LOCUS       NM_001005550            2519 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase core subunit S1
            (Ndufs1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001005550 XM_217417
VERSION     NM_001005550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Wan,S., Maitiabula,G., Wang,P., Zhang,Y., Gao,X., Zhang,L., Gao,T.
            and Wang,X.
  TITLE     Down regulation of NDUFS1 is involved in the progression of
            parenteral-nutrition-associated liver disease by increasing
            Oxidative stress
  JOURNAL   J Nutr Biochem 112, 109221 (2023)
   PUBMED   36402252
  REMARK    GeneRIF: Down regulation of NDUFS1 is involved in the progression
            of parenteral-nutrition-associated liver disease by increasing
            Oxidative stress.
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Signorile,A., Sardaro,N., De Rasmo,D., Scacco,S., Papa,F.,
            Borracci,P., Carratu,M.R. and Papa,S.
  TITLE     Rat embryo exposure to all-trans retinoic acid results in postnatal
            oxidative damage of respiratory complex I in the cerebellum
  JOURNAL   Mol Pharmacol 80 (4), 704-713 (2011)
   PUBMED   21752959
  REMARK    GeneRIF: A critical postnatal accumulation of oxidatively damaged
            respiratory complex I occurs in the cerebellum following prenatal
            exposure to all-trans retinoic acid.
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Shinmura,K., Tamaki,K., Sano,M., Nakashima-Kamimura,N., Wolf,A.M.,
            Amo,T., Ohta,S., Katsumata,Y., Fukuda,K., Ishiwata,K., Suematsu,M.
            and Adachi,T.
  TITLE     Caloric restriction primes mitochondria for ischemic stress by
            deacetylating specific mitochondrial proteins of the electron
            transport chain
  JOURNAL   Circ Res 109 (4), 396-406 (2011)
   PUBMED   21700931
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Kelly-Aubert,M., Trudel,S., Fritsch,J., Nguyen-Khoa,T.,
            Baudouin-Legros,M., Moriceau,S., Jeanson,L., Djouadi,F., Matar,C.,
            Conti,M., Ollero,M., Brouillard,F. and Edelman,A.
  TITLE     GSH monoethyl ester rescues mitochondrial defects in cystic
            fibrosis models
  JOURNAL   Hum Mol Genet 20 (14), 2745-2759 (2011)
   PUBMED   21518732
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Danielson,S.R., Held,J.M., Oo,M., Riley,R., Gibson,B.W. and
            Andersen,J.K.
  TITLE     Quantitative mapping of reversible mitochondrial Complex I cysteine
            oxidation in a Parkinson disease mouse model
  JOURNAL   J Biol Chem 286 (9), 7601-7608 (2011)
   PUBMED   21196577
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Martin,M.A., Blazquez,A., Gutierrez-Solana,L.G.,
            Fernandez-Moreira,D., Briones,P., Andreu,A.L., Garesse,R.,
            Campos,Y. and Arenas,J.
  TITLE     Leigh syndrome associated with mitochondrial complex I deficiency
            due to a novel mutation in the NDUFS1 gene
  JOURNAL   Arch Neurol 62 (4), 659-661 (2005)
   PUBMED   15824269
REFERENCE   7  (bases 1 to 2519)
  AUTHORS   Ricci,J.E., Munoz-Pinedo,C., Fitzgerald,P., Bailly-Maitre,B.,
            Perkins,G.A., Yadava,N., Scheffler,I.E., Ellisman,M.H. and
            Green,D.R.
  TITLE     Disruption of mitochondrial function during apoptosis is mediated
            by caspase cleavage of the p75 subunit of complex I of the electron
            transport chain
  JOURNAL   Cell 117 (6), 773-786 (2004)
   PUBMED   15186778
REFERENCE   8  (bases 1 to 2519)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2519)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   10 (bases 1 to 2519)
  AUTHORS   Benit,P., Chretien,D., Kadhom,N., de Lonlay-Debeney,P.,
            Cormier-Daire,V., Cabral,A., Peudenier,S., Rustin,P., Munnich,A.
            and Rotig,A.
  TITLE     Large-scale deletion and point mutations of the nuclear NDUFV1 and
            NDUFS1 genes in mitochondrial complex I deficiency
  JOURNAL   Am J Hum Genet 68 (6), 1344-1352 (2001)
   PUBMED   11349233
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081892.1.
            
            On Oct 8, 2004 this sequence version replaced XM_217417.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081892.1, AY724535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2519
                     /gene="Ndufs1"
                     /note="NADH:ubiquinone oxidoreductase core subunit S1"
                     /db_xref="GeneID:301458"
                     /db_xref="RGD:1359670"
     exon            1..57
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..123
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2246
                     /gene="Ndufs1"
                     /EC_number="7.1.1.2"
                     /note="NADH-ubiquinone oxidoreductase 75 kDa subunit,
                     mitochondrial; NADH dehydrogenase (ubiquinone) Fe-S
                     protein 1, 75kDa"
                     /codon_start=1
                     /product="NADH-ubiquinone oxidoreductase 75 kDa subunit,
                     mitochondrial precursor"
                     /protein_id="NP_001005550.1"
                     /db_xref="GeneID:301458"
                     /db_xref="RGD:1359670"
                     /translation="MLRIPVKRALIGLSKSPKGYVRSTGTAASNLIEVFVDGQSVMVE
                     PGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNI
                     LTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAV
                     EDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSEL
                     SGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPR
                     MHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFE
                     GKAVAAIAGGLVDAEALVALKDLLNKVDSDTLCTEEIFPNEGAGTDLRSNYLLNTTIA
                     GVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPK
                     ILQDIASGNHEFSKVLNAAKKPMVVLGSSALQRDDGAAILAAVSSIAQKIRVASGAAA
                     EWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRQDLPKDCFI
                     VYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIR
                     ALSEIAGITLPYDTLDQVRNRLGEVSPNLVRYDDVEEANYFQQASELAKLVDQEFLAD
                     PLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC"
     exon            124..215
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..323
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..400
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..482
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..613
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..799
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..934
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1049
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1195
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1324
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1454
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1615
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1770
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1946
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2081
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2154
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2478
                     /gene="Ndufs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtcaggg ggatccggac aaatcagcgg gacaacttgg tgagctctag aggaaagcca
       61 tcatgttaag gatacctgta aaaagggcct tgataggcct ttctaagtct cctaaaggat
      121 atgttcgatc aactggcaca gcagcaagta acttgattga agtatttgtt gatggtcagt
      181 ctgtcatggt ggaaccagga accactgtcc tgcaggcctg cgagaaggtt ggcatgcaaa
      241 tccctcgatt ctgttaccat gaaaggttgt ctgtagctgg aaattgcagg atgtgcctgg
      301 tagagattga gaaagctcca aaggttgttg ctgcttgtgc tatgcctgtt atgaagggct
      361 ggaatatcct gacaaactca gaaaaatcta agaaagccag agaaggtgtg atggagtttt
      421 tattagcaaa tcacccattg gattgtccta tttgtgacca gggaggtgaa tgtgatctac
      481 aggaccagtc catgatgttt ggaagtgata ggagccgatt tctagagggg aagcgtgctg
      541 tggaggacaa gaacattggg cccctggtaa agaccatcat gactagatgc atacagtgta
      601 cccgctgcat caggtttgca agtgaaattg caggagtaga tgatttggga acaacgggga
      661 gaggaaatga catgcaagtt ggaacataca ttgagaaaat gttcatgtct gaactgtctg
      721 ggaacatcat tgatatctgc cctgtcgggg ccctaacctc taagccttat gcctttactg
      781 cccggccttg ggaaacaaga aagacagagt ccattgatgt aatggatgca gtgggaagta
      841 acattgtggt tagcacaaga actggagagg taatgaggat tttgccaaga atgcatgaag
      901 atattaatga agaatggatc tctgataaaa ccagatttgc ctatgatgga ctgaaacggc
      961 aaagacttac cgaaccaatg gtcagaaatg aaaaggggct tttaacttat acctcctggg
     1021 aagatgcact ctctcgtgta gctggaatgt tacagagttt tgaaggcaag gctgtggcag
     1081 caattgcagg tggcttggtg gatgctgaag ccttggtagc tctgaaagat ttgcttaata
     1141 aagttgactc tgacacctta tgcactgaag agatcttccc caatgaagga gctggcacag
     1201 atttacgttc caattatctt ctcaatacca caattgccgg tgtggaagaa gcagatgttg
     1261 ttcttctagt tggtacaaat ccacgttttg aggcaccgct gtttaatgct agaatcagaa
     1321 agagctggct gcataatgac ttaaaagtgg ccctaatagg cagtccagta gacctcactt
     1381 acagatacga ccatctagga gactctccca aaattctgca agacattgct tcagggaatc
     1441 atgaattcag caaggtctta aacgcagcta aaaaaccaat ggtggtttta ggcagttctg
     1501 cactccagag agatgatggg gcagcaattc ttgcagctgt gtccagcatt gcacaaaaga
     1561 ttcgggtggc aagtggtgct gctgcagagt ggaaagttat gaatattctg cataggattg
     1621 caagccaggt agctgctttg gaccttggct ataaacctgg ggtagaagca attaggaaga
     1681 acccacccaa actgctgttt cttctgggag cagatggagg ttgtatcacc cggcaggact
     1741 tgccaaagga ttgtttcatt gtttatcaag gacatcatgg tgatgttggt gctcccatag
     1801 ctgatgttat tctcccaggg gctgcttaca cagaaaagtc tgctacttac gtcaatactg
     1861 agggcagagc tcaacaaacc aaagtagcag tgacacctcc tggcttggca agagaagact
     1921 ggaaaatcat aagagctctc tctgagattg caggtatcac tctcccatat gatactctgg
     1981 atcaagtgag aaaccgtctc ggagaagtct ctcctaacct ggttcgatat gatgatgttg
     2041 aagaagctaa ttactttcaa caagcaagtg agcttgccaa gctagtagac caggaatttc
     2101 ttgctgaccc actggttcca cctcagctaa ctataaaaga cttctatatg acagattcaa
     2161 ttagcagagc ctcacagaca atggccaagt gtgtcaaagc cgtcacagaa ggcgctcagg
     2221 cagtagagga gccatccata tgctgacaca tctatcaggg accctgtttt gctacggaca
     2281 gtaaatggac attggtgtaa cccttataag ttaacgtttt ccaacatgag tctaaatgat
     2341 gtaatattta aagttagact atgcttattt gaaaatggtg ttgcacttat caaaaatctt
     2401 ggcagtttaa aatttatgta agtgtgtgca agcattaagt agtttaataa aactatcatt
     2461 tgttctttca tgttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
