LOCUS       NM_001100476            5664 bp    mRNA    linear   ROD 03-JUL-2024
DEFINITION  Rattus norvegicus nectin cell adhesion molecule 1 (Nectin1), mRNA.
ACCESSION   NM_001100476 XM_001066246 XM_236210
VERSION     NM_001100476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5664)
  AUTHORS   Gao,Y.Y., Hong,X.Y. and Wang,H.J.
  TITLE     Role of Nectin-1/c-Src Signaling in the Analgesic Effect of GDNF on
            a Rat Model of Chronic Constrictive Injury
  JOURNAL   J Mol Neurosci 60 (2), 258-266 (2016)
   PUBMED   27394444
REFERENCE   2  (bases 1 to 5664)
  AUTHORS   Sipe,C.W., Liu,L., Lee,J., Grimsley-Myers,C. and Lu,X.
  TITLE     Lis1 mediates planar polarity of auditory hair cells through
            regulation of microtubule organization
  JOURNAL   Development 140 (8), 1785-1795 (2013)
   PUBMED   23533177
REFERENCE   3  (bases 1 to 5664)
  AUTHORS   Fantin,M., van der Kooij,M.A., Grosse,J., Krummenacher,C. and
            Sandi,C.
  TITLE     A key role for nectin-1 in the ventral hippocampus in contextual
            fear memory
  JOURNAL   PLoS One 8 (2), e56897 (2013)
   PUBMED   23418609
  REMARK    GeneRIF: Data indicate that contextual fear conditioning showed
            transient nectin-1 upregulation in synapse-enriched hippocampal
            fractions at about 2 h posttraining.
REFERENCE   4  (bases 1 to 5664)
  AUTHORS   Harrison,O.J., Vendome,J., Brasch,J., Jin,X., Hong,S.,
            Katsamba,P.S., Ahlsen,G., Troyanovsky,R.B., Troyanovsky,S.M.,
            Honig,B. and Shapiro,L.
  TITLE     Nectin ectodomain structures reveal a canonical adhesive interface
  JOURNAL   Nat Struct Mol Biol 19 (9), 906-915 (2012)
   PUBMED   22902367
REFERENCE   5  (bases 1 to 5664)
  AUTHORS   Ishiuchi,T. and Takeichi,M.
  TITLE     Nectins localize Willin to cell-cell junctions
  JOURNAL   Genes Cells 17 (5), 387-397 (2012)
   PUBMED   22512338
REFERENCE   6  (bases 1 to 5664)
  AUTHORS   Ng,C.E., Mazaheri,K., Payant,C. and Raaphorst,G.P.
  TITLE     Evaluation of cell survival, DNA double strand breaks, and DNA
            synthesis during concurrent camptothecin and X-radiation treatments
  JOURNAL   Int J Cancer 96 (5), 277-285 (2001)
   PUBMED   11582580
REFERENCE   7  (bases 1 to 5664)
  AUTHORS   Milne,R.S., Connolly,S.A., Krummenacher,C., Eisenberg,R.J. and
            Cohen,G.H.
  TITLE     Porcine HveC, a member of the highly conserved HveC/nectin 1
            family, is a functional alphaherpesvirus receptor
  JOURNAL   Virology 281 (2), 315-328 (2001)
   PUBMED   11277703
REFERENCE   8  (bases 1 to 5664)
  AUTHORS   Shukla,D., Dal Canto,M.C., Rowe,C.L. and Spear,P.G.
  TITLE     Striking similarity of murine nectin-1alpha to human nectin-1alpha
            (HveC) in sequence and activity as a glycoprotein D receptor for
            alphaherpesvirus entry
  JOURNAL   J Virol 74 (24), 11773-11781 (2000)
   PUBMED   11090177
REFERENCE   9  (bases 1 to 5664)
  AUTHORS   Suzuki,K., Hu,D., Bustos,T., Zlotogora,J., Richieri-Costa,A.,
            Helms,J.A. and Spritz,R.A.
  TITLE     Mutations of PVRL1, encoding a cell-cell adhesion
            molecule/herpesvirus receptor, in cleft lip/palate-ectodermal
            dysplasia
  JOURNAL   Nat Genet 25 (4), 427-430 (2000)
   PUBMED   10932188
REFERENCE   10 (bases 1 to 5664)
  AUTHORS   Takahashi,K., Nakanishi,H., Miyahara,M., Mandai,K., Satoh,K.,
            Satoh,A., Nishioka,H., Aoki,J., Nomoto,A., Mizoguchi,A. and
            Takai,Y.
  TITLE     Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited
            to cadherin-based adherens junctions through interaction with
            Afadin, a PDZ domain-containing protein
  JOURNAL   J Cell Biol 145 (3), 539-549 (1999)
   PUBMED   10225955
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Jan 15, 2015 this sequence version replaced
            XM_236210.8, XM_001066246.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.28028.1,
                                           SRR26643299.34618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-775               JAXUCZ010000008.1  52998662-52999436
            776-1126            JAXUCZ010000008.1  53045130-53045480
            1127-1429           JAXUCZ010000008.1  53045978-53046280
            1430-1547           JAXUCZ010000008.1  53046558-53046675
            1548-1699           JAXUCZ010000008.1  53048216-53048367
            1700-5664           JAXUCZ010000008.1  53057781-53061745
FEATURES             Location/Qualifiers
     source          1..5664
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..5664
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /note="nectin cell adhesion molecule 1"
                     /db_xref="GeneID:192183"
                     /db_xref="RGD:620791"
     exon            1..775
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             697..2244
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /note="poliovirus receptor-related protein 1; nectin);
                     poliovirus receptor-related 1 (herpesvirus entry mediator
                     C; poliovirus receptor-related 1 (herpesvirus entry
                     mediator C; nectin)"
                     /codon_start=1
                     /product="nectin-1 precursor"
                     /protein_id="NP_001093946.1"
                     /db_xref="GeneID:192183"
                     /db_xref="RGD:620791"
                     /translation="MARMGLAGAAGRWWGLALGLTAFFLPGTHTQVVQVNDSMYGFIG
                     TDVILHCSFANPLPTVKITQVTWQKASNGSKQNMAIYNPTMGVSVLPPYEKRVEFLRP
                     SFIDGTIRLSHLELEDEGMYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAR
                     KGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSRE
                     AHRQSLACIVNYHLDRFRESLTLNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPP
                     ATEYHWTTLNGSLPKGVEAQNRTLFFRGPINYSLAGTYICEATNPIGTRSGQVEVNIT
                     EFPYTPTPEHGRRAGQMPTAIIGGVAGSVLLVLIVVGGIIVALRRRRHTFKGDYSTKK
                     HVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEGGGGGERK
                     VGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFI
                     SKKEWYV"
     exon            776..1126
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1429
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1547
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1699
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..5664
                     /gene="Nectin1"
                     /gene_synonym="HveC; nectin-1; Pvrl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtgagag gctggatcgg cgagtgagag aaagagaggg agaggagcga gcgcggctcg
       61 cctcgtcgcc ggggcagctc cacattgttg cggatcgccc gcacccagcg cggtggcggc
      121 ggtggggacc cgtggcgcac ccagctcgct cccctcgctc ctcggagacc gtgcagccca
      181 gagccccgcg ggcagctggc cgctgtagcc gcacaccacc gcctgggccc cgagccctcc
      241 tcaccgcccg gccaccctcg gagaacaacc ggccatggac gcctgcaagt tggagccgag
      301 cgggagggtg tgagcgcgcc ccagggccgg gagcctgcgc cgcgttagcc cggtagccgg
      361 gcgagccggg ggtgggtccc tctccccagc cccgctttgc gtggaagaag agggcgggga
      421 ccggggcgag gaggagagcg gaggaggcga agggggcatg actcgtgcaa cttactgcgg
      481 gcatctgccg aggctctgag ccggcggcag ccggggcccg gattgcggcc gcgcggatcc
      541 cacccagccc accccgcccc gaccgacggc tgcggctgac ctggatcctc cgagtgcccg
      601 cggaccgcca gcgatccgcc ctcgtcttcc aggctggttt ctggagcgcg aggagcgccc
      661 tcctggcagc cccttttgct ggacccccgc cccccgatgg ctcggatggg gcttgcgggc
      721 gccgctggac gctggtgggg actcgctctc ggcttgaccg ccttcttcct cccaggcact
      781 cacacgcagg tggtgcaggt gaacgactcc atgtatggct tcatcggcac agatgtgatt
      841 ctgcactgca gctttgccaa cccactgccc actgtgaaga tcacccaggt cacatggcag
      901 aaggcctcca atggctccaa gcagaacatg gccatctaca acccaacgat gggtgtttcc
      961 gtgctgcctc cctacgagaa acgagtggag ttcctgcggc cctccttcat tgacggcacc
     1021 atccgcctct cccacctgga gctggaggac gagggcatgt acatctgtga atttgccacc
     1081 ttccccacgg gcaaccggga aagccagctc aatctcactg tgatggccaa acccaccaac
     1141 tggatcgagg gcactcaggc tgtgcttcga gccaggaagg gacaggatga caaggtcctg
     1201 gtggccacct gcacctcagc caacgggaag cctcccagcg tggtgtcctg ggaaacgagg
     1261 ctgaagggcg aggcagagta ccaggaaatt cggaacccca acggcacagt gacagtcatc
     1321 agccgttacc gcttggtgcc cagcagggaa gcccaccggc agtccctggc ctgcatcgtc
     1381 aactatcacc tggaccgctt cagggagagc ctgacactca acgtgcagta tgaacctgag
     1441 gtgaccattg aaggcttcga tggcaactgg tacctacagc ggacagatgt aaagcttacg
     1501 tgcaaagcag acgctaatcc gccggccact gagtaccact ggaccacgtt gaatggctct
     1561 ctccccaagg gtgtagaggc ccagaacaga accctcttct tccggggacc tatcaactac
     1621 agcctagcag gaacctacat ctgtgaggcc accaacccta ttggcacccg ctctggccag
     1681 gtggaggtca atatcacaga attcccctac accccgactc ctgaacatgg gcggcgcgcg
     1741 gggcagatgc ccacagccat cattgggggc gtggcaggga gtgtcctgct ggtgctgatt
     1801 gtggttggag ggatcatagt ggccctgcgc cggcgccggc acaccttcaa gggtgactac
     1861 agcaccaaga aacacgtata cggcaacggc tacagcaagg caggaatccc ccagcatcac
     1921 ccgcccatgg cacagaacct gcagtacccg gatgactcgg atgatgaaaa gaaggccggc
     1981 ccattgggcg ggagcagcta tgaggaggaa gaagaggagg agggcggtgg aggaggcgaa
     2041 cgcaaagtgg gcggccccca ccccaaatat gacgaggacg ccaaacggcc ctacttcact
     2101 gtggatgagg ctgaggcccg tcaggacggc tatggggacc ggactctggg ctaccaatac
     2161 gaccctgaac agctggactt ggctgagaac atggtttctc agaacgacgg gtctttcatt
     2221 tccaagaaag agtggtatgt gtagccccgc cttctggagc ctctgtctgt gcccacttct
     2281 tcctggcccc tacccgcacg ccccctgacc acccccacag cccactgccc caggagctcc
     2341 acagagactt gaccagctgc cctaaaccag ccccaaactc ctggggagcc aggggagctc
     2401 agggcagacc ccacttggct tccttttttt ttttatttcc tccctcaccc accctttccc
     2461 catggtgttg tgttcgaccg tggctttggt gttgctgtat ctttccttta aggacccctt
     2521 ccactgccct atgtgtaggg agccctgttc ttgtcttgtg tgcttgggca tccctccagg
     2581 gtttggggag ccagtcctct cccacccccc aacactggaa tttgtttgtg ttctcttcgt
     2641 tgggaatgga gggcaaaggg agcttcaaga tgaagcgcac cctcaccccc atcccatatg
     2701 ctgctcctct tcccagagag aagtaaccca atgtccccca ctaagctgat gcagccagtg
     2761 cacctaagag gttttagagg agttctcggt ggtacccagg ggagtcttgt atgtgaaata
     2821 atggagccaa gggagggtcc tgggcagtgt gttttcctgg tgagggtggt tttatgtttt
     2881 cttttttttt tcccttctgg cccccaaaat ggagttggcc taggtctcat atacccctct
     2941 ccgttaaccc cagtctgttc tctacacagt gggtgacccc aggtggactc tacccacagt
     3001 tcctacatgc ctctgccaac acgtgcacac atatccatgc acacatccct gggcctatgc
     3061 caatctctca tgccctgccc aggctgaaca ctgcccgagg ctcacccctc tgccccagct
     3121 cttactcgtt cccagctcag gaagggatca gctcacagaa gcatccagag acagctaggg
     3181 tgaacacccc cccacacaca cacacacaca cacacacttc tgccactcta agagttcagt
     3241 gtcgctccaa cctttcctta cagtatacag gtttctcaga tgtctcctta tctgtcaagt
     3301 gctagcaaca cttgactctt ctggaaagtc agggctgggg tcccgggaag gaacttgagg
     3361 cacagaagta ttgatatgga gaaggctgct ttgcgggagc tctgcaaaca gtccgaaggg
     3421 actgctggta tctcataggg gaaggctggc ctagatgcca cagccctcaa agaaagtgca
     3481 ggggccccca agaacttgct gcttatccat agtctgattc ctgctcggtc tctcctggtg
     3541 ccatgctgac cagaggggag tgtggaaggg ccttcctttg catgcagact ccctctctga
     3601 atgggattct ggcttcatca gccgtttggg gctggggcct tctcttgagt gcatggagaa
     3661 aggtccctcc tagccctctg tccccaagct caaagtgcct cagtttctcc atctgtgccc
     3721 cccccccaga ttaccctcat tctaaatggg catgcctagg gcctgcctgt cagaatctca
     3781 gctaactcag cccaaggtga cactcactga gggatagcaa atgttgggga gagggaggta
     3841 ggccattctg tgccccacgg gcactgaccc accctgccat aggcttcctg agggagcccc
     3901 agcccctcac cccactcttc cctggtgctg ctattaaatt cccagtccaa gcgccatctc
     3961 tgacgtccca cagcccacca gttggggccc ttctgccagg ccctcactgc cctagtccca
     4021 gcccaggccg cccagtagcc acgtagcaga agtctgaagc catgccagcc ctggggcggc
     4081 tctcccctct tggtattggg gacactggat ggggcgaagt ttggagacga ttctggggcc
     4141 tttctagcca cagggcggag gaagatggag gagctgggct gcttctccca gaagtattaa
     4201 tgtccttccc atgtcacagc tcgtcctgat cctcatgcta ctccatccct ctccttggtc
     4261 cccttcttcc caaggcaggt ggcagaacct tgactacccc cacaggggca tttctgtccc
     4321 tctggggcca taagactaaa agactcaccc tccgcgtctc tcacctttca cggtcatccc
     4381 ctatcccttg tcttgtgatg aactgaggag gccctgggcc cggacaaagc acctgagctc
     4441 cctttacaga cctgcacgcc tttcccccaa gcaaagcaca atttatagga tccatgcagc
     4501 aggatctagg gtccccagct gtggcaccaa gcgcttccag gcagctgcca cctgggctaa
     4561 gagagggcat aaagcagggg tcagtagctg ggcccaaaga gggggccttt ctttgccctg
     4621 tgtttgtggg acagtggaca cagctggctg acagtgtagc agagaggagg gcattctgct
     4681 tcaccttcct gcctccaaca cagctgagct tctgccagac tgcagagagt gaacctggtg
     4741 tgttacctgc ccagacccct ccagttgtca tccctagctg ccctccccct cctgtctctc
     4801 cactgcccct ggaccctgct tcccgacaga ttttggtatt gttctggtgt gcaacaaccc
     4861 tcagagtctc ttttaccaga cggacctgaa aaacagcaac acacgattag tgaacacatg
     4921 cccagcacgc cgacacacgc cttccacagg ccaagcacag gtgtgtgtgt gcacaaatac
     4981 acacgaggaa cgaacgggaa acccatacta atgctcgggc cccaagccct gggaaggcac
     5041 accctctgcc ggccacccca gtgtgcccca gtcactggtg caataaactt cctgccgtcc
     5101 tcgagatggg agaatcagga ctcatgtcag gtgggtgagg ccacccctct gagcccagta
     5161 gacactgcat tccctttcct gggaggaggg gggtgctccc aggcctctgg ggggtccagg
     5221 tagagacttc cccaagccta actgccaact gaaaccctct cctggtgagg gcaggtggct
     5281 caagctgacc tgggccagag ataaccagag gtgaggaacc cgcctcactg atgctgcttt
     5341 ctgaccctgg ctgtgaggaa tgggctggga gtgagggggt ggctttttct ttctttcttt
     5401 tctttttttt tttaataaat ggaaacaaaa tccaggagga gctgtcaccc tcacctgagt
     5461 gtgactaagc ttcctttgct tcagtttcta tgtcactctt ttcctctttg gtcccgggga
     5521 cagcccagca gattctcctg gtcctgacct ggagggggaa ggagttgccc tgcccccttt
     5581 tacttgtatt aaaaaaaaaa aaagatgggt tgaaaatgta ctgagaaaaa atgtactttt
     5641 ttataaataa agtgtttaaa acaa
//
