LOCUS       NM_001100752            1289 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A9
            (Ndufa9), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001100752 XM_001064382
VERSION     NM_001100752.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Lin,R., Mo,Y., Zha,H., Qu,Z., Xie,P., Zhu,Z.J., Xu,Y., Xiong,Y. and
            Guan,K.L.
  TITLE     CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis
  JOURNAL   Mol Cell 68 (1), 198-209 (2017)
   PUBMED   28985504
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   Triepels,R.H., Hanson,B.J., van den Heuvel,L.P., Sundell,L.,
            Marusich,M.F., Smeitink,J.A. and Capaldi,R.A.
  TITLE     Human complex I defects can be resolved by monoclonal antibody
            analysis into distinct subunit assembly patterns
  JOURNAL   J Biol Chem 276 (12), 8892-8897 (2001)
   PUBMED   11112787
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Loeffen,J.L., Triepels,R.H., van den Heuvel,L.P., Schuelke,M.,
            Buskens,C.A., Smeets,R.J., Trijbels,J.M. and Smeitink,J.A.
  TITLE     cDNA of eight nuclear encoded subunits of NADH:ubiquinone
            oxidoreductase: human complex I cDNA characterization completed
  JOURNAL   Biochem Biophys Res Commun 253 (2), 415-422 (1998)
   PUBMED   9878551
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Baens,M., Chaffanet,M., Cassiman,J.J., van den Berghe,H. and
            Marynen,P.
  TITLE     Construction and evaluation of a hncDNA library of human 12p
            transcribed sequences derived from a somatic cell hybrid
  JOURNAL   Genomics 16 (1), 214-218 (1993)
   PUBMED   8486360
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168777.1.
            
            On Sep 7, 2008 this sequence version replaced XM_001064382.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168777.1, FQ225095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1289
                     /gene="Ndufa9"
                     /note="NADH:ubiquinone oxidoreductase subunit A9"
                     /db_xref="GeneID:362440"
                     /db_xref="RGD:1307307"
     exon            1..62
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1147
                     /gene="Ndufa9"
                     /EC_number="7.1.1.2"
                     /note="CI-39kD; complex I-39kD; NADH-ubiquinone
                     oxidoreductase 39 kDa subunit; sperm flagella protein 3;
                     NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 9, mitochondrial"
                     /protein_id="NP_001094222.1"
                     /db_xref="GeneID:362440"
                     /db_xref="RGD:1307307"
                     /translation="MAAAVRFQVVRALPMSRPAISAAATSVFCSSSHRQLHHAVIPHG
                     KGGRSSVSGVVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDIYDTMHLRLMGDLGQ
                     LIFLEWDARDKDSIRKAVQHSNVVINLIGREWETRNFDFEDVFVNIPRAIAQASKEAG
                     VERFIHVSHLNASMKSSAKSLRSKAVGEKEVRTVFPDAIIIRPSDMFGREDRFLNHFA
                     NYRWFLAVPLVSLGFKTVKQPVYVADVSKGIANATKNPDAIGKTFAFTGPNRYLLFHL
                     VKYIFGMTHRTFIPYPLPRFVYSWIGRLFGLSPFEPWTTKDKVERIHISDVMATDLPG
                     LEDLGVQPTPLELKSIEVLRRHRTYRWLSSEIEETKPAKTVNY"
     exon            63..233
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            234..331
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            332..423
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            424..565
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            566..668
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            669..736
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            737..813
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            814..909
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            910..976
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1228
                     /gene="Ndufa9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtgggag aagatggcgg ccgccgtccg ctttcaggtt gttagagcgc ttccaatgtc
       61 acgtcctgcc atttctgcag cagccacatc tgtgttctgc agctcatccc atcgccagct
      121 tcaccatgct gtcatacctc atgggaaagg tggccgctca tccgtcagtg gagttgtggc
      181 caccgtgttc ggagcaacag gcttcctggg tcgatacgtt gtcaaccatc ttggacgaat
      241 ggggtcacaa gtgatcatac catatcggtg cgatatatat gacaccatgc accttcgtct
      301 aatgggtgac ctgggccagc ttatctttct ggagtgggat gctcgagaca aggattctat
      361 caggaaagca gtgcagcaca gcaatgtggt catcaatctc attgggcggg agtgggagac
      421 cagaaacttt gattttgagg atgtttttgt gaatattcct cgagcaatag ctcaggcatc
      481 caaggaagct ggggttgaga gattcattca tgtctcacac ttgaatgcca gtatgaagag
      541 ttctgctaag tcactgagaa gcaaggcagt gggagagaag gaagtgagaa ctgtgtttcc
      601 tgatgccatc atcatacgac catctgacat gttcggaagg gaggacaggt tcctcaacca
      661 ctttgcaaat tatcgttggt ttcttgctgt gcctctcgtt tctttgggct ttaagacagt
      721 gaaacaacca gtatatgttg cagatgtttc caaagggatt gctaacgcga ctaaaaatcc
      781 agatgccata ggaaaaacct ttgccttcac cgggccaaat cggtacctgc tcttccactt
      841 ggtgaagtac atctttggca tgacccacag gaccttcatc ccttacccct tgccacggtt
      901 tgtgtatagc tggattggca gactcttcgg gctgagtcca tttgagccct ggacaacaaa
      961 ggacaaggtg gagcggatac atatctcaga tgtgatggcg accgacctgc ccggcctgga
     1021 agatcttggc gttcagccca caccactgga gctcaagtcc atcgaggtgc tccggcgaca
     1081 tcgcacttac cgctggctgt cttctgagat cgaggaaacc aagcctgcca agacagtcaa
     1141 ctattagtgc cacccaggcc acctgtgtcc tctccagggt tttgtactga aggagggtgc
     1201 tctattaaat atccgaggat tcggtctaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
