LOCUS       NM_031064                883 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase core subunit V2
            (Ndufv2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_031064 XM_343638
VERSION     NM_031064.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Xu,J., Bian,X., Liu,Y., Hong,L., Teng,T., Sun,Y. and Xu,Z.
  TITLE     Adenosine A2 receptor activation ameliorates mitochondrial
            oxidative stress upon reperfusion through the posttranslational
            modification of NDUFV2 subunit of complex I in the heart
  JOURNAL   Free Radic Biol Med 106, 208-218 (2017)
   PUBMED   28219781
  REMARK    GeneRIF: NECA prevents mitochondrial oxidative stress by decreasing
            mitochondrial superoxide generation through inhibition of complex I
            via the mitochondrial Src tyrosine kinase. Phosphorylation of
            Tyr(118) residue in NDUFV2 subunit may account for the inhibitory
            effect of NECA on complex I.
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Benit,P., Beugnot,R., Chretien,D., Giurgea,I., De
            Lonlay-Debeney,P., Issartel,J.P., Corral-Debrinski,M., Kerscher,S.,
            Rustin,P., Rotig,A. and Munnich,A.
  TITLE     Mutant NDUFV2 subunit of mitochondrial complex I causes early onset
            hypertrophic cardiomyopathy and encephalopathy
  JOURNAL   Hum Mutat 21 (6), 582-586 (2003)
   PUBMED   12754703
REFERENCE   5  (bases 1 to 883)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Hattori,N., Yoshino,H., Tanaka,M., Suzuki,H. and Mizuno,Y.
  TITLE     Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial
            complex I and susceptibility to Parkinson disease
  JOURNAL   Genomics 49 (1), 52-58 (1998)
   PUBMED   9570948
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Nishikimi,M., Hosokawa,Y., Toda,H., Suzuki,H. and Ozawa,T.
  TITLE     The amino acid sequence of the 24-kDa subunit, an iron-sulfur
            protein, of rat liver mitochondrial NADH dehydrogenase deduced from
            cDNA sequence
  JOURNAL   Biochem Biophys Res Commun 157 (3), 914-920 (1988)
   PUBMED   2974699
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058495.1.
            
            On Aug 30, 2012 this sequence version replaced NM_031064.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058495.1, M22756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-883               BC058495.1         5-887
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..883
                     /gene="Ndufv2"
                     /note="NADH:ubiquinone oxidoreductase core subunit V2"
                     /db_xref="GeneID:81728"
                     /db_xref="RGD:621733"
     exon            1..105
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..801
                     /gene="Ndufv2"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] flavoprotein 2,
                     mitochondrial; NADH-ubiquinone oxidoreductase 24 kDa
                     subunit; 24-kDa subunit of mitochondrial NADH
                     dehydrogenase; NADH dehydrogenase (ubiquinone)
                     flavoprotein 2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] flavoprotein 2,
                     mitochondrial precursor"
                     /protein_id="NP_112326.1"
                     /db_xref="GeneID:81728"
                     /db_xref="RGD:621733"
                     /translation="MFSLALRARASGLTAQWGRHARNLHKTAVQNGAGGALFVHRDTP
                     ENNPDTPFDFTPENYERIEAIVRNYPEGHRAAAVLPVLDLAQRQNGWLPISAMNKVAE
                     VLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVG
                     ETTPDKLFTLIEVECLGACVNAPMVQINDDYYEDLTPKDIEEIIDELRAGKVPKPGPR
                     SGRFCCEPAGGLTSLTEPPKGPGFGVQAGL"
     exon            106..171
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..234
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..351
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..520
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..630
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..707
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..853
                     /gene="Ndufv2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgttccc tgtcagccta gagcggccag ggtcggagaa ccgcgtaccc cgccatgttc
       61 tccttggcgc tgcgggccag ggcgtccggc ctcaccgctc agtggggaag acatgcaagg
      121 aatttgcata agacagcagt gcaaaatggt gctggaggag ccttatttgt gcatagagat
      181 actcctgaga ataacccaga tactccattt gatttcacac cagaaaacta cgagaggata
      241 gaggcaatag tcagaaacta cccggaaggg cacagagcag cagctgtgct tccagtgctg
      301 gacctggccc aaaggcagaa tgggtggctg cctatctctg ccatgaacaa ggtggcagaa
      361 gttttacaag tgcctccaat gagagtctat gaagtggcga ctttttacac aatgtacaat
      421 cgaaagccag ttgggaagta ccacattcag gtctgcacta ctacaccttg catgcttcga
      481 gactctgaca gcatcctgga gacccttcag agaaagctgg gaataaaagt tggagagact
      541 acgcctgaca agcttttcac tcttatagaa gtagaatgtt taggggcctg tgtaaacgca
      601 ccgatggttc aaataaacga cgactactac gaggatctga cacccaagga tattgaagag
      661 attattgatg aactcagagc tgggaaagtt ccaaaaccag ggccaaggag tggccgcttc
      721 tgttgtgagc cagccggagg ccttacttct ttgactgaac cacccaaagg acctggcttt
      781 ggtgtgcaag caggccttta acttacattc aactgtaaaa atgtcactgg agaaataaaa
      841 tatgaaccta ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
