LOCUS       NM_012985                546 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus NADH:ubiquinone oxidoreductase subunit A5
            (Ndufa5), mRNA.
ACCESSION   NM_012985
VERSION     NM_012985.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 546)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 546)
  AUTHORS   Stroud,D.A., Surgenor,E.E., Formosa,L.E., Reljic,B., Frazier,A.E.,
            Dibley,M.G., Osellame,L.D., Stait,T., Beilharz,T.H., Thorburn,D.R.,
            Salim,A. and Ryan,M.T.
  TITLE     Accessory subunits are integral for assembly and function of human
            mitochondrial complex I
  JOURNAL   Nature 538 (7623), 123-126 (2016)
   PUBMED   27626371
REFERENCE   3  (bases 1 to 546)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   4  (bases 1 to 546)
  AUTHORS   George,A.J., Gordon,L., Beissbarth,T., Koukoulas,I.,
            Holsinger,R.M., Perreau,V., Cappai,R., Tan,S.S., Masters,C.L.,
            Scott,H.S. and Li,Q.X.
  TITLE     A serial analysis of gene expression profile of the Alzheimer's
            disease Tg2576 mouse model
  JOURNAL   Neurotox Res 17 (4), 360-379 (2010)
   PUBMED   19760337
REFERENCE   5  (bases 1 to 546)
  AUTHORS   Brunmair,B., Staniek,K., Gras,F., Scharf,N., Althaym,A., Clara,R.,
            Roden,M., Gnaiger,E., Nohl,H., Waldhausl,W. and Furnsinn,C.
  TITLE     Thiazolidinediones, like metformin, inhibit respiratory complex I:
            a common mechanism contributing to their antidiabetic actions?
  JOURNAL   Diabetes 53 (4), 1052-1059 (2004)
   PUBMED   15047621
  REMARK    GeneRIF: inhibition of this enzyme by antidiabetics such as
            metformin may contribute to the understanding of antidiabetic
            actions.
REFERENCE   6  (bases 1 to 546)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 546)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
REFERENCE   8  (bases 1 to 546)
  AUTHORS   Kitahara,T., Takeda,N., Kubo,T. and Kiyama,H.
  TITLE     Molecular cloning of the rat NADH:ubiquinone oxidoreductase subunit
            and its up-regulation in the facial muscle after denervation:
            detected by means of differential display
  JOURNAL   Neurol Res 18 (4), 329-336 (1996)
   PUBMED   8875451
REFERENCE   9  (bases 1 to 546)
  AUTHORS   Cleeter,M.W. and Ragan,C.I.
  TITLE     The polypeptide composition of the mitochondrial NADH: ubiquinone
            reductase complex from several mammalian species
  JOURNAL   Biochem J 230 (3), 739-746 (1985)
   PUBMED   3933483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012985.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86215.1, FM055398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000004.1  53971076-53971235   c
            161-205             JAXUCZ010000004.1  53970756-53970800   c
            206-322             JAXUCZ010000004.1  53965842-53965958   c
            323-388             JAXUCZ010000004.1  53963366-53963431   c
            389-546             JAXUCZ010000004.1  53962877-53963034   c
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..546
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /note="NADH:ubiquinone oxidoreductase subunit A5"
                     /db_xref="GeneID:25488"
                     /db_xref="RGD:3155"
     exon            1..160
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..490
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /note="CI-13kD-B; complex I-13kD-B; complex I subunit B13;
                     NADH-ubiquinone oxidoreductase 13 kDa-B subunit; NADH
                     ubiquinone oxidoreductase subunit B13; NADH dehydrogenase
                     (ubiquinone) 1 alpha subcomplex 5"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 5"
                     /protein_id="NP_037117.1"
                     /db_xref="GeneID:25488"
                     /db_xref="RGD:3155"
                     /translation="MAGLVKKTTGLVGLAVCDTPHERLTILYTKILDLLKHFPKHAAY
                     RKYTEQITSEKLELVKLEPDVKKLENLLQGGEVEEVILQAEKELSLARKMLQWKPWEP
                     LVEEPPANQWKWPI"
     exon            161..205
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /inference="alignment:Splign:2.1.0"
     exon            206..322
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /inference="alignment:Splign:2.1.0"
     exon            323..388
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /inference="alignment:Splign:2.1.0"
     exon            389..546
                     /gene="Ndufa5"
                     /gene_synonym="NADHUO"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagttac ccctagcccc gcctgagagg tgggagccaa gtgctttctt gggtgacaca
       61 ggagcagctt ctacgttcga ttgagcgggc ctgggaaagg ttcccagaag gccgcgcgct
      121 ggagtctctg agcgcagtca tggcgggctt ggtgaagaag actactggcc tggtgggatt
      181 ggccgtttgc gacactccac acgagaggct aacaatattg tatacaaaga ttcttgatct
      241 tctgaagcac tttcctaaac atgcagccta cagaaagtac acagaacaga tcaccagtga
      301 gaagctggag ttggtcaaat tggaaccaga tgttaaaaaa ttagaaaact tgcttcaggg
      361 tggtgaagta gaagaggtga ttcttcaggc tgaaaaagaa ctaagtctgg caagaaaaat
      421 gttgcagtgg aagccctggg agccactggt ggaggagccc cctgctaacc agtggaagtg
      481 gccaatataa tccccgtgtc tgatgatgga tgtggatcta atgtgcaatt aaatgttctg
      541 tgatgc
//
