LOCUS       NM_001012064            2681 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus nectin cell adhesion molecule 2 (Nectin2), mRNA.
ACCESSION   NM_001012064 XM_218427
VERSION     NM_001012064.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2681)
  AUTHORS   Deuss FA, Gully BS, Rossjohn J and Berry R.
  TITLE     Recognition of nectin-2 by the natural killer cell receptor T cell
            immunoglobulin and ITIM domain (TIGIT)
  JOURNAL   J Biol Chem 292 (27), 11413-11422 (2017)
   PUBMED   28515320
REFERENCE   2  (bases 1 to 2681)
  AUTHORS   Zhu Y, Paniccia A, Schulick AC, Chen W, Koenig MR, Byers JT, Yao S,
            Bevers S and Edil BH.
  TITLE     Identification of CD112R as a novel checkpoint for human T cells
  JOURNAL   J Exp Med 213 (2), 167-176 (2016)
   PUBMED   26755705
REFERENCE   3  (bases 1 to 2681)
  AUTHORS   Oshima T, Sato S, Kato J, Ito Y, Watanabe T, Tsuji I, Hori A,
            Kurokawa T and Kokubo T.
  TITLE     Nectin-2 is a potential target for antibody therapy of breast and
            ovarian cancers
  JOURNAL   Mol Cancer 12, 60 (2013)
   PUBMED   23758976
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2681)
  AUTHORS   Sipe CW, Liu L, Lee J, Grimsley-Myers C and Lu X.
  TITLE     Lis1 mediates planar polarity of auditory hair cells through
            regulation of microtubule organization
  JOURNAL   Development 140 (8), 1785-1795 (2013)
   PUBMED   23533177
REFERENCE   5  (bases 1 to 2681)
  AUTHORS   Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG
            and Almo SC.
  TITLE     Structure of Nectin-2 reveals determinants of homophilic and
            heterophilic interactions that control cell-cell adhesion
  JOURNAL   Proc Natl Acad Sci U S A 109 (37), 14836-14840 (2012)
   PUBMED   22927415
REFERENCE   6  (bases 1 to 2681)
  AUTHORS   Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S,
            Satoh K, Takeuchi M, Imai T, Monden M and Takai Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
REFERENCE   7  (bases 1 to 2681)
  AUTHORS   Martinez WM and Spear PG.
  TITLE     Structural features of nectin-2 (HveB) required for herpes simplex
            virus entry
  JOURNAL   J Virol 75 (22), 11185-11195 (2001)
   PUBMED   11602758
REFERENCE   8  (bases 1 to 2681)
  AUTHORS   Bouchard MJ, Dong Y, McDermott BM Jr, Lam DH, Brown KR, Shelanski
            M, Bellve AR and Racaniello VR.
  TITLE     Defects in nuclear and cytoskeletal morphology and mitochondrial
            localization in spermatozoa of mice lacking nectin-2, a component
            of cell-cell adherens junctions
  JOURNAL   Mol Cell Biol 20 (8), 2865-2873 (2000)
   PUBMED   10733589
REFERENCE   9  (bases 1 to 2681)
  AUTHORS   Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A,
            Nishioka H, Aoki J, Nomoto A, Mizoguchi A and Takai Y.
  TITLE     Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited
            to cadherin-based adherens junctions through interaction with
            Afadin, a PDZ domain-containing protein
  JOURNAL   J Cell Biol 145 (3), 539-549 (1999)
   PUBMED   10225955
REFERENCE   10 (bases 1 to 2681)
  AUTHORS   Lopez M, Aoubala M, Jordier F, Isnardon D, Gomez S and Dubreuil P.
  TITLE     The human poliovirus receptor related 2 protein is a new
            hematopoietic/endothelial homophilic adhesion molecule
  JOURNAL   Blood 92 (12), 4602-4611 (1998)
   PUBMED   9845526
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC090075.1.
            
            On Feb 11, 2005 this sequence version replaced XM_218427.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090075.1, SRR8487231.149405.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2681
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /note="nectin cell adhesion molecule 2"
                     /db_xref="GeneID:308417"
                     /db_xref="RGD:1309505"
     exon            1..300
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1805
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /note="nectin-2; poliovirus receptor-related 2
                     (herpesvirus entry mediator B); poliovirus receptor
                     related 2; poliovirus receptor-related protein 2"
                     /codon_start=1
                     /product="nectin-2 precursor"
                     /protein_id="NP_001012064.1"
                     /db_xref="GeneID:308417"
                     /db_xref="RGD:1309505"
                     /translation="MARAAVLPPSRLSPTLPLLPLLLLLLQETGAQDVRVRVLPEVRG
                     RLGGTVELPCHLLPPTTERVSQVTWQRLDGTVVAAFHPSFGVDFPNSQFNKDRLSFVR
                     AKQEANADLRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPENHAEAQ
                     EVTIGPQSVAVARCISTGGRPPARITWISSLGGEARDIQEPGLQAGTVTVISRYSMVP
                     VGRADGVKVTCRVEHESLEEPELLPVILSVRYPPEVSISGYDDNWYLGRSEATLTCEV
                     RSNPEPTGYDWSTTSGVFPASAVAQGSQLLVHSVDRMVNTTFICTATNAVGTGRAEQV
                     ILVRESPSTAGAGATGGIIGGIIAAIIATAVAGTGILICRQQRKEQRLQAADEEEELE
                     GPPSYKPPTPKAKLEEPEMPSQLFTLGPSEHSPVKTPYFDAGVSCADQEMPRYHELPT
                     LEERSGPLLLGATGLGPSLLVPPGPNVVEGVSLGLEDEEEDEEEEDFLDKINPIYDAL
                     SYPSPSDSYQSKDFFVSRAMYV"
     exon            301..663
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..960
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1078
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1227
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1381
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1445
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1532
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..2647
                     /gene="Nectin2"
                     /gene_synonym="Pvrl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgggagct aagcgagggg ccggggggcg cggatcctga gagccaggcg agggaaagct
       61 gggccgaaag aactgatccg gtgagctgtg agctgcggga gccggcctgg agccggacac
      121 ttcagacctg tgactgctct cccacccgat cggtacacga gagtggtccc taggcacccc
      181 ctgcccgggc ccagtccctc cccgggcccc ccatggcccg ggccgcagtc ctcccgccgt
      241 ccagattgtc accgacgctg ccgttgttgc cgctgctact gctcctgctt caggaaacag
      301 gagcccaaga tgtgcgggta cgagtgctcc ctgaggttcg tggccgcctg ggaggcacgg
      361 tggagttacc atgccacctg ctcccaccca cgacggagcg cgtctctcag gtgacctggc
      421 agcgcctgga tggcacagtt gtggctgcct tccacccatc cttcggcgtg gatttcccca
      481 actctcagtt caacaaggac cgtctgtcct tcgtccgagc gaaacaagaa gcaaacgcgg
      541 acctgcggga cgccacgctg gccttccggg gtctgagggt agaggacgag ggcaattaca
      601 cttgcgagtt tgccacgttt cccaacggta cccgcagggg agtgacctgg ctcagagtca
      661 tagcccagcc ggagaaccat gctgaggccc aagaggtcac aattggcccc cagtcggtag
      721 ctgttgcccg ctgtatctcc acggggggcc gcccccctgc ccgaatcacc tggatctcat
      781 ccctgggtgg agaggccaga gatattcagg agcccggact acaggctggc acggtcactg
      841 tcatcagtcg atactccatg gtgccggtgg gccgagcgga tggcgtcaag gtcacgtgca
      901 gagtggaaca tgagagcttg gaagagcccg agctgctgcc cgtgatcctc tccgtgcgct
      961 accctcccga agtatccatc tccggctatg atgacaactg gtacctaggc cgcagcgagg
     1021 ccacactgac ctgtgaagta cgaagcaacc cagagcctac aggctatgac tggagcacga
     1081 cctcgggggt cttcccagcc tccgcagtgg cccagggctc tcagctgctt gtccactctg
     1141 tggatcgaat ggtcaacact accttcatct gcacagccac caatgctgtg gggacaggcc
     1201 gtgctgagca ggtcatcctg gtgcgagagt cacctagcac ggcaggagca ggggccacgg
     1261 gaggcatcat tggaggcatc atcgctgcca tcatcgccac cgcagtggct ggcacaggca
     1321 tcctcatctg ccgacaacag cggaaggagc agaggcttca ggcggccgac gaggaagaag
     1381 aactggaagg acctccctcc tataagccac ccaccccaaa ggccaagctg gaggaaccag
     1441 aaatgccctc acaactcttc actttgggac cctcggaaca cagcccagtg aagacgccat
     1501 actttgatgc tggtgtctct tgtgctgatc aggagatgcc tcgatatcac gagctgccca
     1561 ccctggaaga gcggtcaggg cccctgctgt taggggctac aggcctggga ccttctcttc
     1621 ttgtgcctcc aggacccaat gttgtggagg gggtttccct gggtctcgaa gatgaggagg
     1681 aagatgagga ggaggaagat ttcctggata aaatcaaccc tatttatgat gccctatcct
     1741 accccagccc ctctgactcc taccagagca aagacttttt tgtgtcacgg gccatgtatg
     1801 tgtgagggag gcacaagggc tctgacctct cacctttcac ccttgacccc tcagctttcc
     1861 accagtgatc taggacactc tgacttccag gcaggccagg gacagctatc acccatgcaa
     1921 tccacctgtg acttcttaat ggctccacca tgacatccaa cctatgattt ctgaggcagg
     1981 caaacctgca taactggaaa cctagggatt ttacctccca aggcagggag ctcagaatat
     2041 tcttctgtac cacctgtccc ccacaaggac tcctaaggct gcgacccttt gaccacggca
     2101 ttcaccgaat acttctatct caactaccct taaagtctca aagaatccgg accttgcact
     2161 tatcctcagg ccttagagtc cccacagtta tgcaagaaca ggatccaggg ctccctgctg
     2221 ctcagacctg agccctccag gcagcagagg ctcccaccct gctccccaaa ggtgaaaagg
     2281 gagaggattc cccagtgtca ggtaggacct ccccatttcc acccactcct gcaggcagga
     2341 atctcagggt tcacaccctc tcctcatcac ccagcacccc agttcctgtc tccagagcat
     2401 gaattccagg tccagtgctg gaggggagag cctaatgcaa gtgtgccttg ccaccccaag
     2461 tttgggagaa tctgctctta tcggaagact actgaattct tataacccct acccagtgag
     2521 atgagaacta cacatccctc tttaggggat ggtgtgtgtg tgtgtgtgtg tgatggagaa
     2581 tctggcaatc tgggttggga atattatttt gtaagcattt cctacataat atgagtttat
     2641 actttgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
