LOCUS       NM_019223                473 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit S6
            (Ndufs6), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019223
VERSION     NM_019223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 473)
  AUTHORS   Guo R, Zong S, Wu M, Gu J and Yang M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 473)
  AUTHORS   Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley
            MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A and
            Ryan MT.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 473)
  AUTHORS   Forbes JM, Ke BX, Nguyen TV, Henstridge DC, Penfold SA, Laskowski
            A, Sourris KC, Groschner LN, Cooper ME, Thorburn DR and Coughlan
            MT.
  TITLE     Deficiency in mitochondrial complex I activity due to Ndufs6 gene
            trap insertion induces renal disease
  JOURNAL   Antioxid Redox Signal 19 (4), 331-343 (2013)
   PUBMED   23320803
REFERENCE   4  (bases 1 to 473)
  AUTHORS   Ke BX, Pepe S, Grubb DR, Komen JC, Laskowski A, Rodda FA, Hardman
            BM, Pitt JJ, Ryan MT, Lazarou M, Koleff J, Cheung MM, Smolich JJ
            and Thorburn DR.
  TITLE     Tissue-specific splicing of an Ndufs6 gene-trap insertion generates
            a mitochondrial complex I deficiency-specific cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), 6165-6170 (2012)
   PUBMED   22474353
REFERENCE   5  (bases 1 to 473)
  AUTHORS   Scotto L, Narayan G, Nandula SV, Subramaniyam S, Kaufmann AM,
            Wright JD, Pothuri B, Mansukhani M, Schneider A, Arias-Pulido H and
            Murty VV.
  TITLE     Integrative genomics analysis of chromosome 5p gain in cervical
            cancer reveals target over-expressed genes, including Drosha
  JOURNAL   Mol Cancer 7, 58 (2008)
   PUBMED   18559093
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 473)
  AUTHORS   Almofti MR, Huang Z, Yang P, Rui Y and Yang P.
  TITLE     Proteomic analysis of rat aorta during atherosclerosis induced by
            high cholesterol diet and injection of vitamin D3
  JOURNAL   Clin Exp Pharmacol Physiol 33 (4), 305-309 (2006)
   PUBMED   16620292
REFERENCE   7  (bases 1 to 473)
  AUTHORS   Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF,
            Ghosh SS and Capaldi RA.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   8  (bases 1 to 473)
  AUTHORS   Watson JD, Beckett-Jones B, Roy RN, Green NC and Flynn TG.
  TITLE     Genomic sequence, structural organization and evolutionary
            conservation of the 13.2-kDa subunit of rat NADH:ubiquinone
            oxidoreductase
  JOURNAL   Gene 158 (2), 275-280 (1995)
   PUBMED   7607554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1.
            
            On Jun 1, 2021 this sequence version replaced NM_019223.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB697762.1, SRR8487227.53882.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on expression, longest
                                                  protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JACYVU010000065.1  19706976-19707090
            116-473             JACYVU010000065.1  19707154-19707511
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..473
                     /gene="Ndufs6"
                     /gene_synonym="Ip13dis; Ndub13; RATIp13dis"
                     /note="NADH:ubiquinone oxidoreductase subunit S6"
                     /db_xref="GeneID:29478"
                     /db_xref="RGD:3156"
     exon            1..115
                     /gene="Ndufs6"
                     /gene_synonym="Ip13dis; Ndub13; RATIp13dis"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..358
                     /gene="Ndufs6"
                     /gene_synonym="Ip13dis; Ndub13; RATIp13dis"
                     /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
                     6, mitochondrial; CI-13kD-A; complex I-13kD-A;
                     NADH-ubiquinone oxidoreductase 13 kDa-A subunit; NADH
                     ubiquinone oxidoreductase; NADH dehydrogenase Fe-S protein
                     6; NADH dehydrogenase (ubiquinone) Fe-S protein 6"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 6, mitochondrial precursor"
                     /protein_id="NP_062096.2"
                     /db_xref="GeneID:29478"
                     /db_xref="RGD:3156"
                     /translation="MVAALTFRRLLALPRAARGFGVRVSLSGEKITHTGQVSDGKDYR
                     GIRFVDRQKEVNENFAIDLIAQQPVNEVDRRIIACDGGGGALGHPKVYINLDKETKTG
                     TCGYCGLQFKQQHH"
     exon            116..473
                     /gene="Ndufs6"
                     /gene_synonym="Ip13dis; Ndub13; RATIp13dis"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaagatg gtggcggcgc tgaccttccg ccggctgttg gctctcccta gggctgcccg
       61 gggtttcggg gtgcgagtgt cgctgagcgg ggagaagatc acgcataccg gccaggtgtc
      121 tgatggaaaa gactacaggg ggattcgttt tgtagatcgt cagaaagagg tgaatgagaa
      181 ctttgccatt gatttgatag cacaacaacc tgtgaatgag gtggaccgtc gtatcatagc
      241 ctgtgatgga gggggtggag ccttgggcca ccccaaggtg tatataaacc tggacaaaga
      301 aacaaaaacg ggtacgtgtg gctactgcgg cctgcagttc aagcagcagc atcactagtg
      361 tgggctgtgt cctggtcctc tgacacccgt ggagcatctc atgcttagtg ttctggtgtg
      421 aggtcactgc tctgtgaatg gtgtcccttg ttatgaataa aggatgctcc cac
//
