LOCUS       NM_020080               1465 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase complex assembly
            factor 3 (Ndufaf3), transcript variant 1, mRNA.
ACCESSION   NM_020080
VERSION     NM_020080.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1465)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1465)
  AUTHORS   Saada,A., Vogel,R.O., Hoefs,S.J., van den Brand,M.A., Wessels,H.J.,
            Willems,P.H., Venselaar,H., Shaag,A., Barghuti,F., Reish,O.,
            Shohat,M., Huynen,M.A., Smeitink,J.A., van den Heuvel,L.P. and
            Nijtmans,L.G.
  TITLE     Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4
            (C6ORF66)-interacting complex I assembly protein, cause fatal
            neonatal mitochondrial disease
  JOURNAL   Am J Hum Genet 84 (6), 718-727 (2009)
   PUBMED   19463981
REFERENCE   3  (bases 1 to 1465)
  AUTHORS   Hammami-Hamza,S., Doussau,M., Allemand,I., Segretain,D., Gasc,J.M.
            and Finaz,C.
  TITLE     2P1, a novel male mouse cDNA specifically expressed during meiosis
  JOURNAL   Int J Dev Biol 47 (1), 71-76 (2003)
   PUBMED   12653254
REFERENCE   4  (bases 1 to 1465)
  AUTHORS   Hartmann,A.M. and Stamm,S.
  TITLE     Molecular cloning of a novel alternatively spliced nuclear protein
  JOURNAL   Biochim Biophys Acta 1353 (3), 224-230 (1997)
   PUBMED   9349717
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000008.1, BC079306.1
            and CB609164.1.
            
            On Mar 24, 2015 this sequence version replaced NM_020080.2.
            
            Summary: This gene encodes a protein that is required for assembly
            of mitochondrial NADH: ubiquinone oxidoreductase complex I, a
            multiprotein enzyme complex that is part of the oxidative
            phosphorylation pathway. In humans, mutations in this gene are
            associated with fatal neonatal mitochondrial disease and lactic
            acidosis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216095.1, BP483802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000008.1  118141688-118141723 c
            37-488              BC079306.1         1-452
            489-1052            CB609164.1         1-564
            1053-1465           BC079306.1         999-1411
FEATURES             Location/Qualifiers
     source          1..1465
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1465
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /note="NADH:ubiquinone oxidoreductase complex assembly
                     factor 3"
                     /db_xref="GeneID:56769"
                     /db_xref="RGD:708545"
     exon            1..556
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1037
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /note="isoform a is encoded by transcript variant 1;
                     nuclear protein E3-3; NADH dehydrogenase (ubiquinone) 1
                     alpha subcomplex, assembly factor 3; NADH dehydrogenase
                     (ubiquinone) complex I, assembly factor 3"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex assembly factor 3 isoform a"
                     /protein_id="NP_064465.1"
                     /db_xref="GeneID:56769"
                     /db_xref="RGD:708545"
                     /translation="MATALGFRCLYRTRPATLGRYVDRLWRSPSRGHRLSPADDELYQ
                     RTRISLLQNEFPQAVYIDSYNSRGFTINGNRVFGPCALLPQTVVQWNVGSHQDITEES
                     FSIFWMLEPRIEIVVVGTGNKTERLHSQVLQAMRQRGIAVEIQDTPNACATFNFLCHE
                     GRVTGAALIPPPGETALASSGQTTE"
     exon            557..752
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /inference="alignment:Splign:2.1.0"
     exon            753..819
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /inference="alignment:Splign:2.1.0"
     exon            820..920
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1437
                     /gene="Ndufaf3"
                     /gene_synonym="RGD708545"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggttggg gaaagcagcg atttcgagac tagctaggga aaccttagcc atccgccccg
       61 ccctcggagc ccggctctcc aaagcctggg attaagggcc tggaggctgg caccacaccc
      121 tggccaggtg ttcataacag gaccaggtgc gcagctgccc cgccctggtc cctgggagcc
      181 cgaataatgg ctgagaatcc gaggaacagg ccgtggcggt ggcctaaaca ataccctgag
      241 ggcacccgta ctagcaggtg ttttcccccc tcctccttag ggactgtcgc aggagtcctg
      301 gggcggggtg ggcgacaggt gctgacataa gaaccgcact aggggacaga ggctctctgt
      361 tctggcccac tgcgacagct aaggtgcgcg ttgccctccg ggacgcaggg gggcgctgtg
      421 gccgatttga gacagacaac tctgcccctg agaccgggtc attacgcgcc gttgcagcta
      481 tggccactgc tctaggattt cgctgccttt accgaacgcg acctgcgacg ctcggtcggt
      541 acgtcgatag gctgtggagg agcccgagtc gggggcaccg gctttctccg gctgacgatg
      601 agttatacca gcggacgcgt atctctttgc tgcaaaacga gttccctcag gccgtataca
      661 tcgacagcta caatagcaga ggtttcacta tcaacggaaa ccgcgtgttt ggaccttgtg
      721 cgctgctccc acagaccgtg gtccagtgga acgtgggatc tcatcaggat atcactgaag
      781 agagcttctc gattttctgg atgctggaac ctaggataga gattgttgtg gtgggcaccg
      841 gaaacaagac tgagcggctg cactctcaag tcctgcaggc catgaggcag cggggaattg
      901 cggtggagat acaggacacg cctaacgcct gtgccacctt caacttcctg tgccacgaag
      961 gtcgagtgac aggagctgcc ctcatccccc cacctggaga gactgcactt gcctcttctg
     1021 gtcaaaccac agagtgaacc atccagaaca gtcaaggagg gcactgagct tcgtgatctc
     1081 cccgtgcctt ccctactccc cctcttggca cactagctgt catgctcacc caggataata
     1141 atttatgatc ttcttatata ttagttgtgt tgctgggttt ggctggtgac tggggaagag
     1201 gggaagtaag ggctgttttc actcagacaa ttccctgagc ccataaaaac caggatgcag
     1261 tgttcaatat ctactttgct catgtacaga tttgaggaga ccccagtagc ttttctgact
     1321 tctttagaag tagaactaag gtctgaacta cacatggcat ggcccaaggc tgtcacaaac
     1381 gagatcatac tctgaacatg tgcgatggtg gtgagaatga aaagaattca aaattcaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaa
//
