LOCUS       NM_001276441            1035 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase complex assembly
            factor 6 (Ndufaf6), mRNA.
ACCESSION   NM_001276441 XM_001072347 XM_232684
VERSION     NM_001276441.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1035)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1035)
  AUTHORS   McKenzie,M., Tucker,E.J., Compton,A.G., Lazarou,M., George,C.,
            Thorburn,D.R. and Ryan,M.T.
  TITLE     Mutations in the gene encoding C8orf38 block complex I assembly by
            inhibiting production of the mitochondria-encoded subunit ND1
  JOURNAL   J Mol Biol 414 (3), 413-426 (2011)
   PUBMED   22019594
REFERENCE   3  (bases 1 to 1035)
  AUTHORS   Mckenzie,M. and Ryan,M.T.
  TITLE     Assembly factors of human mitochondrial complex I and their defects
            in disease
  JOURNAL   IUBMB Life 62 (7), 497-502 (2010)
   PUBMED   20552642
  REMARK    GeneRIF: This review summarizes the current model of human complex
            I assembly and the roles played by different assembly factors at
            early, mid, and late assembly stages. For complex I assembly to
            proceed effectively in forming the holoenzyme, a group of proteins
            termed ''assembly factors'' are required. Defects in assembly
            factors which disrupt complex I assembly may contribute to human
            disease pathogenesis.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Feb 16, 2013 this sequence version replaced
            XM_001072347.3, XM_232684.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215404.1, SRR26643429.18841.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000005.1  28969023-28969230   c
            209-308             JAXUCZ010000005.1  28966092-28966191   c
            309-431             JAXUCZ010000005.1  28963017-28963139   c
            432-488             JAXUCZ010000005.1  28959658-28959714   c
            489-591             JAXUCZ010000005.1  28954580-28954682   c
            592-725             JAXUCZ010000005.1  28953450-28953583   c
            726-827             JAXUCZ010000005.1  28951429-28951530   c
            828-884             JAXUCZ010000005.1  28947982-28948038   c
            885-1035            JAXUCZ010000005.1  28945014-28945164   c
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1035
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /note="NADH:ubiquinone oxidoreductase complex assembly
                     factor 6"
                     /db_xref="GeneID:297821"
                     /db_xref="RGD:1309085"
     exon            1..208
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1013
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /note="NADH dehydrogenase (ubiquinone) complex I, assembly
                     factor 6"
                     /codon_start=1
                     /product="NADH dehydrogenase (ubiquinone) complex I,
                     assembly factor 6 precursor"
                     /protein_id="NP_001263370.1"
                     /db_xref="GeneID:297821"
                     /db_xref="RGD:1309085"
                     /translation="MATSMLGSVPGPRPFGLAGLFRRRPPRDPWERVRRLPRLSAVRR
                     SVAAASGPGIPDSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKD
                     SVSEKTIGLMRMQFWRKAVEDMFCDNPPHQPVAMELWKAVKRHNLTKRWLLRIIDERE
                     KNLDDKAYRSIRELETYAENTQSSLLYLTLEVLGVKDVHADHAASHIGKAQGIVTCLR
                     ATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSF
                     HSRVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNTLLPLSLYIQSWRKRY"
     exon            209..308
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            309..431
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            432..488
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            489..591
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            592..725
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            726..827
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            828..884
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1035
                     /gene="Ndufaf6"
                     /gene_synonym="RGD1309085"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaaggtgt catggcgacc tccatgctgg gatcagtccc cggtccaagg ccgttcggtt
       61 tggctggtct gttccgtcgc cgaccgcctc gggatccgtg ggaacgtgtg cggcgcctgc
      121 cgaggctctc ggcagtccgg cgcagcgtgg ctgcagccag cgggccgggc atcccggatt
      181 cccacctcta ttgcctggag ctgctgagga aacgggatta tgaaagctac ttgtgttcct
      241 tactgttccc tgcagagtgt caaaggtctg cttctgcact gcgggccttc aatgtggaac
      301 tggctcaggt taaggactcg gtctctgaga aaacaattgg cctgatgcgc atgcagttct
      361 ggagaaaagc tgtggaagac atgttctgtg acaacccgcc acaccagcca gtggccatgg
      421 agctctggaa ggctgtcaag agacataacc taactaaaag gtggctcctg agaatcatcg
      481 atgaaagaga gaaaaacctg gatgacaaag cataccgcag catccgggaa cttgaaacct
      541 acgctgagaa cacgcagagt tccctgctct acctgacact ggaggtgctg ggcgtgaagg
      601 atgttcatgc agatcatgct gcaagccaca ttggaaaggc acaaggcatt gtgacatgct
      661 tgagagcaac tccctatcac agtagccgga gacaagtatt cctgcccatg gatgtgtgtg
      721 tacagcatgg tgtttcacaa gaagactttc tacggagaaa tcaagataaa aatgtgagag
      781 atgtagtata tgacattgcc agccaggcac acttgcacct aaagcatgcg aggtccttcc
      841 acagtcgcgt tcctgccgaa gcatttcctg cttttcttca gacggtttct ctagaggact
      901 atttaaagaa aatccagcga gtggactttg atatattcca tccgtcttta cagcagaaga
      961 atacgttact tccgttatct ttatatattc aatcatggag aaaaagatac taaaatgttt
     1021 tatgttgctg attta
//
