQGIYQVPTGHGTPEQDVYQVPPSVQRNIGSTNGPHLGKKVITPVRVG
                     HGYVYEHPSRYQKDVYDVPPSHTTQGVYDIPPSSVKGPVFSVPVGELKPQGVYDIPPT
                     QGVYAIPPSACRDEAGLREKEYDFPPPMKQDGKLDTRPEGVYDIPPTSTKTVGKDLHT
                     KFPCDAPGGAEPMARRHQSLSLHHAPSQVGPSGDTQSDAYDVPRGVQFLEVPTESSEK
                     ANLEERDGVYDVPLHNPADAKGSRDVVDGINRLSFSSTGSTRSNMSTSSTSSKESSLS
                     ASPSQDKRLLLDPDTAIGKLYWLQQTLETGICSLMSLVTIDWRSYGYMERHINEIRTA
                     VDKVELFLREYLHFARGALANASCLPEPVLLNKMNRELQRVDDSHQILSQTSHDLNEC
                     SWSLNVLAINKPQNKCDDLDRFVMVAKTVPDDAKQLTTTISTYAETLFRVDPGNSHLK
                     NGPDSITNSIEYTHTGSQMQPLRPGDYKGQVHNKPLPPTLSKEQPPDCSSSDGSERSW
                     MDDYDYVHLQGKEEFERQQKELLEKENIMKQSKAQLEHHQLSQFQLLEQEITKPVEND
                     ISKWKPSQSLPTTNNSVGAQDRQLLCFYYDQCETHFISLLNAIDALFSCVSSAQPPRI
                     FVAHSKFVILSAHKLVFIGDTLTRQVAAQDIRNKVRNSSNQLCEQLKTIVMATKMAAL
                     HYPSTTALQEMVHQVTDLSRNAQLFKRSLLEMATF"
     exon            116..559
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
     exon            560..661
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
     exon            662..763
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2005
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2095
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..4370
                     /gene="Nedd9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaggcga acgttctcac tcccatccag ccctttgctc aatggagggg cggacactgc
       61 agtgtgacta gataggacca gggctcatct gaccaccgcc gagatgaagt ataagaatct
      121 tatggcgagg gccttgtatg acaatgtccc tgagtgtgct gaggagctgg ccttccgcaa
      181 gggagacatc ttgaccgtca tagagcagaa cacaggagga ctagagggat ggtggctgtg
      241 ttccctacat ggtcgccaag gcatcgtccc aggtaaccgg gtgaaacttc tgattggtcc
      301 agtgcaagag ccctccagtc atgagcagcc tactcctgga cctatgcatc agaactttgg
      361 ccaacagaaa ctctatcaag tgccaaattc ccaggcagca cctcgtgata ccatctacca
      421 agtgccgccc tcctaccaga atcagggaat ttaccaagta cccactggcc atggcactcc
      481 agaacaagat gtatatcaag taccaccatc agttcagagg aacattggca gcactaatgg
      541 accccatcta ggcaaaaagg tgatcacgcc agtgagggtt ggccatggct atgtgtacga
      601 gcacccatcc agataccaaa aggatgtcta cgatgtccct ccttcccaca ccactcaagg
      661 ggtatatgac atccctcctt catcagtaaa aggccctgtg ttttcagttc cagtgggaga
      721 gttaaaacct caaggggtat acgacattcc ccccacccaa ggggtctatg ccattccacc
      781 atcagcttgc cgggatgagg cggggctgag ggaaaaggaa tatgatttcc ctcctccaat
      841 gaaacaagac ggaaaactgg acaccagacc tgagggggtt tatgacatcc ctccaaccag
      901 caccaagaca gtggggaagg accttcacac caaattcccc tgtgatgctc caggaggggc
      961 agaaccaatg gcacgaagac accagagcct ttccctgcac cacgcaccct ctcaggtggg
     1021 accgtccggg gacactcaga gtgatgcata tgatgtcccc cggggagttc agtttctcga
     1081 ggtaccgaca gaatccagtg aaaaggcaaa cctggaggag agagacggtg tttatgatgt
     1141 ccctctgcac aacccagcgg atgctaaagg ctctcgggac gtggtagacg ggatcaacag
     1201 actgtctttc tccagcactg gcagtaccag gagtaacatg tccacatctt ccacctcctc
     1261 aaaggagtcc tcgttgtcag cttctccgtc tcaggacaaa aggctcctcc tggacccaga
     1321 cacagccatt gggaagctct attggctcca gcagaccctg gagacgggca tctgcagcct
     1381 catgtcactg gtcaccatag actggaggtc ttatggatac atggaaaggc acatcaacga
     1441 gatccgcacc gcagtggaca aagtggagct gttcttacga gaatacctcc attttgccag
     1501 gggcgcttta gccaatgcct cctgcctccc agaaccggtc ctcctcaata aaatgaatcg
     1561 ggaactccag agagtagacg attcccacca gatcctaagc caaaccagcc atgatctgaa
     1621 tgaatgcagc tggtccctga atgttttagc tatcaataag ccccaaaata agtgtgatga
     1681 cctagaccgg tttgtgatgg tggccaagac agtgcccgac gatgccaagc aactgaccac
     1741 caccatcagc acctacgcag agactctctt tagagtagat cctggcaatt cccatctgaa
     1801 gaatgggcct gacagtatca cgaactcaat cgagtacaca catacgggct cccagatgca
     1861 gccactgcgc cccggtgact acaaaggcca ggttcacaat aagccattgc ctcctactct
     1921 aagcaaggag cagccaccag actgcagcag cagtgacggt tccgagagga gttggatgga
     1981 cgattatgac tatgtccacc tgcagggcaa agaggagttt gagagacaac agaaggaact
     2041 cttggaaaaa gagaacatca tgaagcagag caaggcgcag ctggagcatc atcagctgag
     2101 tcagttccag ctgttagaac aagaaatcac caagcccgtg gagaatgaca tttccaaatg
     2161 gaaaccctct cagagcctcc caaccacaaa caacagtgtg ggtgctcagg ataggcaatt
     2221 gctttgcttc tactatgacc aatgcgagac ccatttcatc tccctcctca atgccattga
     2281 cgccctcttc agctgcgtca gctcagccca gcccccgcgg atctttgtgg cgcacagcaa
     2341 gtttgtcatt ctcagtgcac acaaactggt gttcattgga gacactctga caaggcaggt
     2401 ggccgcccag gacattcgca acaaagtcag gaactccagc aaccagctct gcgaacagct
     2461 caagacgatt gtgatggcga ccaagatggc cgccctccac tacccgagca ctacggcttt
     2521 acaggaaatg gtgcaccaag taacagacct gtccagaaat gctcaactgt tcaagcgttc
     2581 cttgctggag atggccacct tctgagaaga cacggaagta gaaaggactg gttgaataat
     2641 tactaaggaa aactggaaat actatctagt ttttgtaaat gttatctatt tttgtagata
     2701 ttttatatga aattgaaatg ttttaatgtt ttgtgagtta gtcgattttc atcaattcag
     2761 ggagctgaag tgggaattca ttttgtttcc cctgtgtggt tcttatataa acatataagt
     2821 atctaagaca taagttgtac agaaatgtgt ccacatttgt gtatgcctac gtatccgtat
     2881 ttgtttatag atgtgtgtct gatacagtcc attaaaacca tgaattgaga agcaccttag
     2941 taagcaccta atgctgcatt gtttgggttt tgtagaaaaa ttatactact tagttgtaat
     3001 attactctac gtgtagtagt agtagtctga gcccagcaca cccaactttc ttgtctgaaa
     3061 tctcttttaa acttgacttg tctttaacac agtggtaaat ctgaccaact tctagttgaa
     3121 agggggtgag gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga
     3181 gagagagaaa aaaaaaaaac attaacctaa gatccagtgt ttcaggtgct agagaaaggc
     3241 aagacatgtg tgctgtacta agaggccatg tctacagtgg ttattgagtt atttcagttc
     3301 tgagagaaac tataataaag agagaacatt tgtttccctg gggctacatt tgtgagtgat
     3361 tcagtcatga ggttttctaa tggatgtttt tagagttgaa tttaaaaaaa aaaaattgca
     3421 acaagaattc atgaagatac atcagaactg tgattgtggg caaaaagaag ggatgtttcc
     3481 aacagccagt agttaaataa agacctctct accctcatta tctaatgaaa atggccagtt
     3541 tcttagtcac tgaactatgg agccaccagg cgctgtcctc tctcattgct tgatggagca
     3601 atgttctaca ccattctaaa accttacata agcagaccaa cactcaaaaa agctgcagag
     3661 atctgacctt cacaacccat tgtggccatg gaccttgtgg ataagtcaca ttacctgtaa
     3721 gctactcaca gcattgatcc tgtggtcttt cccttcacac ctgctgtgta gatacagctc
     3781 agaacagatt catcatcggc agataaagca cttccctctt ccattatgac caactcaaga
     3841 aatatgtttc ttgtagcctc tgttctattt cattccagcc tattcagaaa cgtgttttta
     3901 tttgttatgg atatgtcttg actgagttaa tgttatttgt tttaagcaac caaatgacaa
     3961 aaacaaggag ggacttaaga agaacatgtg atctcagttg tttttttttt gttttgtttt
     4021 gttttgtttt tttttaagta agtggaagat agcaaaggaa gggtgctttt caaaacaaac
     4081 tatagctgta attctcaaag ttctgcactg ccagaagata aacagctgga ctattggaca
     4141 gcaattcact gtgtctggca tgtggaggaa gagggtcctg cagcattagt gccattgcaa
     4201 aaagtcaagg tatccttgta gatcttacta cacaacgtgt gtctgttgag tgatggctac
     4261 cttgtcctaa cctgagtaat gacattccac attgtaaaaa aacaaactat tcaattcgta
     4321 atgatgattg acattttgta tattcaagtc attaaatgtt taaatctttc
//
