LOCUS       NM_001399052             596 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase complex assembly
            factor 2 (Ndufaf2), mRNA.
ACCESSION   NM_001399052 XM_342191
VERSION     NM_001399052.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 596)
  AUTHORS   Schlehe,J.S., Journel,M.S., Taylor,K.P., Amodeo,K.D. and
            LaVoie,M.J.
  TITLE     The mitochondrial disease associated protein Ndufaf2 is dispensable
            for Complex-1 assembly but critical for the regulation of oxidative
            stress
  JOURNAL   Neurobiol Dis 58, 57-67 (2013)
   PUBMED   23702311
REFERENCE   2  (bases 1 to 596)
  AUTHORS   Hanzelka,K., Skalniak,L., Jura,J., Lenzen,S. and Gurgul-Convey,E.
  TITLE     Effects of the novel mitochondrial protein mimitin in
            insulin-secreting cells
  JOURNAL   Biochem J 445 (3), 349-359 (2012)
   PUBMED   22587331
  REMARK    GeneRIF: Mimitin overexpression protected INS1E pancreatic beta
            cells against cytokine-induced caspase 3 activation, mitochondrial
            membrane potential reduction and ATP production inhibition.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 30, 2021 this sequence version replaced XM_342191.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224641.1, FM063556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840130, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000002.1  41380615-41380763   c
            150-239             JAXUCZ010000002.1  41307089-41307178   c
            240-280             JAXUCZ010000002.1  41296815-41296855   c
            281-596             JAXUCZ010000002.1  41269141-41269456   c
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..596
                     /gene="Ndufaf2"
                     /gene_synonym="Ndufa12l; RGD1560158"
                     /note="NADH:ubiquinone oxidoreductase complex assembly
                     factor 2"
                     /db_xref="GeneID:361894"
                     /db_xref="RGD:1560158"
     exon            1..149
                     /gene="Ndufaf2"
                     /gene_synonym="Ndufa12l; RGD1560158"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..523
                     /gene="Ndufaf2"
                     /gene_synonym="Ndufa12l; RGD1560158"
                     /note="mimitin, mitochondrial; NADH dehydrogenase
                     (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH
                     dehydrogenase (ubiquinone) complex I, assembly factor 2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex assembly factor 2"
                     /protein_id="NP_001385981.1"
                     /db_xref="GeneID:361894"
                     /db_xref="RGD:1560158"
                     /translation="MSWWRGVVRSVWSALSREVREHVGTDHLGNKYYYVAEYKNWRGQ
                     TMREKRIVETANRTEVDYEAGDIPTEWEAWIRRKRKTPPTMEEILKNEKYREEIKIKS
                     QDFYEKDKLGKETSEELLPSPTATQIKGHASAPYFGKEEPSVVPTSTGKTFQPGSWVP
                     EDRKRQ"
     exon            150..239
                     /gene="Ndufaf2"
                     /gene_synonym="Ndufa12l; RGD1560158"
                     /inference="alignment:Splign:2.1.0"
     exon            240..280
                     /gene="Ndufaf2"
                     /gene_synonym="Ndufa12l; RGD1560158"
                     /inference="alignment:Splign:2.1.0"
     exon            281..596
                     /gene="Ndufaf2"
                     /gene_synonym="Ndufa12l; RGD1560158"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccttgag ctgcgcgcta gcatgagctg gtggcgggga gtggtgcgct ctgtttggag
       61 tgccttgtcc agggaggtaa gggagcacgt gggcacggac catctgggga acaaatacta
      121 ctacgtcgcc gagtacaaga actggagagg gcagactatg cgagagaaaa ggattgtaga
      181 aacagcaaac agaaccgagg tagactatga agcaggagac atcccaacag agtgggaagc
      241 atggataaga agaaaaagaa agactccacc tactatggag gaaatactaa agaatgaaaa
      301 atacagagaa gaaattaaaa taaaaagcca agatttttat gaaaaagata aactcggtaa
      361 agaaaccagt gaagaactct tgccttcacc tactgcaact caaattaaag ggcatgcctc
      421 tgccccctat tttgggaagg aagaaccctc agtggttccc accagcactg gcaaaacttt
      481 ccagccagga tcctgggtgc cagaagacag aaaaagacag tgaatgcact gtggtgacgt
      541 catatggtct atatggatat cgttatttta acaaataaaa agagattaaa agttga
//
