LOCUS       NP_001011922             833 aa            linear   ROD 30-MAR-2024
DEFINITION  enhancer of filamentation 1 [Rattus norvegicus].
ACCESSION   NP_001011922 XP_225245
VERSION     NP_001011922.1
DBSOURCE    REFSEQ: accession NM_001011922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 833)
  AUTHORS   Latasa,M.J., Jimenez-Lara,A.M. and Cosgaya,J.M.
  TITLE     Retinoic acid regulates Schwann cell migration via NEDD9 induction
            by transcriptional and post-translational mechanisms
  JOURNAL   Biochim Biophys Acta 1863 (7 Pt A), 1510-1518 (2016)
   PUBMED   27085739
  REMARK    GeneRIF: Retinoic acid regulates Schwann cell migration by inducing
            NEDD9 levels by both transcriptional and post-translational
            mechanisms.
REFERENCE   2  (residues 1 to 833)
  AUTHORS   Huang,Y., Clarke,F., Karimi,M., Roy,N.H., Williamson,E.K.,
            Okumura,M., Mochizuki,K., Chen,E.J., Park,T.J., Debes,G.F.,
            Zhang,Y., Curran,T., Kambayashi,T. and Burkhardt,J.K.
  TITLE     CRK proteins selectively regulate T cell migration into inflamed
            tissues
  JOURNAL   J Clin Invest 125 (3), 1019-1032 (2015)
   PUBMED   25621495
REFERENCE   3  (residues 1 to 833)
  AUTHORS   Zheng,P. and Dean,J.
  TITLE     Role of Filia, a maternal effect gene, in maintaining euploidy
            during cleavage-stage mouse embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7473-7478 (2009)
   PUBMED   19376971
REFERENCE   4  (residues 1 to 833)
  AUTHORS   Singh,M.K., Dadke,D., Nicolas,E., Serebriiskii,I.G., Apostolou,S.,
            Canutescu,A., Egleston,B.L. and Golemis,E.A.
  TITLE     A novel Cas family member, HEPL, regulates FAK and cell spreading
  JOURNAL   Mol Biol Cell 19 (4), 1627-1636 (2008)
   PUBMED   18256281
REFERENCE   5  (residues 1 to 833)
  AUTHORS   Sasaki,T., Iwata,S., Okano,H.J., Urasaki,Y., Hamada,J., Tanaka,H.,
            Dang,N.H., Okano,H. and Morimoto,C.
  TITLE     Nedd9 protein, a Cas-L homologue, is upregulated after transient
            global ischemia in rats: possible involvement of Nedd9 in the
            differentiation of neurons after ischemia
  JOURNAL   Stroke 36 (11), 2457-2462 (2005)
   PUBMED   16210561
  REMARK    GeneRIF: Nedd9 has a role in the differentiation of neurons after
            ischemia
REFERENCE   6  (residues 1 to 833)
  AUTHORS   Merrill,R.A., See,A.W., Wertheim,M.L. and Clagett-Dame,M.
  TITLE     Crk-associated substrate (Cas) family member, NEDD9, is regulated
            in human neuroblastoma cells and in the embryonic hindbrain by
            all-trans retinoic acid
  JOURNAL   Dev Dyn 231 (3), 564-575 (2004)
   PUBMED   15376324
  REMARK    GeneRIF: Nedd9_predicted is regulated in the embryonic hindbrain by
            all-trans retinoic acid.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Feb 11, 2005 this sequence version replaced XP_225245.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085812.1, SRR26643297.48396.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     Protein         1..833
                     /product="enhancer of filamentation 1"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 9"
                     /calculated_mol_wt=92849
     Region          7..63
                     /region_name="SH3_NEDD9"
                     /note="Src homology 3 domain of CAS (Crk-Associated
                     Substrate) scaffolding protein family member, Neural
                     precursor cell Expressed, Developmentally Down-regulated
                     9; cd12002"
                     /db_xref="CDD:212935"
     Site            order(12,14,17,21,42..43,56,58..59)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212935"
     Region          400..561
                     /region_name="Serine_rich_CAS"
                     /note="Serine rich Four helix bundle domain of CAS
                     (Crk-Associated Substrate) scaffolding proteins; a protein
                     interaction module; cl07433"
                     /db_xref="CDD:471673"
     Region          618..827
                     /region_name="CAS_C"
                     /note="Crk-Associated Substrate C-terminal domain;
                     pfam12026"
                     /db_xref="CDD:463437"
     CDS             1..833
                     /gene="Nedd9"
                     /coded_by="NM_001011922.3:104..2605"
                     /db_xref="GeneID:291044"
                     /db_xref="RGD:1306276"
ORIGIN      
        1 mkyknlmara lydnvpecae elafrkgdil tvieqntggl egwwlcslhg rqgivpgnrv
       61 klligpvqep ssheqptpgp mhqnfgqqkl yqvpnsqaap rdtiyqvpps yqnqgiyqvp
      121 tghgtpeqdv yqvppsvqrn igstngphlg kkvitpvrvg hgyvyehpsr yqkdvydvpp
      181 shttqgvydi ppssvkgpvf svpvgelkpq gvydipptqg vyaippsacr deaglrekey
      241 dfpppmkqdg kldtrpegvy dipptstktv gkdlhtkfpc dapggaepma rrhqslslhh
      301 apsqvgpsgd tqsdaydvpr gvqflevpte ssekanleer dgvydvplhn padakgsrdv
      361 vdginrlsfs stgstrsnms tsstsskess lsaspsqdkr llldpdtaig klywlqqtle
      421 tgicslmslv tidwrsygym erhineirta vdkvelflre ylhfargala nasclpepvl
      481 lnkmnrelqr vddshqilsq tshdlnecsw slnvlainkp qnkcddldrf vmvaktvpdd
      541 akqltttist yaetlfrvdp gnshlkngpd sitnsieyth tgsqmqplrp gdykgqvhnk
      601 plpptlskeq ppdcsssdgs erswmddydy vhlqgkeefe rqqkelleke nimkqskaql
      661 ehhqlsqfql leqeitkpve ndiskwkpsq slpttnnsvg aqdrqllcfy ydqcethfis
      721 llnaidalfs cvssaqppri fvahskfvil sahklvfigd tltrqvaaqd irnkvrnssn
      781 qlceqlktiv matkmaalhy psttalqemv hqvtdlsrna qlfkrsllem atf
//
