LOCUS       NM_001106646             629 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit B6
            (Ndufb6), mRNA.
ACCESSION   NM_001106646 XM_001058166 XM_216378
VERSION     NM_001106646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 629)
  AUTHORS   Guo R, Zong S, Wu M, Gu J and Yang M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   2  (bases 1 to 629)
  AUTHORS   Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley
            MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A and
            Ryan MT.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 629)
  AUTHORS   Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A,
            Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, Duru N, He F,
            Chen M, Finkel T, Weinstein LS and Li JJ.
  TITLE     Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle
            G2/M progression
  JOURNAL   Dev Cell 29 (2), 217-232 (2014)
   PUBMED   24746669
REFERENCE   4  (bases 1 to 629)
  AUTHORS   Lomba A, Martinez JA, Garcia-Diaz DF, Paternain L, Marti A, Campion
            J and Milagro FI.
  TITLE     Weight gain induced by an isocaloric pair-fed high fat diet: a
            nutriepigenetic study on FASN and NDUFB6 gene promoters
  JOURNAL   Mol Genet Metab 101 (2-3), 273-278 (2010)
   PUBMED   20729114
  REMARK    GeneRIF: Epididymal adipose tissue expression of the fatty acid
            synthase (FASN) gene and NADH dehydrogenase (ubiquinone)
            1beta-subcomplex 6 (NDUFB6) were significantly reduced in the high
            fat diet group
REFERENCE   5  (bases 1 to 629)
  AUTHORS   Lomba A, Milagro FI, Garcia-Diaz DF, Campion J, Marzo F and
            Martinez JA.
  TITLE     A high-sucrose isocaloric pair-fed model induces obesity and
            impairs NDUFB6 gene function in rat adipose tissue
  JOURNAL   J Nutrigenet Nutrigenomics 2 (6), 267-272 (2009)
   PUBMED   20559011
  REMARK    GeneRIF: Effect of consumption of a high sucrose diet on Ndufb6
            gene function in adipose tissue.
REFERENCE   6  (bases 1 to 629)
  AUTHORS   Kruse SE, Watt WC, Marcinek DJ, Kapur RP, Schenkman KA and Palmiter
            RD.
  TITLE     Mice with mitochondrial complex I deficiency develop a fatal
            encephalomyopathy
  JOURNAL   Cell Metab 7 (4), 312-320 (2008)
   PUBMED   18396137
REFERENCE   7  (bases 1 to 629)
  AUTHORS   Wiley SE, Murphy AN, Ross SA, van der Geer P and Dixon JE.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
REFERENCE   8  (bases 1 to 629)
  AUTHORS   Vogel RO, Dieteren CE, van den Heuvel LP, Willems PH, Smeitink JA,
            Koopman WJ and Nijtmans LG.
  TITLE     Identification of mitochondrial complex I assembly intermediates by
            tracing tagged NDUFS3 demonstrates the entry point of mitochondrial
            subunits
  JOURNAL   J Biol Chem 282 (10), 7582-7590 (2007)
   PUBMED   17209039
REFERENCE   9  (bases 1 to 629)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 629)
  AUTHORS   Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF,
            Ghosh SS and Capaldi RA.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216378.4, XM_001058166.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB547407.1, CB586692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..629
                     /gene="Ndufb6"
                     /gene_synonym="DD6C4-3; DD6C4-4"
                     /note="NADH:ubiquinone oxidoreductase subunit B6"
                     /db_xref="GeneID:297990"
                     /db_xref="RGD:1311354"
     exon            1..277
                     /gene="Ndufb6"
                     /gene_synonym="DD6C4-3; DD6C4-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..484
                     /gene="Ndufb6"
                     /gene_synonym="DD6C4-3; DD6C4-4"
                     /note="NADH dehydrogenase (ubiquinone) 1 beta subcomplex,
                     6"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 6"
                     /protein_id="NP_001100116.1"
                     /db_xref="GeneID:297990"
                     /db_xref="RGD:1311354"
                     /translation="MSGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPRRMWPLE
                     RFWNNFLRDRALWKYMIFKAYRTSLFTVSHVIIPLWFVHYYVKYHVATKPYAIVGTKP
                     RIFPGDTILETGEVIPPMRDFPDKHH"
     exon            278..370
                     /gene="Ndufb6"
                     /gene_synonym="DD6C4-3; DD6C4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            371..415
                     /gene="Ndufb6"
                     /gene_synonym="DD6C4-3; DD6C4-4"
                     /inference="alignment:Splign:2.1.0"
     exon            416..629
                     /gene="Ndufb6"
                     /gene_synonym="DD6C4-3; DD6C4-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcctcaa ggtcgctttg cggagcggga tcgcgcgtaa gtgaccggcc ccaggttcgg
       61 gtgcgcgctg tcactctctg gtaagctcgc cggcgacatg tcggggtaca cgcccgatga
      121 gaagctgcgg ctgcagcagc tgcgggagct gagaaggcga tggctgaagg accaagagct
      181 gagcccccgg gagcccgtgt tgcccccgcg caggatgtgg cccctggagc gattctggaa
      241 taactttttg cgggaccggg ccctgtggaa gtacatgatc ttcaaggcgt accgcaccag
      301 tctcttcact gtttcccatg tgatcatacc tctctggttc gtccactatt acgtcaaata
      361 tcatgtggct actaaaccat atgccattgt tggcacgaag cccagaatat ttccaggtga
      421 tacaattctg gagactggag aagtaattcc accaatgaga gattttcctg ataaacatca
      481 ttgaagagct cttaaaaatt taaaaaactt gtgtaacagc acaagtatgt ttcaaaagtg
      541 ctgtatttac tgaatctatt tcctagaaaa gtaattaata aaacttattc ctgtccttgt
      601 cactgtactt gttactgtct ccgatttga
//
