LOCUS       NM_001130505             517 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A6
            (Ndufa6), mRNA.
ACCESSION   NM_001130505 XM_001077432 XM_235518
VERSION     NM_001130505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Alston,C.L., Heidler,J., Dibley,M.G., Kremer,L.S., Taylor,L.S.,
            Fratter,C., French,C.E., Glasgow,R.I.C., Feichtinger,R.G.,
            Delon,I., Pagnamenta,A.T., Dolling,H., Lemonde,H., Aiton,N.,
            Bjornstad,A., Henneke,L., Gartner,J., Thiele,H., Tauchmannova,K.,
            Quaghebeur,G., Houstek,J., Sperl,W., Raymond,F.L., Prokisch,H.,
            Mayr,J.A., McFarland,R., Poulton,J., Ryan,M.T., Wittig,I.,
            Henneke,M. and Taylor,R.W.
  TITLE     Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset
            Isolated Mitochondrial Complex I Deficiency
  JOURNAL   Am J Hum Genet 103 (4), 592-601 (2018)
   PUBMED   30245030
REFERENCE   3  (bases 1 to 517)
  AUTHORS   Guo,R., Zong,S., Wu,M., Gu,J. and Yang,M.
  TITLE     Architecture of Human Mitochondrial Respiratory Megacomplex
            I2III2IV2
  JOURNAL   Cell 170 (6), 1247-1257 (2017)
   PUBMED   28844695
REFERENCE   4  (bases 1 to 517)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   5  (bases 1 to 517)
  AUTHORS   Ma,S.L., Tang,N.L. and Lam,L.C.
  TITLE     Association of gene expression and methylation of UQCRC1 to the
            predisposition of Alzheimer's disease in a Chinese population
  JOURNAL   J Psychiatr Res 76, 143-147 (2016)
   PUBMED   26943237
REFERENCE   6  (bases 1 to 517)
  AUTHORS   Vogel,R.O., Dieteren,C.E., van den Heuvel,L.P., Willems,P.H.,
            Smeitink,J.A., Koopman,W.J. and Nijtmans,L.G.
  TITLE     Identification of mitochondrial complex I assembly intermediates by
            tracing tagged NDUFS3 demonstrates the entry point of mitochondrial
            subunits
  JOURNAL   J Biol Chem 282 (10), 7582-7590 (2007)
   PUBMED   17209039
REFERENCE   7  (bases 1 to 517)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 517)
  AUTHORS   Murray,J., Taylor,S.W., Zhang,B., Ghosh,S.S. and Capaldi,R.A.
  TITLE     Oxidative damage to mitochondrial complex I due to peroxynitrite:
            identification of reactive tyrosines by mass spectrometry
  JOURNAL   J Biol Chem 278 (39), 37223-37230 (2003)
   PUBMED   12857734
REFERENCE   9  (bases 1 to 517)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 27, 2008 this sequence version replaced
            XM_001077432.1, XM_235518.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM083695.1, FQ218741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132275, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..517
                     /gene="Ndufa6"
                     /note="NADH:ubiquinone oxidoreductase subunit A6"
                     /db_xref="GeneID:315167"
                     /db_xref="RGD:1309818"
     exon            1..163
                     /gene="Ndufa6"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..411
                     /gene="Ndufa6"
                     /note="NADH dehydrogenase (ubiquinone) 1 alpha subcomplex,
                     6 (B14)"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 6"
                     /protein_id="NP_001123977.1"
                     /db_xref="GeneID:315167"
                     /db_xref="RGD:1309818"
                     /translation="MAAAASGLRQAASAASTSVKPIFSRDLKEAKRRVRELYRAWYRE
                     VPNTVHLMQLDITVKQGRDKVREMFMKNAHVTDPRVVDLLVIKGKMELQETIKVWKQR
                     THIMRFFHETETPRPKDFLSKFYIGHDP"
     exon            164..279
                     /gene="Ndufa6"
                     /inference="alignment:Splign:2.1.0"
     exon            280..517
                     /gene="Ndufa6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggcttcc ttagcaagat ggcggccgcg gccagcggcc tgcgccaggc tgcttctgca
       61 gccagtacct cggtgaagcc cattttcagt cgggacctga aagaggccaa gcggagggtg
      121 cgcgagctct accgcgcttg gtaccgggag gtgccaaaca ctgtgcactt aatgcagctg
      181 gatatcacgg tgaaacaagg acgggataaa gtccgagaaa tgttcatgaa gaatgcccat
      241 gtcaccgacc ccagagtggt tgacctcctg gtcattaagg gaaagatgga gctccaggaa
      301 accattaaag tgtggaagca gcggacacac attatgcggt tcttccatga aacagaaaca
      361 ccaaggccaa aagatttctt gtccaagttc tatattggcc atgacccatg aggtcacctg
      421 atgggaaggt gcatgttaat atttaattat cttagagtac aaataaaccc attatttgat
      481 ggtcgtgata aagttgcact ggtgaaccct tttcctg
//
