LOCUS       NM_001126371            1119 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase complex assembly
            factor 5 (Ndufaf5), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001126371 XM_001080214 XM_215857
VERSION     NM_001126371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Rhein,V.F., Carroll,J., Ding,S., Fearnley,I.M. and Walker,J.E.
  TITLE     NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of
            Human Complex I
  JOURNAL   J Biol Chem 291 (28), 14851-14860 (2016)
   PUBMED   27226634
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Sugiana,C., Pagliarini,D.J., McKenzie,M., Kirby,D.M., Salemi,R.,
            Abu-Amero,K.K., Dahl,H.H., Hutchison,W.M., Vascotto,K.A.,
            Smith,S.M., Newbold,R.F., Christodoulou,J., Calvo,S., Mootha,V.K.,
            Ryan,M.T. and Thorburn,D.R.
  TITLE     Mutation of C20orf7 disrupts complex I assembly and causes lethal
            neonatal mitochondrial disease
  JOURNAL   Am J Hum Genet 83 (4), 468-478 (2008)
   PUBMED   18940309
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166551.1.
            
            On or before May 8, 2008 this sequence version replaced
            XM_001080214.1, XM_215857.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166551.1, FQ213977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1119
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /note="NADH:ubiquinone oxidoreductase complex assembly
                     factor 5"
                     /db_xref="GeneID:296190"
                     /db_xref="RGD:1309829"
     exon            1..257
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1067
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /note="probable methyltransferase C20orf7 homolog,
                     mitochondrial; NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex assembly factor 5; NADH dehydrogenase
                     (ubiquinone) complex I, assembly factor 5; putative
                     methyltransferase NDUFAF5; arginine-hydroxylase NDUFAF5,
                     mitochondrial"
                     /codon_start=1
                     /product="arginine-hydroxylase NDUFAF5, mitochondrial
                     precursor"
                     /protein_id="NP_001119843.1"
                     /db_xref="GeneID:296190"
                     /db_xref="RGD:1309829"
                     /translation="MLRRVVLSRLYARLGGPAVSAGRGGRRGVASSVPPSGSTSPRAL
                     NIFDRELKRKQKNWAARQPEPMKFDYLKEEIGSRIADRVYDIARDFPLALDIGCGRGY
                     IAQHLNKETVGKIFQTDIAEHALKNSIETDIPTVNILADEEFLPFPENTFDLVVSSLS
                     LHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISP
                     FTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHR
                     DTMLAAAAVYREMYSNEDGSIPATYQIYHMIGWKYHDSQARPAERGSATVSFGDLARL
                     NDTMSQGKK"
     exon            258..298
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            299..362
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            363..410
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            411..514
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            515..554
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            555..752
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            753..813
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            814..897
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            898..980
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1089
                     /gene="Ndufaf5"
                     /gene_synonym="RGD1309829"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaacatg cccagctgta gcgccgcggc tagagatgct gcgacgagtc gttctttcgc
       61 gcctatacgc aaggcttgga ggtcctgctg tctctgcagg gagaggtggt cgcagggggg
      121 tcgcttccag tgttcctcct tcgggcagca cctcgcccag agctctaaac atcttcgaca
      181 gggaattgaa gaggaagcag aagaattggg ctgcccggca gcccgagccc atgaaatttg
      241 actacctgaa ggaggagatt ggaagtcgga ttgcagaccg tgtatacgac atagccagag
      301 attttcccct tgcactggac ataggatgtg gaagaggcta catagcacaa catttgaata
      361 aggagactgt gggaaagatc ttccaaacag acattgcaga acatgctttg aaaaattcca
      421 tagaaacaga tattcctact gtgaatattt tagctgatga agaattcctt cccttcccag
      481 aaaacacgtt tgacctggtg gttagcagct taagtttgca ctgggtgaat gacctcccta
      541 gagcacttga acagattcat tatgtcttaa aaccagatgg agtgtttgtt ggtgcaatgt
      601 ttggaggtga cacgctctat gaactccggt gttcactaca gttagcagag acagaaaggg
      661 aaggaggctt ttccccacac atttctcctt tcactgctgt caatgaccta gggcatctgc
      721 tgggaagagc tggcttcaac actctgactg tggatactga tgaaattcaa gttaactatc
      781 ctggaatgtt tgaattgatg gaagatttaa aagggatggg tgagagcaac tgttcttgga
      841 acagaaaagc cctgctgcac cgagacacaa tgctggcagc tgcggcggtg tacagagaaa
      901 tgtacagcaa tgaggatggt tccattcctg ccacatatca gatctaccat atgataggat
      961 ggaaatacca tgactctcag gcaaggccag ctgaaagagg ttcagcaacc gtgtcatttg
     1021 gagatctagc aagactaaat gataccatgt cacaggggaa aaaataataa acatttgatt
     1081 caattgtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
