LOCUS       NM_138878                795 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Rattus norvegicus NEDD8 ubiquitin like modifier (Nedd8), mRNA.
ACCESSION   NM_138878
VERSION     NM_138878.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Bayraktar,G., Yuanxiang,P., Confettura,A.D., Gomes,G.M., Raza,S.A.,
            Stork,O., Tajima,S., Suetake,I., Karpova,A., Yildirim,F. and
            Kreutz,M.R.
  TITLE     Synaptic control of DNA methylation involves activity-dependent
            degradation of DNMT3A1 in the nucleus
  JOURNAL   Neuropsychopharmacology 45 (12), 2120-2130 (2020)
   PUBMED   32726795
REFERENCE   2  (bases 1 to 795)
  AUTHORS   Zhang,Q.G., Han,D., Wang,R.M., Dong,Y., Yang,F., Vadlamudi,R.K. and
            Brann,D.W.
  TITLE     C terminus of Hsc70-interacting protein (CHIP)-mediated degradation
            of hippocampal estrogen receptor-alpha and the critical period
            hypothesis of estrogen neuroprotection
  JOURNAL   Proc Natl Acad Sci U S A 108 (35), E617-E624 (2011)
   PUBMED   21808025
REFERENCE   3  (bases 1 to 795)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 795)
  AUTHORS   Buchwalter,A., Van Dort,C., Schultz,S., Smith,R., Le,I.P.,
            Abbott,J.L., Oosterhouse,E., Johnson,A.E., Hansen-Smith,F. and
            Burnatowska-Hledin,M.
  TITLE     Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK
            phosphorylation and maspin degradation and converts cells to the
            angiogenic phenotype
  JOURNAL   Microvasc Res 75 (2), 155-168 (2008)
   PUBMED   17950367
REFERENCE   5  (bases 1 to 795)
  AUTHORS   Huang,D.T., Paydar,A., Zhuang,M., Waddell,M.B., Holton,J.M. and
            Schulman,B.A.
  TITLE     Structural basis for recruitment of Ubc12 by an E2 binding domain
            in NEDD8's E1
  JOURNAL   Mol Cell 17 (3), 341-350 (2005)
   PUBMED   15694336
REFERENCE   6  (bases 1 to 795)
  AUTHORS   Dil Kuazi,A., Kito,K., Abe,Y., Shin,R.W., Kamitani,T. and Ueda,N.
  TITLE     NEDD8 protein is involved in ubiquitinated inclusion bodies
  JOURNAL   J Pathol 199 (2), 259-266 (2003)
   PUBMED   12533840
REFERENCE   7  (bases 1 to 795)
  AUTHORS   Antenos,M., Casper,R.F. and Brown,T.J.
  TITLE     Interaction with Nedd8, a ubiquitin-like protein, enhances the
            transcriptional activity of the aryl hydrocarbon receptor
  JOURNAL   J Biol Chem 277 (46), 44028-44034 (2002)
   PUBMED   12215427
REFERENCE   8  (bases 1 to 795)
  AUTHORS   Singer,J.D., Gurian-West,M., Clurman,B. and Roberts,J.M.
  TITLE     Cullin-3 targets cyclin E for ubiquitination and controls S phase
            in mammalian cells
  JOURNAL   Genes Dev 13 (18), 2375-2387 (1999)
   PUBMED   10500095
REFERENCE   9  (bases 1 to 795)
  AUTHORS   Page,R., Morris,C., Williams,J., von Ruhland,C. and Malik,A.N.
  TITLE     Isolation of diabetes-associated kidney genes using differential
            display
  JOURNAL   Biochem Biophys Res Commun 232 (1), 49-53 (1997)
   PUBMED   9125149
REFERENCE   10 (bases 1 to 795)
  AUTHORS   Lee,N.H., Weinstock,K.G., Kirkness,E.F., Earle-Hughes,J.A.,
            Fuldner,R.A., Marmaros,S., Glodek,A., Gocayne,J.D., Adams,M.D.,
            Kerlavage,A.R. et al.
  TITLE     Comparative expressed-sequence-tag analysis of differential gene
            expression profiles in PC-12 cells before and after nerve growth
            factor treatment
  JOURNAL   Proc Natl Acad Sci U S A 92 (18), 8303-8307 (1995)
   PUBMED   7667285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB581170.1 and BC084728.1.
            
            On Oct 20, 2007 this sequence version replaced NM_138878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084728.1, CB576942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMD00132295
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-596               CB581170.1         12-607
            597-795             BC084728.1         417-615
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..795
                     /gene="Nedd8"
                     /gene_synonym="CDK8"
                     /note="NEDD8 ubiquitin like modifier"
                     /db_xref="GeneID:25490"
                     /db_xref="RGD:3158"
     exon            1..277
                     /gene="Nedd8"
                     /gene_synonym="CDK8"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..505
                     /gene="Nedd8"
                     /gene_synonym="CDK8"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated gene 8; neddylin; neural precursor cell
                     expressed, developmentally down-regulated 8"
                     /codon_start=1
                     /product="ubiquitin-like protein NEDD8"
                     /protein_id="NP_620233.1"
                     /db_xref="GeneID:25490"
                     /db_xref="RGD:3158"
                     /translation="MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLI
                     YSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ"
     exon            278..325
                     /gene="Nedd8"
                     /gene_synonym="CDK8"
                     /inference="alignment:Splign:2.1.0"
     exon            326..408
                     /gene="Nedd8"
                     /gene_synonym="CDK8"
                     /inference="alignment:Splign:2.1.0"
     exon            409..770
                     /gene="Nedd8"
                     /gene_synonym="CDK8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacacgtgcg gggtctcagg tgtcgtctgg ctcttcctaa atcggttttc ctttctcttt
       61 acaacccaac tgacacaaaa tccgagggca ctcctgagcg tttcgggaac cggctggaaa
      121 gaggagcggg tgggtccgga gagtgacccg gaagcagaag tgttcctcgc cgtggagtgc
      181 tgggaagcgg cagcggcagt agcgaccaca gcgggagaag cagcactcta gccgcctgta
      241 accccaacct gggaggaaga tgctaattaa agtgaagacg ctgactggaa aggagattga
      301 gattgacatc gaacccacag acaaggtgga acgaatcaag gagcgtgtgg aagaaaaaga
      361 aggaattccc ccacaacagc agcggctcat ctacagtggc aaacaaatga atgatgagaa
      421 gacagcagct gattacaaga ttctaggtgg ttccgtcctc cacctggtgt tggctcttag
      481 aggaggtggt ggtcttgggc aatgaagaaa cttgattctg ttttacctcc ttgtcctgcc
      541 gctcataatg tggcatcaca tatcctctca ctctctggga caccagagct actgccccct
      601 tccttggatg cccaatcttg tgtgtctact ggtgggagaa tgtgaggacc ccaggatgca
      661 gtgttcctgg cccaaatggc ccttgctggc cattgggttt tagtttgcag tcctgtgtgc
      721 ttccctctct tatggctata tccttggttg tcaataaaat atttcctggc aaaaaaaaaa
      781 aaaaaaaaaa aaaaa
//
