LOCUS       NM_001106322             773 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase core subunit S8
            (Ndufs8), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106322 XM_001069669 XM_215197
VERSION     NM_001106322.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 773)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   2  (bases 1 to 773)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   3  (bases 1 to 773)
  AUTHORS   Procaccio,V. and Wallace,D.C.
  TITLE     Late-onset Leigh syndrome in a patient with mitochondrial complex I
            NDUFS8 mutations
  JOURNAL   Neurology 62 (10), 1899-1901 (2004)
   PUBMED   15159508
  REMARK    Review article
REFERENCE   4  (bases 1 to 773)
  AUTHORS   Ugalde,C., Janssen,R.J., van den Heuvel,L.P., Smeitink,J.A. and
            Nijtmans,L.G.
  TITLE     Differences in assembly or stability of complex I and other
            mitochondrial OXPHOS complexes in inherited complex I deficiency
  JOURNAL   Hum Mol Genet 13 (6), 659-667 (2004)
   PUBMED   14749350
REFERENCE   5  (bases 1 to 773)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 773)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   7  (bases 1 to 773)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
REFERENCE   8  (bases 1 to 773)
  AUTHORS   Loeffen,J., Elpeleg,O., Smeitink,J., Smeets,R.,
            Stockler-Ipsiroglu,S., Mandel,H., Sengers,R., Trijbels,F. and van
            den Heuvel,L.
  TITLE     Mutations in the complex I NDUFS2 gene of patients with
            cardiomyopathy and encephalomyopathy
  JOURNAL   Ann Neurol 49 (2), 195-201 (2001)
   PUBMED   11220739
REFERENCE   9  (bases 1 to 773)
  AUTHORS   Loeffen,J., Smeitink,J., Triepels,R., Smeets,R., Schuelke,M.,
            Sengers,R., Trijbels,F., Hamel,B., Mullaart,R. and van den
            Heuvel,L.
  TITLE     The first nuclear-encoded complex I mutation in a patient with
            Leigh syndrome
  JOURNAL   Am J Hum Genet 63 (6), 1598-1608 (1998)
   PUBMED   9837812
REFERENCE   10 (bases 1 to 773)
  AUTHORS   de Sury,R., Martinez,P., Procaccio,V., Lunardi,J. and Issartel,J.P.
  TITLE     Genomic structure of the human NDUFS8 gene coding for the
            iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone
            oxidoreductase
  JOURNAL   Gene 215 (1), 1-10 (1998)
   PUBMED   9666055
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158791.1.
            
            On Jan 27, 2008 this sequence version replaced NM_001106322.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158791.1, CO554275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132308, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..773
                     /gene="Ndufs8"
                     /note="NADH:ubiquinone oxidoreductase core subunit S8"
                     /db_xref="GeneID:293652"
                     /db_xref="RGD:1309436"
     exon            1..38
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..677
                     /gene="Ndufs8"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 8"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 8, mitochondrial"
                     /protein_id="NP_001099792.1"
                     /db_xref="GeneID:293652"
                     /db_xref="RGD:1309436"
                     /translation="MYRLSSSVLPRALAQAMRTGHLNGQSLHSSAVAATYKYVNMKAQ
                     ELDVDMKSATDSAARILMWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHA
                     LRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQE
                     ACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR"
     exon            39..96
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
     exon            97..147
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
     exon            148..243
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
     exon            244..416
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
     exon            417..545
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
     exon            546..749
                     /gene="Ndufs8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcacctgg gccagggacg gagccgctgc acttcaagat gtaccgcctg agctcgtcag
       61 tgctgccccg ggccttggcc caggccatgc gcacaggaca tcttaatggc caaagccttc
      121 atagcagtgc agtggccgct acgtacaagt atgtgaatat gaaggcacag gaacttgatg
      181 tggacatgaa gtctgcgact gacagtgcag ctcggattct gatgtggaca gaactcttcc
      241 gaggcctggg catgacccta agctacctct ttcgggagcc cgccaccatc aactacccct
      301 ttgagaaggg cccactgagt ccgcgcttcc gtggggagca tgcactgcgc cgctacccgt
      361 ctggggagga gcgttgcatc gcctgcaagc tctgtgaggc catctgtcct gcacaggcca
      421 tcaccattga ggctgagcca agagcagatg gcagccgccg gactacacgc tatgacattg
      481 acatgaccaa gtgtatctac tgtggtttct gccaggaagc ctgccctgtt gacgctatcg
      541 tggagggccc caactttgag ttctccaccg agacgcatga ggagttgctg tacaacaagg
      601 agaagctact caacaatggt gacaagtggg aggccgagat cgcggccaac atccaggctg
      661 actacctgta tcggtgaccg ggccaccggt gaccttgcca cctggccagc cttgtggccc
      721 ctatagccca taaagaaact ctgatcccaa aaaaaaaaaa aaaaaaaaaa aaa
//
