LOCUS       NM_001271272             943 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus NDUFA4, mitochondrial complex associated like 2
            (Ndufa4l2), mRNA.
ACCESSION   NM_001271272 XM_002726953 XM_002729801
VERSION     NM_001271272.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 943)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 943)
  AUTHORS   Liu,Y., Nie,X., Zhu,J., Wang,T., Li,Y., Wang,Q. and Sun,Z.
  TITLE     NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic
            pulmonary arterial hypertension
  JOURNAL   J Cell Mol Med 25 (2), 1221-1237 (2021)
   PUBMED   33340241
  REMARK    GeneRIF: NDUFA4L2 in smooth muscle promotes vascular remodeling in
            hypoxic pulmonary arterial hypertension.
REFERENCE   3  (bases 1 to 943)
  AUTHORS   Xu,W.N., Zheng,H.L., Yang,R.Z., Liu,T., Yu,W., Zheng,X.F., Li,B.,
            Jiang,S.D. and Jiang,L.S.
  TITLE     Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus
            cells induced by oxidative stress via the inhibition of mitophagy
  JOURNAL   Exp Mol Med 51 (11), 1-16 (2019)
   PUBMED   31740659
  REMARK    GeneRIF: The results demonstrated that the upregulation of NDUFA4L2
            ameliorated the apoptosis of NP cells by repressing excessive
            mitophagy, which ultimately alleviated IVDD. These findings show
            for the first time that NDUFA4L2 and mitophagy may be potential
            therapeutic targets for IVDD.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 943)
  AUTHORS   Li,J., Bai,C., Guo,J., Liang,W. and Long,J.
  TITLE     NDUFA4L2 protects against ischaemia/reperfusion-induced
            cardiomyocyte apoptosis and mitochondrial dysfunction by inhibiting
            complex I
  JOURNAL   Clin Exp Pharmacol Physiol 44 (7), 779-786 (2017)
   PUBMED   28429857
  REMARK    GeneRIF: NDUFA4L2 protects against H/R injury by preventing
            myocardium apoptosis and mitochondrial dysfunction via the complex
            I
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM120013.1 and JAXUCZ010000007.1.
            
            On or before Sep 13, 2012 this sequence version replaced
            XM_002726953.1, XM_002729801.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM120013.1, SRR26360172.1102300.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               FM120013.1         4-503
            501-943             JAXUCZ010000007.1  65243854-65244296
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..943
                     /gene="Ndufa4l2"
                     /note="NDUFA4, mitochondrial complex associated like 2"
                     /db_xref="GeneID:100362331"
                     /db_xref="RGD:2324558"
     exon            1..59
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..266
                     /gene="Ndufa4l2"
                     /note="NADH dehydrogenase (ubiquinone) 1 alpha subcomplex,
                     4-like 2; rCG59612-like"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 4-like 2"
                     /protein_id="NP_001258201.1"
                     /db_xref="GeneID:100362331"
                     /db_xref="RGD:2324558"
                     /translation="MAGTSLGARFYRQIKRHPGLIPMIGFICLGMGSAGLYLLRLALR
                     SPDVCWDRKNNPEPWNRMSPNDQYKFLAVSTDYKKLKKDRPDF"
     exon            60..148
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..209
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..943
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatggcagg aaccagtcta ggggcccgct tctaccggca gataaaaaga caccctgggc
       61 tcatcccaat gatcggcttc atctgcttgg gcatgggcag tgccggactc tacttgctgc
      121 ggcttgccct tcgcagccct gatgtctgct gggacagaaa gaacaaccca gagccctgga
      181 accgcatgag tcccaatgac cagtacaagt tccttgctgt ttccaccgac tacaagaagc
      241 tgaagaagga ccggcctgac ttctaaagcg ggggtggggg gtgttccatc taaatcactc
      301 ccttccaccc cttgccccag accctagggc atccgtctag caacatggtc aagcttttgc
      361 tttctgctta cacaggccag attcccacga agaaggaagg cggctccacc cccaccctcc
      421 tcccttgctc ccaggagagg aaaagcctct gaccctccgc ttgagtccca cgtgggggag
      481 ggaactcaag gcagcaggca acagtttggg ttgacccaaa aggcccaagt cagtcccctt
      541 ctcctcctgc ccctccccat gcccgactgg gtgtggcaca ggctacgtgt tgatcgtgtc
      601 tgacgtgtgc caacagcgag cagcggcctc agtgccagca acgtggcagg gcccattagt
      661 gtgagttttg agcagggttc agggcggcgt ctgcccaggc tcggctgggc tcgtcctggg
      721 tacctagccc gcctaggatg tatctctacc ctgcaatgag cttctttcct gcccaagcct
      781 gcagcctccc atcaaggaca cccctcccgc cttgcacctg ggcactcctg cggctctccc
      841 cacccctccc ttcccctgct tctctgtccc tggggatcaa acagaagcag ccgtgggcaa
      901 aatacaattt catttaacaa attgaatttg ctgcgcctgc taa
//
