LOCUS       NM_001106360             670 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit B8
            (Ndufb8), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001106360 XM_001062275 XM_215269
VERSION     NM_001106360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 670)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 670)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 670)
  AUTHORS   Grunewald,A., Rygiel,K.A., Hepplewhite,P.D., Morris,C.M., Picard,M.
            and Turnbull,D.M.
  TITLE     Mitochondrial DNA Depletion in Respiratory Chain-Deficient
            Parkinson Disease Neurons
  JOURNAL   Ann Neurol 79 (3), 366-378 (2016)
   PUBMED   26605748
REFERENCE   4  (bases 1 to 670)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   5  (bases 1 to 670)
  AUTHORS   Funk,J.A. and Schnellmann,R.G.
  TITLE     Accelerated recovery of renal mitochondrial and tubule homeostasis
            with SIRT1/PGC-1alpha activation following ischemia-reperfusion
            injury
  JOURNAL   Toxicol Appl Pharmacol 273 (2), 345-354 (2013)
   PUBMED   24096033
REFERENCE   6  (bases 1 to 670)
  AUTHORS   Oswald,C., Krause-Buchholz,U. and Rodel,G.
  TITLE     Knockdown of human COX17 affects assembly and supramolecular
            organization of cytochrome c oxidase
  JOURNAL   J Mol Biol 389 (3), 470-479 (2009)
   PUBMED   19393246
REFERENCE   7  (bases 1 to 670)
  AUTHORS   Li,Y.J., Oliveira,S.A., Xu,P., Martin,E.R., Stenger,J.E.,
            Scherzer,C.R., Hauser,M.A., Scott,W.K., Small,G.W., Nance,M.A.,
            Watts,R.L., Hubble,J.P., Koller,W.C., Pahwa,R., Stern,M.B.,
            Hiner,B.C., Jankovic,J., Goetz,C.G., Mastaglia,F., Middleton,L.T.,
            Roses,A.D., Saunders,A.M., Schmechel,D.E., Gullans,S.R.,
            Haines,J.L., Gilbert,J.R., Vance,J.M., Pericak-Vance,M.A.,
            Hulette,C. and Welsh-Bohmer,K.A.
  TITLE     Glutathione S-transferase omega-1 modifies age-at-onset of
            Alzheimer disease and Parkinson disease
  JOURNAL   Hum Mol Genet 12 (24), 3259-3267 (2003)
   PUBMED   14570706
  REMARK    Erratum:[Hum Mol Genet. 2004 Mar 1;13(5):573]
REFERENCE   8  (bases 1 to 670)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 670)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 670)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 8, 2021 this sequence version replaced NM_001106360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217646.1, BI277451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               JAXUCZ010000001.1  253362828-253362936 c
            110-236             JAXUCZ010000001.1  253362447-253362573 c
            237-336             JAXUCZ010000001.1  253361102-253361201 c
            337-492             JAXUCZ010000001.1  253360155-253360310 c
            493-670             JAXUCZ010000001.1  253357878-253358055 c
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..670
                     /gene="Ndufb8"
                     /note="NADH:ubiquinone oxidoreductase subunit B8"
                     /db_xref="GeneID:293991"
                     /db_xref="RGD:1309129"
     exon            1..109
                     /gene="Ndufb8"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..585
                     /gene="Ndufb8"
                     /note="NADH dehydrogenase (ubiquinone) 1 beta subcomplex
                     8"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 8, mitochondrial"
                     /protein_id="NP_001099830.1"
                     /db_xref="GeneID:293991"
                     /db_xref="RGD:1309129"
                     /translation="MAASRAAALGVRWLQRTSRCVVPLEARRAFHMTKDMMPGSYPRT
                     PEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPMLPNRSQHERDPWYEWDHPDLRLNWG
                     EPIHWDLDMYIRNRVDTSPTPVSWDVMCRHLFGFVAFMVFMFWVGDMFPSYQPVGPKQ
                     YPYNNLYLERGGDPSKEPEPVVHYEI"
     exon            110..236
                     /gene="Ndufb8"
                     /inference="alignment:Splign:2.1.0"
     exon            237..336
                     /gene="Ndufb8"
                     /inference="alignment:Splign:2.1.0"
     exon            337..492
                     /gene="Ndufb8"
                     /inference="alignment:Splign:2.1.0"
     exon            493..670
                     /gene="Ndufb8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcgagcgt cggagaaggt gaagatggcg gcgtcccggg ctgcggccct gggagtccgg
       61 tggctgcaaa ggacatcccg ctgcgtggtg ccacttgagg cacggagagc cttccacatg
      121 accaaggaca tgatgccggg gtcatatcct aggaccccag aagaacgggc cgcggccgcc
      181 aagaagtata atatgcgtgt ggaagactac gagccgtacc cagatgatgg catggggtat
      241 ggtgactacc cgatgctccc taaccgctca cagcatgaga gggatccgtg gtatgaatgg
      301 gaccacccag acctcaggct gaactggggt gaaccgatac actgggacct agacatgtac
      361 atcaggaatc gtgtggacac atctcctaca ccggtttcct gggatgtcat gtgtagacat
      421 ctcttcggct ttgtggcttt catggttttc atgttctggg taggggacat gttcccttcc
      481 taccagcctg tgggtccgaa gcagtacccg tacaataatc tgtacctgga gcgaggcggt
      541 gatccttcca aagaacctga gcccgtggtt cactatgaga tctgaggagg ctccgtgggc
      601 tctcgtgccc tctgaatggg actccttgtt cctagaggtt tcaccttaat aaaatcccta
      661 ataaagctca
//
