LOCUS       NM_001127684             785 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus Ndufa4, mitochondrial complex associated
            (Ndufa4), mRNA.
ACCESSION   NM_001127684 XM_001056666 XM_001059983
VERSION     NM_001127684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 785)
  AUTHORS   Chen,D., Hou,Y. and Cai,X.
  TITLE     MiR-210-3p Enhances Cardiomyocyte Apoptosis and Mitochondrial
            Dysfunction by Targeting the NDUFA4 Gene in Sepsis-Induced
            Myocardial Dysfunction
  JOURNAL   Int Heart J 62 (3), 636-646 (2021)
   PUBMED   33994501
  REMARK    GeneRIF: MiR-210-3p Enhances Cardiomyocyte Apoptosis and
            Mitochondrial Dysfunction by Targeting the NDUFA4 Gene in
            Sepsis-Induced Myocardial Dysfunction.
REFERENCE   2  (bases 1 to 785)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   3  (bases 1 to 785)
  AUTHORS   Yagil,C., Varadi-Levi,R. and Yagil,Y.
  TITLE     A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha
            subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the
            development of diabetes in a rodent model
  JOURNAL   Dis Model Mech 11 (11) (2018)
   PUBMED   30361421
  REMARK    GeneRIF: a major deletion that leads to lack of expression of the
            NDUFA4 protein that has been reported to be involved in the
            activities of mitochondrial complexes I and IV.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 785)
  AUTHORS   Zong,S., Wu,M., Gu,J., Liu,T., Guo,R. and Yang,M.
  TITLE     Structure of the intact 14-subunit human cytochrome c oxidase
  JOURNAL   Cell Res 28 (10), 1026-1034 (2018)
   PUBMED   30030519
REFERENCE   5  (bases 1 to 785)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   6  (bases 1 to 785)
  AUTHORS   Barkalifa,R., Yagil,Y. and Yagil,C.
  TITLE     Sex-specific genetic dissection of diabetes in a rodent model
            identifies Ica1 and Ndufa4 as major candidate genes
  JOURNAL   Physiol Genomics 42 (3), 445-455 (2010)
   PUBMED   20530722
  REMARK    GeneRIF: Sex-specific genetic dissection of diabetes in a rodent
            model identifies Ica1 and Ndufa4 as major candidate genes.
REFERENCE   7  (bases 1 to 785)
  AUTHORS   Lamhonwah,A.M. and Tein,I.
  TITLE     Novel localization of OCTN1, an organic cation/carnitine
            transporter, to mammalian mitochondria
  JOURNAL   Biochem Biophys Res Commun 345 (4), 1315-1325 (2006)
   PUBMED   16729965
REFERENCE   8  (bases 1 to 785)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 785)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 785)
  AUTHORS   Murray,J., Zhang,B., Taylor,S.W., Oglesbee,D., Fahy,E.,
            Marusich,M.F., Ghosh,S.S. and Capaldi,R.A.
  TITLE     The subunit composition of the human NADH dehydrogenase obtained by
            rapid one-step immunopurification
  JOURNAL   J Biol Chem 278 (16), 13619-13622 (2003)
   PUBMED   12611891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, FM088467.1 and FM055502.1.
            
            On Nov 27, 2013 this sequence version replaced NM_001127684.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB568251.1, CF976278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000004.1  40975540-40975559   c
            21-285              FM088467.1         1-265
            286-602             FM055502.1         182-498
            603-785             JAXUCZ010000004.1  40968391-40968573   c
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..785
                     /gene="Ndufa4"
                     /note="Ndufa4, mitochondrial complex associated"
                     /db_xref="GeneID:681024"
                     /db_xref="RGD:1584719"
     exon            1..161
                     /gene="Ndufa4"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..368
                     /gene="Ndufa4"
                     /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
                     subunit 4; NADH dehydrogenase (ubiquinone) 1 alpha
                     subcomplex, 4; NADH:ubiquinone oxidoreductase subunit A4"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit NDUFA4"
                     /protein_id="NP_001121156.1"
                     /db_xref="GeneID:681024"
                     /db_xref="RGD:1584719"
                     /translation="MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVS
                     WDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF"
     exon            162..250
                     /gene="Ndufa4"
                     /inference="alignment:Splign:2.1.0"
     exon            251..311
                     /gene="Ndufa4"
                     /inference="alignment:Splign:2.1.0"
     exon            312..785
                     /gene="Ndufa4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtccttc aggtaggagg tcctgggtga ctttggacgt ccgctcagcc aggttgcaga
       61 agcggtttag tgtgtgtcct aatcttctct ctcggtgtag gtaggcctgt gccgcaaaca
      121 tgctccgcca gatcctcggg caagccaaga aacatcccag cttgatccct ctcttcgtgt
      181 ttattggagc agggggtact ggagcagcac tgtatgtgat gcgcttggca ttgttcaatc
      241 cagatgtcag ctgggacagg aagaataacc cagagccttg gaacaaactg ggtcccaatg
      301 aacaatataa gttctattct gtgaacgtgg actacagcaa actgaaaaaa gaaggcccag
      361 acttctaaac tgtgaagttc actgcaaagc tgcttacaat gaaggtcttt cagaagccat
      421 ccgcacaatt ttccacttaa gcaggaacta tgtctccgaa tgcatgaaat catgttgatt
      481 tttttttttg agtttattac actgatgaat aaatctctga aacttgatat gtgtcactat
      541 ttaatgctga aaattcatat gggatttgat agctaggata taagaaataa agtatcagga
      601 tttaaagaat ctcttgaatt tctctttata catttgaaag tgagacctat gctgctttaa
      661 taagggtgtg tgtgtatgtg tatataggcc cacacttgat aacttcaaac tggaaattaa
      721 agggcttctg ggaagaatat tcacgtcttt gtcaaatgaa cacaatagaa agctctggat
      781 ttctg
//
