LOCUS       NM_198783               2053 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase complex assembly
            factor 4 (Ndufaf4), mRNA.
ACCESSION   NM_198783 XM_342813
VERSION     NM_198783.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Schlehe,J.S., Journel,M.S., Taylor,K.P., Amodeo,K.D. and
            LaVoie,M.J.
  TITLE     The mitochondrial disease associated protein Ndufaf2 is dispensable
            for Complex-1 assembly but critical for the regulation of oxidative
            stress
  JOURNAL   Neurobiol Dis 58, 57-67 (2013)
   PUBMED   23702311
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Saada,A., Vogel,R.O., Hoefs,S.J., van den Brand,M.A., Wessels,H.J.,
            Willems,P.H., Venselaar,H., Shaag,A., Barghuti,F., Reish,O.,
            Shohat,M., Huynen,M.A., Smeitink,J.A., van den Heuvel,L.P. and
            Nijtmans,L.G.
  TITLE     Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4
            (C6ORF66)-interacting complex I assembly protein, cause fatal
            neonatal mitochondrial disease
  JOURNAL   Am J Hum Genet 84 (6), 718-727 (2009)
   PUBMED   19463981
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Saada,A., Edvardson,S., Rapoport,M., Shaag,A., Amry,K., Miller,C.,
            Lorberboum-Galski,H. and Elpeleg,O.
  TITLE     C6ORF66 is an assembly factor of mitochondrial complex I
  JOURNAL   Am J Hum Genet 82 (1), 32-38 (2008)
   PUBMED   18179882
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Karp,C.M., Pan,H., Zhang,M., Buckley,D.J., Schuler,L.A. and
            Buckley,A.R.
  TITLE     Identification of HRPAP20: a novel phosphoprotein that enhances
            growth and survival in hormone-responsive tumor cells
  JOURNAL   Cancer Res 64 (3), 1016-1025 (2004)
   PUBMED   14871833
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_198783.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF283900.1, SRR26360172.602501.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000005.1  43401795-43401966
            173-276             JAXUCZ010000005.1  43402229-43402332
            277-2053            JAXUCZ010000005.1  43405191-43406967
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..2053
                     /gene="Ndufaf4"
                     /gene_synonym="Hrpap20"
                     /note="NADH:ubiquinone oxidoreductase complex assembly
                     factor 4"
                     /db_xref="GeneID:362495"
                     /db_xref="RGD:735162"
     exon            1..172
                     /gene="Ndufaf4"
                     /gene_synonym="Hrpap20"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..561
                     /gene="Ndufaf4"
                     /gene_synonym="Hrpap20"
                     /note="hormone-regulated proliferation-associated protein
                     of 20 kDa homolog; hormone-regulated proliferation
                     associated protein 20; hormone-regulated
                     proliferation-associated 20 kDa protein; NADH
                     dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly
                     factor 4; NADH dehydrogenase (ubiquinone) complex I,
                     assembly factor 4"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex assembly factor 4"
                     /protein_id="NP_942078.1"
                     /db_xref="GeneID:362495"
                     /db_xref="RGD:735162"
                     /translation="MGARMTRAFRNFNVEKRAEQEISKRKPSMAPKHPSTRSLLQEHL
                     SQYPEIEEEVSRKDNKLLSLLRDVYVNSKDPVPSLPVKAIEPQQQPKEFRLPIGDQFD
                     KNIKDIPKGKITVVEALTLLNNHKLSPETWTAEKIAQEYHLELEDVNSLLKYFVTFEV
                     KIVPPEDRKAIQSK"
     exon            173..276
                     /gene="Ndufaf4"
                     /gene_synonym="Hrpap20"
                     /inference="alignment:Splign:2.1.0"
     exon            277..2053
                     /gene="Ndufaf4"
                     /gene_synonym="Hrpap20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acgtgcgtag tgaactaagg gcatcatgag gtagagatgg gggctcgcat gacccgcgcc
       61 ttcaggaact tcaacgtgga gaagcgagcg gagcaggaga tcagcaagag gaagccctcc
      121 atggcaccca agcacccttc cacccgcagt ctcctgcagg agcacctgag tcagtatcca
      181 gaaatcgagg aagaagtttc tagaaaagat aacaagctgc tgtccttact aagagatgta
      241 tatgtcaatt ccaaagatcc ggtgccttcc ttgccggtaa aagccattga accacagcaa
      301 caaccaaagg agttcagatt gccgatagga gatcaatttg acaagaatat caaggacatt
      361 cccaaaggca agatcactgt tgtagaagca ctgacccttc tcaataacca taaactctct
      421 ccagagacat ggactgctga gaaaatcgcc caggaatacc atttagaact ggaggatgta
      481 aattcccttc tcaaatattt cgttactttt gaagtcaaaa tcgttcctcc tgaagacagg
      541 aaagcaatac aatcaaagtg aagaaaatca caaaacgatt tcctatgtgc gctcccaagc
      601 tctgagtcct tgtttttcgt gtatataaat tatacaagtt actgtgattg tgattataac
      661 ttggatagcc ctttgatctc ttcaggattg ttcatataat ttttttttta atttatgtgt
      721 agttcctggc tgtatgtcag tgttgatcat gtgactgatt caatattaag tttcactttc
      781 caatttagga tggtttgttc tttggaggag acactgaaag aagagccctc cctcctgact
      841 cctataagac tggcattgtg ctagggacag ataatcagca atgagacata gtgactatat
      901 ttcccaagtg aagaaagaga gaaaactgag tgcaaaggaa gaaaaatata tattagtact
      961 caacaaaata aaaatccgtg agggttttta atgttttaaa tatgaaatca ctttttagaa
     1021 ttattattag tatctgtgac ctactagctg tctcttgaca aatagaaata ggtaacttga
     1081 aaagttttct gagaggcaat acttaagact atttgaacaa aataacttcc tttaatttag
     1141 aaatgagaga aatattaata gctaaaaata agaggatccg atttgataac caaatattta
     1201 tacctgtttt cattctagga gaaaaagtag ccagtagaag tataaaatcc ctgaagggac
     1261 ctagaaagtt actgattcat tcacttaaac tcgagtctga cacattccag tattagaatc
     1321 tcaaatgagg taatatgagt ttggttcatt ctggcatgct gtacctgtgg gttcttggcc
     1381 acattgtttg acctctctga aagtgaattt ctgtaaaagt agaactctgc ttatgtaaat
     1441 tccaggacaa cagtgaagtt aaatggcaaa aggccaggcg agcacagagt cttatagtta
     1501 aaatgggtgt ctacagaact tatgatggag ttgtctatag tttatgatgc aaggagacca
     1561 gaatttaggt tctcagaatc ctactcgtat ttttatttat tctgccaaat gaaacccatt
     1621 tcaagaggac agaatggagt tgggggaact gggcttgtcc aaattctttc aagggaacaa
     1681 acagacatat ttgcctcgag attcccctgg aaatgatgtg gaagatgaga ggaattcagc
     1741 atggtgatgg agggaggcag agtaacagcg aagaggggag atgaatggaa agtttgtaag
     1801 gtttttcaga tctaggtcca gtgaacaaac tatacctact tatttgtggt tcggtacaga
     1861 agtttaagag aacatgctaa gtctaatcat tgcaaattat attggacaat atagtcaaaa
     1921 ccatcttcct tcaattcaaa ataagtatgt gaatcagtag tactgactcg tgtttcctag
     1981 gtggttagca gatataaata cggtttctta tacggtatca caataaaatc cttccatttt
     2041 actcattagc cca
//
