LOCUS       NM_001030052             538 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit S5
            (Ndufs5), mRNA.
ACCESSION   NM_001030052 XM_342907
VERSION     NM_001030052.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 538)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 538)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 538)
  AUTHORS   Huang,G., Chen,Y., Lu,H. and Cao,X.
  TITLE     Coupling mitochondrial respiratory chain to cell death: an
            essential role of mitochondrial complex I in the interferon-beta
            and retinoic acid-induced cancer cell death
  JOURNAL   Cell Death Differ 14 (2), 327-337 (2007)
   PUBMED   16826196
REFERENCE   4  (bases 1 to 538)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 538)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   6  (bases 1 to 538)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CB716681.1 and
            AW525881.1.
            
            On Aug 11, 2005 this sequence version replaced XM_342907.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB716681.1, BC168721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               CB716681.1         1-514
            515-538             AW525881.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..538
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /note="NADH:ubiquinone oxidoreductase subunit S5"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
     exon            1..92
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     exon            93..310
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..415
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 5b,
                     15kDa (NADH-coenzyme Q reductase)"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 5"
                     /protein_id="NP_001025223.1"
                     /db_xref="GeneID:362588"
                     /db_xref="RGD:1311081"
                     /translation="MPFLDVQKRLGISLDRHFIFLSAEQPYKNAARCHAFEKEWIECA
                     HGIGATRAKKECKIEYEDFEECFLRFKTIRRMHEIKKQREKLMKEGKYTPPPHHLGKE
                     EPRP"
     exon            311..524
                     /gene="Ndufs5"
                     /gene_synonym="Ndufs5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaagccgg cggtcgtgag ctgcgcccag ggacctgaga agggcattgc tgaggtgcgg
       61 taggcgcttg ctgtgtccgg tcagccaaga agtcatgcct ttccttgatg tgcagaaaag
      121 gctgggcatt agcctagatc gacactttat attcctaagt gctgagcagc cttacaagaa
      181 tgccgctcga tgccacgcat ttgaaaagga gtggatagaa tgcgcacatg ggatcggtgc
      241 tacccgggct aaaaaagagt gcaagataga gtatgaagac tttgaagaat gctttcttcg
      301 gttcaaaacg ataaggcgga tgcatgaaat caagaaacag cgggagaagc tgatgaaaga
      361 ggggaagtac acccctccgc ctcaccattt gggcaaggag gagcccaggc cctgagcaga
      421 gcagctagaa gctgctctcc atgctctgtt ttccgctgga gagaatgttt aagggaagca
      481 ccttcatcaa gtatgtacaa ataaagaatt actcaaccta gaaaaaaaaa aaaaaaaa
//
