LOCUS       NM_012986               5373 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus NEDD4 E3 ubiquitin protein ligase (Nedd4), mRNA.
ACCESSION   NM_012986 XM_001053672 XM_343427
VERSION     NM_012986.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5373)
  AUTHORS   Lei,J., Zheng,F., Chen,L., Zhang,R., Yang,Y., Yin,Z. and Luo,L.
  TITLE     Gstp1 negatively regulates blood pressure in hypertensive rat via
            promoting APLNR ubiquitination degradation mediated by Nedd4
  JOURNAL   Clin Sci (Lond) 138 (14), 883-900 (2024)
   PUBMED   38959295
  REMARK    GeneRIF: Gstp1 negatively regulates blood pressure in hypertensive
            rat via promoting APLNR ubiquitination degradation mediated by
            Nedd4.
REFERENCE   2  (bases 1 to 5373)
  AUTHORS   Liu,Y., Yang,H., Zeng,R., He,L., Xiao,T., Peng,X., Kuang,Z. and
            Wu,L.
  TITLE     NEDD4-2 and the CLC-2 channel regulate neuronal excitability in the
            pathogenesis of mesial temporal lobe epilepsy
  JOURNAL   Sci Rep 14 (1), 4835 (2024)
   PUBMED   38418461
  REMARK    GeneRIF: NEDD4-2 and the CLC-2 channel regulate neuronal
            excitability in the pathogenesis of mesial temporal lobe epilepsy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5373)
  AUTHORS   Zou,Z., Zhao,T., Zeng,Z. and An,Y.
  TITLE     Serum and glucocorticoid inducible kinase 1 modulates mitochondrial
            dysfunction and oxidative stress in doxorubicin-induced
            cardiomyocytes by regulating Hippo pathway via Neural precursor
            cell-expressed developmentally down-regulated 4 type 2
  JOURNAL   Hum Exp Toxicol 42, 9603271231158039 (2023)
   PUBMED   36781297
  REMARK    GeneRIF: Serum and glucocorticoid inducible kinase 1 modulates
            mitochondrial dysfunction and oxidative stress in
            doxorubicin-induced cardiomyocytes by regulating Hippo pathway via
            Neural precursor cell-expressed developmentally down-regulated 4
            type 2.
REFERENCE   4  (bases 1 to 5373)
  AUTHORS   Shao,Y., Jiang,Z., He,D. and Shen,J.
  TITLE     NEDD4 attenuates phosgene-induced acute lung injury through the
            inhibition of Notch1 activation
  JOURNAL   J Cell Mol Med 26 (10), 2831-2840 (2022)
   PUBMED   35355403
  REMARK    GeneRIF: NEDD4 attenuates phosgene-induced acute lung injury
            through the inhibition of Notch1 activation.
REFERENCE   5  (bases 1 to 5373)
  AUTHORS   Hu,Y., Hong,X.Y., Yang,X.F., Ma,R.H., Wang,X., Zhang,J.F., Feng,Q.,
            Li,X.G., Sun,D.S., Li,X., Wan,H.L., Li,T., Wang,Q., Ke,D.,
            Wang,J.Z. and Liu,G.P.
  TITLE     Inflammation-dependent ISG15 upregulation mediates MIA-induced
            dendrite damages and depression by disrupting NEDD4/Rap2A signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1477-1489 (2019)
   PUBMED   30826466
  REMARK    GeneRIF: The data revealed that maternal immune activation impedes
            offspring's dendrite development and causes depressive like
            behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A
            signaling.
REFERENCE   6  (bases 1 to 5373)
  AUTHORS   Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
  TITLE     Interaction of WW domains with hematopoietic transcription factor
            p45/NF-E2 and RNA polymerase II
  JOURNAL   J Biol Chem 272 (39), 24105-24108 (1997)
   PUBMED   9305852
REFERENCE   7  (bases 1 to 5373)
  AUTHORS   Hatakeyama,S., Jensen,J.P. and Weissman,A.M.
  TITLE     Subcellular localization and ubiquitin-conjugating enzyme (E2)
            interactions of mammalian HECT family ubiquitin protein ligases
  JOURNAL   J Biol Chem 272 (24), 15085-15092 (1997)
   PUBMED   9182527
REFERENCE   8  (bases 1 to 5373)
  AUTHORS   Staub,O., Yeger,H., Plant,P.J., Kim,H., Ernst,S.A. and Rotin,D.
  TITLE     Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues
            expressing the epithelial Na+ channel (ENaC)
  JOURNAL   Am J Physiol 272 (6 Pt 1), C1871-C1880 (1997)
   PUBMED   9227416
REFERENCE   9  (bases 1 to 5373)
  AUTHORS   Imhof,M.O. and McDonnell,D.P.
  TITLE     Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent
            activation of transcription by human progesterone and
            glucocorticoid receptors
  JOURNAL   Mol Cell Biol 16 (6), 2594-2605 (1996)
   PUBMED   8649367
REFERENCE   10 (bases 1 to 5373)
  AUTHORS   Staub,O., Dho,S., Henry,P., Correa,J., Ishikawa,T., McGlade,J. and
            Rotin,D.
  TITLE     WW domains of Nedd4 bind to the proline-rich PY motifs in the
            epithelial Na+ channel deleted in Liddle's syndrome
  JOURNAL   EMBO J 15 (10), 2371-2380 (1996)
   PUBMED   8665844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK365888.1, U50842.1, CB615796.1, CB568921.1, DY312717.1,
            BQ191927.1, EV775947.1, DY318090.1, CF110862.1 and CB326200.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_343427.3, XM_001053672.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-736               CK365888.1         1-736
            737-961             U50842.1           663-887
            962-1448            CB615796.1         72-558
            1449-1578           U50842.1           1375-1504
            1579-2059           CB568921.1         41-521
            2060-2604           DY312717.1         184-728
            2605-3275           BQ191927.1         5-675               c
            3276-3963           EV775947.1         38-725
            3964-4587           DY318090.1         131-754
            4588-5355           CF110862.1         199-966
            5356-5373           CB326200.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..5373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..5373
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /note="NEDD4 E3 ubiquitin protein ligase"
                     /db_xref="GeneID:25489"
                     /db_xref="RGD:3157"
     exon            1..122
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2735
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /EC_number="2.3.2.26"
                     /note="neural precursor cell expressed, developmentally
                     down-regulated 4, E3 ubiquitin protein ligase; neural
                     precursor cell expressed, developmentally down-regulated
                     gene 4A; HECT-type E3 ubiquitin transferase NEDD4"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEDD4"
                     /protein_id="NP_037118.1"
                     /db_xref="GeneID:25489"
                     /db_xref="RGD:3157"
                     /translation="MSSDMAADDTEAPVLSEDEVWEFCLDKNEEGGGSPGSDVTDTCE
                     PPCGCWELNPSSLEEEHVLFTADPYLELHNDDTRVVRVKVIAGIGLAKKDILGASDPY
                     VRVTLYDPMSGVLTSVQTKTIKKSLNPKWNEEILFRVLPQQHRILFEVFDENRLTRDD
                     FLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKNGSDDE
                     NADQAEELEPGWVVLDQPDAATHLQHPPEPSPLPPGWEERQDVLGRTYYVNHESRTTQ
                     WKRPSPEDDLTDDENGDIQLQAQRAFTTRRQISEDVDGPDNHESPENWEIVREDENTM
                     YSGQAVQSPPSGHPDVQVRLAEELDTRLTMYGNPATSQPVTSSNHSSRGGSSQTCIFE
                     EQPTLPVLLPTSSGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHL
                     RGKTPVDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRMQNVAITGPAVPYS
                     RDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADFLKARLWIEF
                     DGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYF
                     KFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDP
                     TELDLRFIIDEELFGQTHQHELKTGGSEVVVTNKNKKEYIYLVIQWRFVNRIQKQMAA
                     FKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSLNHQVIHWFW
                     KAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTC
                     FNRLDLPPYESFDELWDKLQMAIENTQGFDGVD"
     exon            123..287
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            288..361
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            362..440
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            441..479
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            480..533
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            534..584
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            585..646
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            647..746
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            747..913
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1031
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1196
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1262
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1382
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1460
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1515
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1574
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1640
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1870
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1992
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2063
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2159
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2233
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2294
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2354
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2462
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2559
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2632
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..5358
                     /gene="Nedd4"
                     /gene_synonym="Nedd4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgacgcc tcctcctcct cttcctctcc ggctgctgca gcctagcagg ggcggttcgt
       61 ccagtatgag ctcggacatg gcagccgacg acactgaggc cccagtgctt tcggaggacg
      121 aggtatggga gttctgtctg gataagaatg aagagggtgg tggatccccc ggaagtgatg
      181 tcacagatac ttgtgagcca ccatgtggat gctgggagtt aaatccgagt tccctggaag
      241 aggagcacgt gcttttcact gccgatccat atctcgagct tcacaatgat gacacgcgag
      301 ttgtgagagt gaaggttata gctggcatag gtctggccaa gaaagacatc ttgggagcca
      361 gtgatcctta tgtaagagtg acattgtatg acccgatgag tggagtcctt accagcgtgc
      421 agacgaaaac tatcaaaaag tctttgaatc caaaatggaa cgaagaaata ctgttcagag
      481 tccttccaca acagcaccgg attcttttcg aagtgtttga tgaaaatcgt ttgacaagag
      541 atgatttcct gggtcaagtg gatgtccctc tctatccttt accgactgaa aacccaagaa
      601 tggagagacc atatacattt aaggattttg ttcttcatcc aagaagccac aaatcaagag
      661 ttaaaggtta tctgagatta aaaatgactt acttacctaa aaacggctca gatgatgaaa
      721 atgcagacca ggctgaggag ttagagcctg gctgggttgt tttggaccaa ccagatgctg
      781 ccacccattt gcagcatcca ccagaacctt ctcccctacc tccagggtgg gaagagaggc
      841 aggatgtcct tggaaggacc tactacgtaa accatgagtc tagaacaaca caatggaaaa
      901 gaccaagccc tgaggatgac ctcacagatg atgagaatgg tgacattcag ctgcaggcgc
      961 agcgagcatt taccaccagg cggcagatat cggaggatgt ggatggccct gacaaccacg
     1021 agtcccctga gaattgggag attgtacgag aagatgagaa caccatgtac agtggtcagg
     1081 ctgttcagtc gcctccgtca ggtcacccag acgtgcaggt ccgcctcgca gaggagttag
     1141 ataccagact caccatgtat ggaaacccgg ccaccagcca gccagtcacc agctcaaacc
     1201 attccagcag aggaggcagc tcgcaaacct gtatctttga ggaacagcct acacttcctg
     1261 tgcttttgcc tacttcatct ggattgccac caggttggga agaaaaacaa gatgacagag
     1321 gacgatcgta ctatgtagac cacaactcta agacaaccac atggtccaag cccaccatgc
     1381 aggatgatcc aagatcgaaa attcctgctc atctgagagg aaagacacca gtcgactcca
     1441 atgacctggg acctttacct ccaggctggg aagaaagaac gcacacagat ggaagggtct
     1501 tcttcataaa tcacaatata aagaagacac agtgggaaga tcctcggatg cagaatgtgg
     1561 ccataactgg accagcagtg ccctactcca gagattacaa aagaaagtat gagtttttcc
     1621 gaaggaagct gaagaagcag actgacattc caaacaaatt tgaaatgaaa cttcgccgtg
     1681 caaacattct ggaggattct taccggagaa ttatgggtgt gaagagagct gacttcctca
     1741 aggcccgact ctggattgag tttgatggtg aaaagggcct tgactatgga ggagttgccc
     1801 gagaatggtt cttcctcatc tcaaaggaga tgtttaatcc ctattatggc ctgtttgaat
     1861 attccgctac ggacaattac actctgcaga taaatccaaa ctcgggcttg tgtaatgaag
     1921 atcacctctc atacttcaag ttcattggcc gtgtggctgg gatggcggtt tatcatggca
     1981 agctgttgga tgggtttttc atccgcccct tttacaagat gatgcttcag aaactgataa
     2041 cactgcacga catggagtcc gtggatagtg aatattacag ttctctgcga tggattcttg
     2101 aaaatgaccc gacggagctg gacctgagat ttatcataga tgaagagctt tttggacaga
     2161 cacatcaaca cgagctgaaa actggtggat cggaggttgt ggtcaccaac aagaacaaaa
     2221 aggagtatat ctaccttgta atccagtggc gatttgtgaa cagaatccag aagcaaatgg
     2281 ctgcttttaa agagggattt tttgaactga taccacagga tctgatcaag atattcgatg
     2341 aaaatgaact agagcttctc atgtgtggtc tgggagatgt ggacgtgaac gactggaggg
     2401 aacatacaaa atacaaaaat ggatacagct taaaccacca ggtcatccac tggttctgga
     2461 aggctgtttt gatgatggat tcagaaaaaa gaatacgctt acttcagttt gttactggca
     2521 catcccgtgt gcctatgaat ggatttgctg aactctatgg ctcaaatgga ccacagtcct
     2581 tcacagtgga acagtggggc acccctgata agctgcccag agcacatacc tgcttcaacc
     2641 gcctggacct gccaccctat gaatcctttg acgaactctg ggataaactt cagatggcga
     2701 ttgagaacac gcagggcttt gatggggttg attagattac aaaaaaccaa gctgtggtgt
     2761 cttatacacc atagttccta agcaaaagca aaaacaaaat cacattttag cattttccag
     2821 ataacttcta aaagatggcc actggctctt caagagtcca gaggacagtt tgtttatcca
     2881 tgatttcagc caccaccacg ctgacttgtt cctttgtcca gttgttgggg ttcatgtgta
     2941 cggcaggatg tgagtcctgt gtgcctgagt tctgaccgta tttcatcttg ctaggcacat
     3001 ccttctaaaa ctactgagat tccaactgtg aaatatctgt aatgagtagc tggtgggaaa
     3061 aattgacgct tttttaagat gaaatttgga caaagaaagt ctttaatgat tgattcataa
     3121 accgcgacac acttagtacc acgtgtcgct tacttactct gtagacctgc ctagtgtacc
     3181 ttatcgccta gaccccttga agccgctttg gaagatgtat cacatgtgtt tttagtcact
     3241 taagtaagtc acttgtgttt taaaaaaaaa aaaaagttac tcttcacttg gaagtatttc
     3301 acgtgtgtta gcatgcagct tgagcctaag gcgagtctgg agacaagtgg ggcaagcttt
     3361 tgtccgcagt gtgtagtgag tactaggcct cctttttgcc tgtgcaccct caaggctaga
     3421 gtcctgtgtt agcgttagaa ttccttcaaa cacgaaacaa gctccacacg cagtgtttct
     3481 aagcatgccg tgaagaaccg agttacatgt atgacttgcc cttaccagcc actcttcacg
     3541 cttgcagtca cgtagtacat acgtgtttac ggagttcatt atgtttacag attaagcgaa
     3601 tttctgtagt tgcattttta tatttttagt atcacattag tataaaaatt tgtttaaaat
     3661 aaccaaagag tagttcaatg cataatttgt atgaatttgt taccaggttt cttatgcttt
     3721 ctaaaaaata ctgtttccta tgaaaattat gttttattaa agtcaaaaac ccttggggca
     3781 agcaaaagct acaggtggac tcccaccata accacattga agcacaggaa gagatcccac
     3841 gcgtgagccc acgcgtgagc ccacgcgtga gcagtgcggg ctggctgtgt accaggccct
     3901 tgaggtaaaa ccgtcagctc catctttatc ctcaagctta gagatgtgta ggcgactgta
     3961 ctaacagtag aaagcaggag ttagcagaat acggcagaag gacaggaaag cgaggtccta
     4021 gtccgactgc aaggttatgt ctgccaaggt tccttgtatt caccttacac tggtgactga
     4081 tcagaaaagg ctctttatac atgagaaaag cgaagcctgt ttttcagtgt ggcatgtaat
     4141 gagttaatgt aagcttgtgt tataaacttt ctggaatgct tataagtggc ctgtgggagc
     4201 tgtaagaaat aacttggggc cattggttta agcttactgg ctctgacatg actagtgcct
     4261 gtcagcccat ggtagggatt tcagtgacga tagcagaaac gctttccata ggccagtgca
     4321 tgcttccagg gtgatcagag tcagccaggc atggccaccg tccagtcttg attttatcgt
     4381 tggccagccg agcctgcggt acagggctcc agttccctgt ctggcagatg tgaatacctg
     4441 tgcccgccct ctctgtctct aaaggctatg ttaagttctt aaaaaggtac ttcctgcaag
     4501 ccaccagtct cagtcagctc cccctcccag tgagcatgtt aacctaaaaa taaaagttca
     4561 tttaccgtag gcaagggtga tccctaatga gtactggctt atgtgcgttt tcatgtatgg
     4621 atctcagtgt cagagttcac tttctccata gtggcaaagt aacactaata tgggccggtg
     4681 tgttacctgg aatgtcccca tagtatagaa ctatgggtga aaccatcttg tgaaaacaga
     4741 attgtacaca cggttattca gtgtcgcctc tgagagaact catccacagc agagcttaga
     4801 aaacacgagc ttcctcttcc tcacacccat ttcccgttgg atgattctgt gacttcacta
     4861 gaacctggtg ttaaggagac caggtgtgtt gcacccctac cccagtgtgt agtgacagtc
     4921 tggagggacc ctgggtggaa caccacagcc cctcatgcca gtgcatgaaa acaccttgtt
     4981 gacattctgc cactggggca ttgtgaagtc acttacacga aacacaaagg ctttgtactt
     5041 ctctagggaa aaaaaagtat tttagccttt ttctctaatc cttaccccca acaaatgaaa
     5101 cacaaaattg cattataaaa gcaaacccaa atggtatttg ttttcaattt tatttatacc
     5161 tttcaagtta ttccttataa gtatcaagtt aaacacaatt ggttttaatg agaagctatt
     5221 tgacattgtt tttaaatttt ttcttatatg gtaaatgtat atccagaata atgtatcgaa
     5281 atttattgca taaactataa aatcattttc aaaatctcaa ttccacaaat aaagttctat
     5341 tctaatttta aaaacaaaaa aaaaaaaaaa aaa
//
