LOCUS       NM_001106489            1056 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase core subunit S3
            (Ndufs3), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106489 XM_001077876 XM_215776
VERSION     NM_001106489.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1056)
  AUTHORS   Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A,
            Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J,
            Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G,
            Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki
            Y, Foster LJ, Bader GD, Cayabyab FS and Babu M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   2  (bases 1 to 1056)
  AUTHORS   Mukherjee S, Russell JC, Carr DT, Burgess JD, Allen M, Serie DJ,
            Boehme KL, Kauwe JSK, Naj AC, Fardo DW, Dickson DW, Montine TJ,
            Ertekin-Taner N, Kaeberlein MR and Crane PK.
  TITLE     Systems biology approach to late-onset Alzheimer's disease
            genome-wide association study identifies novel candidate genes
            validated using brain expression data and Caenorhabditis elegans
            experiments
  JOURNAL   Alzheimers Dement 13 (10), 1133-1142 (2017)
   PUBMED   28242297
REFERENCE   3  (bases 1 to 1056)
  AUTHORS   Peralta S, Torraco A, Wenz T, Garcia S, Diaz F and Moraes CT.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   4  (bases 1 to 1056)
  AUTHORS   Tang Y, Mi C, Liu J, Gao F and Long J.
  TITLE     Compromised mitochondrial remodeling in compensatory hypertrophied
            myocardium of spontaneously hypertensive rat
  JOURNAL   Cardiovasc Pathol 23 (2), 101-106 (2014)
   PUBMED   24388463
REFERENCE   5  (bases 1 to 1056)
  AUTHORS   Chen S, Lu FF, Seeman P and Liu F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   6  (bases 1 to 1056)
  AUTHORS   Huang G, Chen Y, Lu H and Cao X.
  TITLE     Coupling mitochondrial respiratory chain to cell death: an
            essential role of mitochondrial complex I in the interferon-beta
            and retinoic acid-induced cancer cell death
  JOURNAL   Cell Death Differ 14 (2), 327-337 (2007)
   PUBMED   16826196
REFERENCE   7  (bases 1 to 1056)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1056)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1056)
  AUTHORS   Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF,
            Ghosh SS and Capaldi RA.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   10 (bases 1 to 1056)
  AUTHORS   Triepels RH, Hanson BJ, van den Heuvel LP, Sundell L, Marusich MF,
            Smeitink JA and Capaldi RA.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215776.4, XM_001077876.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212516.1, FQ229308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1056
                     /gene="Ndufs3"
                     /note="NADH:ubiquinone oxidoreductase core subunit S3"
                     /db_xref="GeneID:295923"
                     /db_xref="RGD:1309406"
     exon            1..244
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..975
                     /gene="Ndufs3"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase (ubiquinone) Fe-S protein 3"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 3, mitochondrial"
                     /protein_id="NP_001099959.1"
                     /db_xref="GeneID:295923"
                     /db_xref="RGD:1309406"
                     /translation="MASAAARVWCRGLLGAASVARGAGRPSVLLQQRVRRESAAADKR
                     PTVRPSSDVTHKRLSAFGEYVAEILPKYVQQVQVTCFDELEICIHPDGVIPTITFLKD
                     HTNAQFKSLADLTAVDVPTRQNRFEIVYNLLSLRFNSRIRVKTYADELTAIDSIVSVH
                     IAANWYEREVWDMFGVFFFNHPDLRRILTDYGFEGHPFRKDFPLTGYVELRYDDEVKR
                     VVAEPVELAQEFRKFDLNSPWEAFPAYRQPPEHLKLEAGDKKPEAK"
     exon            245..313
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
     exon            314..411
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
     exon            412..561
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..687
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..807
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1056
                     /gene="Ndufs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggtcttt cttacctgcg ttacctcctt tcatgccaat gttcagatcc ggaacctctg
       61 cttcccgccc cgtgtccgcc cggaagaaga ttcattgcac atttccactt ccggtccgtg
      121 cccttgaggc tccgtggcct gtgtgtgttt tccggctact tagtcggcac cctaaggaac
      181 atggcgtctg ctgcagccag ggtctggtgc cgtgggctct tgggggctgc ttccgtagcc
      241 aggggggctg ggcgaccctc agtgctgttg cagcagcgtg tgagaaggga gagcgcggcg
      301 gctgacaagc gccccactgt cagaccctcg agtgatgtaa cccacaagcg gctctcagca
      361 tttggagagt atgtggctga aatcttacct aagtatgtcc aacaagttca ggtgacctgc
      421 tttgatgagt tagaaatctg catccatcct gatggagtca tcccaacgat aacctttctc
      481 aaggatcata ccaatgcaca gttcaaatcc ttggctgact tgacagcagt ggatgtccca
      541 actcggcaga accgttttga gattgtctac aacctgctgt ccctgcggtt taactctagg
      601 attcgtgtga agacctatgc agatgagctg acagccattg actccatagt gtctgtgcac
      661 attgcggcca attggtatga gagggaggtc tgggacatgt ttggagtttt cttcttcaac
      721 caccctgact tgagaaggat cctgacagat tatggcttcg agggacatcc tttccggaaa
      781 gactttcccc tcactggcta tgttgagcta cgttatgacg atgaggtgaa gcgggtagtg
      841 gctgagccag tggagttggc acaagagttc cgcaagtttg acctgaacag cccctgggag
      901 gctttccctg cctatcgtca gccccctgag catctcaagc ttgaagctgg agacaagaag
      961 cctgaagcca agtaacttca caagatgtag atcctagagg aaaatgcctt acctaaggtt
     1021 gtctgtaaat aaactccagt ggacattcac tccttc
//
