LOCUS       NM_001399228            7461 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus nectin cell adhesion molecule 3 (Nectin3),
            transcript variant 1, mRNA.
ACCESSION   NM_001399228 XM_006248335
VERSION     NM_001399228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7461)
  AUTHORS   Adams,A. and Wayne Vogl,A.
  TITLE     High Resolution Localization of Rab5, EEA1, and Nectin-3 to
            Tubulobulbar Complexes in the Rat Testis
  JOURNAL   Anat Rec (Hoboken) 300 (6), 1160-1170 (2017)
   PUBMED   28176461
  REMARK    GeneRIF: spermatid junction molecule that is internalized by
            adjacent Sertoli cells
REFERENCE   2  (bases 1 to 7461)
  AUTHORS   Poon,C.E., Madawala,R.J., Dowland,S.N. and Murphy,C.R.
  TITLE     Nectin-3 Is Increased in the Cell Junctions of the Uterine
            Epithelium at Implantation
  JOURNAL   Reprod Sci 23 (11), 1580-1592 (2016)
   PUBMED   27217376
  REMARK    GeneRIF: Nectin-3 is increased in the cell junctions of the uterine
            epithelium at implantation. Results suggest that at the time of
            implantation, nectin-3 may contribute to the formation of the tight
            junction in a protein complex independent from occludin and
            l-afadin.
REFERENCE   3  (bases 1 to 7461)
  AUTHORS   Guerrera,D., Shah,J., Vasileva,E., Sluysmans,S., Mean,I., Jond,L.,
            Poser,I., Mann,M., Hyman,A.A. and Citi,S.
  TITLE     PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins
  JOURNAL   J Biol Chem 291 (21), 11016-11029 (2016)
   PUBMED   27044745
  REMARK    GeneRIF: PDZD11 forms a complex with nectin-1 and nectin-3, and its
            PDZ domain interacts directly with the PDZ-binding motif of
            nectin-1.
REFERENCE   4  (bases 1 to 7461)
  AUTHORS   van der Kooij,M.A., Fantin,M., Rejmak,E., Grosse,J., Zanoletti,O.,
            Fournier,C., Ganguly,K., Kalita,K., Kaczmarek,L. and Sandi,C.
  TITLE     Role for MMP-9 in stress-induced downregulation of nectin-3 in
            hippocampal CA1 and associated behavioural alterations
  JOURNAL   Nat Commun 5, 4995 (2014)
   PUBMED   25232752
  REMARK    GeneRIF: MMP-9 has a role in stress-induced downregulation of
            nectin-3 in hippocampal CA1 and associated behavioral alterations
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7461)
  AUTHORS   Kurita,S., Yamada,T., Rikitsu,E., Ikeda,W. and Takai,Y.
  TITLE     Binding between the junctional proteins afadin and PLEKHA7 and
            implication in the formation of adherens junction in epithelial
            cells
  JOURNAL   J Biol Chem 288 (41), 29356-29368 (2013)
   PUBMED   23990464
REFERENCE   6  (bases 1 to 7461)
  AUTHORS   Ikeda,W., Kakunaga,S., Itoh,S., Shingai,T., Takekuni,K., Satoh,K.,
            Inoue,Y., Hamaguchi,A., Morimoto,K., Takeuchi,M., Imai,T. and
            Takai,Y.
  TITLE     Tage4/Nectin-like molecule-5 heterophilically trans-interacts with
            cell adhesion molecule Nectin-3 and enhances cell migration
  JOURNAL   J Biol Chem 278 (30), 28167-28172 (2003)
   PUBMED   12740392
REFERENCE   7  (bases 1 to 7461)
  AUTHORS   Takekuni,K., Ikeda,W., Fujito,T., Morimoto,K., Takeuchi,M.,
            Monden,M. and Takai,Y.
  TITLE     Direct binding of cell polarity protein PAR-3 to cell-cell adhesion
            molecule nectin at neuroepithelial cells of developing mouse
  JOURNAL   J Biol Chem 278 (8), 5497-5500 (2003)
   PUBMED   12515806
REFERENCE   8  (bases 1 to 7461)
  AUTHORS   Struyf,F., Martinez,W.M. and Spear,P.G.
  TITLE     Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal
            differences in requirements for entry of various alphaherpesviruses
            and for nectin-nectin interactions
  JOURNAL   J Virol 76 (24), 12940-12950 (2002)
   PUBMED   12438620
REFERENCE   9  (bases 1 to 7461)
  AUTHORS   Mizoguchi,A., Nakanishi,H., Kimura,K., Matsubara,K.,
            Ozaki-Kuroda,K., Katata,T., Honda,T., Kiyohara,Y., Heo,K.,
            Higashi,M., Tsutsumi,T., Sonoda,S., Ide,C. and Takai,Y.
  TITLE     Nectin: an adhesion molecule involved in formation of synapses
  JOURNAL   J Cell Biol 156 (3), 555-565 (2002)
   PUBMED   11827984
REFERENCE   10 (bases 1 to 7461)
  AUTHORS   Satoh-Horikawa,K., Nakanishi,H., Takahashi,K., Miyahara,M.,
            Nishimura,M., Tachibana,K., Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-3, a new member of immunoglobulin-like cell adhesion
            molecules that shows homophilic and heterophilic cell-cell adhesion
            activities
  JOURNAL   J Biol Chem 275 (14), 10291-10299 (2000)
   PUBMED   10744716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006248335.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.41047.1,
                                           SRR26643293.69013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               JAXUCZ010000011.1  67826944-67827305
            363-704             JAXUCZ010000011.1  67854990-67855331
            705-1001            JAXUCZ010000011.1  67859901-67860197
            1002-1119           JAXUCZ010000011.1  67861726-67861843
            1120-1271           JAXUCZ010000011.1  67864808-67864959
            1272-7461           JAXUCZ010000011.1  67870542-67876731
FEATURES             Location/Qualifiers
     source          1..7461
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..7461
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /note="nectin cell adhesion molecule 3"
                     /db_xref="GeneID:288124"
                     /db_xref="RGD:1309516"
     exon            1..362
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1852
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     poliovirus receptor-related protein 3; nectin-3;
                     poliovirus receptor-related 3"
                     /codon_start=1
                     /product="nectin-3 isoform 1"
                     /protein_id="NP_001386157.1"
                     /db_xref="GeneID:288124"
                     /db_xref="RGD:1309516"
                     /translation="MARTPGPALLCPGGGKAQLSSASPPAAGLLLPAPTPPPLLLLLI
                     PLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTV
                     AVHHPQYGFSVQGEYQGRILFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQS
                     STTVTVLVEPTVSLMKGPDSLIDGGNETVAAVCIAATGKPVARIDWEGDLGEMESTIT
                     SFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGY
                     DGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGEWPDGLLASDNTLHFVHPLTFNYSG
                     VYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTVQWRSSTADVQDLATEHKKLPFPLS
                     TLATLKDDTIGTIIASVVGGALFVVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQ
                     KESQIDVLQHDEHDSYPDSVKKENKAPVNNLIRKDYLEEPEKTQWNNVENLTRFERPM
                     DYYEDLKMGMKFVSDERYNENEDDLVSHVDGSVISRREWYV"
     exon            363..704
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1001
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1119
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1271
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..7461
                     /gene="Nectin3"
                     /gene_synonym="Pvrl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctcggca gtggcgtcgg cgacggcgga gtcgaggcag ccgcgagcgc tcggccgagt
       61 ggcggcgggc ggcgacggcg caggagccgg gggttgagga cacgcgcgct ggcccttccg
      121 cgccgcggcc gccgccgccg ccgccaccca gagcctgagg cgccggggcg cgggcgagcg
      181 ggtgggccgg ggcaaggcgg gcatggcgcg gaccccgggc ccggccctgt tgtgtcctgg
      241 aggcggcaaa gcacaacttt cctcggcgtc tcctcccgcg gccggactcc tgctgccggc
      301 cccgacgccg ccgccgctgc tgctgctgct cattcccctg cttctcttct cccggctctg
      361 tggtgcctta gctggatcaa ttattgtgga gccgcatgtc acagcagtgt ggggaaagaa
      421 tgtgtccttg aagtgtttaa ttgaagtgaa tgagactatc acacagatct catgggagaa
      481 gatacacggc aagagcacac agaccgttgc ggtgcatcat cctcagtatg gattctctgt
      541 tcagggagag tatcagggaa gaatcttgtt taaaaactat tcacttaatg atgcaacaat
      601 tactctgcat aacataggct tctcagattc tggaaaatac atatgcaaag ctgtcacatt
      661 cccacttgga aatgcccagt cctctacaac tgtgactgtg ctagttgaac ccaccgtgag
      721 cctgatgaaa gggccagact ctttaattga tggaggaaat gagaccgtag cagccgtttg
      781 tatagcggcc actggaaaac cagttgcacg tattgactgg gaaggggatc tcggcgaaat
      841 ggaatctact ataacttctt ttcccaatga aacagcaacg attatcagcc aatacaagct
      901 gtttcccaca agatttgcta gaggaaggcg aattacttgt gttgtaaaac atccagcctt
      961 agaaaaggac attcgatact ctttcatact cgacatccag tatgctcctg aagtctcagt
     1021 gacaggatat gatggaaatt ggtttgtggg aagaaaaggt gttaacctca agtgtaatgc
     1081 tgacgcaaat cctccaccct tcaagtctgt gtggagcagg ttggatggag aatggcctga
     1141 tggtttattg gcgtcagaca atactcttca ttttgttcat ccactgactt tcaattattc
     1201 tggtgtttat gtctgtaaag tgacaaattc ccttggtcaa agaagtgatc aaaaggtcat
     1261 ctacatttca gatcctccca ctaccaccac ccttcagcct acagttcagt ggcgttcctc
     1321 aactgctgac gtccaggatc tagcaacaga acataaaaag ttgcccttcc cattgtcaac
     1381 tttggcaaca cttaaggatg acacaattgg caccatcatt gctagcgtag tgggtggggc
     1441 tctcttcgta gtgcttgtga gcattttggc tggagtattc tgctatagga gacgacggac
     1501 gtttcgtgga gactactttg ccaaaaacta cattccacca tcagacatgc aaaaagagtc
     1561 gcagatcgat gttcttcaac acgatgagca tgattcttac ccagacagtg tgaaaaagga
     1621 aaacaaagcc ccagtgaaca acctaatacg taaagactac ttagaagagc ccgagaaaac
     1681 tcagtggaat aatgtagaga atctcactag gtttgaaaga ccgatggatt attacgaaga
     1741 tctaaaaatg ggaatgaagt tcgtcagtga tgaacggtat aatgaaaatg aagatgattt
     1801 agtttcccat gtagatggtt ccgtaatttc caggagggag tggtatgttt aacagccact
     1861 gatgtgactt cactatgtac agtgtttcat tcatactagt tgatcatttt cagattgttc
     1921 atactttttc ttgaggaaga ataagctttt tcaagttgat ttcgagctta ctttttatat
     1981 tctgatctga caaatgaaaa tgtaaaacct gggttcaatg tatctgagct gctttacagt
     2041 ttttcactgc tatactactg tctccagatt taaattctaa tgcagagtac ttttattggt
     2101 ctgaggcaca caggtaagaa agatgtcaac gttaaatgta tgacgttttt ggtataaaaa
     2161 ttaaaaacag aaaaaaatga aactaccttg gcattgcgta ttaaatattt acctaagact
     2221 ataatctcaa gtataatgat tgtgtaacat atacctctca aaacttatca ccactaagta
     2281 tactccatca aaattgacag taaaactcat tcaagaaatg cttctatatt tttagtatac
     2341 tgaaatcatt catcctgatg gagtatcttt tcctctgcaa acattatttt ctaagtcttg
     2401 tgtagttagg atcttcacct ctgcatttaa gtgagccttg ccgtaattac tgtagagtgg
     2461 cttctcagtg agattctgtt gcactaaaac tgtggccata aactcagtga gtgtgatgtg
     2521 tgcaagagca gaagtggctc ttcactattt ttgtccaaaa tacatgcaag agtaataaaa
     2581 tatatgcctc ctgacacaat aattaataat tttttcatct ctggaagaaa attctttagt
     2641 tgtttgtgaa catggttttg gtacaggaag cattaacctt attttaatgc tttatttgct
     2701 aagcgtgtga acaatgatga aaacgcggta caggacagag agggtacttg agtctgtttg
     2761 tgtgccaggg ttagacgtga gtcgttccat ccaagaacct atacaaaggg ttttctagat
     2821 cttcttgttt tagttattta atgttggtat tgttcaaacg ggtacatgta caaaaacaat
     2881 attaaactaa actttgaagc ttgaggtttc gttaagagaa aggtgaagta cataactagt
     2941 cattgataac acttgctgat ggatactggt gctccctccc tttttccttc attttctcct
     3001 aattggatgt atatgtttca aatttttccc tttgtttgtt tgtttggatt ttttttttca
     3061 aattaaaact ggaaacatga gatttttggg ggtttatttt gttcatttgt ttcatatagc
     3121 tcattaacta cattctttcc agtatcatgt aacttctgag atgttatata aatcttcaaa
     3181 tgttaatatt ctttgtatgg taaattactt ctgcagtaga gttcttaaaa ttgtgataat
     3241 ggaaactgct ttaaggcccg aagaatgttt ttctatggat tgattgtggg aaaggattgt
     3301 gtagaaccag tgtcttgcca ggacattgaa gatgttatta aatgaatcat aacataaatt
     3361 atttttaata ataaagcaaa ttagatgcca accaccacca accacctact cccaatcctc
     3421 tttcattcat atatatgtgt gaattatata tacatatata taatagattt ttattatatg
     3481 tttcatatag aagacagaat tgtgacatat tcctaaaata ttgtaagtag tgaaagcttt
     3541 attctgaatg attagacact atttttcttt agcagtgtta ttaaaattag ctctacccca
     3601 acatgtatta caaggcaata acagaagatt gagtagtata gttagcttgc caatatatca
     3661 cttttaatat tttaatatgt ttaatcacta tgtttaatac agacacctta gttcaagttg
     3721 ttggaagtac actttttagt aataatacac tgtgacagaa ctaactttat cagtaataat
     3781 ataagccaca ggaaaaatag gtctaaaatt tctttccgtg aaagataaga atttattgct
     3841 cttttgatca aagattttat cttaagaagt ggggttttga tgtgttgtat gagtccaagc
     3901 agagtggtca catgtaggct tctatataaa tctccactta aatatctaat gtaaaagaaa
     3961 tgagcaatgc tctcttgaga actgtgtcct gaacttcacg tacctacaga tgatgaaccc
     4021 ctttgtgttt tgtttatgaa ctggctagtc taggcatttt gtttgatttg tgggcaaagg
     4081 gcaatctcaa gacctgtaga gtatttgata cagtctgtat ccataatttg gatcacttgg
     4141 catgctagag gcttggcagg ttctaggaat cttacactgg tacttaaggc ttttggaagc
     4201 attgcactct tgttcattaa agctttatgt acatacactg tatgtagggg gttgtctgtg
     4261 aacacaagta ttcatatgaa tactgattcc gtgcacagct gattgtcagg tatataaaaa
     4321 tcacaactcc ttaaaaaatt tgaaagataa tttttactct attgagacca tgtttacttt
     4381 tgttactttg atatgttttg aaccgttttt acatttttat atttacttca tggtttcttt
     4441 cctactggta aacatatttc aataatacaa attgttttct tccaataaaa ttttattaaa
     4501 atacactcaa cttccataag ctacaagtta actataaaat agtacttgat tatatttaaa
     4561 catttggtat ttaaccatgt gcctgataag agctctgtgt gtgtttctcc cctgccactc
     4621 ccccccatac acacagctgt ctatatataa agaagtcatt acgtttttta gtagtaacta
     4681 ctgcttctga tagtcaccca tgtgtgaaaa gtttaggaag aaactatagc tacacatttt
     4741 acactaaggg attataggat ttagaataag tgcaaaattt ggcaagaatg tagccatgtc
     4801 atatgcaaaa atatttgatg tgattttgat aaagactgtc aaagtatata aatataatag
     4861 gtcatatatg gaagtaataa cataaagtat gagaggaaaa atggcacaca tactgaattt
     4921 ttaatctaga gtctagaata taaacagatt ttctccccta cttgtttatt ggaaatgacc
     4981 tgtcagaaag ggggacgtat ttctcagatg ttttttgaca ctgggttcag ttttcttccg
     5041 ttttagtgta accaagttac ttactaggtg atgaccctca ttgattgcca tgcagtaaat
     5101 catgaaatag actttcaaac aaagcctttc agtggtatac ttctaaaatg aagctcaatt
     5161 ctgtattctt ttcttcattc tcatatgagc ttctgtgcct gtgttttatt tcatgtatgc
     5221 gtagcccact gtccttgcaa ttaaccctta aaatgccatt ggactcgtag aaattagagt
     5281 ctacgtcatt tgtcttcaca aacagctaat atcaggttaa cgatagagtt aagtaaactt
     5341 gacagtgcct ataagtagac atgttagcca cattgacatg ttaaccacat tgacatgtta
     5401 gccattgtgt ggtttggctt taacacgtaa tctgtagcta tttgtgtgtt catcatcaat
     5461 gatattcaga aatatttgaa aaactgcatc tgcatcaaac acccaacttg tttatctcac
     5521 ctcttcttaa gcactacgta caacagttac acagaattta caaatcatta ggcatcttaa
     5581 atgatctgaa ggtaaaagtc tgtaggagga tatgtacagg ttatattcat ttcatagatt
     5641 gctagggatt tgtacatcac tgtaatgtga cattttggaa tcctggaacc cttgtgtgta
     5701 gaaatcagtt ggtttttatt ttgaaattag ctccatttaa gaaatactta gcttgccatt
     5761 tagtggtgtt tacttactgc ttatgaactg ttttgaatag aagtaacaca ttataatcaa
     5821 tttcctgttt actgttcgtt atttttaaca atggcatata tttttccaag ctgtttttga
     5881 acaagcagcc ctttcaagtg gcatacactt tgttttgttc acttcatggt atacacataa
     5941 gagttcactc atgagagcac cttcataata gtgtcagcat attccaactt caaagtttta
     6001 agcatgtctc tgcttacata tgtctgtttt cttcttttat ggtacgtcca gatttttaaa
     6061 acatgatact gagtagtgag actcagccta gttttacaaa aggtcgcact gtattatgtt
     6121 attggcgttt ggcagtagtt aatactggtt acaatttgga atagtaaagc ttacttcatt
     6181 atgggaagaa agtagcattc tgctgctgct gtagctgcac cccatgatga cagcagagac
     6241 agtgagctct ctcggtaata gtgccacaga agtcattcat aattcttgac aacaatccaa
     6301 agccttattc cttacatgca cgatactgct atataataca tcgatacaga aattattcca
     6361 tttcagttgc cagaagtgtc tcagggaaaa cctacttgta gatttgtttg tttgtttgtt
     6421 tcaaagccag cactttggtt attaccatgc cactgctgtt gcattttaag cccgacactc
     6481 ttcttgacat tacctcattg ggagtaaatc cttatccatt ctaaaagata aagattgttc
     6541 taaacaccag ccatagtatc ttttttaaaa gtaagtttcc atggtatctt tattatacca
     6601 aaaatgaaca tttctctaat ttcaagcagt aagtattcac atttgtgtta cttcagcggt
     6661 tttgattagg atccaagtat gatctgtgca ttgtaatttt agaactccct tttcatgtgt
     6721 tctggctgac atgccgggag cttcttccat ctgtcttttc actctaaaaa tgtcttaatt
     6781 ttctgatagt ttccctgtgt tggttgttcc attgcaccct gaatgcatcc tctgcatttt
     6841 tacaagttgt tggtacggtc tagaaccttg ctcgcattca agatccattg tgtacacggg
     6901 gttgcttcct aggagatgat gcgttcttcc acccagaggc tcgtagtact tgctttccgc
     6961 tctgacactg gcagccgctt ggccctcagt gcagacacag gaagagaggg cctactcatg
     7021 ctaggatgtg ttaactgtgc tttcccattg cagcgtgcct gattcacgct tccctcctca
     7081 cactgggagc cagtccatag aagtgtgtct caaatggtag atttatgaca cttcaacgga
     7141 attaacaaat ggtcttttct gttaccttgt atgtatccca gatttctatt ttattatttt
     7201 tgtctatctt gtagatcagt gaaaactctt gattgtaaca tgagctaaaa ttagtatgta
     7261 ttccaagtat atttgtgctt ctagagaaac tcagttgtat gtattttaag atagtctgaa
     7321 atggacattt taagtgataa ataatacttt taaatgtcag tgtaattgtc actatttggg
     7381 atacataatg tgcttcattt taaaagttaa ccttttctca cagaatattt aaaaatgatt
     7441 aaatgtgctt catttttaaa a
//
