LOCUS       NM_001025146            1512 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit S4
            (Ndufs4), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001025146 XM_574853
VERSION     NM_001025146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1512)
  AUTHORS   Terburgh,K., Lindeque,Z., Mason,S., van der Westhuizen,F. and
            Louw,R.
  TITLE     Metabolomics of Ndufs4-/- skeletal muscle: Adaptive mechanisms
            converge at the ubiquinone-cycle
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (1), 98-106 (2019)
   PUBMED   30391276
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Kuksal,N., Gardiner,D., Qi,D. and Mailloux,R.J.
  TITLE     Partial loss of complex I due to NDUFS4 deficiency augments
            myocardial reperfusion damage by increasing mitochondrial
            superoxide/hydrogen peroxide production
  JOURNAL   Biochem Biophys Res Commun 498 (1), 214-220 (2018)
   PUBMED   29501746
REFERENCE   3  (bases 1 to 1512)
  AUTHORS   de Haas,R., Das,D., Garanto,A., Renkema,H.G., Greupink,R., van den
            Broek,P., Pertijs,J., Collin,R.W.J., Willems,P., Beyrath,J.,
            Heerschap,A., Russel,F.G. and Smeitink,J.A.
  TITLE     Therapeutic effects of the mitochondrial ROS-redox modulator KH176
            in a mammalian model of Leigh Disease
  JOURNAL   Sci Rep 7 (1), 11733 (2017)
   PUBMED   28916769
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1512)
  AUTHORS   Choi,W.S., Kim,H.W., Tronche,F., Palmiter,R.D., Storm,D.R. and
            Xia,Z.
  TITLE     Conditional deletion of Ndufs4 in dopaminergic neurons promotes
            Parkinson's disease-like non-motor symptoms without loss of
            dopamine neurons
  JOURNAL   Sci Rep 7, 44989 (2017)
   PUBMED   28327638
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1512)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   6  (bases 1 to 1512)
  AUTHORS   Raha,S., Myint,A.T., Johnstone,L. and Robinson,B.H.
  TITLE     Control of oxygen free radical formation from mitochondrial complex
            I: roles for protein kinase A and pyruvate dehydrogenase kinase
  JOURNAL   Free Radic Biol Med 32 (5), 421-430 (2002)
   PUBMED   11864782
REFERENCE   7  (bases 1 to 1512)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
REFERENCE   8  (bases 1 to 1512)
  AUTHORS   Petruzzella,V., Vergari,R., Puzziferri,I., Boffoli,D., Lamantea,E.,
            Zeviani,M. and Papa,S.
  TITLE     A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ)
            subunit of complex I abolishes assembly and activity of the complex
            in a patient with Leigh-like syndrome
  JOURNAL   Hum Mol Genet 10 (5), 529-535 (2001)
   PUBMED   11181577
REFERENCE   9  (bases 1 to 1512)
  AUTHORS   Papa,S., Scacco,S., Sardanelli,A.M., Vergari,R., Papa,F., Budde,S.,
            van den Heuvel,L. and Smeitink,J.
  TITLE     Mutation in the NDUFS4 gene of complex I abolishes cAMP-dependent
            activation of the complex in a child with fatal neurological
            syndrome
  JOURNAL   FEBS Lett 489 (2-3), 259-262 (2001)
   PUBMED   11165261
REFERENCE   10 (bases 1 to 1512)
  AUTHORS   Scacco,S., Vergari,R., Scarpulla,R.C., Technikova-Dobrova,Z.,
            Sardanelli,A., Lambo,R., Lorusso,V. and Papa,S.
  TITLE     cAMP-dependent phosphorylation of the nuclear encoded 18-kDa (IP)
            subunit of respiratory complex I and activation of the complex in
            serum-starved mouse fibroblast cultures
  JOURNAL   J Biol Chem 275 (23), 17578-17582 (2000)
   PUBMED   10747996
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083729.1.
            
            On Jul 1, 2005 this sequence version replaced XM_574853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083729.1, FQ214408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1512
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..1512
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /note="NADH:ubiquinone oxidoreductase subunit S4"
                     /db_xref="GeneID:499529"
                     /db_xref="RGD:1594380"
     exon            1..105
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..535
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
                     4, mitochondrial; CI-18 kDa; complex I-18 kDa;
                     NADH-ubiquinone oxidoreductase 18 kDa subunit; NADH
                     dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa
                     (NADH-coenzyme Q reductase)"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 4, mitochondrial precursor"
                     /protein_id="NP_001020317.1"
                     /db_xref="GeneID:499529"
                     /db_xref="RGD:1594380"
                     /translation="MAAVSMSVSLRQALLRQRAVATAAVSVCRVPSRLLNTSTWKLAD
                     GQTRDTQLITVDEKLDVTPLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFD
                     TRERWENPLMGWASTADPLSNMVLTFSAKEDAVAFAEKHGWSYDVEGRKVPKPKSKSY
                     GANFSWNKRTRVSTK"
     exon            106..184
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /inference="alignment:Splign:2.1.0"
     exon            185..357
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /inference="alignment:Splign:2.1.0"
     exon            358..431
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /inference="alignment:Splign:2.1.0"
     exon            432..1487
                     /gene="Ndufs4"
                     /gene_synonym="Aqdq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaagatg gcggcggtct caatgtcagt gtcgctgaga caggcgttgt tgaggcaaag
       61 ggcagtagct acagctgcgg tttccgtctg cagagttcca tccaggttgt tgaacacatc
      121 gacatggaag ctggcagacg gccaaactcg ggacacccag cttataacag ttgatgagaa
      181 actggatgtt actcctctaa ctggtgttcc agaagagcac atcaaaacca gaaaggtcag
      241 aatctttgtt cctgctcgca ataacatgca gtctggagta aacaacacga agaaatggaa
      301 gatggagttt gataccagag agagatggga aaatcctttg atgggttggg catcaacggc
      361 cgatcccctc tccaacatgg ttctcacctt cagtgccaaa gaagatgcgg ttgcctttgc
      421 agaaaagcat ggatggagct atgacgtgga agggaggaag gttccgaaac ccaagtccaa
      481 gtcttacggt gcaaactttt cttggaacaa aagaacaaga gtgtctacaa aataggttgg
      541 agctggctac atttctgctt gactgtgact gaagtgtcag ctgtgcacta tttatagtcc
      601 atggataatg caccccttaa tctcctaata aatgtgacct ttaaactaca ggtacacttg
      661 gcagtttcca ttttaagtgt ttttgatgtc ttacactgaa cacattacag tttcctgcac
      721 agacagattt gagatgttca cccctctaag aaatcatggc acttagaatc tacgatgaat
      781 gcctgggatc tgctgcagcc taggtgttct ctggttgttt tttatagcca cacacaagtc
      841 aatatcatgc acaaactcca agccattatt actaaactac tctgagaaat tcttttgtca
      901 caggtagaga agtacatgat tatactacaa cccagtaatc ctcaacttaa ttcccttata
      961 ggcagtgttc tcctttttga ctggagattt gtattttctc agtgcttatg agcataaaag
     1021 gatttgtctg tagaagttaa gtccattctt cccagtccca tgctcccaga aataagactc
     1081 agactcaaaa tgcattacag ataccttggc catattgcta ggcttttttt ccccttacta
     1141 ggtcctaact taaaccgtcc catttattct aatctacatt cttccatgtg gtgattacct
     1201 gtgcccaggt accatatgtc cgtttcctcg cttcttctcg ggaggatctt tcatgcctgg
     1261 ctctatccca gaattctttc tgcctcccag atgtcccacc ttttattcta cccttcccta
     1321 taggccatag gctctttaat tgacaggcga tacatccata taatacacaa ggtattctct
     1381 ctacatttgt ctatacgttt ctgtcttatg acatctggtg attgtgagaa cttcaatgga
     1441 gatcttttat tcttaggaaa taaagattca atatgaaata aaaccaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aa
//
