LOCUS       NM_001011907            1612 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase core subunit S2
            (Ndufs2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001011907 XM_213940
VERSION     NM_001011907.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Dunham-Snary,K.J., Wu,D., Potus,F., Sykes,E.A., Mewburn,J.D.,
            Charles,R.L., Eaton,P., Sultanian,R.A. and Archer,S.L.
  TITLE     Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for
            Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction
  JOURNAL   Circ Res 124 (12), 1727-1746 (2019)
   PUBMED   30922174
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Wang,Z., Fan,M., Candas,D., Zhang,T.Q., Qin,L., Eldridge,A.,
            Wachsmann-Hogiu,S., Ahmed,K.M., Chromy,B.A., Nantajit,D., Duru,N.,
            He,F., Chen,M., Finkel,T., Weinstein,L.S. and Li,J.J.
  TITLE     Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle
            G2/M progression
  JOURNAL   Dev Cell 29 (2), 217-232 (2014)
   PUBMED   24746669
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Akude,E., Zherebitskaya,E., Chowdhury,S.K., Smith,D.R.,
            Dobrowsky,R.T. and Fernyhough,P.
  TITLE     Diminished superoxide generation is associated with respiratory
            chain dysfunction and changes in the mitochondrial proteome of
            sensory neurons from diabetic rats
  JOURNAL   Diabetes 60 (1), 288-297 (2011)
   PUBMED   20876714
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Tuppen,H.A., Hogan,V.E., He,L., Blakely,E.L., Worgan,L.,
            Al-Dosary,M., Saretzki,G., Alston,C.L., Morris,A.A., Clarke,M.,
            Jones,S., Devlin,A.M., Mansour,S., Chrzanowska-Lightowlers,Z.M.,
            Thorburn,D.R., McFarland,R. and Taylor,R.W.
  TITLE     The p.M292T NDUFS2 mutation causes complex I-deficient Leigh
            syndrome in multiple families
  JOURNAL   Brain 133 (10), 2952-2963 (2010)
   PUBMED   20819849
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Davison,E.J., Pennington,K., Hung,C.C., Peng,J., Rafiq,R.,
            Ostareck-Lederer,A., Ostareck,D.H., Ardley,H.C., Banks,R.E. and
            Robinson,P.A.
  TITLE     Proteomic analysis of increased Parkin expression and its
            interactants provides evidence for a role in modulation of
            mitochondrial function
  JOURNAL   Proteomics 9 (18), 4284-4297 (2009)
   PUBMED   19725078
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   Murray,J., Taylor,S.W., Zhang,B., Ghosh,S.S. and Capaldi,R.A.
  TITLE     Oxidative damage to mitochondrial complex I due to peroxynitrite:
            identification of reactive tyrosines by mass spectrometry
  JOURNAL   J Biol Chem 278 (39), 37223-37230 (2003)
   PUBMED   12857734
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Loeffen,J., Elpeleg,O., Smeitink,J., Smeets,R.,
            Stockler-Ipsiroglu,S., Mandel,H., Sengers,R., Trijbels,F. and van
            den Heuvel,L.
  TITLE     Mutations in the complex I NDUFS2 gene of patients with
            cardiomyopathy and encephalomyopathy
  JOURNAL   Ann Neurol 49 (2), 195-201 (2001)
   PUBMED   11220739
REFERENCE   10 (bases 1 to 1612)
  AUTHORS   Procaccio,V., de Sury,R., Martinez,P., Depetris,D., Rabilloud,T.,
            Soularue,P., Lunardi,J. and Issartel,J.
  TITLE     Mapping to 1q23 of the human gene (NDUFS2) encoding the 49-kDa
            subunit of the mitochondrial respiratory Complex I and
            immunodetection of the mature protein in mitochondria
  JOURNAL   Mamm Genome 9 (6), 482-484 (1998)
   PUBMED   9585441
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082067.1.
            
            On Feb 11, 2005 this sequence version replaced XM_213940.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082067.1, FQ215922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1612
                     /gene="Ndufs2"
                     /note="NADH:ubiquinone oxidoreductase core subunit S2"
                     /db_xref="GeneID:289218"
                     /db_xref="RGD:1307109"
     exon            1..101
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1398
                     /gene="Ndufs2"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] iron-sulfur protein
                     2, mitochondrial; CI-49kD; complex I-49kD; NADH-ubiquinone
                     oxidoreductase 49 kDa subunit; NADH dehydrogenase
                     (ubiquinone) Fe-S protein 2; NADH dehydrogenase
                     [ubiquinone] iron-sulfur protein 2, mitochondrial-like"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] iron-sulfur
                     protein 2, mitochondrial precursor"
                     /protein_id="NP_001011907.1"
                     /db_xref="GeneID:289218"
                     /db_xref="RGD:1307109"
                     /translation="MAALRAVCSLRGVGAQVLRAGSGIRLPSQPSRGARRWQPDIEWA
                     EQFSGAVMYPSKETAHWKPPPWNDVDVLKEKVVTNVTLNFGPQHPAAHGVLRLVLELS
                     GEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLN
                     IQPPPRAQWIRVLFGEITRILNHIMAVTTHALDIGAMTPFFWMFEEREKMFEFYERVS
                     GARMHAAYIRPGGVHQDLPLGLMDDIYEFSKNFSLRIDEVEEMLTNNRIWRNRTVDIG
                     VVSAEDALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPIGSRGDCYDRYLCRV
                     EEMRQSLRIIEQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVP
                     PGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAI
                     IGTQDIVFGEIDR"
     exon            102..208
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..399
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..520
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..708
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..786
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..872
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..992
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1122
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1218
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1302
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1360
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1584
                     /gene="Ndufs2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaagatgg cggccctcag ggctgtgtgc agcctccgcg gtgtcggggc ccaggtgctg
       61 cgggccgggt ctgggattcg tctgccgagt cagcccagca gaggtgctcg gcgatggcag
      121 ccagatatag aatgggcaga gcagttttcg ggagctgtca tgtatccctc caaggaaaca
      181 gcccactgga aacctcctcc ttggaatgat gtggatgttt tgaaggagaa agtggtgacc
      241 aacgtgaccc tgaactttgg gccccagcac ccagcagctc atggagtcct gagactcgtg
      301 ctggaattga gtggagagat ggtgcggaaa tgtgaccctc acatcgggct cctacaccga
      361 ggcacggaga agctcatcga gtacaagacc tatctgcagg cccttccata ttttgaccgg
      421 ttggactatg tgtccatgat gtgtaatgaa caggcgtatt cactagctgt ggagaagttg
      481 ctaaacatcc agcctcctcc ccgggcgcag tggatccgag tgctctttgg agagatcaca
      541 cggattttaa accatatcat ggctgtcacc acacatgccc tggacattgg tgccatgacg
      601 cctttcttct ggatgtttga agaaagggag aagatgttcg agttctatga gcgggtgtct
      661 ggagcccgta tgcatgctgc ttatatccga ccaggaggag tgcaccagga cctacctctt
      721 gggcttatgg atgacattta tgaattttcc aagaacttct ctcttcggat tgatgaggtg
      781 gaggagatgc tgaccaacaa tagaatctgg cgaaatagga cagtcgacat tggggttgta
      841 tctgcagaag atgcactgaa ctatggattc agtggagtga tgctccgagg ctcaggcatc
      901 cagtgggact tgcggaagac ccagccatat gatgtttacg accaggtgga gtttgatgtt
      961 cctattggtt ctcgagggga ctgctacgat aggtatctgt gtcgtgtgga agagatgcgc
     1021 cagtcccttc gaatcatcga acagtgtctg aacaagatgc cgccggggga gatcaaggtt
     1081 gatgacgcca aagtgtcccc acctaaacga gcagagatga agacgtccat ggagtcacta
     1141 attcatcact ttaagctgta tactgagggc taccaagttc ctccaggagc cacatacacc
     1201 gccattgaag ctcctaaggg cgagtttggg gtgtacttgg tatctgatgg cagcagccga
     1261 ccttatcggt gtaagatcaa ggctcccggt tttgcccacc tggcaggttt ggacaagatg
     1321 tctaaaggac acatgctggc agatgtcgta gccatcatag gcacccagga tattgtattt
     1381 ggagaaatag accgatgagc aaaagcacag cctgtgagct cccttgcctg tcagctgctt
     1441 catcgagcga ggcctttgtg tggtgggaaa cgaggctgtg tttcagcaaa catacatgta
     1501 ctcgttgact tagctgcaca ggctttctgt gcatgtacta gaaaaggaga aattatatta
     1561 aattagccac ctttggcccc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
